{ "uniprot_canonical_ac": "Q13002-1", "uniprot_ac": "Q13002", "uniprot_id": "GRIK2_HUMAN", "mass": { "chemical_mass": 102583.0, "monoisotopic_mass": 102583.0 }, "refseq": { "ac": "NP_001159719", "name": "glutamate receptor ionotropic, kainate 2 isoform 3 precursor", "summary": "Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719" }, "gene_names": [ { "name": "GRIK2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q13002", "id": "Q13002" }, { "name": "EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6; NEDLAS", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719", "id": "NP_001159719" }, { "name": "GLUR6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q13002", "id": "Q13002" }, { "name": "GRIK2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719", "id": "NP_001159719" }, { "name": "hCG_16784", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q13002", "id": "Q13002" } ], "protein_names": [ { "name": "Glutamate receptor ionotropic, kainate 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q13002" }, { "name": "EAA4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13002" }, { "name": "Excitatory amino acid receptor 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13002" }, { "name": "GluK2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13002" }, { "name": "GluR-6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13002" }, { "name": "GluR6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13002" }, { "name": "Glutamate receptor 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q13002" }, { "name": "excitatory amino acid receptor 4; bA487F5.1; glutamate receptor 6; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; glutamate receptor form A; gluR-6; glutamate receptor ionotropic, kainate 2; GluK2(alt_5'UTR); putative NMDtranscript(cassette_171nt)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719", "id": "NP_001159719" }, { "name": "glutamate receptor ionotropic, kainate 2 isoform 3 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719", "id": "NP_001159719" } ], "function": [ { "annotation": "Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. Erratum:[Am J Hum Genet. 2021 Nov 4;108(11):2206. PMID: 34739836]", "evidence": [ { "database": "RefSeq", "id": "NP_001159719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719" }, { "database": "PubMed", "id": "34375587", "url": "https://glygen.org/publication/PubMed/34375587" } ] }, { "annotation": "Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001159719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719" } ] }, { "annotation": "Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002#function" }, { "database": "UniProtKB", "id": "P39087", "url": "https://www.uniprot.org/uniprot/P39087#function" }, { "database": "PubMed", "id": "31474366", "url": "https://glygen.org/publication/PubMed/31474366" } ] }, { "annotation": "Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002#function" }, { "database": "UniProtKB", "id": "P39087", "url": "https://www.uniprot.org/uniprot/P39087#function" }, { "database": "PubMed", "id": "28180184", "url": "https://glygen.org/publication/PubMed/28180184" } ] }, { "annotation": "Kainate receptor modulation by NETO2.", "evidence": [ { "database": "RefSeq", "id": "NP_001159719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719" }, { "database": "PubMed", "id": "34552241", "url": "https://glygen.org/publication/PubMed/34552241" } ] }, { "annotation": "Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.", "evidence": [ { "database": "UniProtKB", "id": "F8WEZ8", "url": "https://www.uniprot.org/uniprot/F8WEZ8#function" }, { "database": "UniProtKB", "id": "RU367118", "url": "https://www.uniprot.org/uniprot/RU367118#function" }, { "database": "UniProtKB", "id": "A0A804HIH6", "url": "https://www.uniprot.org/uniprot/A0A804HIH6#function" }, { "database": "UniProtKB", "id": "A0A804HI04", "url": "https://www.uniprot.org/uniprot/A0A804HI04#function" }, { "database": "UniProtKB", "id": "A0A804HKP5", "url": "https://www.uniprot.org/uniprot/A0A804HKP5#function" } ] }, { "annotation": "The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.", "evidence": [ { "database": "RefSeq", "id": "NP_001159719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159719" }, { "database": "PubMed", "id": "34730179", "url": "https://glygen.org/publication/PubMed/34730179" } ] } ], "disease": [ { "disease_id": "DOID:0081182", "recommended_name": { "id": "DOID:0081182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081182", "name": "autosomal recessive intellectual developmental disorder 6", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the ionotropic glutamate receptor-6 gene (GRIK2) on chromosome 6q16." }, "synonyms": [ { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "intellectual disability, autosomal recessive 6", "description": "Any autosomal recessive non-syndromic intellectual disability in which the cause of the disease is a mutation in the GRIK2 gene." }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "GRIK2 autosomal recessive non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "autosomal recessive non-syndromic intellectual disability caused by mutation in GRIK2", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "intellectual developmental disorder, autosomal recessive 6", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "intellectual disability, autosomal recessive 6", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "intellectual disability, autosomal recessive type 6", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "mental retardation, autosomal recessive type 6", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "MRT6", "description": "" }, { "id": "MONDO:0012614", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012614", "name": "mental retardation, autosomal recessive 6", "description": "" }, { "id": "MIM:611092", "resource": "MIM", "url": "https://www.omim.org/entry/611092", "name": "Intellectual developmental disorder, autosomal recessive 6", "description": "Intellectual developmental disorder, autosomal recessive 6" } ], "evidence": [ { "id": "611092", "database": "MIM", "url": "https://www.omim.org/entry/611092" } ] }, { "disease_id": "MONDO:0859201", "recommended_name": { "id": "MONDO:0859201", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0859201", "name": "neurodevelopmental disorder with impaired language and ataxia and with or without seizures", "description": "" }, "synonyms": [ { "id": "MIM:619580", "resource": "MIM", "url": "https://www.omim.org/entry/619580", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q13002", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13002" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13002" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q13002", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q13002" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"url": "https://www.uniprot.org/uniprot/Q13002-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q13002-5", "url": "https://www.uniprot.org/uniprot/Q13002-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q13002-6", "url": "https://www.uniprot.org/uniprot/Q13002-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q13002-7", "url": "https://www.uniprot.org/uniprot/Q13002-7", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA", "length": 908, "header": "sp|Q13002-1|GRIK2_HUMAN Isoform 1 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "isoforms": [ { "isoform_ac": "A0A0A0MRL4-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFDGVSLCRPVWSAVALCWLTTTSASWVQTILMPQLPK", "length": 74, "header": "tr|A0A0A0MRL4-1|A0A0A0MRL4_HUMAN Computationally mapped isoform of Glutamate ionotropic receptor kainate type subunit 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=4 SV=2 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101496073, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369137.8", "url": "https://www.ensembl.org/id/ENST00000369137.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000358133.5", "url": "https://www.ensembl.org/id/ENSP00000358133.5" } ] } }, { "isoform_ac": "A0A804HHV9-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFEMRQLRLRF", "length": 47, "header": "tr|A0A804HHV9-1|A0A804HHV9_HUMAN Computationally mapped isoform of Putative NMDtranscript(Cassette_171nt) OS=Homo sapiens OX=9606 GN=GRIK2 PE=2 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101620118, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000683806.1", "url": "https://www.ensembl.org/id/ENST00000683806.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506783.1", "url": "https://www.ensembl.org/id/ENSP00000506783.1" } ] } }, { "isoform_ac": "A0A804HI04-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQDVLPYCIRDYTKDMTVLSSCPKHCPPG", "length": 649, "header": "tr|A0A804HI04-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101928450, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000682222.1", "url": "https://www.ensembl.org/id/ENST00000682222.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506840.1", "url": "https://www.ensembl.org/id/ENSP00000506840.1" } ] } }, { "isoform_ac": "A0A804HIH6-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA", "length": 832, "header": "tr|A0A804HIH6-1|A0A804HIH6_HUMAN Computationally mapped isoform of Glutamate receptor OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 102068508, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000683903.1", "url": "https://www.ensembl.org/id/ENST00000683903.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000507071.1", "url": "https://www.ensembl.org/id/ENSP00000507071.1" } ] } }, { "isoform_ac": "A0A804HKP5-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGETQWK", "length": 908, "header": "tr|A0A804HKP5-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 102080197, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000681975.1", "url": "https://www.ensembl.org/id/ENST00000681975.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508014.1", "url": "https://www.ensembl.org/id/ENSP00000508014.1" } ] } }, { "isoform_ac": "A0A804HKS7-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKVPSRPSTSPGGALPETQLKHLLWEHAAPRHTAVGKAGLGLWPLLSTVS", "length": 449, "header": "tr|A0A804HKS7-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101816938, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684027.1", "url": "https://www.ensembl.org/id/ENST00000684027.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508056.1", "url": "https://www.ensembl.org/id/ENSP00000508056.1" } ] } }, { "isoform_ac": "A0A804HKU0-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGLVLMSGIIHTLATLTQTWWKTILPC", "length": 572, "header": "tr|A0A804HKU0-1|A0A804HKU0_HUMAN Computationally mapped isoform of Glutamate ionotropic receptor kainate type subunit 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101924677, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000682115.1", "url": "https://www.ensembl.org/id/ENST00000682115.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508069.1", "url": "https://www.ensembl.org/id/ENSP00000508069.1" } ] } }, { "isoform_ac": "A0A804HL10-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHDSG", "length": 511, "header": "tr|A0A804HL10-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101879026, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000683208.1", "url": "https://www.ensembl.org/id/ENST00000683208.