{ "uniprot_canonical_ac": "Q08622-1", "uniprot_ac": "Q08622", "uniprot_id": "GEP3_YEAST", "mass": { "chemical_mass": 63853.0, "monoisotopic_mass": 63853.0 }, "refseq": { "ac": "NP_014848", "name": "Gep3p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014848" }, "gene_names": [ { "name": "GEP3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q08622", "id": "Q08622" }, { "name": "AIM40; FMP38; MTG3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014848", "id": "NP_014848" }, { "name": "AIM40", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q08622", "id": "Q08622" }, { "name": "FMP48", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q08622", "id": "Q08622" }, { "name": "GEP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014848", "id": "NP_014848" } ], "protein_names": [ { "name": "Genetic interactor of prohibitins 3, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q08622" }, { "name": "Altered inheritance of mitochondria protein 40", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q08622" }, { "name": "Found in mitochondrial proteome protein 38", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q08622" }, { "name": "Gep3p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014848", "id": "NP_014848" } ], "function": [ { "annotation": "Interacts genetically with prohibitins and thus may be involved in the mitochondrial lipid metabolism.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622#function" }, { "database": "PubMed", "id": "19751518", "url": "https://glygen.org/publication/PubMed/19751518" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "common_name": "Yeast" } ], "gene": [ { "name": "GEP3", "url": "https://www.uniprot.org/uniprot/Q08622", "locus": { "chromosome": "XV", "start_pos": 725564, "end_pos": 727234, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YOR205C", "url": "https://www.ensembl.org/id/YOR205C" } ] } } ], "crossref": [ { "id": "cd01855", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01855", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "854380", "url": "https://www.ncbi.nlm.nih.gov/gene/854380", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q08622", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q08622*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR205C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR205C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IIPPFYG", "url": "https://omabrowser.org/oma/group/IIPPFYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1983973at2759", "url": "http://www.orthodb.org/?query=1983973at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46434", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46434", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46434:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46434:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "http://pfam.xfam.org/family/PF01926", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q08622", "url": "http://purl.obolibrary.org/obo/PR_Q08622", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014848", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005731", "url": "https://www.yeastgenome.org/locus/S000005731", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q08622-1", "url": "https://www.uniprot.org/uniprot/Q08622-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNLCHALRGVRQFSCSVIVKVKCASCSIKLQDQDPSKPGYYTKPKSLPDSKLNPDLQDLKYLLFSQDIQLSKQATQNDPDLKTKRDLLLRVICKRCSNALHHNNYNPEEFPESTLNDILNYVPRGSNVMHIVPFVEFPLHLDPNVLKRNDLDTTLVLTKSDQVFKDKNAVSKKVPIFMKQFLKNTLRIDSNKTFAISALKNWNISMFYNYFKNYTYLLGNPNVGKSTLINTLLQKYLGYKVKIDSTGKINSPSEEVMQEAFTNPKNFFKIQAAGVSHIPNLTRSVQAYQVGGKILFDLPGYSTSTSRLRLEELIDERWLQRLRKTDLFNRKHIKQKTYESMKGTSQGGCYTVGGIFYLVPPKGSINQIVKYIPGPSKTFKNIEKGIDVFNSCNSSSGTHPLSRYCGIKSVICEKSQYKRYAIPPFIGSIEIVLKDIGYILLRTTGRYEFKGLHEIWIPRGIQVGIREPLENLIESGYQRYIETNGKESSCPRDRPIISSLYEMAPDEADTLNAVKKSYLEKTEKDLSARRFVDDDPYDLVQHLEKKKNPYWYYQW", "length": 556, "header": "sp|Q08622-1|GEP3_YEAST Isoform 1 of Genetic interactor of prohibitins 3, mitochondrial OS=Saccharomyces cerevisiae S288C OX=559292 GN=GEP3 PE=1 SV=1 