{ "uniprot_canonical_ac": "Q12816-1", "uniprot_ac": "Q12816", "uniprot_id": "TROP_HUMAN", "mass": { "chemical_mass": 143716.0, "monoisotopic_mass": 143716.0 }, "refseq": { "ac": "NP_001034794", "name": "trophinin isoform 5", "summary": "This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" }, "gene_names": [ { "name": "TRO", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q12816", "id": "Q12816" }, { "name": "KIAA1114", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12816", "id": "Q12816" }, { "name": "MAGE-d3; MAGED3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794", "id": "NP_001034794" }, { "name": "MAGED3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12816", "id": "Q12816" }, { "name": "TRO", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794", "id": "NP_001034794" }, { "name": "hCG_18641", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12816", "id": "Q12816" } ], "protein_names": [ { "name": "Trophinin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q12816" }, { "name": "MAGE superfamily protein; magphinin; MAGE-D3 antigen; melanoma antigen, family D, 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794", "id": "NP_001034794" }, { "name": "MAGE-D3 antigen", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q12816" }, { "name": "trophinin isoform 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794", "id": "NP_001034794" } ], "function": [ { "annotation": "Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "Q12816", "url": "https://www.uniprot.org/uniprot/Q12816#function" } ] }, { "annotation": "Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study.", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" }, { "database": "PubMed", "id": "27035766", "url": "https://glygen.org/publication/PubMed/27035766" } ] }, { "annotation": "Report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" }, { "database": "PubMed", "id": "22201876", "url": "https://glygen.org/publication/PubMed/22201876" } ] }, { "annotation": "This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" } ] }, { "annotation": "Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" }, { "database": "PubMed", "id": "34307667", "url": "https://glygen.org/publication/PubMed/34307667" } ] }, { "annotation": "When magphinin-gamma was expressed in NIH3T3 cells, cells underwent G1 arrest. These results suggest that human magphinin-gamma inhibits cell cycle progression through nuclear activity. GeneRIF: Confocal microscopy analysis of ectopically expressed magphinins revealed that magphinin-alpha and -beta localize in the cytoplasm, whereas magphinin-gamma lacking the peptide encoded by exon-3 is nuclear.", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" }, { "database": "PubMed", "id": "17559068", "url": "https://glygen.org/publication/PubMed/17559068" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "Q12816", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q12816" } ], "glycoeffect": [], "start_pos": 686, "end_pos": 686, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "X", "chr_pos": "54928780", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D686", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { 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"id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, 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"https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung 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"present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000067445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067445" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "66.77", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000067445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067445" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "74.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000067445", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000067445" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "82.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000067445", "url": 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"https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": 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"https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": 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"database": "BioXpress", "id": "Q12816", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q12816" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q12816", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q12816" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q12816" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", 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"http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "Q12816", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q12816" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": 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"https://www.ensembl.org/id/ENSP00000483142.2" } ] } }, { "isoform_ac": "B1AKE6-1", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKS", "length": 168, "header": "tr|B1AKE6-1|B1AKE6_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=8 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54923036, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416704.1", "url": "https://www.ensembl.org/id/ENST00000416704.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000404767.1", "url": "https://www.ensembl.org/id/ENSP00000404767.1" } ] } }, { "isoform_ac": "B1AKE7-1", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLP", "length": 176, "header": "tr|B1AKE7-1|B1AKE7_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54923060, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440759.5", "url": "https://www.ensembl.org/id/ENST00000440759.