The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-SCE-212078" ], "enzyme_list": [ "Q12341-1" ], "evidence": [ { "id": "R-SCE-3662318", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-3662318" } ] } ], "reaction_participants": [ { "participant_id": "R-SCE-212078", "participant_name": "HHF2 [nucleoplasm]", "crossref": [ { "id": "P02309", "database": "UniProt", "url": "" }, { "id": "4JJN", "database": "PDB", "url": "" }, { "id": "6QLD", "database": "PDB", "url": "" }, { "id": "7Z0O", "database": "PDB", "url": "" }, { "id": "6GEN", "database": "PDB", "url": "" }, { "id": "1SZC", "database": "PDB", "url": "" }, { "id": "1Q1A", "database": "PDB", "url": "" }, { "id": "NP_014368.1", "database": "RefSeq", "url": "" }, { "id": "2L5A", "database": "PDB", "url": "" }, { "id": "5ZBA", "database": "PDB", "url": "" }, { "id": "1E6I", "database": "PDB", "url": "" }, { "id": "2QQF", "database": "PDB", "url": "" }, { "id": "NP_009563.1", "database": "RefSeq", "url": "" }, { "id": "5ZBB", "database": "PDB", "url": "" }, { "id": "1ID3", "database": "PDB", "url": "" }, { "id": "7ON1", "database": "PDB", "url": "" }, { "id": "2QQG", "database": "PDB", "url": "" }, { "id": "6GEJ", "database": "PDB", "url": "" }, { "id": "P02309", "database": "PRO", "url": "" }, { "id": "7XAY", "database": "PDB", "url": "" }, { "id": "6RXL", "database": "PDB", "url": "" }, { "id": "2DVR", "database": "PDB", "url": "" }, { "id": "6RXP", "database": "PDB", "url": "" }, { "id": "6RXQ", "database": "PDB", "url": "" }, { "id": "6RXM", "database": "PDB", "url": "" }, { "id": "2E3K", "database": "PDB", "url": "" }, { "id": "6RXO", "database": "PDB", "url": "" }, { "id": "7E9F", "database": "PDB", "url": "" }, { "id": "6RXR", "database": "PDB", "url": "" }, { "id": "4TWJ", "database": "PDB", "url": "" }, { "id": "7E9C", "database": "PDB", "url": "" }, { "id": "7K78", "database": "PDB", "url": "" }, { "id": "2H2H", "database": "PDB", "url": "" }, { "id": "7K7G", "database": "PDB", "url": "" }, { "id": "5W0V", "database": "PDB", "url": "" }, { "id": "1SZD", "database": "PDB", "url": "" }, { "id": "4KUD", "database": "PDB", "url": "" }, { "id": "2DVQ", "database": "PDB", "url": "" }, { "id": "6RXJ", "database": "PDB", "url": "" }, { "id": "4PSX", "database": "PDB", "url": "" }, { "id": "6RXK", "database": "PDB", "url": "" }, { "id": "4TWI", "database": "PDB", "url": "" }, { "id": "3TO6", "database": "PDB", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A8I5Y222", "gene_name": "Kat2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8I5Y222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y222" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8I5Y222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y222" } ] } ] }, { "uniprot_ac": "A0A8I6GLZ3", "gene_name": "Kat6b", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8I6GLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GLZ3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8I6GLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GLZ3" } ] } ] }, { "uniprot_ac": "B0G130", "gene_name": "", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "B0G130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G130" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "B0G130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G130" } ] } ] }, { "uniprot_ac": "B2RWS6", "gene_name": "Ep300", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] } ] }, { "uniprot_ac": "D4ACX5", "gene_name": "Kat2a", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "D4ACX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACX5" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "D4ACX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACX5" } ] } ] }, { "uniprot_ac": "E0CYR6", "gene_name": "Nat8f7", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "E0CYR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E0CYR6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E0CYR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E0CYR6" } ] } ] }, { "uniprot_ac": "O02193", "gene_name": "mof", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "O02193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02193" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O02193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02193" } ] } ] }, { "uniprot_ac": "O08785", "gene_name": "Clock", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "O08785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08785" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O08785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08785" } ] } ] }, { "uniprot_ac": "O09000", "gene_name": "Ncoa3", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "O09000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09000" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O09000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09000" } ] } ] }, { "uniprot_ac": "O14929", "gene_name": "HAT1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "O14929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14929" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O14929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14929" } ] } ] }, { "uniprot_ac": "O15516", "gene_name": "CLOCK", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "O15516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15516" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O15516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15516" } ] } ] }, { "uniprot_ac": "P21675", "gene_name": "TAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] } ] }, { "uniprot_ac": "P34218", "gene_name": "SAS3", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P34218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34218" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P34218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34218" } ] } ] }, { "uniprot_ac": "P39979", "gene_name": "HPA3", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P39979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39979" } ] }, { "ec_number": "2.3.1.36", "activity": "a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+).", "evidence": [ { "id": "P39979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39979" } ] }, { "ec_number": "2.3.1.36", "activity": "", "evidence": [ { "id": "P39979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39979" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P39979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39979" } ] } ] }, { "uniprot_ac": "P40963", "gene_name": "SAS2", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P40963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40963" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P40963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40963" } ] } ] }, { "uniprot_ac": "P45481", "gene_name": "Crebbp", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P45481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45481" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P45481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45481" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P45481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45481" } ] } ] }, { "uniprot_ac": "P46677", "gene_name": "TAF1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P46677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46677" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P46677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46677" } ] } ] }, { "uniprot_ac": "P62915", "gene_name": "Gtf2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P62915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62915" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P62915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62915" } ] } ] }, { "uniprot_ac": "P62916", "gene_name": "Gtf2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P62916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62916" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P62916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62916" } ] } ] }, { "uniprot_ac": "P70365", "gene_name": "Ncoa1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P70365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70365" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P70365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70365" } ] } ] }, { "uniprot_ac": "Q00403", "gene_name": "GTF2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q00403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00403" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q00403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00403" } ] } ] }, { "uniprot_ac": "Q00972", "gene_name": "Bckdk", "activity": [ { "ec_number": "2.7.11.4", "activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.7.11.4", "activity": "", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] } ] }, { "uniprot_ac": "Q03330", "gene_name": "GCN5", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q03330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03330" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q03330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03330" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q03330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03330" } ] } ] }, { "uniprot_ac": "Q06592", "gene_name": "HPA2", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q06592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06592" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q06592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06592" } ] } ] }, { "uniprot_ac": "Q07794", "gene_name": "RTT109", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q07794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07794" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q07794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07794" } ] } ] }, { "uniprot_ac": "Q08649", "gene_name": "ESA1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q08649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08649" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q08649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08649" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q08649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08649" } ] } ] }, { "uniprot_ac": "Q09472", "gene_name": "EP300", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q09472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09472" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q09472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09472" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q09472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09472" } ] } ] }, { "uniprot_ac": "Q0KIB3", "gene_name": "Hat1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q0KIB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KIB3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q0KIB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KIB3" } ] } ] }, { "uniprot_ac": "Q12341", "gene_name": "HAT1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q12341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12341" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q12341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12341" } ] } ] }, { "uniprot_ac": "Q15788", "gene_name": "NCOA1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q15788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15788" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q15788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15788" } ] } ] }, { "uniprot_ac": "Q3MHC1", "gene_name": "Naa60", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] }, { "ec_number": "2.3.1.259", "activity": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein].", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] }, { "ec_number": "2.3.1.259", "activity": "", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] } ] }, { "uniprot_ac": "Q56NI9", "gene_name": "ESCO2", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q56NI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56NI9" } ] } ] }, { "uniprot_ac": "Q5FWF5", "gene_name": "ESCO1", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q5FWF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWF5" } ] } ] }, { "uniprot_ac": "Q5M939", "gene_name": "Hat1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q5M939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M939" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5M939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M939" } ] } ] }, { "uniprot_ac": "Q5SVQ0", "gene_name": "Kat7", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q5SVQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SVQ0" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5SVQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SVQ0" } ] } ] }, { "uniprot_ac": "Q5TKR9", "gene_name": "Kat6a", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q5TKR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TKR9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5TKR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TKR9" } ] } ] }, { "uniprot_ac": "Q5XI06", "gene_name": "Kat8", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q5XI06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI06" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5XI06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI06" } ] } ] }, { "uniprot_ac": "Q69Z69", "gene_name": "Esco1", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q69Z69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69Z69" } ] } ] }, { "uniprot_ac": "Q6DGG1", "gene_name": "Abhd14b", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q6DGG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6DGG1" } ] } ] }, { "uniprot_ac": "Q6JHU9", "gene_name": "Crebbp", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q6JHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6JHU9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q6JHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6JHU9" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q6JHU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6JHU9" } ] } ] }, { "uniprot_ac": "Q80UV9", "gene_name": "Taf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] }, { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