{
    "uniprot_canonical_ac": "Q12094-1",
    "uniprot_ac": "Q12094",
    "uniprot_id": "TSR3_YEAST",
    "mass": {
        "chemical_mass": 35686.0,
        "monoisotopic_mass": 35686.0
    },
    "refseq": {
        "ac": "NP_014648",
        "name": "ribosome biogenesis protein TSR3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014648"
    },
    "gene_names": [
        {
            "name": "TSR3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q12094",
            "id": "Q12094"
        },
        {
            "name": "TSR3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014648",
            "id": "NP_014648"
        },
        {
            "name": "UND313",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q12094",
            "id": "Q12094"
        }
    ],
    "protein_names": [
        {
            "name": "18S rRNA aminocarboxypropyltransferase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q12094"
        },
        {
            "name": "2.5.1.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q12094"
        },
        {
            "name": "20S rRNA accumulation protein 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q12094"
        },
        {
            "name": "ScTsr3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q12094"
        },
        {
            "name": "ribosome biogenesis protein TSR3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014648",
            "id": "NP_014648"
        }
    ],
    "function": [
        {
            "annotation": "Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA (PubMed:27084949). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (PubMed:27084949). Required for processing 35S pre-rRNA at site D (PubMed:19806183).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094#function"
                },
                {
                    "database": "PubMed",
                    "id": "19806183",
                    "url": "https://glygen.org/publication/PubMed/19806183"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 111,
            "end_pos": 111,
            "sequence_org": "E",
            "sequence_mut": "A",
            "comment": "Reduced aminocarboxypropyltransferase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        },
        {
            "start_pos": 131,
            "end_pos": 131,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Decreased aminocarboxypropyltransferase activity; when associated with A-60 and A-65.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        },
        {
            "start_pos": 60,
            "end_pos": 60,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Decreased aminocarboxypropyltransferase activity; when associated with A-65 and A-131.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        },
        {
            "start_pos": 62,
            "end_pos": 62,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Does not affect S-adenosyl-L-methionine-binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        },
        {
            "start_pos": 62,
            "end_pos": 62,
            "sequence_org": "S",
            "sequence_mut": "D",
            "comment": "Decreased S-adenosyl-L-methionine-binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        },
        {
            "start_pos": 65,
            "end_pos": 65,
            "sequence_org": "K",
            "sequence_mut": "A",
            "comment": "Decreased aminocarboxypropyltransferase activity; when associated with A-60 and A-131.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "27084949",
                    "url": "https://glygen.org/publication/PubMed/27084949"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                }
            ],
            "common_name": "Yeast"
        }
    ],
    "gene": [
        {
            "name": "TSR3",
            "url": "https://www.uniprot.org/uniprot/Q12094",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "854167",
            "url": "https://www.ncbi.nlm.nih.gov/gene/854167",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q12094",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q12094*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR007177",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007177",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR007209",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007209",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR022968",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR022968",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YOR006C",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR006C",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HHIRKGR",
            "url": "https://omabrowser.org/oma/group/HHIRKGR/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5485881at2759",
            "url": "http://www.orthodb.org/?query=5485881at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR20426",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20426",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR20426:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20426:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04034",
            "url": "http://pfam.xfam.org/family/PF04034",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04068",
            "url": "http://pfam.xfam.org/family/PF04068",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q12094",
            "url": "http://purl.obolibrary.org/obo/PR_Q12094",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_014648",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014648",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000005532",
            "url": "https://www.yeastgenome.org/locus/S000005532",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "Q12094",
            "url": "https://www.uniprot.org/uniprot/Q12094",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q12094-1",
