{ "uniprot_canonical_ac": "Q11205-1", "uniprot_ac": "Q11205", "uniprot_id": "SIA4B_RAT", "mass": { "chemical_mass": 40166.0, "monoisotopic_mass": 40166.0 }, "refseq": { "ac": "NP_113883", "name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883" }, "gene_names": [ { "name": "St3gal2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q11205", "id": "Q11205" }, { "name": "Siat4b; Siat5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883", "id": "NP_113883" }, { "name": "Siat4b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q11205", "id": "Q11205" }, { "name": "Siat5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q11205", "id": "Q11205" }, { "name": "St3gal2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883", "id": "NP_113883" } ], "protein_names": [ { "name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q11205" }, { "name": "2.4.3.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "2.4.3.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "Alpha 2,3-ST 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "Beta-galactoside alpha-2,3-sialyltransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883", "id": "NP_113883" }, { "name": "Gal-NAc6S", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "Monosialoganglioside sialyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "SIAT4-B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "ST3Gal II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "ST3GalA.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "ST3GalII", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "Sialyltransferase 4B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q11205" }, { "name": "monosialoganglioside sialyltransferase; SIAT4-B; ST3GALA.2; ST3Gal II; gal-NAc6S; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; ST3GalII; alpha 2,3-ST 2; beta-galactoside alpha-2,3-sialyltransferase 2; sialyltransferase 5; sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883", "id": "NP_113883" } ], "function": [ { "annotation": "A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 gangliosides to form GD1a and GM1b, respectively (PubMed:8144500). Together with ST3GAL3, primarily responsible for biosynthesis of brain gangliosides that function as ligand for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500).", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205#function" }, { "database": "UniProtKB", "id": "Q11204", "url": "https://www.uniprot.org/uniprot/Q11204#function" }, { "database": "PubMed", "id": "8144500", "url": "https://glygen.org/publication/PubMed/8144500" }, { "database": "UniProtKB", "id": "Q16842", "url": "https://www.uniprot.org/uniprot/Q16842#function" } ] }, { "annotation": "Use of sialyl mucin core 2 compounds shows how ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit, while also radiolabeling sialyl residues in gangliosides GD1a and GT1b, but not GM1.", "evidence": [ { "database": "RefSeq", "id": "NP_113883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883" }, { "database": "PubMed", "id": "21913655", "url": "https://glygen.org/publication/PubMed/21913655" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "common_name": "Rat" } ], "gene": [ { "name": "St3gal2", "url": "https://www.uniprot.org/uniprot/Q11205", "locus": { "chromosome": "19", "start_pos": 38939869, "end_pos": 38923999, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017932", "url": "https://www.ensembl.org/id/ENSRNOG00000017932" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017932", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017932", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.4.99.4", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.99.4&UniProtAcc=Q11205", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GT29", "url": "http://www.cazy.org/GT29.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3638362", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3638362", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "64442", "url": "https://www.ncbi.nlm.nih.gov/gene/64442", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:64442", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64442", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ISPVWTK", "url": "https://omabrowser.org/oma/group/ISPVWTK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5348004at2759", "url": "http://www.orthodb.org/?query=5348004at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46032", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46032", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46032:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46032:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00777", "url": "http://pfam.xfam.org/family/PF00777", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q11205", "url": "http://purl.obolibrary.org/obo/PR_Q11205", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-2022854", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022854", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-4085001", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4085001", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-977068", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-977068", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_113883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "68413", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=68413", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "18021", "url": "https://www.rhea-db.org/rhea/18021", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "21616", "url": "https://www.rhea-db.org/rhea/21616", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47560", "url": "https://www.rhea-db.org/rhea/47560", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48244", "url": "https://www.rhea-db.org/rhea/48244", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48248", "url": "https://www.rhea-db.org/rhea/48248", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "65372", "url": "https://www.rhea-db.org/rhea/65372", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "G3V8B2", "url": "https://www.uniprot.org/uniprot/G3V8B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V8B2-1", "url": "https://www.uniprot.org/uniprot/G3V8B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q11205-1", "url": "https://www.uniprot.org/uniprot/Q11205-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGTLGGTHRVKLVPGYTGQQRLVKEGLSGKSCTCSRCMGDAGTSEWFDSHFDSNISPVWTRDNMNLTPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDILAKASKIEVYRGN", "length": 350, "header": "sp|Q11205-1|SIA4B_RAT Isoform 1 of CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 OS=Rattus norvegicus OX=10116 GN=St3gal2 PE=1 SV=1 CANONICAL=Q11205-1" }, "isoforms": [ { "isoform_ac": "G3V8B2-1", "url": "", "sequence": { "sequence": "MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGTLGGTHRVKLVPGYTGQQRLVKEGLSGKSCTCSRCMGDAGTSEWFDSHFDSNISPVWTRDNMNLTPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN", "length": 350, "header": "tr|G3V8B2-1|G3V8B2_RAT Computationally mapped isoform of ST3 beta-galactoside alpha-2,3-sialyltransferase 2 OS=Rattus norvegicus OX=10116 GN=St3gal2 PE=3 SV=1 CANONICAL=Q11205-1" }, "locus": { "chromosome": "19", "start_pos": 38937766, "end_pos": 38924067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000024248.4", "url": "https://www.ensembl.org/id/ENSRNOT00000024248.