{ "uniprot_canonical_ac": "Q13526-1", "uniprot_ac": "Q13526", "uniprot_id": "PIN1_HUMAN", "mass": { "chemical_mass": 18243.0, "monoisotopic_mass": 18243.0 }, "refseq": { "ac": "NP_006212", "name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "summary": "Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" }, "gene_names": [ { "name": "PIN1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q13526", "id": "Q13526" }, { "name": "DOD; UBL5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212", "id": "NP_006212" }, { "name": "PIN1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212", "id": "NP_006212" } ], "protein_names": [ { "name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q13526" }, { "name": "5.2.1.8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13526" }, { "name": "PPIase Pin1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13526" }, { "name": "Peptidyl-prolyl cis-trans isomerase Pin1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13526" }, { "name": "Rotamase Pin1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13526" }, { "name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212", "id": "NP_006212" }, { "name": "protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; PPIase Pin1; rotamase Pin1; protein interacting with never in mitosis A1; parvulin PIN1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212", "id": "NP_006212" } ], "function": [ { "annotation": "Key role of PIN1 in telomere maintenance and oncogenic behavior in a human glioblastoma model.", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" }, { "database": "PubMed", "id": "36960859", "url": "https://glygen.org/publication/PubMed/36960859" } ] }, { "annotation": "Mechanical Regulation of Redox Balance via the Induction of the PIN1/NRF2/ARE Axis in Pancreatic Cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" }, { "database": "PubMed", "id": "36834887", "url": "https://glygen.org/publication/PubMed/36834887" } ] }, { "annotation": "Oxygen-independent stabilization of HIF-2alpha in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" }, { "database": "PubMed", "id": "37473874", "url": "https://glygen.org/publication/PubMed/37473874" } ] }, { "annotation": "Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383).", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526#function" }, { "database": "PubMed", "id": "21497122", "url": "https://glygen.org/publication/PubMed/21497122" }, { "database": "PubMed", "id": "22608923", "url": "https://glygen.org/publication/PubMed/22608923" }, { "database": "PubMed", "id": "23623683", "url": "https://glygen.org/publication/PubMed/23623683" }, { "database": "PubMed", "id": "27561354", "url": "https://glygen.org/publication/PubMed/27561354" }, { "database": "PubMed", "id": "17828269", "url": "https://glygen.org/publication/PubMed/17828269" }, { "database": "PubMed", "id": "15664191", "url": "https://glygen.org/publication/PubMed/15664191" }, { "database": "PubMed", "id": "16644721", "url": "https://glygen.org/publication/PubMed/16644721" }, { "database": "PubMed", "id": "29686383", "url": "https://glygen.org/publication/PubMed/29686383" }, { "database": "PubMed", "id": "22033920", "url": "https://glygen.org/publication/PubMed/22033920" } ] }, { "annotation": "Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" } ] }, { "annotation": "Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex.", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" }, { "database": "PubMed", "id": "36906101", "url": "https://glygen.org/publication/PubMed/36906101" } ] }, { "annotation": "The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C theta; via a critical Phospho-Thr-Pro motif in the V3 regulatory domain. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" }, { "database": "PubMed", "id": "36969236", "url": "https://glygen.org/publication/PubMed/36969236" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 113, "end_pos": 113, "sequence_org": "C", "sequence_mut": "A", "comment": "Loss of peptidyl-prolyl cis/trans isomerase activity; decrease in DNA repair of double-strand breaks by homologous recombination slightly less efficient than that observed with wild-type protein. No effect on RBBP8/CtIP.", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "23623683", "url": "https://glygen.org/publication/PubMed/23623683" } ] }, { "start_pos": 23, "end_pos": 23, "sequence_org": "Y", "sequence_mut": "A", "comment": "Reduced affinity for KIF20B.", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "11470801", "url": "https://glygen.org/publication/PubMed/11470801" } ] }, { "start_pos": 34, "end_pos": 34, "sequence_org": "W", "sequence_mut": "A", "comment": "Loss of binding to phosphorylated target proteins, including to phosphorylated RBBP8/CtIP; decrease in DNA repair of double-strand breaks by homologous recombination less efficient than that observed with wild-type protein. Abolishes interaction with IRAK3/IRAK-M. Abolishes IL33-mediated increase of IRAK3/IRAK-M protein levels.", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "22608923", "url": "https://glygen.org/publication/PubMed/22608923" }, { "database": "PubMed", "id": "23623683", "url": "https://glygen.org/publication/PubMed/23623683" }, { "database": "PubMed", "id": "29686383", "url": "https://glygen.org/publication/PubMed/29686383" } ] }, { "start_pos": 63, "end_pos": 63, "sequence_org": "K", "sequence_mut": "A", "comment": "Loss of peptidyl-prolyl cis/trans isomerase activity. No effect on the interaction with IRAK3/IRAK-M. Abolishes IL33-mediated increase of IRAK3/IRAK-M protein levels.", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "22608923", "url": "https://glygen.org/publication/PubMed/22608923" }, { "database": "PubMed", "id": "29686383", "url": "https://glygen.org/publication/PubMed/29686383" } ] }, { "start_pos": 71, "end_pos": 71, "sequence_org": "S", "sequence_mut": "D", "comment": "Loss of peptidyl-prolyl cis/trans isomerase activity, nuclear localization and cellular function.", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "21497122", "url": "https://glygen.org/publication/PubMed/21497122" } ] }, { "start_pos": 71, "end_pos": 71, "sequence_org": "S", "sequence_mut": "E", "comment": "Loss of peptidyl-prolyl cis/trans isomerase activity, nuclear localization and cellular function.", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "21497122", "url": "https://glygen.org/publication/PubMed/21497122" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "82.46", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "79.57", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "86.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "79.46", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "96.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "85.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "75.51", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "70.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "85.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "96.