{ "uniprot_canonical_ac": "Q12232-1", "uniprot_ac": "Q12232", "uniprot_id": "SLP1_YEAST", "mass": { "chemical_mass": 67452.0, "monoisotopic_mass": 67452.0 }, "refseq": { "ac": "NP_014797", "name": "Slp1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014797" }, "gene_names": [ { "name": "SLP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q12232", "id": "Q12232" }, { "name": "O3545", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12232", "id": "Q12232" }, { "name": "SLP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014797", "id": "NP_014797" } ], "protein_names": [ { "name": "Uncharacterized protein SLP1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q12232" }, { "name": "SUN-like protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q12232" }, { "name": "Slp1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014797", "id": "NP_014797" } ], "function": [ { "annotation": "May be involved in membrane protein folding (PubMed:19325107). Required for localization of MPS3 to the nuclear envelope (PubMed:23275891).", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232#function" }, { "database": "PubMed", "id": "23275891", "url": "https://glygen.org/publication/PubMed/23275891" }, { "database": "PubMed", "id": "19325107", "url": "https://glygen.org/publication/PubMed/19325107" } ] } ], "disease": [ { "disease_id": "DOID:0110344", "recommended_name": { "id": "DOID:0110344", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110344", "name": "osteogenesis imperfecta type 5", "description": "An osteogenesis imperfecta that has_material_basis_in mutation in the IFITM5 gene on chromosome 11p15." }, "synonyms": [ { "id": "DOID:0110344", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110344", "name": "OI5", "description": "" }, { "id": "DOID:0110344", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110344", "name": "osteogenesis imperfecta type V", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "osteogenesis imperfecta type 5", "description": "Osteogenesis imperfecta type V is a moderate type of osteogenesis imperfecta (OI), a genetic disorder characterized by increased bone fragility, low bone mass and susceptibility to bone fractures with variable severity. OI type V is characterized by mild to moderate short stature, dislocation of the radial head, mineralized interosseous membranes, hyperplasic callus, white sclera and no dentinogenesis imperfecta (DI)." }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "IFITM5 osteogenesis imperfecta", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "OI type 5", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "OI5", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "osteogenesis imperfecta caused by mutation in IFITM5", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "osteogenesis imperfecta type V", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "OI type V", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "OI with calcification in interosseous membranes", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "OI, type 5", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "osteogenesis imperfecta, type 5", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "osteogenesis imperfecta, type V", "description": "" }, { "id": "MONDO:0012591", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012591", "name": "type V OI", "description": "" }, { "id": "MIM:610967", "resource": "MIM", "url": "https://www.omim.org/entry/610967", "name": "Osteogenesis imperfecta 5", "description": "Osteogenesis imperfecta 5" } ], "evidence": [ { "id": "0110344", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110344" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SLP1", "url": "https://www.uniprot.org/uniprot/Q12232", "locus": {} } ], "crossref": [ { "id": "854325", "url": "https://www.ncbi.nlm.nih.gov/gene/854325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q12232", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q12232*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR154W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR154W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVIIELC", "url": "https://omabrowser.org/oma/group/YVIIELC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "103878at2759", "url": "http://www.orthodb.org/?query=103878at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12953", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12953", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12953:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12953:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07738", "url": "http://pfam.xfam.org/family/PF07738", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q12232", "url": "http://purl.obolibrary.org/obo/PR_Q12232", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014797", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005680", "url": "https://www.yeastgenome.org/locus/S000005680", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q12232-1", "url": "https://www.uniprot.org/uniprot/Q12232-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANRLLIYGLILWVSIIGSFALDRNKTAQNAKIGLHDTTVITTGSTTNVQKEHSSPLSTGSLRTHDFRQASKVDIRQADIRENGERKEQDALTQPATPRNPGDSSNSFLSFDEWKKVKSKEHSSGPERHLSRVREPVDPSCYKEKECIGEELEIDLGFLTNKNEWSEREENQKGFNEEKDIEKVYKKKFNYASLDCAATIVKSNPEAIGATSTLIESKDKYLLNPCSAPQQFIVIELCEDILVEEIEIANYEFFSSTFKRFRVSVSDRIPMVKNEWTILGEFEARNSRELQKFQIHNPQIWASYLKIEILSHYEDEFYCPISLIKVYGKSMMDEFKIDQLKAQEDKEQSIGTNNINNLNEQNIQDRCNNIETRLETPNTSNLSDLAGALSCTSKLIPLKFDEFFKVLNASFCPSKQMISSSSSSAVPVIPEESIFKNIMKRLSQLETNSSLTVSYIEEQSKLLSKSFEQLEMAHEAKFSHLVTIFNETMMSNLDLLNNFANQLKDQSLRILEEQKLENDKFTNRHLLHLERLEKEVSFQRRIVYASFFAFVGLISYLLITRELYFEDFEESKNGAIEKADIVQQAIR", "length": 587, "header": "sp|Q12232-1|SLP1_YEAST Isoform 1 of Uncharacterized protein SLP1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SLP1 PE=1 SV=1 CANONICAL=Q12232-1" }, "isoforms": [ { "isoform_ac": "Q12232-1", "url": "", "sequence": { "sequence": "MANRLLIYGLILWVSIIGSFALDRNKTAQNAKIGLHDTTVITTGSTTNVQKEHSSPLSTGSLRTHDFRQASKVDIRQADIRENGERKEQDALTQPATPRNPGDSSNSFLSFDEWKKVKSKEHSSGPERHLSRVREPVDPSCYKEKECIGEELEIDLGFLTNKNEWSEREENQKGFNEEKDIEKVYKKKFNYASLDCAATIVKSNPEAIGATSTLIESKDKYLLNPCSAPQQFIVIELCEDILVEEIEIANYEFFSSTFKRFRVSVSDRIPMVKNEWTILGEFEARNSRELQKFQIHNPQIWASYLKIEILSHYEDEFYCPISLIKVYGKSMMDEFKIDQLKAQEDKEQSIGTNNINNLNEQNIQDRCNNIETRLETPNTSNLSDLAGALSCTSKLIPLKFDEFFKVLNASFCPSKQMISSSSSSAVPVIPEESIFKNIMKRLSQLETNSSLTVSYIEEQSKLLSKSFEQLEMAHEAKFSHLVTIFNETMMSNLDLLNNFANQLKDQSLRILEEQKLENDKFTNRHLLHLERLEKEVSFQRRIVYASFFAFVGLISYLLITRELYFEDFEESKNGAIEKADIVQQAIR", "length": 587, "header": "sp|Q12232-1|SLP1_YEAST Isoform 1 of Uncharacterized protein SLP1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SLP1 PE=1 SV=1 CANONICAL=Q12232-1" }, "locus": { "chromosome": "XV", "start_pos": 626489, "end_pos": 624729, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR154W_mRNA", "url": "https://www.ensembl.org/id/YOR154W_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR154W", "url": "https://www.ensembl.org/id/YOR154W" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 25, "start_aa": "Asn", "end_pos": 25, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn25", "evidence": [ { "id": "Q12232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12232#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 378, "start_aa": "Asn", "end_pos": 378, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn378", "evidence": [ { "id": "Q12232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12232#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 381, "start_aa": "Asn", "end_pos": 381, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn381", "evidence": [ { "id": "Q12232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12232#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 408, "start_aa": "Asn", "end_pos": 408, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn408", "evidence": [ { "id": "Q12232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12232#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 448, "start_aa": "Asn", "end_pos": 448, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn448", "evidence": [ { "id": "Q12232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12232#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 486, "start_aa": "Asn", "end_pos": 486, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn486", "evidence": [ { "id": "Q12232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12232#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae.", "journal": "Curr. Genet.", "date": "2002", "authors": "Nakai K., Hamada K., Arisawa M., Terashima H., Kitada K., Yabuki N., Fukuchi S.", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "11935221", "url": "https://glygen.org/publication/PubMed/11935221" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.", "journal": "J. Cell Biol.", "date": "2006", "authors": "Jaspersen Sue L, Martin Adriana E, Glazko Galina, Giddings Thomas H, Morgan Garry, Mushegian Arcady, Winey Mark", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "16923827", "url": "https://glygen.org/publication/PubMed/16923827" } ] }, { "title": "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.", "journal": "Science", "date": "2009", "authors": "Schwappach B., Oh E., Schuldiner M., Walter P., Weissman J.S., Collins S.R., Denic V., Schmid V., Jonikas M.C., Quan E.M., Weibezahn J.", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "19325107", "url": "https://glygen.org/publication/PubMed/19325107" } ] }, { "title": "Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1.", "journal": "G3 (Bethesda)", "date": "2012", "authors": "Gardner J.M., Jaspersen S.L., Slaughter B.D., Gogol M., Friederichs J.M., Smoyer C.J., Whetstine C.R.", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "23275891", "url": "https://glygen.org/publication/PubMed/23275891" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV.", "journal": "Yeast", "date": "1997", "authors": "Camasses A., Poch O., Winsor B., Martin R.P., Bordonne R., Madania A., Tarassov I.A.", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "9046089", "url": "https://glygen.org/publication/PubMed/9046089" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Mewes H.-W., Wambutt R., Wedler H., Wiemann S., Pujol A., Uhlen M., Camasses A., Poch O., Benes V., Durand P., Vlcek C., Winsor B., Landt O., Portetelle D., Casas C., Lafuente M.J., Paces V., Delius H., Michaux G., Schweizer M., Feldmann H., Kleine K., Martin R.P., Hofmann B., Schwager C., Voss H., Cziepluch C., Jauniaux J.-C., Hughes B., Galisson F., Volckaert G., Hattenhorst U., Cheret G., Sor F., Herrero E., Arino J., Vetter I., Casamayor A., Bordonne R., Perrin A., Thierry A., Kordes E., Louis E.J., Hollenberg C.P., Maarse A.C., Marck C., Vandenbol M., Pohl T.M., Tobiasch E., Pearson B.M., Poirey R., Hand N.J., Goulding S.E., Daignan-Fornier B., Dujon B., Goffeau A., Grivell L.A., Hani J., Hernando Y., Hilger F., Madania A., Mannhaupt G., Zollner A., Aldea M., Alexandraki D., Bolotin-Fukuhara M., Fairhead C., Gancedo C., Purnelle B., Ramezani Rad M., Tarassov I.A., Tzermia M., Voet M., Albermann K., Bohn C., Boyer J., Dang V.-D., Gaillon L., Gamo F.-J., Habbig B., Hebling U., Heumann K., Hiesel R., Kalogeropoulos A., Katsoulou C., Parle-McDermott A.G., Pettersson B., Rechmann S., Sterky F., Teodoru C., Tettelin H., Unseld M., Valens M., Wolfe K.H., Zumstein E., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "reference": [ { "type": "PubMed", "id": "9169874", "url": "https://glygen.org/publication/PubMed/9169874" } ] } ], "pathway": [ { "id": "sce:YOR154W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR154W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q12232", "url": "https://www.uniprot.org/uniprot/Q12232" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": 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