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000406574.1", "url": "https://www.ensembl.org/id/ENSP00000406574.1" } ] } }, { "isoform_ac": "B1AKE8-1", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRV", "length": 102, "header": "tr|B1AKE8-1|B1AKE8_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54925603, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000431115.5", "url": "https://www.ensembl.org/id/ENST00000431115.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000407996.1", "url": "https://www.ensembl.org/id/ENSP00000407996.1" } ] } }, { "isoform_ac": "B1AKF2-1", "url": "", "sequence": { "sequence": "MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALN", "length": 64, "header": "tr|B1AKF2-1|TROP_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54922856, "end_pos": 54922665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000453081.5", "url": "https://www.ensembl.org/id/ENST00000453081.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000412588.1", "url": "https://www.ensembl.org/id/ENSP00000412588.1" } ] } }, { "isoform_ac": "B1AKF3-1", "url": "", "sequence": { "sequence": "MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQI", "length": 71, "header": "tr|B1AKF3-1|B1AKF3_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54922877, "end_pos": 54922665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452830.5", "url": "https://www.ensembl.org/id/ENST00000452830.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000387676.1", "url": "https://www.ensembl.org/id/ENSP00000387676.1" } ] } }, { "isoform_ac": "B1AKF4-1", "url": "", "sequence": { "sequence": "MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLK", "length": 123, "header": "tr|B1AKF4-1|B1AKF4_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54923033, "end_pos": 54922665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000449980.1", "url": "https://www.ensembl.org/id/ENST00000449980.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000392841.1", "url": "https://www.ensembl.org/id/ENSP00000392841.1" } ] } }, { "isoform_ac": "B1AKF5-1", "url": "", "sequence": { "sequence": "MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQG", "length": 192, "header": "tr|B1AKF5-1|B1AKF5_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54923240, "end_pos": 54922665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430420.5", "url": "https://www.ensembl.org/id/ENST00000430420.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000411717.1", "url": "https://www.ensembl.org/id/ENSP00000411717.1" } ] } }, { "isoform_ac": "B1AKF6-1", "url": "", "sequence": { "sequence": "MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEH", "length": 230, "header": "tr|B1AKF6-1|B1AKF6_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54923354, "end_pos": 54922665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000411534.1", "url": "https://www.ensembl.org/id/ENST00000411534.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000388947.1", "url": "https://www.ensembl.org/id/ENSP00000388947.1" } ] } }, { "isoform_ac": "E7ERU6-1", "url": "", "sequence": { "sequence": "MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQ", "length": 121, "header": "tr|E7ERU6-1|TROP_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54923027, "end_pos": 54922665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427099.1", "url": "https://www.ensembl.org/id/ENST00000427099.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000405311.1", "url": "https://www.ensembl.org/id/ENSP00000405311.1" } ] } }, { "isoform_ac": "G5E9N2-1", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEWFQHQHWLYWRTQHQHGLQ", "length": 681, "header": "tr|G5E9N2-1|TROP_HUMAN Computationally mapped isoform of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=1 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54930797, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445561.5", "url": "https://www.ensembl.org/id/ENST00000445561.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000404794.1", "url": "https://www.ensembl.org/id/ENSP00000404794.1" } ] } }, { "isoform_ac": "Q12816-1", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG", "length": 1431, "header": "sp|Q12816-1|TROP_HUMAN Isoform 1 of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54931017, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000173898.12", "url": "https://www.ensembl.org/id/ENST00000173898.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000173898.7", "url": "https://www.ensembl.org/id/ENSP00000173898.7" } ] } }, { "isoform_ac": "Q12816-2", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEIYSPCLQIPLINCSSPSHGAKVHPWNLCPHSSQGSYGQSAEGVM", "length": 706, "header": "sp|Q12816-2|TROP_HUMAN Isoform 2 of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54931335, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000319167.12", "url": "https://www.ensembl.org/id/ENST00000319167.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000318278.8", "url": "https://www.ensembl.org/id/ENSP00000318278.8" } ] } }, { "isoform_ac": "Q12816-3", "url": "", "sequence": { "sequence": "MLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG", "length": 962, "header": "sp|Q12816-3|TROP_HUMAN Isoform 3 of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54931017, "end_pos": 54924991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420798.6", "url": "https://www.ensembl.org/id/ENST00000420798.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000405126.2", "url": "https://www.ensembl.org/id/ENSP00000405126.2" } ] } }, { "isoform_ac": "Q12816-4", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG", "length": 1034, "header": "sp|Q12816-4|TROP_HUMAN Isoform 4 of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54931017, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375041.6", "url": "https://www.ensembl.org/id/ENST00000375041.