{ "uniprot_canonical_ac": "Q12171-1", "uniprot_ac": "Q12171", "uniprot_id": "MDM32_YEAST", "mass": { "chemical_mass": 72028.0, "monoisotopic_mass": 72028.0 }, "refseq": { "ac": "NP_014790", "name": "Mdm32p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014790" }, "gene_names": [ { "name": "MDM32", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q12171", "id": "Q12171" }, { "name": "MDM32", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014790", "id": "NP_014790" }, { "name": "O3521", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q12171", "id": "Q12171" } ], "protein_names": [ { "name": "Mitochondrial distribution and morphology protein 32", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q12171" }, { "name": "Mdm32p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014790", "id": "NP_014790" } ], "function": [ { "annotation": "Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171#function" }, { "database": "PubMed", "id": "15631992", "url": "https://glygen.org/publication/PubMed/15631992" }, { "database": "PubMed", "id": "11907266", "url": "https://glygen.org/publication/PubMed/11907266" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "common_name": "Yeast" } ], "gene": [ { "name": "MDM32", "url": "https://www.uniprot.org/uniprot/Q12171", "locus": {} } ], "crossref": [ { "id": "854318", "url": "https://www.ncbi.nlm.nih.gov/gene/854318", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q12171", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q12171*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR012571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR147W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR147W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FAKEMVG", "url": "https://omabrowser.org/oma/group/FAKEMVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1989162at2759", "url": "http://www.orthodb.org/?query=1989162at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31068", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31068", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31068:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31068:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08118", "url": "http://pfam.xfam.org/family/PF08118", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q12171", "url": "http://purl.obolibrary.org/obo/PR_Q12171", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014790", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005673", "url": "https://www.yeastgenome.org/locus/S000005673", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q12171-1", "url": "https://www.uniprot.org/uniprot/Q12171-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLITRLRVPTIKRPLLPITSHLVRHCIRTYVATNHGNVRPFITPYKSSLPVRCLIAQRHIRTFPSNDKFTTKASNIETILLRKNNEREFKQSLLADAKNFQERFKINLKWILIKNNRPFSLNEISIIASWLILSQILWLILSTTTFISFYLFVINSVFSQEYIHEKKIYERLLKWLLKDHKCSNQDLEITFSPEDKASMLVLSPDWESNSILIKRLNVRDEILDLDLKFHHINLNVSLKNWLLGRGLITNVSIYGIRGCLNLSNFINLVNSFQGDQKTENFLKTLNNVEITDSEILLKQSLSAQETPSLKFSIYNLSLPRLRLNHFISDILSAKTFSGSINNSLFNLFKRQQKLTAVIENNNKNRMASSKFDFTDNNQENYRTVTHQDDPNYVTTLRLNFININDLKFNGDGKFNWLKDGQVEILADIMLTNSTSHLSSESKYAVVDLKVTCRDLKTTFPQEPPVLSTGDSIVSLDELKPIITFINSYEGMANPILKDFSENERLTNSIIWNSPNVSINRQRKSYPLTTKVTSNSTKEIIKFHNQPNTNANEIVLRCKMVKNLSDLQLININQILDQITMELYVDLTKIVEDWEFKNKNDWMKQWGTTFASQLLLFGFGAMV", "length": 622, "header": "sp|Q12171-1|MDM32_YEAST Isoform 1 of Mitochondrial distribution and morphology protein 32 OS=Saccharomyces cerevisiae S288C OX=559292 GN=MDM32 PE=1 SV=2 CANONICAL=Q12171-1" }, "isoforms": [ { "isoform_ac": "Q12171-1", "url": "", "sequence": { "sequence": "MLITRLRVPTIKRPLLPITSHLVRHCIRTYVATNHGNVRPFITPYKSSLPVRCLIAQRHIRTFPSNDKFTTKASNIETILLRKNNEREFKQSLLADAKNFQERFKINLKWILIKNNRPFSLNEISIIASWLILSQILWLILSTTTFISFYLFVINSVFSQEYIHEKKIYERLLKWLLKDHKCSNQDLEITFSPEDKASMLVLSPDWESNSILIKRLNVRDEILDLDLKFHHINLNVSLKNWLLGRGLITNVSIYGIRGCLNLSNFINLVNSFQGDQKTENFLKTLNNVEITDSEILLKQSLSAQETPSLKFSIYNLSLPRLRLNHFISDILSAKTFSGSINNSLFNLFKRQQKLTAVIENNNKNRMASSKFDFTDNNQENYRTVTHQDDPNYVTTLRLNFININDLKFNGDGKFNWLKDGQVEILADIMLTNSTSHLSSESKYAVVDLKVTCRDLKTTFPQEPPVLSTGDSIVSLDELKPIITFINSYEGMANPILKDFSENERLTNSIIWNSPNVSINRQRKSYPLTTKVTSNSTKEIIKFHNQPNTNANEIVLRCKMVKNLSDLQLININQILDQITMELYVDLTKIVEDWEFKNKNDWMKQWGTTFASQLLLFGFGAMV", "length": 622, "header": "sp|Q12171-1|MDM32_YEAST Isoform 1 of Mitochondrial distribution and morphology protein 32 OS=Saccharomyces cerevisiae S288C OX=559292 GN=MDM32 PE=1 SV=2 CANONICAL=Q12171-1" }, "locus": { "chromosome": "XV", "start_pos": 608472, "end_pos": 606607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR147W_mRNA", "url": "https://www.ensembl.org/id/YOR147W_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR147W", "url": "https://www.ensembl.org/id/YOR147W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.", "journal": "Mol. Biol. Cell", "date": "2002", "authors": "Fritz S., Neupert W., Westermann B., Messerschmitt M., Fuchs F., Dimmer K.S., Weinbach N.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "11907266", "url": "https://glygen.org/publication/PubMed/11907266" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast.", "journal": "J. Cell Biol.", "date": "2005", "authors": "Jakobs S., Vogel F., Westermann B., Dimmer K.S., Altmann K.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "15631992", "url": "https://glygen.org/publication/PubMed/15631992" } ] }, { "title": "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.", "journal": "Nucleic Acids Res.", "date": "2005", "authors": "Zhang Z., Dietrich F.S.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "15905473", "url": "https://glygen.org/publication/PubMed/15905473" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV.", "journal": "Yeast", "date": "1997", "authors": "Camasses A., Poch O., Winsor B., Martin R.P., Bordonne R., Madania A., Tarassov I.A.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "9046089", "url": "https://glygen.org/publication/PubMed/9046089" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Mewes H.-W., Wambutt R., Wedler H., Wiemann S., Pujol A., Uhlen M., Camasses A., Poch O., Benes V., Durand P., Vlcek C., Winsor B., Landt O., Portetelle D., Casas C., Lafuente M.J., Paces V., Delius H., Michaux G., Schweizer M., Feldmann H., Kleine K., Martin R.P., Hofmann B., Schwager C., Voss H., Cziepluch C., Jauniaux J.-C., Hughes B., Galisson F., Volckaert G., Hattenhorst U., Cheret G., Sor F., Herrero E., Arino J., Vetter I., Casamayor A., Bordonne R., Perrin A., Thierry A., Kordes E., Louis E.J., Hollenberg C.P., Maarse A.C., Marck C., Vandenbol M., Pohl T.M., Tobiasch E., Pearson B.M., Poirey R., Hand N.J., Goulding S.E., Daignan-Fornier B., Dujon B., Goffeau A., Grivell L.A., Hani J., Hernando Y., Hilger F., Madania A., Mannhaupt G., Zollner A., Aldea M., Alexandraki D., Bolotin-Fukuhara M., Fairhead C., Gancedo C., Purnelle B., Ramezani Rad M., Tarassov I.A., Tzermia M., Voet M., Albermann K., Bohn C., Boyer J., Dang V.-D., Gaillon L., Gamo F.-J., Habbig B., Hebling U., Heumann K., Hiesel R., Kalogeropoulos A., Katsoulou C., Parle-McDermott A.G., Pettersson B., Rechmann S., Sterky F., Teodoru C., Tettelin H., Unseld M., Valens M., Wolfe K.H., Zumstein E., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "reference": [ { "type": "PubMed", "id": "9169874", "url": "https://glygen.org/publication/PubMed/9169874" } ] } ], "pathway": [ { "id": "sce:YOR147W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR147W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q12171", "url": "https://www.uniprot.org/uniprot/Q12171" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": 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