CANONICAL=Q08622-1" }, "isoforms": [ { "isoform_ac": "Q08622-1", "url": "", "sequence": { "sequence": "MLNLCHALRGVRQFSCSVIVKVKCASCSIKLQDQDPSKPGYYTKPKSLPDSKLNPDLQDLKYLLFSQDIQLSKQATQNDPDLKTKRDLLLRVICKRCSNALHHNNYNPEEFPESTLNDILNYVPRGSNVMHIVPFVEFPLHLDPNVLKRNDLDTTLVLTKSDQVFKDKNAVSKKVPIFMKQFLKNTLRIDSNKTFAISALKNWNISMFYNYFKNYTYLLGNPNVGKSTLINTLLQKYLGYKVKIDSTGKINSPSEEVMQEAFTNPKNFFKIQAAGVSHIPNLTRSVQAYQVGGKILFDLPGYSTSTSRLRLEELIDERWLQRLRKTDLFNRKHIKQKTYESMKGTSQGGCYTVGGIFYLVPPKGSINQIVKYIPGPSKTFKNIEKGIDVFNSCNSSSGTHPLSRYCGIKSVICEKSQYKRYAIPPFIGSIEIVLKDIGYILLRTTGRYEFKGLHEIWIPRGIQVGIREPLENLIESGYQRYIETNGKESSCPRDRPIISSLYEMAPDEADTLNAVKKSYLEKTEKDLSARRFVDDDPYDLVQHLEKKKNPYWYYQW", "length": 556, "header": "sp|Q08622-1|GEP3_YEAST Isoform 1 of Genetic interactor of prohibitins 3, mitochondrial OS=Saccharomyces cerevisiae S288C OX=559292 GN=GEP3 PE=1 SV=1 CANONICAL=Q08622-1" }, "locus": { "chromosome": "XV", "start_pos": 727234, "end_pos": 725567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR205C_mRNA", "url": "https://www.ensembl.org/id/YOR205C_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR205C", "url": "https://www.ensembl.org/id/YOR205C" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The proteome of Saccharomyces cerevisiae mitochondria.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Sickmann A., Zahedi R.P., Rehling P., Chacinska A., Guiard B., Meyer H.E., Meisinger C., Reinders J., Pfanner N., Joppich C., Perschil I., Schoenfisch B., Wagner Y.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "14576278", "url": "https://glygen.org/publication/PubMed/14576278" } ] }, { "title": "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.", "journal": "PLoS Genet.", "date": "2009", "authors": "Costanzo M., Nislow C., Caudy A.A., Giaever G., Huttenhower C., Troyanskaya O.G., Clore J.J., Hayes A.P., Hess D.C., Hibbs M.A., Luis B.S., Mendoza R.M., Myers C.L., Paw J.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "19300474", "url": "https://glygen.org/publication/PubMed/19300474" } ] }, { "title": "Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae.", "journal": "Genome Biol.", "date": "2009", "authors": "Westermann B., Merz S.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "19751518", "url": "https://glygen.org/publication/PubMed/19751518" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Mewes H.-W., Wambutt R., Wedler H., Wiemann S., Pujol A., Uhlen M., Camasses A., Poch O., Benes V., Durand P., Vlcek C., Winsor B., Landt O., Portetelle D., Casas C., Lafuente M.J., Paces V., Delius H., Michaux G., Schweizer M., Feldmann H., Kleine K., Martin R.P., Hofmann B., Schwager C., Voss H., Cziepluch C., Jauniaux J.-C., Hughes B., Galisson F., Volckaert G., Hattenhorst U., Cheret G., Sor F., Herrero E., Arino J., Vetter I., Casamayor A., Bordonne R., Perrin A., Thierry A., Kordes E., Louis E.J., Hollenberg C.P., Maarse A.C., Marck C., Vandenbol M., Pohl T.M., Tobiasch E., Pearson B.M., Poirey R., Hand N.J., Goulding S.E., Daignan-Fornier B., Dujon B., Goffeau A., Grivell L.A., Hani J., Hernando Y., Hilger F., Madania A., Mannhaupt G., Zollner A., Aldea M., Alexandraki D., Bolotin-Fukuhara M., Fairhead C., Gancedo C., Purnelle B., Ramezani Rad M., Tarassov I.A., Tzermia M., Voet M., Albermann K., Bohn C., Boyer J., Dang V.-D., Gaillon L., Gamo F.-J., Habbig B., Hebling U., Heumann K., Hiesel R., Kalogeropoulos A., Katsoulou C., Parle-McDermott A.G., Pettersson B., Rechmann S., Sterky F., Teodoru C., Tettelin H., Unseld M., Valens M., Wolfe K.H., Zumstein E., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "reference": [ { "type": "PubMed", "id": "9169874", "url": "https://glygen.org/publication/PubMed/9169874" } ] } ], "pathway": [ { "id": "sce:YOR205C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR205C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "maturation of SSU-rRNA", "id": "GO:0030490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030490", "evidence": [ { "database": "UniProtKB", "id": "Q08622", "url": "https://www.uniprot.org/uniprot/Q08622" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }