{ "uniprot_canonical_ac": "Q12415-1", "uniprot_ac": "Q12415", "uniprot_id": "TFC7_YEAST", "mass": { "chemical_mass": 49146.0, "monoisotopic_mass": 49146.0 }, "refseq": { "ac": "NP_014753", "name": "transcription factor TFIIIC subunit TFC7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014753" }, "gene_names": [ { "name": "TFC7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q12415", "id": "Q12415" }, { "name": "O3234", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12415", "id": "Q12415" }, { "name": "TFC7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014753", "id": "NP_014753" }, { "name": "YOR3234w", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12415", "id": "Q12415" } ], "protein_names": [ { "name": "Transcription factor tau 55 kDa subunit", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q12415" }, { "name": "TFIIIC 55 kDa subunit", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q12415" }, { "name": "Transcription factor C subunit 7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q12415" }, { "name": "transcription factor TFIIIC subunit TFC7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014753", "id": "NP_014753" } ], "function": [ { "annotation": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes.", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415#function" }, { "database": "PubMed", "id": "9584160", "url": "https://glygen.org/publication/PubMed/9584160" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" } ], "common_name": "Yeast" } ], "gene": [ { "name": "TFC7", "url": "https://www.uniprot.org/uniprot/Q12415", "locus": {} } ], "crossref": [ { "id": "cd07067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "854277", "url": "https://www.ncbi.nlm.nih.gov/gene/854277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q12415", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q12415*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR013078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR110W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR110W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GWDCVAN", "url": "https://omabrowser.org/oma/group/GWDCVAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1327387at2759", "url": "http://www.orthodb.org/?query=1327387at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16469", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16469", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16469:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16469:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2YN0", "url": "https://www.rcsb.org/structure/2YN0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6YJ6", "url": "https://www.rcsb.org/structure/6YJ6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00300", "url": "http://pfam.xfam.org/family/PF00300", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10419", "url": "http://pfam.xfam.org/family/PF10419", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q12415", "url": "http://purl.obolibrary.org/obo/PR_Q12415", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014753", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005636", "url": "https://www.yeastgenome.org/locus/S000005636", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q12415-1", "url": "https://www.uniprot.org/uniprot/Q12415-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVNTIYIARHGYRSNWLPEGPYPDPLTGIDSDVPLAEHGVQQAKELAHYLLSLDNQPEAAFASPFYRCLETVQPIAKLLEIPVYLERGIGEWYRPDRKPVIPVPAGYEILSKFFPGVISQEWDSTLTPNEKGETEQEMYMRFKKFWPLFIERVEKEYPNVECILLVTHAASKIALGMSLLGYDNPRMSLNENGDKIRSGSCSLDKYEILKKSYDTIDETDDQTSFTYIPFSDRKWVLTMNGNTEFLSSGEEMNWNFDCVAEAGSDADIKKRQMTKKTSSPIPEADDQTEVETVYISVDIPSGNYKERTEIAKSAILQYSGLETDAPLFRIGNRLYEGSWERLVGTELAFPNAAHVHKKTAGLLSPTEENETTNAGQSKGSSTANDPNIQIQEEDVGLPDSTNTSRDHTGDKEEVQSEKIYRIKERIVLSNVRPM", "length": 435, "header": "sp|Q12415-1|TFC7_YEAST Isoform 1 of Transcription factor tau 55 kDa subunit OS=Saccharomyces cerevisiae S288C OX=559292 GN=TFC7 PE=1 SV=1 CANONICAL=Q12415-1" }, "isoforms": [ { "isoform_ac": "Q12415-1", "url": "", "sequence": { "sequence": "MVVNTIYIARHGYRSNWLPEGPYPDPLTGIDSDVPLAEHGVQQAKELAHYLLSLDNQPEAAFASPFYRCLETVQPIAKLLEIPVYLERGIGEWYRPDRKPVIPVPAGYEILSKFFPGVISQEWDSTLTPNEKGETEQEMYMRFKKFWPLFIERVEKEYPNVECILLVTHAASKIALGMSLLGYDNPRMSLNENGDKIRSGSCSLDKYEILKKSYDTIDETDDQTSFTYIPFSDRKWVLTMNGNTEFLSSGEEMNWNFDCVAEAGSDADIKKRQMTKKTSSPIPEADDQTEVETVYISVDIPSGNYKERTEIAKSAILQYSGLETDAPLFRIGNRLYEGSWERLVGTELAFPNAAHVHKKTAGLLSPTEENETTNAGQSKGSSTANDPNIQIQEEDVGLPDSTNTSRDHTGDKEEVQSEKIYRIKERIVLSNVRPM", "length": 435, "header": "sp|Q12415-1|TFC7_YEAST Isoform 1 of Transcription factor tau 55 kDa subunit OS=Saccharomyces cerevisiae S288C OX=559292 GN=TFC7 PE=1 SV=1 CANONICAL=Q12415-1" }, "locus": { "chromosome": "XV", "start_pos": 530245, "end_pos": 528941, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR110W_mRNA", "url": "https://www.ensembl.org/id/YOR110W_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR110W", "url": "https://www.ensembl.org/id/YOR110W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 201, "end_pos": 201, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" }, { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser201" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" } ], "site_lbl": "Thr224" }, { "start_pos": 225, "end_pos": 225, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" } ], "site_lbl": "Ser225" }, { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" } ], "site_lbl": "Ser279" }, { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" } ], "site_lbl": "Ser280" }, { "start_pos": 360, "end_pos": 360, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Thr360" }, { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser365" }, { "start_pos": 367, "end_pos": 367, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "Q12415", "url": "https://www.yeastgenome.org/locus/Q12415" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr367" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.", "journal": "Genome Res.", "date": "2007", "authors": "Hu Y., LaBaer J., Moreira D., Raphael J., Rolfs A., Zuo D., Richardson A., Simpson A.J.G., Zhu C., Harlow E., Camargo A.A., Jepson D., Kelley F., McCarron S., Taycher E., Kolodner R.D., Kane M.F., Williamson J., Berger M.F., Bulyk M.L., Bhullar B., Mohr S., Marsischky G., Murthy T.V.S.", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" } ], "reference": [ { "type": "PubMed", "id": "17322287", "url": "https://glygen.org/publication/PubMed/17322287" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" }, { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" }, { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science", "date": "2009", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "Q12415", "url": "https://www.uniprot.org/uniprot/Q12415" }, { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.", "journal": "Proteomics", "date": "2009-10", "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" } ] }, { "title": "Global analysis of the yeast osmotic stress response by quantitative proteomics.", "journal": "Molecular bioSystems", "date": "2009-11", "authors": "Soufi Boumediene, Kelstrup Christian D, Stoehr Gabriele, Fr\u00f6hlich Florian, Walther Tobias C, Olsen Jesper V", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ] }, { "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.", "journal": "BMC genomics", "date": "2010-12-02", "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R", "evidence": [ { "database": "iPTMnet", "id": "Q12415", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12415" } ], "reference": [ { "type": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ] }, { "title": "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.", "journal": "Proc. Natl. Acad. Sci. 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