            "url": "https://www.uniprot.org/uniprot/Q12094-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGKGKNKMHEPKNGRPQRGANGHSSRQNHRRMEMKYDNSEKMKFPVKLAMWDFDHCDPKRCSGKKLERLGLIKSLRVGQKFQGIVVSPNGKGVVCPDDLEIVEQHGASVVECSWARLEEVPFNKIGGKHERLLPYLVAANQVNYGRPWRLNCVEALAACFAIVGRMDWASELLSHFSWGMGFLELNKELLEIYQQCTDCDSVKRAEEEWLQKLEKETQERKSRAKEEDIWMMGNINRRGNGSQSDTSESEENSEQSDLEGNNQCIEYDSLGNAIRIDNMKSREAQSEESEDEESGSKENGEPLSYDPLGNLIR",
        "length": 313,
        "header": "sp|Q12094-1|TSR3_YEAST Isoform 1 of 18S rRNA aminocarboxypropyltransferase  OS=Saccharomyces cerevisiae S288C OX=559292 GN=TSR3 PE=1 SV=1 CANONICAL=Q12094-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q12094-1",
            "url": "",
            "sequence": {
                "sequence": "MGKGKNKMHEPKNGRPQRGANGHSSRQNHRRMEMKYDNSEKMKFPVKLAMWDFDHCDPKRCSGKKLERLGLIKSLRVGQKFQGIVVSPNGKGVVCPDDLEIVEQHGASVVECSWARLEEVPFNKIGGKHERLLPYLVAANQVNYGRPWRLNCVEALAACFAIVGRMDWASELLSHFSWGMGFLELNKELLEIYQQCTDCDSVKRAEEEWLQKLEKETQERKSRAKEEDIWMMGNINRRGNGSQSDTSESEENSEQSDLEGNNQCIEYDSLGNAIRIDNMKSREAQSEESEDEESGSKENGEPLSYDPLGNLIR",
                "length": 313,
                "header": "sp|Q12094-1|TSR3_YEAST Isoform 1 of 18S rRNA aminocarboxypropyltransferase  OS=Saccharomyces cerevisiae S288C OX=559292 GN=TSR3 PE=1 SV=1 CANONICAL=Q12094-1"
            },
            "locus": {
                "chromosome": "XV",
                "start_pos": 338621,
                "end_pos": 337683,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YOR006C_mRNA",
                        "url": "https://www.ensembl.org/id/YOR006C_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YOR006C",
                        "url": "https://www.ensembl.org/id/YOR006C"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 286,
            "end_pos": 286,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "19684113",
                    "url": "https://glygen.org/publication/PubMed/19684113"
                },
                {
                    "database": "SGD",
                    "id": "Q12094",
                    "url": "https://www.yeastgenome.org/locus/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser286"
        },
        {
            "start_pos": 289,
            "end_pos": 289,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "19684113",
                    "url": "https://glygen.org/publication/PubMed/19684113"
                },
                {
                    "database": "PubMed",
                    "id": "19795423",
                    "url": "https://glygen.org/publication/PubMed/19795423"
                },
                {
                    "database": "PubMed",
                    "id": "19823750",
                    "url": "https://glygen.org/publication/PubMed/19823750"
                },
                {
                    "database": "SGD",
                    "id": "Q12094",
                    "url": "https://www.yeastgenome.org/locus/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser289"
        },
        {
            "start_pos": 294,
            "end_pos": 294,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                }
            ],
            "site_lbl": "Ser294"
        },
        {
            "start_pos": 296,
            "end_pos": 296,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                }
            ],
            "site_lbl": "Ser296"
        },
        {
            "start_pos": 74,
            "end_pos": 74,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                },
                {
                    "database": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                }
            ],
            "site_lbl": "Ser74"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Global analysis of protein localization in budding yeast.",
            "journal": "Nature",
            "date": "2003",
            "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14562095",
                    "url": "https://glygen.org/publication/PubMed/14562095"
                }
            ]
        },
        {
            "title": "Global analysis of protein expression in yeast.",
            "journal": "Nature",
            "date": "2003",
            "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14562106",
                    "url": "https://glygen.org/publication/PubMed/14562106"
                }
            ]
        },
        {
            "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.",
            "journal": "J. Proteome Res.",
            "date": "2007",
            "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                }
            ]
        },
        {
            "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2007-06-19",
            "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                }
            ]
        },
        {
            "title": "Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.",
            "journal": "Genes & development",
            "date": "2009-08-15",
            "authors": "Huber Alexandre, Bodenmiller Bernd, Uotila Aino, Stahl Michael, Wanka Stefanie, Gerrits Bertran, Aebersold Ruedi, Loewith Robbie",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19684113",
                    "url": "https://glygen.org/publication/PubMed/19684113"
                }
            ]
        },
        {
            "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.",
            "journal": "Science (New York, N.Y.)",
            "date": "2009-09-25",
            "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12094",
                    "url": "https://www.uniprot.org/uniprot/Q12094"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                }
            ]
        },
        {
            "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.",
            "journal": "Proteomics",
            "date": "2009-10",
            "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12094",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12094"
                }
            ],
            "reference": [
                {
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