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127445" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "Q13526", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13526" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, 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}, { "database": "Ensembl Peptide", "id": "ENSP00000466656.1", "url": "https://www.ensembl.org/id/ENSP00000466656.1" } ] } }, { "isoform_ac": "K7EN45-1", "url": "", "sequence": { "sequence": "XQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE", "length": 90, "header": "tr|K7EN45-1|PIN1_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1 CANONICAL=Q13526-1" }, "locus": { "chromosome": "19", "start_pos": 9849198, "end_pos": 9838599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000591777.1", "url": "https://www.ensembl.org/id/ENST00000591777.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000466780.1", "url": "https://www.ensembl.org/id/ENSP00000466780.1" } ] } }, { "isoform_ac": "K7EP26-1", "url": "", "sequence": { "sequence": "XADEEKLPPGWEKRMSRSSGENTKAQGRYITFEPRFRFESRPSVLLQPHH", "length": 50, "header": "tr|K7EP26-1|K7EP26_HUMAN Computationally mapped isoform of Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=4 SV=1 CANONICAL=Q13526-1" }, "locus": { "chromosome": "19", "start_pos": 9838464, "end_pos": 9835346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586352.5", "url": "https://www.ensembl.org/id/ENST00000586352.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467197.1", "url": "https://www.ensembl.org/id/ENSP00000467197.1" } ] } }, { "isoform_ac": "Q13526-1", "url": "", "sequence": { "sequence": "MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE", "length": 163, "header": "sp|Q13526-1|PIN1_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1 CANONICAL=Q13526-1" }, "locus": { "chromosome": "19", "start_pos": 9849196, "end_pos": 9835345, "strand": "-", 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"http://phospho.elm.eu.org/byAccession/Q13526.html" }, { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" }, { "database": "PubMed", "id": "11723108", "url": "https://glygen.org/publication/PubMed/11723108" }, { "database": "PubMed", "id": "20060900", "url": "https://glygen.org/publication/PubMed/20060900" }, { "database": "PubMed", "id": "20529865", "url": "https://glygen.org/publication/PubMed/20529865" }, { "database": "PubMed", "id": "22261503", "url": "https://glygen.org/publication/PubMed/22261503" }, { "database": "PubMed", "id": "22562304", "url": "https://glygen.org/publication/PubMed/22562304" }, { "database": "PubMed", "id": "23456038", "url": "https://glygen.org/publication/PubMed/23456038" }, { "database": "PubMed", "id": "23970419", "url": "https://glygen.org/publication/PubMed/23970419" }, { "database": "PubMed", "id": "29665256", "url": "https://glygen.org/publication/PubMed/29665256" } ], "site_lbl": "Ser16" }, { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser43" }, { "start_pos": 65, "end_pos": 65, "kinase_uniprot_canonical_ac": "P53350-1", "kinase_gene_name": "PLK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q13526", "url": "http://phospho.elm.eu.org/byAccession/Q13526.html" }, { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" }, { "database": "PubMed", "id": "16118204", "url": "https://glygen.org/publication/PubMed/16118204" } ], "site_lbl": "Ser65" }, { "start_pos": 65, "end_pos": 65, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" }, { "database": "PubMed", "id": "16118204", "url": "https://glygen.org/publication/PubMed/16118204" }, { "database": "PubMed", "id": "29665256", "url": "https://glygen.org/publication/PubMed/29665256" } ], "site_lbl": "Ser65" }, { "start_pos": 71, "end_pos": 71, "kinase_uniprot_canonical_ac": "P53355-1", "kinase_gene_name": "DAPK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" }, { "database": "PubMed", "id": "21497122", "url": "https://glygen.org/publication/PubMed/21497122" } ], "site_lbl": "Ser71" }, { "start_pos": 71, "end_pos": 71, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by DAPK1", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" }, { "database": "PubMed", "id": "21497122", "url": "https://glygen.org/publication/PubMed/21497122" }, { "database": "PubMed", "id": "24853415", "url": "https://glygen.org/publication/PubMed/24853415" }, { "database": "PubMed", "id": "25849135", "url": "https://glygen.org/publication/PubMed/25849135" }, { "database": "PubMed", "id": "29665256", "url": "https://glygen.org/publication/PubMed/29665256" }, { "database": "PubMed", "id": "29686383", "url": "https://glygen.org/publication/PubMed/29686383" } ], "site_lbl": "Ser71" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.", "journal": "Immunity", "date": "1999", "authors": "Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5668599", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5668599" } ], "reference": [ { "type": "PubMed", "id": "10072071", "url": "https://glygen.org/publication/PubMed/10072071" } ] }, { "title": "Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47(phox).", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Dang PM, Dewas C, Gaudry M, Fay M, Pedruzzi E, Gougerot-Pocidalo MA, El Benna J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5668599", "url": 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"Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "10570149", "url": "https://glygen.org/publication/PubMed/10570149" } ] }, { "title": "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.", "journal": "Nature", "date": "1999", "authors": "Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "10604467", "url": "https://glygen.org/publication/PubMed/10604467" } ] }, { "title": "Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.", "journal": "Genes & development", "date": "2000", "authors": "Chehab NH, Malikzay A, Appel M, Halazonetis TD", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "10673500", "url": "https://glygen.org/publication/PubMed/10673500" } ] }, { "title": "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.", "journal": "Genes & development", "date": "2000", "authors": "Shieh SY, Ahn J, Tamai K, Taya Y, Prives C", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "10673501", "url": "https://glygen.org/publication/PubMed/10673501" } ] }, { "title": "Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7.", "journal": "The Biochemical journal", "date": "2000", "authors": "Ciruela A, Hinchliffe KA, Divecha N, Irvine RF", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811555" } ], "reference": [ { "type": "PubMed", "id": "10698683", "url": "https://glygen.org/publication/PubMed/10698683" } ] }, { "title": "DNA damage-induced activation of p53 by the checkpoint kinase Chk2.", "journal": "Science (New York, N.Y.)", "date": "2000", "authors": "Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "10710310", "url": "https://glygen.org/publication/PubMed/10710310" } ] }, { "title": "The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.", "journal": "Journal of molecular biology", "date": "2000", "authors": "Luciani MG, Hutchins JR, Zheleva D, Hupp TR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "10884347", "url": "https://glygen.org/publication/PubMed/10884347" } ] }, { "title": "Structure of the TPR domain of p67phox in complex with Rac.GTP.", "journal": "Molecular cell", "date": "2000", "authors": "Lapouge K, Smith SJ, Walker PA, Gamblin SJ, Smerdon SJ, Rittinger K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5668599", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5668599" } ], "reference": [ { "type": "PubMed", "id": "11090627", "url": "https://glygen.org/publication/PubMed/11090627" } ] }, { "title": "A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Harty RN, Brown ME, Wang G, Huibregtse J, Hayes FP", "evidence": [ { "database": 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Gougerot-Pocidalo MA, Hurtado-Nedelec M, Dang PM, El-Benna J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5668599", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5668599" } ], "reference": [ { "type": "PubMed", "id": "25877926", "url": "https://glygen.org/publication/PubMed/25877926" } ] }, { "title": "Priming of the neutrophil respiratory burst: role in host defense and inflammation.", "journal": "Immunological reviews", "date": "2016", "authors": "El-Benna J, Hurtado-Nedelec M, Marzaioli V, Marie JC, Gougerot-Pocidalo MA, Dang PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5668599", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5668599" } ], "reference": [ { "type": "PubMed", "id": "27558335", "url": "https://glygen.org/publication/PubMed/27558335" } ] }, { "title": "Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.", "journal": "Nat. Commun.", "date": "2016", "authors": "Ferretti LP, Himmels SF, Trenner A, Walker C, von Aesch C, Eggenschwiler A, Murina O, Enchev RI, Peter M, Freire R, Porro A, Sartori AA", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "reference": [ { "type": "PubMed", "id": "27561354", "url": "https://glygen.org/publication/PubMed/27561354" } ] }, { "title": "BCR-ABL enhances the prolyl isomerase activity of Pin 1 by interacting with DAPK1 in ph(+) ALL.", "journal": "Cancer medicine", "date": "2018", "authors": "Cao WB, Yao JF, Feng SZ, He Y, Jiang EL, Zhang RL, Yang DL, Gong M, Zheng XH, Chen SL, Sun JL, Zhou LK, Han MZ", "evidence": [ { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" } ], "reference": [ { "type": "PubMed", "id": "29665256", "url": "https://glygen.org/publication/PubMed/29665256" } ] }, { "title": "The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.", "journal": "Nat. Commun.", "date": "2018", "authors": "Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "iPTMnet", "id": "Q13526", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13526" } ], "reference": [ { "type": "PubMed", "id": "29686383", "url": "https://glygen.org/publication/PubMed/29686383" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q13526", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q13526" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q13526", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q13526" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Mechanical Regulation of Redox Balance via the Induction of the PIN1/NRF2/ARE Axis in Pancreatic Cancer.", "journal": "International journal of molecular sciences", "date": "2023-02-09", "authors": "Liang Chen, Rong Zeyin, Tuerhong Abudureyimu, Meng Qingcai, Hua Jie, Liu Jiang, Zhang Bo, Wang Wei, Yu Xianjun, Shi Si, Xu Jin", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" } ], "reference": [ { "type": "PubMed", "id": "36834887", "url": "https://glygen.org/publication/PubMed/36834887" } ] }, { "title": "Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex.", "journal": "Experimental cell research", "date": "2023-04-15", "authors": "Aoyama Shunya, Kido Yuri, Kanamoto Mayu, Naito Miki, Nakanishi Mikako, Kanna Machi, Yamamotoya Takeshi, Asano Tomoichiro, Nakatsu Yusuke", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" } ], "reference": [ { "type": "PubMed", "id": "36906101", "url": "https://glygen.org/publication/PubMed/36906101" } ] }, { "title": "Key role of PIN1 in telomere maintenance and oncogenic behavior in a human glioblastoma model.", "journal": "Oncology reports", "date": "2023-05", "authors": "Maggio Juli\u00e1n, Cardama Georgina A, Armando Romina G, Balcone Lara, Sobol Natasha T, Gomez Daniel E, Mengual G\u00f3mez Diego L", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" } ], "reference": [ { "type": "PubMed", "id": "36960859", "url": "https://glygen.org/publication/PubMed/36960859" } ] }, { "title": "The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C \u03b8 via a critical Phospho-Thr-Pro motif in the V3 regulatory domain.", "journal": "Frontiers in immunology", "date": "2023", "authors": "Anto Nikhil Ponnoor, Muraleedharan Amitha, Nath Pulak Ranjan, Sun Zuoming, Keasar Chen, Livneh Etta, Braiman Alex, Altman Amnon, Kong Kok-Fai, Isakov Noah", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" } ], "reference": [ { "type": "PubMed", "id": "36969236", "url": "https://glygen.org/publication/PubMed/36969236" } ] }, { "title": "Oxygen-independent stabilization of HIF-2\u03b1 in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.", "journal": "Free radical biology & medicine", "date": "2023-10", "authors": "Guillen-Quispe Yanymee N, Kim Su-Jung, Saeidi Soma, Zhou Tianchi, Zheng Jie, Kim Seong Hoon, Fang Xizhu, Chelakkot Chaithanya, Rios-Castillo Milton E, Shin Young Kee, Surh Young-Joon", "evidence": [ { "database": "RefSeq", "id": "NP_006212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006212" } ], "reference": [ { "type": "PubMed", "id": "37473874", "url": "https://glygen.org/publication/PubMed/37473874" } ] }, { "title": "Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "O'Neill RE, Jaskunas R, Blobel G, Palese P, Moroianu J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "7559393", "url": "https://glygen.org/publication/PubMed/7559393" } ] }, { "title": "The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035307", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "negative regulation of amyloid-beta formation", "id": "GO:1902430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902430", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "negative regulation of ERK1 and ERK2 cascade", "id": "GO:0070373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of protein phosphorylation", "id": "GO:0001932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001932", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "negative regulation of cell motility", "id": "GO:2000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000146", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "positive regulation of ubiquitin-protein transferase activity", "id": "GO:0051443", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051443", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "protein peptidyl-prolyl isomerization", "id": "GO:0000413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000413", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of pathway-restricted SMAD protein phosphorylation", "id": "GO:0060393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060393", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of protein localization to nucleus", "id": "GO:1900180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900180", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of nitrogen compound metabolic process", "id": "GO:0051171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051171", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "regulation of macromolecule metabolic process", "id": "GO:0060255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060255", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "mitogen-activated protein kinase kinase binding", "id": "GO:0031434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031434", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "phosphoserine residue