{ "uniprot_canonical_ac": "Q12301-1", "uniprot_ac": "Q12301", "uniprot_id": "YD180_YEAST", "mass": { "chemical_mass": 62288.0, "monoisotopic_mass": 62288.0 }, "refseq": { "ac": "NP_010101", "name": "Ait1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010101" }, "gene_names": [ { "name": "AIT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010101", "id": "NP_010101" } ], "protein_names": [ { "name": "Uncharacterized membrane protein YDL180W", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q12301" }, { "name": "Ait1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010101", "id": "NP_010101" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301" } ], "common_name": "Yeast" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/Q12301", "locus": {} } ], "crossref": [ { "id": "851374", "url": "https://www.ncbi.nlm.nih.gov/gene/851374", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q12301", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q12301*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "sce:YDL180W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDL180W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WHIIPRQ", "url": "https://omabrowser.org/oma/group/WHIIPRQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2012408at2759", "url": "http://www.orthodb.org/?query=2012408at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PR_Q12301", "url": "http://purl.obolibrary.org/obo/PR_Q12301", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_010101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010101", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000002339", "url": "https://www.yeastgenome.org/locus/S000002339", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q12301-1", "url": "https://www.uniprot.org/uniprot/Q12301-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRLNHAASYFMPIFCSTRPHIVILSALFSISLFSLFYASSELLLHQYDDPLMFKPNSQDYFRTFLLGLFSPFLYYFLKTFLFNINQRFLILNLIVDFPINDVFMLLILIGLAYPQVQDHEGGTIKHKECSWHIIPRQAYIFGISWALGEFTICIIGNLFNYQEIADPNINSGFTHQESANTYCNNNDMSHNDDCGCSTEYRPNVVDRSDITLSKCIEVRNDSSSISNNVYSSEYHPIKPLRSSSSTYGSIRQQPHENKKQLHVPDNSQDDTIIMMNPIDNSLKLTTLDTGDLSFPIDEEQPILKKSFGYTWAVPNENTQNTTKSFTPIKRFIAFSTAYQLVTGLLLMILVVGSNIMLTIGESLILSMYFVYVRGHEGLFTPVVNYFGSRTISNFILCVIIPFISLNFLINTSIYLRRELDDWFNNSQGEFEDDDENTISKRVATNQEYQHPLSANYISMDSPDVINSSPGHFGMNSGQLLGNTTLYYGSLNGDDDDMTNDSALLRFCKKLVKNWRALARNDSFVLGVMVSWSLLVFVTGILSTVYI", "length": 547, "header": "sp|Q12301-1|YD180_YEAST Isoform 1 of Uncharacterized membrane protein YDL180W OS=Saccharomyces cerevisiae S288C OX=559292 GN= PE=1 SV=1 CANONICAL=Q12301-1" }, "isoforms": [ { "isoform_ac": "Q12301-1", "url": "", "sequence": { "sequence": "MVRLNHAASYFMPIFCSTRPHIVILSALFSISLFSLFYASSELLLHQYDDPLMFKPNSQDYFRTFLLGLFSPFLYYFLKTFLFNINQRFLILNLIVDFPINDVFMLLILIGLAYPQVQDHEGGTIKHKECSWHIIPRQAYIFGISWALGEFTICIIGNLFNYQEIADPNINSGFTHQESANTYCNNNDMSHNDDCGCSTEYRPNVVDRSDITLSKCIEVRNDSSSISNNVYSSEYHPIKPLRSSSSTYGSIRQQPHENKKQLHVPDNSQDDTIIMMNPIDNSLKLTTLDTGDLSFPIDEEQPILKKSFGYTWAVPNENTQNTTKSFTPIKRFIAFSTAYQLVTGLLLMILVVGSNIMLTIGESLILSMYFVYVRGHEGLFTPVVNYFGSRTISNFILCVIIPFISLNFLINTSIYLRRELDDWFNNSQGEFEDDDENTISKRVATNQEYQHPLSANYISMDSPDVINSSPGHFGMNSGQLLGNTTLYYGSLNGDDDDMTNDSALLRFCKKLVKNWRALARNDSFVLGVMVSWSLLVFVTGILSTVYI", "length": 547, "header": "sp|Q12301-1|YD180_YEAST Isoform 1 of Uncharacterized membrane protein YDL180W OS=Saccharomyces cerevisiae S288C OX=559292 GN= PE=1 SV=1 CANONICAL=Q12301-1" }, "locus": { "chromosome": "IV", "start_pos": 137536, "end_pos": 135896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YDL180W_mRNA", "url": "https://www.ensembl.org/id/YDL180W_mRNA" }, { "database": "Ensembl Peptide", "id": "YDL180W", "url": "https://www.ensembl.org/id/YDL180W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 225, "end_pos": 225, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q12301", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12301" }, { "database": "SGD", "id": "Q12301", "url": "https://www.yeastgenome.org/locus/Q12301" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser225" }, { "start_pos": 246, "end_pos": 246, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q12301", "url": 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Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Kim H., von Heijne G., Melen K., Oesterberg M.", "evidence": [ { "database": "UniProtKB", "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301" } ], "reference": [ { "type": "PubMed", "id": "16847258", "url": "https://glygen.org/publication/PubMed/16847258" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "Q12301", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12301" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301" }, { "database": "iPTMnet", "id": "Q12301", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12301" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.", "journal": "Genes & development", "date": "2009-08-15", "authors": "Huber Alexandre, Bodenmiller Bernd, Uotila Aino, Stahl Michael, Wanka Stefanie, Gerrits Bertran, Aebersold Ruedi, Loewith Robbie", "evidence": [ { "database": "iPTMnet", "id": "Q12301", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12301" } ], "reference": [ { "type": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301" }, { "database": "iPTMnet", "id": "Q12301", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12301" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "Q12301", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12301" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q12301", "url": "https://www.uniprot.org/uniprot/Q12301" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.", "journal": "Nature", "date": "1997", "authors": "Andrews S., 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L., Odell C., Menezes S., Johnston M., Pohl T.M., Harris D.E., Schramm S., McDonald S., Salom D., Bargues M., Cherry J.M., Ballesta J.P.G., Churcher C.M., Dedman K., Dietrich F.S., Dujon B., Goffeau A., Hamlin N., Hani J., Jacq C., Mueller-Auer S., Perea J., Perez-Ortin J.E., Rajandream M.A., Remacha M.A., Revuelta J.L., Vissers S., Walsh S.V., Zollner A., del Rey F., Jonniaux J.-L., Purnelle B., Saiz J.E., Urrestarazu L.A., Voet M., Wilcox L., Albermann K., Alt-Moerbe J., Aviles E., Baron L., Biteau N., Blugeon C., Brinkman R., Buitrago M.J., Carpenter J., Coster F., Garcia-Cantalejo J.M., Gattung S., Gomez-Peris A., Granotier C., Hallsworth K., Hanemann V., Heumann K., Hunicke-Smith S., Jier M., Kirsten J., Laamanen P., Langston Y., Legros Y., Moeller-Rieker S., Monnet A., Moro M., Mosedale D., Murphy L.D., Nussbaumer B., Peluso D., Petel F.X., Rasmussen S.W., Richards C., Riles L., Saluz H.P., Saren A.-M., Scholler P., Shogren T., Shore L., Shroff N., Soler-Mira A., Taich A., 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