{ "uniprot_canonical_ac": "Q08412-1", "uniprot_ac": "Q08412", "uniprot_id": "CUE5_YEAST", "mass": { "chemical_mass": 46870.0, "monoisotopic_mass": 46870.0 }, "refseq": { "ac": "NP_014685", "name": "ubiquitin-binding protein CUE5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014685" }, "gene_names": [ { "name": "CUE5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q08412", "id": "Q08412" }, { "name": "CUE5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014685", "id": "NP_014685" } ], "protein_names": [ { "name": "Ubiquitin-binding protein CUE5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q08412" }, { "name": "Coupling of ubiquitin conjugation to ER degradation protein 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q08412" }, { "name": "ubiquitin-binding protein CUE5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014685", "id": "NP_014685" } ], "function": [ { "annotation": "Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 adapter and thus mediating autophagic clearance of ubiquitin conjugates under starvation conditions. The CUE5-dependent selective autophagy pathway plays an important role in clearance of cytotoxic protein aggregates. Not required for cytoplasmic to vacuole pathway (cvt), mitophagy, pexophagy, or ribophagy.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412#function" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" }, { "database": "PubMed", "id": "12628920", "url": "https://glygen.org/publication/PubMed/12628920" } ] } ], "disease": [ { "disease_id": "DOID:1289", "recommended_name": { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "synonyms": [ { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "degenerative disease", "description": "" } ], "evidence": [ { "id": "1289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 109, "end_pos": 109, "sequence_org": "F", "sequence_mut": "A", "comment": "Impairs interaction with ubiquitin; when associated with A-110.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" } ] }, { "start_pos": 110, "end_pos": 110, "sequence_org": "P", "sequence_mut": "A", "comment": "Impairs interaction with ubiquitin; when associated with A-109.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" } ] }, { "start_pos": 135, "end_pos": 135, "sequence_org": "L", "sequence_mut": "A", "comment": "Impairs interaction with ubiquitin; when associated with A-136.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" } ] }, { "start_pos": 136, "end_pos": 136, "sequence_org": "L", "sequence_mut": "A", "comment": "Impairs interaction with ubiquitin; when associated with A-135.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" } ] }, { "start_pos": 373, "end_pos": 373, "sequence_org": "W", "sequence_mut": "A", "comment": "Impairs interaction with ATG8.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" } ] }, { "start_pos": 376, "end_pos": 376, "sequence_org": "L", "sequence_mut": "A", "comment": "Impairs interaction with ATG8.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "25042851", "url": "https://glygen.org/publication/PubMed/25042851" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" } ], "common_name": "Yeast" } ], "gene": [ { "name": "CUE5", "url": "https://www.uniprot.org/uniprot/Q08412", "locus": {} } ], "crossref": [ { "id": "cd14372", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14372", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "854206", "url": "https://www.ncbi.nlm.nih.gov/gene/854206", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q08412", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q08412*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR042W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR042W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VAETTYI", "url": "https://omabrowser.org/oma/group/VAETTYI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2723500at2759", "url": "http://www.orthodb.org/?query=2723500at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16461:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16461:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02845", "url": "http://pfam.xfam.org/family/PF02845", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q08412", "url": "http://purl.obolibrary.org/obo/PR_Q08412", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014685", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005568", "url": "https://www.yeastgenome.org/locus/S000005568", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q08412-1", "url": "https://www.uniprot.org/uniprot/Q08412-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEKEGIKDSSLLEKSNVPESINEDISKTTDVDLNSDGKKDNDTSAKDGTPKVEEKVNKSSGIDEDEVVTPAEDAKEEEEEHPPLPARRKSEEEPSKENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDPESGKDIELPTQPVRKNPEAPARRRQTQLEQDELLARQLDEQFNSSHSRRRNRDRATRSMHEQRRRRHNPNEREQHHEDSEEEDSWSQFVEKDLPELTDRAGRSLQDTANKVSNWISDAYRRNFASGNEQNDNQHGHQDQQEWEPEIVDLSQGGKNSRPQQPERRRFNSFGVQVGDDSLESHGITLHNEDGFEDDEDVPPQLPTRTKSGESTGKVVAETTYIDTPDTETKKKWQPLPPEPLDTTPTKVNAVSRNKKNPDEDEFLINSDDEM", "length": 411, "header": "sp|Q08412-1|CUE5_YEAST Isoform 1 of Ubiquitin-binding protein CUE5 OS=Saccharomyces cerevisiae S288C OX=559292 GN=CUE5 PE=1 SV=1 CANONICAL=Q08412-1" }, "isoforms": [ { "isoform_ac": "Q08412-1", "url": "", "sequence": { "sequence": "MEEKEGIKDSSLLEKSNVPESINEDISKTTDVDLNSDGKKDNDTSAKDGTPKVEEKVNKSSGIDEDEVVTPAEDAKEEEEEHPPLPARRKSEEEPSKENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDPESGKDIELPTQPVRKNPEAPARRRQTQLEQDELLARQLDEQFNSSHSRRRNRDRATRSMHEQRRRRHNPNEREQHHEDSEEEDSWSQFVEKDLPELTDRAGRSLQDTANKVSNWISDAYRRNFASGNEQNDNQHGHQDQQEWEPEIVDLSQGGKNSRPQQPERRRFNSFGVQVGDDSLESHGITLHNEDGFEDDEDVPPQLPTRTKSGESTGKVVAETTYIDTPDTETKKKWQPLPPEPLDTTPTKVNAVSRNKKNPDEDEFLINSDDEM", "length": 411, "header": "sp|Q08412-1|CUE5_YEAST Isoform 1 of Ubiquitin-binding protein CUE5 OS=Saccharomyces cerevisiae S288C OX=559292 GN=CUE5 PE=1 SV=1 CANONICAL=Q08412-1" }, "locus": { "chromosome": "XV", "start_pos": 409657, "end_pos": 408425, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR042W_mRNA", "url": "https://www.ensembl.org/id/YOR042W_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR042W", "url": "https://www.ensembl.org/id/YOR042W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ], "site_lbl": "Ser10" }, { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser11" }, { "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" } ], "site_lbl": "Thr167" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Ser16" }, { "start_pos": 185, "end_pos": 185, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser185" }, { "start_pos": 188, "end_pos": 188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser188" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser21" }, { "start_pos": 220, "end_pos": 220, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser220" }, { "start_pos": 225, "end_pos": 225, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" } ], "site_lbl": "Ser225" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" } ], "site_lbl": "Ser227" }, { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser244" }, { "start_pos": 309, "end_pos": 309, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser309" }, { "start_pos": 318, "end_pos": 318, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser318" }, { "start_pos": 325, "end_pos": 325, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q08412", "url": "https://www.yeastgenome.org/locus/Q08412" } ], "site_lbl": "Thr325" }, { "start_pos": 346, "end_pos": 346, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": 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Biotechnol.", "date": "2003", "authors": "Peng Junmin, Schwartz Daniel, Elias Joshua E, Thoreen Carson C, Cheng Dongmei, Marsischky Gerald, Roelofs Jeroen, Finley Daniel, Gygi Steven P", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" }, { "database": "iPTMnet", "id": "Q08412", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q08412" } ], "reference": [ { "type": "PubMed", "id": "12872131", "url": "https://glygen.org/publication/PubMed/12872131" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q08412", "url": "https://www.uniprot.org/uniprot/Q08412" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Targeted proteomic study of the cyclin-Cdk module.", "journal": "Mol. 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