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508151.1", "url": "https://www.ensembl.org/id/ENSP00000508151.1" } ] } }, { "isoform_ac": "F8WEZ8-1", "url": "", "sequence": { "sequence": "GGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA", "length": 870, "header": "tr|F8WEZ8-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=2 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 102068508, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369134", "url": "https://www.ensembl.org/id/ENST00000369134" }, { "database": "Ensembl Peptide", "id": "ENSP00000358130", "url": "https://www.ensembl.org/id/ENSP00000358130" } ] } }, { "isoform_ac": "G3XAD3-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTMEFHSCCPGWSAMARSQLTATSASWVQAILLPQPPE", "length": 353, "header": "tr|G3XAD3-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101744706, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000358361.7", "url": "https://www.ensembl.org/id/ENST00000358361.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000351128.3", "url": "https://www.ensembl.org/id/ENSP00000351128.3" } ] } }, { "isoform_ac": "H7BZX7-1", "url": "", "sequence": { "sequence": "CSHEMAAGILKQALAMGMMTEYYHYIFTTLTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLL", "length": 180, "header": "tr|H7BZX7-1|H7BZX7_HUMAN Computationally mapped isoform of Glutamate ionotropic receptor kainate type subunit 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101859370, "end_pos": 101676769, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000455610.5", "url": "https://www.ensembl.org/id/ENST00000455610.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000391988.1", "url": "https://www.ensembl.org/id/ENSP00000391988.1" } ] } }, { "isoform_ac": "H7C2P5-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSD", "length": 310, "header": "tr|H7C2P5-1|GRIK2_HUMAN Computationally mapped isoform of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=2 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 101799649, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684518.1", "url": "https://www.ensembl.org/id/ENST00000684518.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000507289.1", "url": "https://www.ensembl.org/id/ENSP00000507289.1" } ] } }, { "isoform_ac": "Q13002-1", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA", "length": 908, "header": "sp|Q13002-1|GRIK2_HUMAN Isoform 1 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 102068508, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000682090.1", "url": "https://www.ensembl.org/id/ENST00000682090.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508130.1", "url": "https://www.ensembl.org/id/ENSP00000508130.1" } ] } }, { "isoform_ac": "Q13002-2", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKESSIWLVPPYHPDTV", "length": 869, "header": "sp|Q13002-2|GRIK2_HUMAN Isoform 2 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 102064006, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000413795.5", "url": "https://www.ensembl.org/id/ENST00000413795.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000405596.1", "url": "https://www.ensembl.org/id/ENSP00000405596.1" } ] } }, { "isoform_ac": "Q13002-3", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARF", "length": 584, "header": "sp|Q13002-3|GRIK2_HUMAN Isoform 3 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": {} }, { "isoform_ac": "Q13002-4", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA", "length": 832, "header": "sp|Q13002-4|GRIK2_HUMAN Isoform 4 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": {} }, { "isoform_ac": "Q13002-5", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRAKTKLPQDYVFLPILESVSISTVLSSSPSSSSLSSCS", "length": 892, "header": "sp|Q13002-5|GRIK2_HUMAN Isoform 5 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": { "chromosome": "6", "start_pos": 102065910, "end_pos": 101399278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684068.1", "url": "https://www.ensembl.org/id/ENST00000684068.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508175.1", "url": "https://www.ensembl.org/id/ENSP00000508175.1" } ] } }, { "isoform_ac": "Q13002-6", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKESSIWLVPPYHPDTV", "length": 682, "header": "sp|Q13002-6|GRIK2_HUMAN Isoform 6 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": {} }, { "isoform_ac": "Q13002-7", "url": "", "sequence": { "sequence": "MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRAKTKLPQDYVFLPILESVSISTVLSSSPSSSSLSSCS", "length": 687, "header": "sp|Q13002-7|GRIK2_HUMAN Isoform 7 of Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens OX=9606 GN=GRIK2 PE=1 SV=1 CANONICAL=Q13002-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 275, "start_aa": "Asn", "end_pos": 275, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn275", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 378, "start_aa": "Asn", "end_pos": 378, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn378", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 412, "start_aa": "Asn", "end_pos": 412, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn412", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 423, "start_aa": "Asn", "end_pos": 423, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn423", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 430, "start_aa": "Asn", "end_pos": 430, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn430", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 546, "start_aa": "Asn", "end_pos": 546, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn546", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 67, "start_aa": "Asn", "end_pos": 67, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn67", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 