{
    "uniprot_canonical_ac": "Q0GGX2-1",
    "uniprot_ac": "Q0GGX2",
    "uniprot_id": "ZN541_MOUSE",
    "mass": {
        "chemical_mass": 148297.0,
        "monoisotopic_mass": 148297.0
    },
    "refseq": {
        "ac": "NP_001092747",
        "name": "zinc finger protein 541 isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
    },
    "gene_names": [
        {
            "name": "Znf541",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2",
            "id": "Q0GGX2"
        },
        {
            "name": "EG666528; Znf541",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747",
            "id": "NP_001092747"
        },
        {
            "name": "Ship1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2",
            "id": "Q0GGX2"
        },
        {
            "name": "Zfp541",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747",
            "id": "NP_001092747"
        },
        {
            "name": "Zfp541",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2",
            "id": "Q0GGX2"
        }
    ],
    "protein_names": [
        {
            "name": "Zinc finger protein 541",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q0GGX2"
        },
        {
            "name": "Spermatogenic cell HDAC-interacting protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q0GGX2"
        },
        {
            "name": "spermatogenic cell HDAC-interacting protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747",
            "id": "NP_001092747"
        },
        {
            "name": "zinc finger protein 541 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747",
            "id": "NP_001092747"
        }
    ],
    "function": [
        {
            "annotation": "KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                },
                {
                    "database": "PubMed",
                    "id": "33961623",
                    "url": "https://glygen.org/publication/PubMed/33961623"
                }
            ]
        },
        {
            "annotation": "Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                },
                {
                    "database": "PubMed",
                    "id": "34075040",
                    "url": "https://glygen.org/publication/PubMed/34075040"
                }
            ]
        },
        {
            "annotation": "The Mm.290718/ZFP541 complex is implicated in chromatin remodeling during spermatogenesis and is renamed SHIP1",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                },
                {
                    "database": "PubMed",
                    "id": "18849567",
                    "url": "https://glygen.org/publication/PubMed/18849567"
                }
            ]
        },
        {
            "annotation": "Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes (PubMed:18849567, PubMed:35341968, PubMed:34075040, PubMed:33961623, PubMed:35320728). Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis and post-meiosis during spermatogenesis (PubMed:35341968). Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression (PubMed:35320728).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2#function"
                },
                {
                    "database": "PubMed",
                    "id": "18849567",
                    "url": "https://glygen.org/publication/PubMed/18849567"
                },
                {
                    "database": "PubMed",
                    "id": "33961623",
                    "url": "https://glygen.org/publication/PubMed/33961623"
                },
                {
                    "database": "PubMed",
                    "id": "35341968",
                    "url": "https://glygen.org/publication/PubMed/35341968"
                },
                {
                    "database": "PubMed",
                    "id": "35320728",
                    "url": "https://glygen.org/publication/PubMed/35320728"
                },
                {
                    "database": "PubMed",
                    "id": "34075040",
                    "url": "https://glygen.org/publication/PubMed/34075040"
                }
            ]
        },
        {
            "annotation": "ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                },
                {
                    "database": "PubMed",
                    "id": "35320728",
                    "url": "https://glygen.org/publication/PubMed/35320728"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Znf541",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000078796",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078796",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "666528",
            "url": "https://www.ncbi.nlm.nih.gov/gene/666528",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q0GGX2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q0GGX2*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000949",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001005",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017884",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036236",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:666528",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:666528",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "3647699",
            "url": "http://www.informatics.jax.org/marker/MGI:3647699",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "FAYDCPD",
            "url": "https://omabrowser.org/oma/group/FAYDCPD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2906194at2759",
            "url": "http://www.orthodb.org/?query=2906194at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR16089",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR16089:SF23",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089:SF23",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00096",
            "url": "http://pfam.xfam.org/family/PF00096",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01448",
            "url": "http://pfam.xfam.org/family/PF01448",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13912",
            "url": "http://pfam.xfam.org/family/PF13912",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q0GGX2",
            "url": "http://purl.obolibrary.org/obo/PR_Q0GGX2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001092747",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q0GGX2",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q0GGX2-1",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q0GGX2-2",
            "url": "https://www.uniprot.org/uniprot/Q0GGX2-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEPYSLGEEGALPSEGHLPSFSESQVLNCSDTLNRDLGPSTRDLLYAGLSGLDLDPSLSTSDMPSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQDLGLGALKVPKEADEGGRATGSTRKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVQHGVCILKETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPNRDLLRCIVSSIVHQKIPSPGPAVGPSDTEARSSACACPTSLGSSSCTPASTPVALGTLGSEIPEETHPPRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRPSSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHNFQWLRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPTSVEPSPSLGTTQEELLPFPPALLKAPGEASSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAQNPGGLPSDATPLFRQLFMKSQESLVSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTVDSFQIGPGHSEPEGSPVRRRKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSSLAKGTLDLGDIIPNAGSRQSQLGGDEPAGTQLVGKQGQGENGLASGAMRGEKGPACPRGGGYRLFSGHPRAQRFSGFRKEKVKMDVCCAASPSQVAMASFSSAGPLADPPRDMKSKLTIFNRIQGGNIYRLPHPVKEESLAGGCHQPNGGPTDWMESKSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEQQVKGQMVASVKRKAGREEGAVEDMKRHYDCSSSEPQDVTILSMLVSSGSCGVTPVVLSSLLQGQEKDGEERDSKESCQYRKRKKRPQPKALFAPPAPSALGEPGPGGCHQSCLHSPVFLVDHLLKGLFQCSPYTPPPMLSPIREGSGLYFNTLCSTSRAGPHLISPVLDQVDSSFGICVVKDDTKISIEPHINVGSRFQAEIPELQERLLARVDENVASLVWKPWGDVMTNPETQDRVMELCNVACSSVMPGGGTNLELALHCLHDAQGSVQVALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFKKAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWKKMVKFDCGRAPGLEKRGRRELDEVERTEDKVTCSPRERPTHRPTPELKIKTKSYRRESILHSSPSAAPKRTPEPPGSVESQGVFPCRECERVFDKIKSRNAHMKRHRLQEHVEPVRVKWPVKPYPLKEEEEEEEEELGADMGPLQW",
        "length": 1363,