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000024248.2", "url": "https://www.ensembl.org/id/ENSRNOP00000024248.2" } ] } }, { "isoform_ac": "Q11205-1", "url": "", "sequence": { "sequence": "MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGTLGGTHRVKLVPGYTGQQRLVKEGLSGKSCTCSRCMGDAGTSEWFDSHFDSNISPVWTRDNMNLTPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDILAKASKIEVYRGN", "length": 350, "header": "sp|Q11205-1|SIA4B_RAT Isoform 1 of CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 OS=Rattus norvegicus OX=10116 GN=St3gal2 PE=1 SV=1 CANONICAL=Q11205-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 211, "start_aa": "Asn", "end_pos": 211, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn211", "evidence": [ { "id": "Q11205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11205#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.", "journal": "Biochemistry", "date": "2011", "authors": "Chandrasekaran EV, Xue J, Xia J, Locke RD, Patil SA, Neelamegham S, Matta KL", "evidence": [ { "database": "RefSeq", "id": "NP_113883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883" } ], "reference": [ { "type": "PubMed", "id": "21913655", "url": "https://glygen.org/publication/PubMed/21913655" } ] }, { "title": "Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase.", "journal": "J. Biol. Chem.", "date": "1994", "authors": "Lee YC, Kojima N, Wada E, Kurosawa N, Nakaoka T, Hamamoto T, Tsuji S", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "reference": [ { "type": "PubMed", "id": "8144500", "url": "https://glygen.org/publication/PubMed/8144500" } ] } ], "pathway": [ { "id": "rno:64442", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64442", "resource": "KEGG Pathway" }, { "id": "R-RNO-2022854", "name": "Keratan sulfate biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022854", "resource": "Reactome", "description": "Keratan sulfate biosynthesis" }, { "id": "R-RNO-4085001", "name": "Sialic acid metabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-RNO-977068", "name": "Termination of O-glycan biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-977068", "resource": "Reactome", "description": "Termination of O-glycan biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q11204-1", "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2", "gene_name": "St3gal2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGALGGTHRVKLVPGYSGLQRLGKEGLLGRNCACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN", "length": 350 }, "evidence": [ { "id": "45228008", "url": "http://www.informatics.jax.org/homology/45228008", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q16842-1", "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2", "gene_name": "ST3GAL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN", "length": 350 }, "evidence": [ { "id": "45228008", "url": "http://www.informatics.jax.org/homology/45228008", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "protein glycosylation", "id": "GO:0006486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "glycolipid biosynthetic process", "id": "GO:0009247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009247", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "lipid glycosylation", "id": "GO:0030259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030259", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "oligosaccharide biosynthetic process", "id": "GO:0009312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009312", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "sialylation", "id": "GO:0097503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097503", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "protein sialylation", "id": "GO:1990743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990743", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "globoside biosynthetic process via lactosylceramide", "id": "GO:0010707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010707", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "ganglioside biosynthetic process via lactosylceramide", "id": "GO:0010706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010706", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "sialyltransferase activity", "id": "GO:0008373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008373", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase", "id": "GO:0047288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047288", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" }, { "name": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "id": "GO:0003836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003836", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated; necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus.", "evidence": [ { "database": "UniProtKB", "id": "Q11205", "url": "https://www.uniprot.org/uniprot/Q11205" }, { "database": "PubMed", "id": "Q16842", "url": "https://glygen.org/publication/PubMed/Q16842" } ] } ], "interactions": [], "reactions": [ { "id": "18021", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q11205-1", "P61131-1", "Q16842-1", "Q11201-1", "Q11206-1", "Q91Y74-1", "P54751-1", "Q11204-1" ], "evidence": [ { "id": "18021", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18021" } ] }, { "id": "21616", "name": "", "equation": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q11205-1", "P61131-1", "Q16842-1", "Q11201-1", "Q11206-1", "Q91Y74-1", "P54751-1", "Q11204-1" ], "evidence": [ { "id": "21616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21616" } ] }, { "id": "47560", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q11205-1", "P61131-1", "Q11201-1", "Q16842-1", "Q11206-1", "P54751-1", "Q91Y74-1", "Q11204-1" ], "evidence": [ { "id": "47560", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47560" } ] }, { "id": "48244", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q11205-1", "Q11201-1", "Q16842-1", "P54751-1", "Q11204-1" ], "evidence": [ { "id": "48244", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48244" } ] }, { "id": "48248", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q11205-1", "Q11201-1", "Q16842-1", "P54751-1", "Q11204-1" ], "evidence": [ { "id": "48248", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48248" } ] }, { "id": "65372", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer = CMP + globoside MSGG + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q11205-1", "Q16842-1", "Q11204-1" ], "evidence": [ { "id": "65372", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65372" } ] }, { "id": "R-RNO-2046285", "name": "The keratan chain can be capped by N-acetylneuraminic acid", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61131-1", "P61943-1", "Q02734-1", "Q11205-1" ], "evidence": [ { "id": "R-RNO-2046285", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2046285" } ] }, { "id": "R-RNO-4084984", "name": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-4086285" ], "output_participant_list": [ "R-ALL-4086277" ], "enzyme_list": [ "P61131-1", "P61943-1", "Q02734-1", "Q11205-1", "Q68G12-1" ], "evidence": [ { "id": "R-RNO-4084984", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4084984" } ] }, { "id": "R-RNO-981497", "name": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61131-1", "Q02734-1", "Q11205-1" ], "evidence": [ { "id": "R-RNO-981497", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-981497" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-4086277", "participant_name": "Neu5Ac-2,3-Gal-R [Golgi lumen]", "crossref": [ { "id": "75127", "database": "ChEBI", "url": "" }, { "id": "75127", "database": "ChEBI", "url": "" }, { "id": "75127", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-4086285", "participant_name": "Gal-R [Golgi lumen]", "crossref": [ { "id": "61248", "database": "ChEBI", "url": "" }, { "id": "61248", "database": "ChEBI", "url": "" }, { "id": "61248", "database": "ChEBI", "url": "" }, { "id": "61248", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P54751", "gene_name": "St3gal1", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "P54751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54751" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "P54751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54751" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "P54751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54751" } ] } ] }, { "uniprot_ac": "P61131", "gene_name": "St3gal4", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "3.6.1.59", "activity": "", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.2", "activity": "", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] } ] }, { "uniprot_ac": "P61943", "gene_name": "St3gal6", "activity": [ { "ec_number": "2.4.99.-", "activity": "", "evidence": [ { "id": "P61943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61943" } ] } ] }, { "uniprot_ac": "Q02734", "gene_name": "St3gal3", "activity": [ { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q02734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02734" } ] }, { "ec_number": "2.4.3.6", "activity": "", "evidence": [ { "id": "Q02734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02734" } ] } ] }, { "uniprot_ac": "Q11201", "gene_name": "ST3GAL1", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q11201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11201" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q11201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11201" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "Q11201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11201" } ] } ] }, { "uniprot_ac": "Q11204", "gene_name": "St3gal2", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q11204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11204" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q11204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11204" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "Q11204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11204" } ] } ] }, { "uniprot_ac": "Q11205", "gene_name": "St3gal2", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q11205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11205" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q11205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11205" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "Q11205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11205" } ] } ] }, { "uniprot_ac": "Q11206", "gene_name": "ST3GAL4", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q11206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11206" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q11206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11206" } ] }, { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q11206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11206" } ] }, { "ec_number": "2.4.3.2", "activity": "", "evidence": [ { "id": "Q11206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11206" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "Q11206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q11206" } ] } ] }, { "uniprot_ac": "Q16842", "gene_name": "ST3GAL2", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q16842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16842" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q16842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16842" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "Q16842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16842" } ] } ] }, { "uniprot_ac": "Q68G12", "gene_name": "St3gal5", "activity": [ { "ec_number": "2.4.3.9", "activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q68G12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68G12" } ] }, { "ec_number": "2.4.3.9", "activity": "", "evidence": [ { "id": "Q68G12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68G12" } ] } ] }, { "uniprot_ac": "Q91Y74", "gene_name": "St3gal4", "activity": [ { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "Q91Y74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Y74" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q91Y74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Y74" } ] }, { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q91Y74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Y74" } ] }, { "ec_number": "2.4.3.4", 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