binding", "id": "GO:0050815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050815", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "tau protein binding", "id": "GO:0048156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048156", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "GTPase activating protein binding", "id": "GO:0032794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032794", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "phosphothreonine residue binding", "id": "GO:0050816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050816", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" }, { "name": "cis-trans isomerase activity", "id": "GO:0016859", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016859", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation (PubMed:21497122). Ser-71 is dephosphorylated upon IL33-stimulation of dendritic cells (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q13526", "url": "https://www.uniprot.org/uniprot/Q13526" }, { "database": "PubMed", "id": "21497122", "url": "https://glygen.org/publication/PubMed/21497122" }, { "database": "PubMed", "id": "Q9QUR7", "url": "https://glygen.org/publication/PubMed/Q9QUR7" } ] } ], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "M0RCP9-1", "P24368-1", "Q9QVC8-1", "P97534-1", "Q3B7U9-1", "Q66H94-1", "Q62658-1", "Q812D3-1", "O55035-1", "Q6DGG0-1", "P10111-1", "P29117-1", "G3V7V5-1", "Q5U2V1-1", "A0A0G2K869-1", "A0A8I6GGK9-1", "A0A8I6AE14-1", "A0A8I6GH88-1", "A0A8I5ZMT9-1", "Q4KLI4-1", "M0RCZ9-1", "G3V6L9-1", "A0A8I6A7U0-1", "D4AEG3-1", "Q6AYQ9-1", "A0A8I6A7W4-1", "A0A8I5ZR77-1", "A0A8I5ZPZ9-1", "A0A8I6A3L4-1", "A0A8I6AK73-1", "A0A8I6AP42-1", "A0A8I6GE67-1", "A0A8I6GJ67-1", "A0A8I6AFJ6-1", "A0A8I6GB94-1", "D3ZQF4-1", "A0A8I6A629-1", "A0A8I5ZVA3-1", "A0A8I5Y1J2-1", "A0A8I6AIC0-1", "A0A8I6ADW5-1", "F7EYK0-1", "A0A8I5ZNP3-1", "Q14318-1", "P68106-1", "Q5VVH2-1", "O75344-1", "O00170-1", "Q02790-1", "Q96AY3-1", "P0DN26-1", "O95302-1", "Q15257-1", "Q13526-1", "P62942-1", "Q9NWM8-1", "Q9NYL4-1", "P26885-1", "Q00688-1", "Q9Y680-2", "Q13451-1", "P0DN37-1", "A0A075B759-1", "Q9Y536-1", "F5H284-1", "P30414-1", "O43447-1", "Q9H2H8-1", "Q8WUA2-1", "Q9Y237-1", "A0A0B4J2A2-1", "Q08752-1", "P30405-1", "Q9Y3C6-1", "P23284-1", "P62937-1", "Q9UNP9-1", "P45877-1", "Q13427-1", "Q96BP3-1", "Q8IXY8-1", "A0A075B767-1", "Q5T1M5-1", "Q6UX04-1", "Q6P9Q6-1", "Q64378-1", "Q3ULQ2-1", "Q62446-1", "P30416-1", "Q9Z2I2-1", "O35465-1", "O54998-1", "Q9Z247-1", "P45878-1", "Q9D1M7-1", "Q61576-1", "P26883-1", "P59024-1", "Q9CXG3-1", "Q9CWW6-1", "P30415-1", "Q9QUR7-1", "Q9CR16-1", "P58389-1", "Q9D6L8-1", "P17742-1", "P24369-1", "Q8CEC6-1", "A2AR02-1", "P30412-1", "Q9D868-1", "Q9QZH3-1", "Q99KR7-1", "Q9D0W5-1", "Q9D6D8-1", "Q3TKY6-1", "P14832-1", "P20081-1", "P25719-1", "P40454-1", "Q12461-1", "P22696-1", "P47103-1", "P53691-1", "Q06205-1", "P32472-1", "P25334-1", "P23285-1", "P35176-1", "P38911-1", "P53728-1", "Q02770-1", "Q54E95-1", "Q54LG6-1", "Q54RW5-1", "Q54Z53-1", "Q554J3-1", "Q54CU3-1", "Q54G21-1", "Q54N80-1", "Q54NB6-1", "Q54SR7-1", "Q54WH6-1", "Q54Y27-1", "Q55CJ3-1", "Q55EZ0-1", "B0G119-1", "Q86J17-1", "Q54QI6-1", "Q54UR2-1", "Q9UA41-1", "Q54SM3-1", "Q9NI62-1", "Q9TW32-1", "P25007-1", "Q9V3G3-1", "P15425-1", "P54353-1", "P54397-1", "P48375-1", "Q9VL78-1", "A0A0B4K7C5-1", "Q4V5H1-1", "Q7K2I4-1", "Q8MKJ6-1", "Q9VNG7-1", "Q9VXN8-1", "Q9VGK3-1", "Q9VBU4-1", "Q9VQQ0-1", "Q9XYZ6-1", "Q7K3D4-1", "Q9W227-1", "Q9W0Q2-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] }, { "id": "R-HSA-3215251", "name": "TP53INP1 and HIPK2 bind TP53", "equation": "", "summary": "TP53INP1 (p53INP1) forms a complex with TP53 and its regulating kinase HIPK2 (Tomasini et al. 2003, Okamura et al. 2001). HIPK2 undergoes autophosphorylation in response to DNA damage, but the mechanism and the identity of autophosphorylation sites have not yet been fully elucidated (Bitomsky et al. 2013, Saul et al. 2013, Siepi et al. 2013). Autophosphorylation enables HIPK2 binding to PIN1. PIN1 likely facilitates a conformational change that enables HIPK2 to phosphorylate its targets, including TP53 (Bitomsky et al. 2013).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q13526-1", "Q9H2X6-1" ], "evidence": [ { "id": "R-HSA-3215251", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3215251" } ] }, { "id": "R-HSA-6799409", "name": "HIPK2 phosphorylates TP53", "equation": "", "summary": "HIPK2, activated by autophosphorylation in response to DNA damage, phosphorylates TP53 (p53) at serine residue S46 (D'Orazi et al. 2002, Hofmann et al. 2002). A TP53 transcriptional target TP53INP1 facilitates TP53 phosphorylation at S46 in response to double strand breaks and, together with HIPK2, promotes the transcription of TP53 apoptotic gene targets (Okamura et al. 2001, Tomasini et al. 2003).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q13526-1", "Q9H2X6-1" ], "evidence": [ { "id": "R-HSA-6799409", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6799409" } ] }, { "id": "R-HSA-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "equation": "", "summary": "Peptidyl-prolyl cis-trans isomerase PIN1 binds to PIP4K2B phosphorylated at serine residue S326. PIP4K2B is phosphorylated at S326 under conditions of cellular stress, such as increased level of reactive oxygen species (ROS). Phosphorylation of PIP4K2B at threonine residue T322 may also contribute to PIN1 binding. PIN1 induces conformational change of PIP4K2B, resulting in inactivation of PIP4K2B dimers. This enables increase of the nuclear PI5P levels. PI5P positively regulates expression of genes involved in neutralization of ROS (Keune et al. 2012).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P78356-1", "P48426-1", "Q8TBX8-1", "Q13526-1" ], "evidence": [ { "id": "R-HSA-8877692", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8877692" } ] }, { "id": "R-HSA-936380", "name": "Interaction of PIN1 with p-IRF3", "equation": "", "summary": "Two cluster of serine residues in the C-terminus of IRF3 are essential for its activation. Cluster 1, comprising Ser385 and Ser386, is essential for the formation of IRF3 dimers. The second cluster include a series of serine and threonine residues between Ser396 and Ser405. Phosphorylation of residues in both clusters has been noted in response to virus infection and dsRNA treatment, and the IKKi/TBK1 kinase complex has been shown to phosphorylate both clusters.
