{ "uniprot_canonical_ac": "Q12418-1", "uniprot_ac": "Q12418", "uniprot_id": "GIS3_YEAST", "mass": { "chemical_mass": 56357.0, "monoisotopic_mass": 56357.0 }, "refseq": { "ac": "NP_013195", "name": "Gis3p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013195" }, "gene_names": [ { "name": "GIS3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q12418", "id": "Q12418" }, { "name": "GIS3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013195", "id": "NP_013195" } ], "protein_names": [ { "name": "Protein GIS3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q12418" }, { "name": "Gis3p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013195", "id": "NP_013195" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "common_name": "Yeast" } ], "gene": [ { "name": "GIS3", "url": "https://www.uniprot.org/uniprot/Q12418", "locus": {} } ], "crossref": [ { "id": "850783", "url": "https://www.ncbi.nlm.nih.gov/gene/850783", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q12418", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q12418*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "sce:YLR094C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR094C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ITRRKLW", "url": "https://omabrowser.org/oma/group/ITRRKLW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2033456at2759", "url": "http://www.orthodb.org/?query=2033456at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PR_Q12418", "url": "http://purl.obolibrary.org/obo/PR_Q12418", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_013195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013195", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000004084", "url": "https://www.yeastgenome.org/locus/S000004084", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q12418-1", "url": "https://www.uniprot.org/uniprot/Q12418-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLDVNTNHTLMHDAHVHEHCLIKSIRDDGALHSWSDSSKVFYPKSFYATATNKKNNKLASASMNKTATSNRTVSDEIYFHSTKPQFDGQGSAERTRTLTKRNSFKRTRILKARDDSELLNENRSSLMTPSLSSVMSQVRKTNSAKTLSGECPIHEGHLTQSIKRKFSEEAQSDCSSLSSSKLHPLTDDIADAVDLQTPAIGDEVLAEPVVPKMKIININDLDLFDDWEVKDLVDIFPPVYERRPRSSSALSLVSASSDAKLRPTSVDFQIIDKKGGKTSRRKSRSKSTTENMIYENDLVELEQWPSASPSPETDGSIASSELLPNKRIRQKSLNTNFLKLYSIETSCKRKSILPEVEVDDHLLKQLTYSEIRSLEIKKEPNVSTNDIKLALITRKKLWSDMVHETRNDLFGDSTPWNLHFVATTSNTEPSQGRESASEHATADLKSSLVRVHSDVKPWFNNGGTMLKPCGKLNLGKVTNKTSAPTREIQYVVKGWCDSRFL", "length": 502, "header": "sp|Q12418-1|GIS3_YEAST Isoform 1 of Protein GIS3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=GIS3 PE=1 SV=1 CANONICAL=Q12418-1" }, "isoforms": [ { "isoform_ac": "Q12418-1", "url": "", "sequence": { "sequence": "MLLDVNTNHTLMHDAHVHEHCLIKSIRDDGALHSWSDSSKVFYPKSFYATATNKKNNKLASASMNKTATSNRTVSDEIYFHSTKPQFDGQGSAERTRTLTKRNSFKRTRILKARDDSELLNENRSSLMTPSLSSVMSQVRKTNSAKTLSGECPIHEGHLTQSIKRKFSEEAQSDCSSLSSSKLHPLTDDIADAVDLQTPAIGDEVLAEPVVPKMKIININDLDLFDDWEVKDLVDIFPPVYERRPRSSSALSLVSASSDAKLRPTSVDFQIIDKKGGKTSRRKSRSKSTTENMIYENDLVELEQWPSASPSPETDGSIASSELLPNKRIRQKSLNTNFLKLYSIETSCKRKSILPEVEVDDHLLKQLTYSEIRSLEIKKEPNVSTNDIKLALITRKKLWSDMVHETRNDLFGDSTPWNLHFVATTSNTEPSQGRESASEHATADLKSSLVRVHSDVKPWFNNGGTMLKPCGKLNLGKVTNKTSAPTREIQYVVKGWCDSRFL", "length": 502, "header": "sp|Q12418-1|GIS3_YEAST Isoform 1 of Protein GIS3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=GIS3 PE=1 SV=1 CANONICAL=Q12418-1" }, "locus": { "chromosome": "XII", "start_pos": 329238, "end_pos": 327733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YLR094C_mRNA", "url": "https://www.ensembl.org/id/YLR094C_mRNA" }, { "database": "Ensembl Peptide", "id": "YLR094C", "url": "https://www.ensembl.org/id/YLR094C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 168, "end_pos": 168, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12418" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q12418", "url": "https://www.yeastgenome.org/locus/Q12418" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser168" }, { "start_pos": 454, "end_pos": 454, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q12418", "url": "https://www.yeastgenome.org/locus/Q12418" }, { "database": "iPTMnet", "id": "Q12418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12418" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser454" }, { "start_pos": 465, "end_pos": 465, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "SGD", "id": "Q12418", "url": "https://www.yeastgenome.org/locus/Q12418" }, { "database": "iPTMnet", "id": "Q12418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12418" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr465" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells.", "journal": "Mol. Gen. Genet.", "date": "1999", "authors": "Ronne H., Balciunas D.", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "reference": [ { "type": "PubMed", "id": "10628841", "url": "https://glygen.org/publication/PubMed/10628841" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.", "journal": "Genome Res.", "date": "2007", "authors": "Hu Y., LaBaer J., Moreira D., Raphael J., Rolfs A., Zuo D., Richardson A., Simpson A.J.G., Zhu C., Harlow E., Camargo A.A., Jepson D., Kelley F., McCarron S., Taycher E., Kolodner R.D., Kane M.F., Williamson J., Berger M.F., Bulyk M.L., Bhullar B., Mohr S., Marsischky G., Murthy T.V.S.", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "reference": [ { "type": "PubMed", "id": "17322287", "url": "https://glygen.org/publication/PubMed/17322287" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" }, { "database": "iPTMnet", "id": "Q12418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12418" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "Q12418", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12418" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Duesterhoeft A., Hillier L.W., Mewes H.-W., Obermaier B., Scharfe M., Wambutt R., Wedler H., Verhasselt P., Rose M., Benes V., Brueckner M., Rieger M., Portetelle D., Delius H., Schwarz S., Kleine K., Floeth M., Schwager C., Voss H., Hoheisel J.D., Dubois E., Volckaert G., Andre B., Koetter P., Entian K.-D., Louis E.J., Vandenbol M., Johnston M., Pohl T.M., Goffeau A., Hani J., Hilger F., Messenguy F., Miosga T., Mueller-Auer S., Scherens B., Zimmermann F.K., Zollner A., Purnelle B., Urrestarazu L.A., Vierendeels F., Voet M., Albermann K., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Moestl D., Nentwich U., Piravandi E., Rechmann S., Riles L., Rinke M., Scholler P., Underwood A.P., Wedler E.", "evidence": [ { "database": "UniProtKB", "id": "Q12418", "url": "https://www.uniprot.org/uniprot/Q12418" } ], "reference": [ { "type": "PubMed", "id": "9169871", "url": "https://glygen.org/publication/PubMed/9169871" } ] } ], "pathway": [ { "id": "sce:YLR094C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR094C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { 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"annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"sort_fields": [ "title", "journal", "date", "authors" ] } ] }