73, "start_aa": "Asn", "end_pos": 73, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn73", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 751, "start_aa": "Asn", "end_pos": 751, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn751", "evidence": [ { "id": "Q13002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13002#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q13002", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q13002" }, { "id": "16408927", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16408927" } ] } ], "phosphorylation": [ { "start_pos": 697, "end_pos": 697, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q13002", "url": "http://phospho.elm.eu.org/byAccession/Q13002.html" }, { "database": "iPTMnet", "id": "Q13002", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002" }, { "database": "PubMed", "id": "8382377", "url": "https://glygen.org/publication/PubMed/8382377" } ], "site_lbl": "Ser697" }, { "start_pos": 715, "end_pos": 715, "kinase_uniprot_canonical_ac": "P17612-1", "kinase_gene_name": "PRKACA", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q13002", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002" }, { "database": "PubMed", "id": "8094892", "url": "https://glygen.org/publication/PubMed/8094892" } ], "site_lbl": "Ser715" }, { "start_pos": 715, "end_pos": 715, "kinase_uniprot_canonical_ac": "Q13131-1", "kinase_gene_name": "PRKAA1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q13002", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002" }, { "database": "PubMed", "id": "8094892", "url": "https://glygen.org/publication/PubMed/8094892" }, { "database": "PubMed", "id": "8163463", "url": "https://glygen.org/publication/PubMed/8163463" } ], "site_lbl": "Ser715" }, { "start_pos": 715, "end_pos": 715, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q13002", "url": "http://phospho.elm.eu.org/byAccession/Q13002.html" }, { "database": "iPTMnet", "id": "Q13002", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002" }, { "database": "PubMed", "id": "8382377", "url": "https://glygen.org/publication/PubMed/8382377" } ], "site_lbl": "Ser715" }, { "start_pos": 846, "end_pos": 846, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKC", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002" }, { "database": "iPTMnet", "id": "Q13002", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002" }, { "database": "PubMed", "id": "19920140", "url": "https://glygen.org/publication/PubMed/19920140" }, { "database": "PubMed", "id": "22808340", "url": "https://glygen.org/publication/PubMed/22808340" } ], "site_lbl": "Ser846" }, { "start_pos": 868, "end_pos": 868, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKC", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002" }, { "database": "iPTMnet", "id": "Q13002", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002" }, { "database": "PubMed", "id": "19920140", "url": "https://glygen.org/publication/PubMed/19920140" }, { "database": "PubMed", "id": "22808340", "url": "https://glygen.org/publication/PubMed/22808340" } ], "site_lbl": "Ser868" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Genomic organization of the human GRIK2 gene and characterization of multiple splicing variants.", "journal": "Gene", "date": "2001", "authors": "Barlati S., Barbon A., Vallini I.", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002" } ], "reference": [ { "type": "PubMed", "id": "11675011", "url": "https://glygen.org/publication/PubMed/11675011" } ] }, { "title": "The PDZ1 domain of SAP90. Characterization of structure and binding.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002" } ], "reference": [ { "type": "PubMed", "id": "11744724", "url": "https://glygen.org/publication/PubMed/11744724" } ] }, { "title": "Q/R site editing controls kainate receptor inhibition by membrane fatty acids.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2005", "authors": "Wilding TJ, Zhou Y, Huettner JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-451307", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-451307" } ], "reference": [ { "type": "PubMed", "id": "16221857", "url": "https://glygen.org/publication/PubMed/16221857" } ] }, { "title": "Global identification of O-GlcNAc-modified proteins.", "journal": "Analytical chemistry", "date": "2006", "authors": "Nandi A, Sprung R, Barma DK, Zhao Y, Kim SC, Falck JR, Zhao Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q13002", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q13002" } ], "reference": [ { "type": "PubMed", "id": "16408927", "url": "https://glygen.org/publication/PubMed/16408927" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.", "journal": "Am. J. Hum. 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"UniProtKB", "id": "Q13002", "url": "https://www.uniprot.org/uniprot/Q13002" } ], "reference": [ { "type": "PubMed", "id": "8034316", "url": "https://glygen.org/publication/PubMed/8034316" } ] }, { "title": "Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.", "journal": "Nature", "date": "1993", "authors": "Raymond LA, Blackstone CD, Huganir RL", "evidence": [ { "database": "iPTMnet", "id": "Q13002-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002-1" } ], "reference": [ { "type": "PubMed", "id": "8094892", "url": "https://glygen.org/publication/PubMed/8094892" } ] }, { "title": "Transmembrane topology of the glutamate receptor subunit GluR6.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Roche KW, Raymond LA, Blackstone C, Huganir RL", "evidence": [ { "database": "iPTMnet", "id": "Q13002-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13002-1" } ], 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