Yamaoka et al has shown that IRF3 is also phosphorylated on Ser339 after dsRNA stimulation, however this phosphorylation is associated with destabilization rather than activation of IRF3. This Ser339 precedes a proline residue 340 (Pro340) and this serine-proline motif acts as a binding site for the protein PIN1, a peptidyl-prolyl-isomerase. PIN1 consist of two distinct domains, a short N-terminal WW domain and a C-terminal catalytic domain. The WW domain of PIN1 is involved in binding the ser339-pro340 region. Yamaoka et al showed that exogenous expression of PIN1 suppresses IRF3 activation and type I interferon production and, conversely, that siRNA silencing of PIN1 leads to enhancement of IRF3 activation and IFNB production.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q13526-1" ], "evidence": [ { "id": "R-HSA-936380", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-936380" } ] }, { "id": "R-HSA-936462", "name": "PIN1 mediated IRF3 degradation", "equation": "", "summary": "PIN1 acts as a negative regulator of IFN induction. Its association with IRF3 leads to ubiquitin-mediated proteosomal degradation of IRF3. PIN1 on its own does not have ubiquitin activation, transfer or ligase activities. Exactly how this IRF3 degradation is achieved is unclear at present. Immunoprecipitation of ubiquitin followed by immunoblot analysis for IRF3 demonstrated that polyubiquitination of IRF3 was induced by RNA stimulation and that polyubiquitination was augmented by PIN1 expression and abrogated by expression of PIN1-specific shRNA.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q13526-1" ], "evidence": [ { "id": "R-HSA-936462", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-936462" } ] }, { "id": "R-HSA-9626816", "name": "PIN1 binds p-S345-NCF1", "equation": "", "summary": "Priming agents such as tumor necrosis factor-\u03b1 (TNF\u03b1) and toll like receptor 7 (TLR7)/TLR8 agonists induced the activation of the peptidyl-prolyl cis/trans isomerase PIN1 in human neutrophils (Boussetta T et al. 2010; Makni-Maalej K et al. 2015). PIN1 is an enzyme that binds to phosphorylated Ser\u2010Pro or Thr\u2010Pro sequences, and subsequently catalyzes their conformational changes (Liou YC et al. 2011). In intact neutrophils, PIN1 was found to bind to the neutrophil cytosol factor 1 (NCF1 or p47phox) via the phosphorylated residue of Ser345 (Boussetta T et al. 2010). PIN1 then catalyzed a conformational change of NCF1 that facilitated subsequent phosphorylation of the protein on other sites by protein kinase C (PKC) (Boussetta T et al. 2010; El-Benna J et al. 2016). Extensive phosphorylation of the subunit NCF1 (p47phox) occurs during the activation of the NADPH oxidase (NOX2) in intact cells.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q13526-1" ], "evidence": [ { "id": "R-HSA-9626816", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9626816" } ] }, { "id": "R-HSA-9626817", "name": "PKC phosphorylates NCF1", "equation": "", "summary": "Neutrophil cytosolic factor 1 (NCF1, also known as p47phox) is a component of the NADPH oxidase (NOX2) complex, which consists of six subunits (Groemping Y et al. 2003; El-Benna J et al. 2005). Two of these subunits, p22phox and gp91phox, are integral membrane proteins and form a heterodimeric flavocytochrome that constitutes the catalytic core of the enzyme. The remaining oxidase components reside in the cytosol and include the small GTPase Rac, as well as a complex of NCF4 (p40phox), NCF1, and NCF2 (p67phox) (Groemping Y et al. 2003; El-Benna J et al. 2005). In the resting state, the interaction of NCF1 (p47phox) with p22phox, and thereby translocation and NADPH oxidase activation, is prevented by an auto-inhibited conformation of NCF1 (Groemping Y et al. 2003; Yuzawa S et al. 2004). This is believed to arise from an intramolecular interaction of the SH3 domains with the C-terminal auto\u2010inhibitory region (AIR) (amino acids 292\u2010340) of NCF1 to keep the protein \u2018locked\u2019 (Groemping Y et al. 2003; El Benna J et al. 2016). Priming induced by TNF-\u03b1 or GM-CSF induces NCF1 phosphorylation on Ser345, activation of the proline isomerase PIN1, which binds to NCF1 to induce conformational changes (Boussetta T et al. 2010). This process facilitates extensive phosphorylation of NCF1 by PKC on other sites and induces full opening of NCF1 (Boussetta T et al. 2010). Phosphorylation studies showed that p47phox is phosphorylated on serines located between Ser303 and Ser379 (El Benna J et al. 1994; 2009). Most of these sites correspond to PKC consensus phosphorylation sites, and PKC\u03b1, -\u03b2, -\u03b4 and -\u03b6 were all shown to phosphorylate NCF1 (p47phox) in vitro or in human neutrophil\u2010like HL\u201060 cells (Dang PM et al. 2001; Fontayne A et al. 2002; Belambri SA et al. 2018). In vitro studies also showed that phosphorylation of p47phox induced its binding to the proline rich region (PRR) of p22phox and enhanced the binding of NCF2 (p67phox) to gp91phox (Fontayne A et al. 2002; Dang PMC et al. 2002; Boussetta T et al. 2010).

The Reactome event depicts the PKC-mediated phosphorylation of NCF1 on Ser303, Ser304, Ser320, Ser328, Ser348. However, NCF1 becomes phosphorylated by PKCs on multiple sites and the number of sites is not defined.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q05655-1", "Q13526-1", "Q05513-1", "P17252-1", "P05771-1" ], "evidence": [ { "id": "R-HSA-9626817", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9626817" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A075B759", "gene_name": "PPIAL4E", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A075B759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B759" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A075B759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B759" } ] } ] }, { "uniprot_ac": "A0A075B767", "gene_name": "PPIAL4H", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A075B767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B767" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A075B767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A075B767" } ] } ] }, { "uniprot_ac": "A0A0B4J2A2", "gene_name": "PPIAL4C", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A0B4J2A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4J2A2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A0B4J2A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4J2A2" } ] } ] }, { "uniprot_ac": "A0A0B4K7C5", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A0B4K7C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K7C5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A0B4K7C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4K7C5" } ] } ] }, { "uniprot_ac": "A0A0G2K869", "gene_name": "AABR07056556.1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A0G2K869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K869" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A0G2K869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K869" } ] } ] }, { "uniprot_ac": "A0A8I5Y1J2", "gene_name": "ENSRNOG00000067128", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5Y1J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1J2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5Y1J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1J2" } ] } ] }, { "uniprot_ac": "A0A8I5ZMT9", "gene_name": "Ppih", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT9" } ] } ] }, { "uniprot_ac": "A0A8I5ZNP3", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNP3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNP3" } ] } ] }, { "uniprot_ac": "A0A8I5ZPZ9", "gene_name": "Ptpa", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZPZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPZ9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZPZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPZ9" } ] } ] }, { "uniprot_ac": "A0A8I5ZR77", "gene_name": "ENSRNOG00000071104", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZR77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR77" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZR77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR77" } ] } ] }, { "uniprot_ac": "A0A8I5ZVA3", "gene_name": "ENSRNOG00000068459", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I5ZVA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVA3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I5ZVA