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000364181.2", "url": "https://www.ensembl.org/id/ENSP00000364181.2" } ] } }, { "isoform_ac": "Q12816-5", "url": "", "sequence": { "sequence": "MDRRNDYGYRVPLFQSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEIYSPCLQIPLINCSSPSHGAKVHPWNLCPHSSQGSYGQSAEGVM", "length": 309, "header": "sp|Q12816-5|TROP_HUMAN Isoform 5 of Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 CANONICAL=Q12816-1" }, "locus": { "chromosome": "X", "start_pos": 54931335, "end_pos": 54922247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000399736.5", "url": "https://www.ensembl.org/id/ENST00000399736.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000382641.1", "url": "https://www.ensembl.org/id/ENSP00000382641.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q12816", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q12816" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Nuclear localization of magphinins, alternative splicing products of the human trophinin gene.", "journal": "Journal of cellular biochemistry", "date": "2008", "authors": "Aoyama J, Akazawa Y, Kasahara K, Higashiyama Y, Kikuchi I, Fukumoto Y, Saburi S, Nakayama Y, Fukuda MN, Yamaguchi N", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" } ], "reference": [ { "type": "PubMed", "id": "17559068", "url": "https://glygen.org/publication/PubMed/17559068" } ] }, { "title": "Trophinin in cell adhesion and signal transduction.", "journal": "Frontiers in bioscience (Elite edition)", "date": "2012", "authors": "Fukuda MN, Sugihara K", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" } ], "reference": [ { "type": "PubMed", "id": "22201876", "url": "https://glygen.org/publication/PubMed/22201876" } ] }, { "title": "Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.", "journal": "Transl. Psychiatry", "date": "2012", "authors": "Nava C, Lamari F, Heron D, Mignot C, Rastetter A, Keren B, Cohen D, Faudet A, Bouteiller D, Gilleron M, Jacquette A, Whalen S, Afenjar A, Perisse D, Laurent C, Dupuits C, Gautier C, Gerard M, Huguet G, Caillet S, Leheup B, Leboyer M, Gillberg C, Delorme R, Bourgeron T, Brice A, Depienne C", "evidence": [ { "database": "UniProtKB", "id": "Q12816", "url": "https://www.uniprot.org/uniprot/Q12816" } ], "reference": [ { "type": "PubMed", "id": "23092983", "url": "https://glygen.org/publication/PubMed/23092983" } ] }, { "title": "Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study.", "journal": "Molecular medicine reports", "date": "2016", "authors": "Dolanbay EG, Yardimoglu M, Yalcinkaya E, Yazir Y, Aksoy A, Karaoz E, Caliskan E", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" } ], "reference": [ { "type": "PubMed", "id": "27035766", "url": "https://glygen.org/publication/PubMed/27035766" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q12816", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q12816" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.", "journal": "BioMed research international", "date": "2021", "authors": "Cai P, Lu Y, Yin Z, Wang X, Zhou X, Li Z", "evidence": [ { "database": "RefSeq", "id": "NP_001034794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034794" } ], "reference": [ { "type": "PubMed", "id": "34307667", "url": "https://glygen.org/publication/PubMed/34307667" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q12816", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q12816" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q12816", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q12816" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation.", "journal": "Genes Dev.", "date": "1995", "authors": "Sato T., Nakayama J., Fukuda M.N., Aoki D., Nozawa S., Mikami M., Klier G.", "evidence": [ { "database": "UniProtKB", "id": "Q12816", "url": "https://www.uniprot.org/uniprot/Q12816" } ], "reference": [ { "type": "PubMed", "id": "7758945", "url": "https://glygen.org/publication/PubMed/7758945" } ] } ], "pathway": [ { "id": "hsa:7216", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7216", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6DIC6-1", "protein_name": "Trophinin", "gene_name": "Tro", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRRNDHGHRVPTFQGPLPPAGSLGLPFSPDVQSETTEKDPPIASRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPMFTQISQASATTEAPNIQASVTSQTQKAKTMRVTPKVSLTGSEDATTQLKPPLQALNLPVTTPTIQTPVANESANSLASTAVNKSKKASTANNAANKTVPSAAEISLASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTNTDNEYVEASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGSRARKAANKNRATESQAQIAEQGAQASEASISALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHPNGEERTGNNYRRIPWGRRLPPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLKDVIQEYEDYFPEIIERASYALEKMFRVNLKEIDKQNNLYILISTQESSAGIMGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLHPGVKHSLFGEVKKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACKVQKKDPKDWAAQYREAVEMDIQAAAVAVAEAKARAEARAQMGIGEEAVAGPWNWDDMDINCLTREELGDDAQAWSRFSFEIEPRAQENADPTTNVLFNQGATTRNSFSDGAGISFGGITNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGRNSITFGSVPNTSANFSSAPSISFGDTPNTSTSFSGGANSSFSGTPSTSAPFCNTASISFGGAPSTSTSFSTASISFGGAPSTSTSLSTASISFGGAPSTSTSFSTASISFGGAPSTSTSLSTASISFGGAPSINSSSGGSSVSFGGAPTTSTSFSGGPCISFGGAPCTTASISGGASSGFGSTLCSTNPGFSALSTNTSFGSAPTTSTVFSGAVSTTTGFGGTLSTSVCFGSSPYSGAGFGGTLSTSISFGGSPSTNTGFGGTLSTSVSFGASSSTSSDFGGTLSTSVSFGGSSGANAGFGGTLNSSTSFGGAISTSTGFGSALNNSANFGGAISTSFSGVLNSSASFGGAINTSAGFGSTLNSSASFGSALSTSASFGGVLNGSAGFGGALNTNATFGGVLNGSAGFGGAMNTNATFGGALNSNAGFGGAISTSTNFGGALNNSAGFGGAMNTSASFGGALNNSAGFGGAISTNATFGGALNNSAGFGGAISTNATFGGALNNSAGFGGAISTSASFGGTLNNSASFGGAINTSASFGGVLNNSAGFGGAINTSANFGGALTNSAGFGGAISTSASFGGALNNSAGFGGAISTSASFGGALNNSAGFGGAISTNASFGGAISNSPDFGGAFSTSVGFGGTLNTTDFGSTHSNSISFGSAPTTSVSFGGSHSTNLCFGGAPSTSLCFGSASNTNLCFGGSNSTNCFSGATSANFNEGHSISFGNGLSTSAGFGNGLGTSAGFGSSLGTSTGFGGSLGPSASFNGGLGTSTGFGGGLGTSTDFSGGLNHNADFNGGLGNSAGFNGGLNTNTDFGGELGTSAGFGDGLGSSTSFGAGLVTSDGFAGNLGTNTGFGGTLGTGAGFSVSLNNGNGFGNGPNASFNRGLNTIIGFGSGSNTSNGFTGEPNTGSSFSNGPSSIVGFSGGPSTGAGFCSGPSTGGFGGGPSTGPGFGGPSTGPGFGGPSTGGGFGGPNTGGGFGGPSTGGGFGGPSTGGGFGGPSTGGGFGGPSTAAGFGSGLSTSTGFGGGLNTSAGFSGGPPSTGTGFGGGASSHGGCGFPYG", 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