        "header": "sp|Q0GGX2-1|ZN541_MOUSE Isoform 1 of Zinc finger protein 541  OS=Mus musculus OX=10090 GN=Znf541 PE=1 SV=1 CANONICAL=Q0GGX2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q0GGX2-1",
            "url": "",
            "sequence": {
                "sequence": "MEPYSLGEEGALPSEGHLPSFSESQVLNCSDTLNRDLGPSTRDLLYAGLSGLDLDPSLSTSDMPSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQDLGLGALKVPKEADEGGRATGSTRKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVQHGVCILKETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPNRDLLRCIVSSIVHQKIPSPGPAVGPSDTEARSSACACPTSLGSSSCTPASTPVALGTLGSEIPEETHPPRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRPSSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHNFQWLRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPTSVEPSPSLGTTQEELLPFPPALLKAPGEASSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAQNPGGLPSDATPLFRQLFMKSQESLVSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTVDSFQIGPGHSEPEGSPVRRRKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSSLAKGTLDLGDIIPNAGSRQSQLGGDEPAGTQLVGKQGQGENGLASGAMRGEKGPACPRGGGYRLFSGHPRAQRFSGFRKEKVKMDVCCAASPSQVAMASFSSAGPLADPPRDMKSKLTIFNRIQGGNIYRLPHPVKEESLAGGCHQPNGGPTDWMESKSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEQQVKGQMVASVKRKAGREEGAVEDMKRHYDCSSSEPQDVTILSMLVSSGSCGVTPVVLSSLLQGQEKDGEERDSKESCQYRKRKKRPQPKALFAPPAPSALGEPGPGGCHQSCLHSPVFLVDHLLKGLFQCSPYTPPPMLSPIREGSGLYFNTLCSTSRAGPHLISPVLDQVDSSFGICVVKDDTKISIEPHINVGSRFQAEIPELQERLLARVDENVASLVWKPWGDVMTNPETQDRVMELCNVACSSVMPGGGTNLELALHCLHDAQGSVQVALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFKKAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWKKMVKFDCGRAPGLEKRGRRELDEVERTEDKVTCSPRERPTHRPTPELKIKTKSYRRESILHSSPSAAPKRTPEPPGSVESQGVFPCRECERVFDKIKSRNAHMKRHRLQEHVEPVRVKWPVKPYPLKEEEEEEEEELGADMGPLQW",
                "length": 1363,
                "header": "sp|Q0GGX2-1|ZN541_MOUSE Isoform 1 of Zinc finger protein 541  OS=Mus musculus OX=10090 GN=Znf541 PE=1 SV=1 CANONICAL=Q0GGX2-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 15829781,
                "end_pos": 15805867,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000108509",
                        "url": "https://www.ensembl.org/id/ENSMUST00000108509"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000104149",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000104149"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q0GGX2-2",
            "url": "",
            "sequence": {
                "sequence": "MEPYSLGEEGALPSEGHLPSFSESQVLNCSDTLNRDLGPSTRDLLYAGLSGLDLDPSLSTSDMPSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQDLGLGALKVPKEADEGGRATGSTRKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVQHGVCILKETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPNRDLLRCIVSSIVHQKIPSPGPAVGPSDTEARSSACACPTSLGSSSCTPASTPVALGTLGSEIPEETHPPRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRPSSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHNFQWLRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPTSVEPSPSLGTTQEELLPFPPALLKAPGEASSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAQNPGGLPSDATPLFRQLFMKSQESLVSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTVDSFQIGPGHSEPEGSPVRRRKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSSLAKGTLDLGDIIPNAGSRQSQLGGDEPAGTQLVGKQGQGENGLASGAMRGEKGPACPRGGGYRLFSGHPRAQRFSGFRKEKVKMDVCCAASPSQVAMASFSSAGPLADPPRDMKSKLTIFNRIQGGNIYRLPHPVKEESLAGGCHQPNGGPTDWMESKSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEQQGQEKDGEERDSKESCQYRKRKKRPQPKALFAPPAPSALGEPGPGGCHQSCLHSPVFLVDHLLKGLFQCSPYTPPPMLSPIREGSGLYFNTLCSTSRAGPHLISPVLDQVDSSFGICVVKDDTKISIEPHINVGSRFQAEIPELQERLLARVDENVASLVWKPWGDVMTNPETQDRVMELCNVACSSVMPGGGTNLELALHCLHDAQGSVQVALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFKKAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWKKMVKFDCGRAPGLEKRGRRELDEVERTEDKVTCSPRERPTHRPTPELKIKTKSYRRESILHSSPSAAPKRTPEPPGSVESQGVFPCRECERVFDKIKSRNAHMKRHRLQEHVEPVRVKWPVKPYPLKEEEEEEEEELGADMGPLQW",
                "length": 1302,
                "header": "sp|Q0GGX2-2|ZN541_MOUSE Isoform 2 of Zinc finger protein 541  OS=Mus musculus OX=10090 GN=Znf541 PE=1 SV=1 CANONICAL=Q0GGX2-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 15829781,