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVA3" } ] } ] }, { "uniprot_ac": "A0A8I6A3L4", "gene_name": "ENSRNOG00000067890", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6A3L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A3L4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6A3L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A3L4" } ] } ] }, { "uniprot_ac": "A0A8I6A629", "gene_name": "LOC100911252", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6A629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A629" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6A629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A629" } ] } ] }, { "uniprot_ac": "A0A8I6A7U0", "gene_name": "Fkbp15", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6A7U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7U0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6A7U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7U0" } ] } ] }, { "uniprot_ac": "A0A8I6A7W4", "gene_name": "ENSRNOG00000062802", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6A7W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7W4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6A7W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7W4" } ] } ] }, { "uniprot_ac": "A0A8I6ADW5", "gene_name": "ENSRNOG00000070232", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6ADW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ADW5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6ADW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ADW5" } ] } ] }, { "uniprot_ac": "A0A8I6AE14", "gene_name": "Fkbp7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AE14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AE14" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AE14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AE14" } ] } ] }, { "uniprot_ac": "A0A8I6AFJ6", "gene_name": "ENSRNOG00000068575", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AFJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFJ6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AFJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFJ6" } ] } ] }, { "uniprot_ac": "A0A8I6AIC0", "gene_name": "ENSRNOG00000066761", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AIC0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AIC0" } ] } ] }, { "uniprot_ac": "A0A8I6AK73", "gene_name": "ENSRNOG00000065084", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AK73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK73" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AK73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK73" } ] } ] }, { "uniprot_ac": "A0A8I6AP42", "gene_name": "Ppia-ps13", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AP42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AP42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AP42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AP42" } ] } ] }, { "uniprot_ac": "A0A8I6GB94", "gene_name": "Nktr", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GB94" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GB94" } ] } ] }, { "uniprot_ac": "A0A8I6GE67", "gene_name": "ENSRNOG00000063066", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GE67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GE67" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GE67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GE67" } ] } ] }, { "uniprot_ac": "A0A8I6GGK9", "gene_name": "Ppie", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GGK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GGK9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GGK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GGK9" } ] } ] }, { "uniprot_ac": "A0A8I6GH88", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GH88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GH88" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GH88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GH88" } ] } ] }, { "uniprot_ac": "A0A8I6GJ67", "gene_name": "Pin1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ67" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ67" } ] } ] }, { "uniprot_ac": "A2AR02", "gene_name": "Ppig", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A2AR02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR02" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A2AR02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR02" } ] } ] }, { "uniprot_ac": "B0G119", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "B0G119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G119" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "B0G119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G119" } ] } ] }, { "uniprot_ac": "D3ZQF4", "gene_name": "Fkbp6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D3ZQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D3ZQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF4" } ] } ] }, { "uniprot_ac": "D4AEG3", "gene_name": "Ppil4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] } ] }, { "uniprot_ac": "F5H284", "gene_name": "PPIAL4D", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F5H284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F5H284" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F5H284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F5H284" } ] } ] }, { "uniprot_ac": "F7EYK0", "gene_name": "Fkbp5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F7EYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EYK0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F7EYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EYK0" } ] } ] }, { "uniprot_ac": "G3V6L9", "gene_name": "Fkbp3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3V6L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6L9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3V6L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6L9" } ] } ] }, { "uniprot_ac": "G3V7V5", "gene_name": "Fkbp11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] } ] }, { "uniprot_ac": "M0RCP9", "gene_name": "Pin4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "M0RCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCP9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "M0RCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCP9" } ] } ] }, { "uniprot_ac": "M0RCZ9", "gene_name": "Ppial4g", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] } ] }, { "uniprot_ac": "O00170", "gene_name": "AIP", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O00170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00170" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O00170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00170" } ] } ] }, { "uniprot_ac": "O35465", "gene_name": "Fkbp8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35465" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35465" } ] } ] }, { "uniprot_ac": "O43447", "gene_name": "PPIH", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O43447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43447" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O43447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43447" } ] } ] }, { "uniprot_ac": "O54998", "gene_name": "Fkbp7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O54998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54998" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O54998