] } ] }, { "uniprot_ac": "Q869X5", "gene_name": "", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q869X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869X5" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q869X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869X5" } ] } ] }, { "uniprot_ac": "Q869X7", "gene_name": "", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q869X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869X7" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q869X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869X7" } ] } ] }, { "uniprot_ac": "Q86J12", "gene_name": "", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q86J12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86J12" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q86J12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86J12" } ] } ] }, { "uniprot_ac": "Q8BMQ2", "gene_name": "Gtf3c4", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8BMQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BMQ2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8BMQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BMQ2" } ] } ] }, { "uniprot_ac": "Q8BRB7", "gene_name": "Kat6b", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8BRB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRB7" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8BRB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRB7" } ] } ] }, { "uniprot_ac": "Q8BY71", "gene_name": "Hat1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8BY71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BY71" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8BY71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BY71" } ] } ] }, { "uniprot_ac": "Q8BZ21", "gene_name": "Kat6a", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8BZ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZ21" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8BZ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZ21" } ] } ] }, { "uniprot_ac": "Q8CHK4", "gene_name": "Kat5", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8CHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHK4" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8CHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHK4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8CHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHK4" } ] } ] }, { "uniprot_ac": "Q8CIB9", "gene_name": "Esco2", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8CIB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIB9" } ] } ] }, { "uniprot_ac": "Q8VCR7", "gene_name": "Abhd14b", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8VCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR7" } ] } ] }, { "uniprot_ac": "Q8WYB5", "gene_name": "KAT6B", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8WYB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYB5" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8WYB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYB5" } ] } ] }, { "uniprot_ac": "Q92793", "gene_name": "CREBBP", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q92793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92793" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q92793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92793" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q92793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92793" } ] } ] }, { "uniprot_ac": "Q92794", "gene_name": "KAT6A", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q92794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92794" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q92794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92794" } ] } ] }, { "uniprot_ac": "Q92830", "gene_name": "KAT2A", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q92830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92830" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q92830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92830" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q92830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92830" } ] } ] }, { "uniprot_ac": "Q92831", "gene_name": "KAT2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q92831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92831" } ] }, { "ec_number": "2.3.1.57", "activity": "acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+).", "evidence": [ { "id": "Q92831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92831" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q92831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92831" } ] } ] }, { "uniprot_ac": "Q92993", "gene_name": "KAT5", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q92993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92993" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q92993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92993" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q92993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92993" } ] } ] }, { "uniprot_ac": "Q95SX8", "gene_name": "Naa60", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q95SX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95SX8" } ] }, { "ec_number": "2.3.1.259", "activity": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein].", "evidence": [ { "id": "Q95SX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95SX8" } ] }, { "ec_number": "2.3.1.259", "activity": "", "evidence": [ { "id": "Q95SX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95SX8" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q95SX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95SX8" } ] } ] }, { "uniprot_ac": "Q960X4", "gene_name": "Tip60", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q960X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q960X4" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q960X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q960X4" } ] } ] }, { "uniprot_ac": "Q96IU4", "gene_name": "ABHD14B", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q96IU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96IU4" } ] } ] }, { "uniprot_ac": "Q99MK2", "gene_name": "Kat5", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q99MK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MK2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q99MK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MK2" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q99MK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MK2" } ] } ] }, { "uniprot_ac": "Q9D1P2", "gene_name": "Kat8", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q9D1P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1P2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q9D1P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1P2" } ] } ] }, { "uniprot_ac": "Q9DBU2", "gene_name": "Naa60", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q9DBU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU2" } ] }, { "ec_number": "2.3.1.259", "activity": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + 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