                "end_pos": 15805867,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000210805",
                        "url": "https://www.ensembl.org/id/ENSMUST00000210805"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000148143",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000148143"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.",
            "journal": "BMC Genomics",
            "date": "2007",
            "authors": "Choi E, Lee J, Oh J, Park I, Han C, Yi C, Kim DH, Cho BN, Eddy EM, Cho C",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17662146",
                    "url": "https://glygen.org/publication/PubMed/17662146"
                }
            ]
        },
        {
            "title": "A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis.",
            "journal": "J. Biol. Chem.",
            "date": "2008",
            "authors": "Choi E, Han C, Park I, Lee B, Jin S, Choi H, Kim DH, Park ZY, Eddy EM, Cho C",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18849567",
                    "url": "https://glygen.org/publication/PubMed/18849567"
                }
            ]
        },
        {
            "title": "KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.",
            "journal": "PLoS Genet.",
            "date": "2021",
            "authors": "Oura S, Koyano T, Kodera C, Horisawa-Takada Y, Matsuyama M, Ishiguro KI, Ikawa M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33961623",
                    "url": "https://glygen.org/publication/PubMed/33961623"
                }
            ]
        },
        {
            "title": "Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.",
            "journal": "Nat. Commun.",
            "date": "2021",
            "authors": "Horisawa-Takada Y, Kodera C, Takemoto K, Sakashita A, Horisawa K, Maeda R, Shimada R, Usuki S, Fujimura S, Tani N, Matsuura K, Akiyama T, Suzuki A, Niwa H, Tachibana M, Ohba T, Katabuchi H, Namekawa SH, Araki K, Ishiguro KI",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34075040",
                    "url": "https://glygen.org/publication/PubMed/34075040"
                }
            ]
        },
        {
            "title": "ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.",
            "journal": "Cell Rep.",
            "date": "2022",
            "authors": "Xu J, Gao J, Liu J, Huang X, Zhang H, Ma A, Ye J, Zhang X, Li Y, Yang G, Yin H, Khan R, Li T, Fan S, Jiang X, Zhang Y, Jiang H, Ma H, Shi Q",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001092747",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "35320728",
                    "url": "https://glygen.org/publication/PubMed/35320728"
                }
            ]
        },
        {
            "title": "The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis.",
            "journal": "J. Genet. Genomics",
            "date": "2022",
            "authors": "Li S., Li Y., Wang F., Wang J., Xu D., Zhang H., Xu X., Tan X., Gu B., Meng R., Shao T.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q0GGX2",
                    "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "35341968",
                    "url": "https://glygen.org/publication/PubMed/35341968"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:666528",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:666528",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3Z8I0-1",
            "protein_name": "Zinc finger protein 541",
            "gene_name": "Zfp541",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEPYSLGEEGPLPSEGHLPSFSESQGLNCSDTLNRDLGPSTRDLLYAGLSGLDLDPSLSTSDMPSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQDLGLGTLKVPKEADEGGRATGSTRKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVQHGVCILKEAPPEEESYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPNRDLLRCIVSSIVHQKIPSPGPAVGSSDTEARSSACACPTSLGSSSCTPASTPVAPGTLGSEIPEETHPPRKEAATEMFTAVQSRAAENSAPDPPESELESESPRLQRPSSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHNFQWLRNLPSCPKNKSSNVFMVHKPSAVASREGSEGGSGPSSTPTSVEPSPSLGTSQEDLLPFPPALLKAPGEASSEVRQVAGEDETWAPKKCKPDCESFPWQSPTELGLQDAQNPGGLPSDATPLFRQLFMKSQESLVSHEQMQVLQMIAKSQRIFSHTQVATAAAQRPGPEGKQSTLKPLQGPWPPQTLPPVPTVDSFQIGPGHSEPEGSPVRRRKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPALHPSRNPDNSSLAKGTLDLGDIIPSAGSRQSQLGGDEPSGTQLVGKQGQGENGLASGAMRGEKGPACPRGGGYRLFSGHPRAQRFSGFRKEKVKMDVCCAASPSQVAMASFSSAGPLADPPRDMKSKLTIFNRIQGGNIYRLPHPVKEESLAGGCHQPNGTPTDWMESKSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEQQGQEKDGEERDSKESSQYRKRKKRPQPKALFAPPAPSALGEPGPGGCHQSCLRSPVFLVDHLLKGLFQCSPYTPPPMLSPIREGSGLYFNTLCSTSRAGPHLVSPVLDQVDGSFGICVVKDDTKISIEPHINVGSRFQAEIPELQERPLTRVDENVASLVWKPWGDVMTNPETQDRVMELCNVACSSVMPGGGTNLELALHCLHDAQGSVQVALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFKKAFCAHKKDFYLIHKTIQTKSVAQCVEYYYIWKKMVKFDCGRAPGLEKRGRRELDEVERTEDKVTCSPRERPTHRPTPELKIKTKSYRRESILHSSPSAAPKRTPEPPGSVESQGVFPCRECERVFDKIKSRNAHMKRHRLQEHVEPVRVKWPVKPYPLKEEEEEEEEELGADMGPLQW",
                "length": 1301
            },
            "evidence": [
                {
                    "id": "45239065",
                    "url": "http://www.informatics.jax.org/homology/45239065",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9H0D2-3",
            "protein_name": "Zinc finger protein 541",
            "gene_name": "ZNF541",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MDQYSLGDEGALPSEMHLPSFSESQGLNCSDTLNRDLGPNTRGFLYAGLSGLDPDPSLPTPDMSSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQASLQDLGLGVLKAKEADEGGRATSGSARKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKICSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVHHGLCILKEAPPEEEACGDSPHAHESAGQPPPSSLRSLVPPEARSPGSLLPHRDLLRRIVSSIVHQKTPSPGPAPAGASDSEGRNTACPCPASSGSSSCTPAGPHAAPAALDTELPEEPCLPQKEPATDVFTAPNSRAAENGAPDPPEPEPDTALLQARSTAECWPEGGSVPACLPLFRGQTVPASSQPSSHSFQWLRNLPGCPKSKGNNVFVVHKPSAVPSREGSESGPGPSSGSPSEESPPGPGGGLEDALPFPAALLRVPAEAPSDPRSASGEDDPCAPKKVKVDCDSFLCQNPGEPGLQEAQKAGGLPADASPLFRQLFLKSQEPLVSHEQMQVFQMITKSQRIFSHAQVAAVSSQLPAPEGKPAALRPLQGPWPQQPPPLAPAVDSLHAGPGNPEAEGSPARRRKTTPGVPREASPGSTRRDAKGGLKVAAVPTPLAAPSLDPSRNPDISSLAKQLRSSKGTLDLEDIFPSTGQRQTQLGGEEPPGASLPGKQAPAENGAASRITKGEKGPACSRGGGYRLLGNPRAPRFSGFRKEKAKMDMCCAASPSQVAMASFSSAGPPADPSKSKLTIFSRIQGGNIYRLPHPVKEENVAGRGNQQNGSPTDWTKPRSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEPQVFGTEFCKPLRQVLRPEGDRHSPPGTKKPLDPTAAAPLVVPQSIPVVPVTRHIGSMAMGQEKDGEERDSKESSQQRKRKKRPPPSTAGEPGPAGCHQSRLRSPMFLVDCLLKGLFQCSPYTPPPMLSPIREGSGVYFNTLCSTSTQASPDQLISSMLDQVDGSFGICVVKDDTKISIEPHINIGSRFQAEIPELQERSLAGTDEHVASLVWKPWGDMMISSETQDRVTELCNVACSSVMPGGGTNLELALHCLHEAQGNVQVALETLLLRGPHKPRTHLLADYRYTGSDVWTPIEKRLFKKAFYAHKKDFYLIHKMIQTKTVAQCVEYYYIWKKMIKFDCGRAPGLEKRVKREPEEVERTEEKVPCSPRERPSHHPTPKLKTKSYRRESILSSSPNAGSKRTPELLGSAESQGIFPCRECERVFDKIKSRNAHMKRHRLQDHVEPIIRVKWPVKPFQLKEEELGADIGPLQW",
                "length": 1346
            },
            "evidence": [
                {
                    "id": "45239065",
                    "url": "http://www.informatics.jax.org/homology/45239065",
                    "database": "MGI"
                },
                {
                    "id": "Q0GGX2",
                    "url": "https://omabrowser.org/oma/group/Q0GGX2/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription regulator complex",
                        "id": "GO:0005667",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone deacetylase complex",
                        "id": "GO:0000118",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spermatogenesis",
                        "id": "GO:0007283",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell differentiation",
                        "id": "GO:0030154",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of DNA-templated transcription",
                        "id": "GO:0045892",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription corepressor activity",
                        "id": "GO:0003714",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q0GGX2",
                                "url": "https://www.uniprot.org/uniprot/Q0GGX2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 28,
            "end_pos": 30,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 842,
            "end_pos": 844,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 6
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}