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54998" } ] } ] }, { "uniprot_ac": "O55035", "gene_name": "Ppig", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] } ] }, { "uniprot_ac": "O75344", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] } ] }, { "uniprot_ac": "O95302", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] } ] }, { "uniprot_ac": "P05771", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05771" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05771" } ] } ] }, { "uniprot_ac": "P0DN26", "gene_name": "PPIAL4F", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] } ] }, { "uniprot_ac": "P0DN37", "gene_name": "PPIAL4G", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] } ] }, { "uniprot_ac": "P10111", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] } ] }, { "uniprot_ac": "P14832", "gene_name": "CPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] } ] }, { "uniprot_ac": "P15425", "gene_name": "ninaA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P15425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15425" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P15425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15425" } ] } ] }, { "uniprot_ac": "P17252", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P17252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17252" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P17252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17252" } ] } ] }, { "uniprot_ac": "P17742", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P17742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17742" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P17742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17742" } ] } ] }, { "uniprot_ac": "P20081", "gene_name": "FPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P20081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20081" } ] } ] }, { "uniprot_ac": "P22696", "gene_name": "ESS1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P22696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22696" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P22696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22696" } ] } ] }, { "uniprot_ac": "P23284", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P23284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23284" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P23284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23284" } ] } ] }, { "uniprot_ac": "P23285", "gene_name": "CPR2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P23285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23285" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P23285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23285" } ] } ] }, { "uniprot_ac": "P24368", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24368" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24368" } ] } ] }, { "uniprot_ac": "P24369", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] } ] }, { "uniprot_ac": "P25007", "gene_name": "Cyp1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] } ] }, { "uniprot_ac": "P25334", "gene_name": "CPR4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25334" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25334" } ] } ] }, { "uniprot_ac": "P25719", "gene_name": "CPR3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25719" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25719" } ] } ] }, { "uniprot_ac": "P26883", "gene_name": "Fkbp1a", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] } ] }, { "uniprot_ac": "P26885", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] } ] }, { "uniprot_ac": "P29117", "gene_name": "Ppif", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] } ] }, { "uniprot_ac": "P30405", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] } ] }, { "uniprot_ac": "P30412", "gene_name": "Ppic", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] } ] }, { "uniprot_ac": "P30414", "gene_name": "NKTR", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30414" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30414" } ] } ] }, { "uniprot_ac": "P30415", "gene_name": "Nktr", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30415" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30415" } ] } ] }, { "uniprot_ac": "P30416", "gene_name": "Fkbp4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30416" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30416" } ] } ] }, { "uniprot_ac": "P32472", "gene_name": "FPR2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P32472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32472" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P32472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32472" } ] } ] }, { "uniprot_ac": "P35176", "gene_name": "CPR5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P35176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35176" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P35176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35176" } ] } ] }, { "uniprot_ac": "P38911", "gene_name": "FPR3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P38911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38911" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P38911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38911" } ] } ] }, { "uniprot_ac": "P40454", "gene_name": "RRD1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] } ] }, { "uniprot_ac": "P45877", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] } ] }, { "uniprot_ac": "P45878", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] } ] }, { "uniprot_ac": "P47103", "gene_name": "CPR7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] } ] }, { "uniprot_ac": "P48375", "gene_name": "Fkbp12", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] } ] }, { "uniprot_ac": "P48426", "gene_name": "PIP4K2A", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P48426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48426" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "P48426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48426" } ] } ] }, { "uniprot_ac": "P53691", "gene_name": "CPR6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] } ] }, { "uniprot_ac": "P53728", "gene_name": "CPR8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] } ] }, { "uniprot_ac": "P54353", "gene_name": "dod", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P54353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54353" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P54353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54353" } ] } ] }, { "uniprot_ac": "P54397", "gene_name": "Fkbp39", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P54397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54397" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P54397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54397" } ] } ] }, { "uniprot_ac": "P58389", "gene_name": "Ptpa", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P58389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58389" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P58389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58389" } ] } ] }, { "uniprot_ac": "P59024", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P59024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59024" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P59024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59024" } ] } ] }, { "uniprot_ac": "P62937", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] } ] }, { "uniprot_ac": "P62942", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] } ] }, { "uniprot_ac": "P68106", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] } ] }, { "uniprot_ac": "P78356", "gene_name": "PIP4K2B", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P78356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78356" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "P78356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78356" } ] } ] }, { "uniprot_ac": "P97534", "gene_name": "Fkbp1b", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P97534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97534" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P97534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97534" } ] } ] }, { "uniprot_ac": "Q00688", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q00688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00688" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q00688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00688" } ] } ] }, { "uniprot_ac": "Q02770", "gene_name": "CWC27", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q02770", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02770" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q02770", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02770" } ] } ] }, { "uniprot_ac": "Q02790", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q02790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02790" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q02790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02790" } ] } ] }, { "uniprot_ac": "Q05513", "gene_name": "PRKCZ", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05513", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05513" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05513", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05513" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06205", "gene_name": "FPR4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q06205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06205" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q06205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06205" } ] } ] }, { "uniprot_ac": "Q08752", "gene_name": "PPID", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q08752", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08752" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q08752", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08752" } ] } ] }, { "uniprot_ac": "Q12461", "gene_name": "RRD2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q12461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12461" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q12461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12461" } ] } ] }, { "uniprot_ac": "Q13427", "gene_name": "PPIG", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q13427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13427" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q13427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13427" } ] } ] }, { "uniprot_ac": "Q13451", "gene_name": "FKBP5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q13451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13451" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q13451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13451" } ] } ] }, { "uniprot_ac": "Q13526", "gene_name": "PIN1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q13526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13526" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q13526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13526" } ] } ] }, { "uniprot_ac": "Q14318", "gene_name": "FKBP8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q14318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14318" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q14318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14318" } ] } ] }, { "uniprot_ac": "Q15257", "gene_name": "PTPA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q15257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15257" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q15257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15257" } ] } ] }, { "uniprot_ac": "Q3B7U9", "gene_name": "Fkbp8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q3B7U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7U9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q3B7U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7U9" } ] } ] }, { "uniprot_ac": "Q3TKY6", "gene_name": "Cwc27", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q3TKY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TKY6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q3TKY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TKY6" } ] } ] }, { "uniprot_ac": "Q3ULQ2", "gene_name": "Pin1rt1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q3ULQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3ULQ2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q3ULQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3ULQ2" } ] } ] }, { "uniprot_ac": "Q4KLI4", "gene_name": "Ppil1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q4KLI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLI4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q4KLI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLI4" } ] } ] }, { "uniprot_ac": "Q4V5H1", "gene_name": "Dmel\\CG17266", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q4V5H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V5H1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q4V5H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V5H1" } ] } ] }, { "uniprot_ac": "Q54CU3", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CU3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CU3" } ] } ] }, { "uniprot_ac": "Q54E95", "gene_name": "ppil3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54E95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54E95" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54E95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54E95" } ] } ] }, { "uniprot_ac": "Q54G21", "gene_name": "fkbp5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54G21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G21" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54G21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G21" } ] } ] }, { "uniprot_ac": "Q54LG6", "gene_name": "flpA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54LG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LG6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54LG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LG6" } ] } ] }, { "uniprot_ac": "Q54N80", "gene_name": "fkbp3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54N80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N80" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54N80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N80" } ] } ] }, { "uniprot_ac": "Q54NB6", "gene_name": "fkbp4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NB6" } ] }, { "ec_number": "5.2.1.8", 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