{ "uniprot_canonical_ac": "Q08409-1", "uniprot_ac": "Q08409", "uniprot_id": "AUS1_YEAST", "mass": { "chemical_mass": 157751.0, "monoisotopic_mass": 157751.0 }, "refseq": { "ac": "NP_014654", "name": "ATP-binding cassette sterol transporter AUS1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014654" }, "gene_names": [ { "name": "AUS1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q08409", "id": "Q08409" }, { "name": "AUS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014654", "id": "NP_014654" } ], "protein_names": [ { "name": "ATP-dependent permease AUS1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q08409" }, { "name": "ATP-binding cassette sterol transporter AUS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014654", "id": "NP_014654" } ], "function": [ { "annotation": "Transporter involved in the uptake of 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"url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR011W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR011W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QAIFCTI", "url": "https://omabrowser.org/oma/group/QAIFCTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2034298at2759", "url": "http://www.orthodb.org/?query=2034298at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19241:SF620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19241:SF620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "http://pfam.xfam.org/family/PF00005", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01061", "url": "http://pfam.xfam.org/family/PF01061", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06422", "url": "http://pfam.xfam.org/family/PF06422", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19055", "url": "http://pfam.xfam.org/family/PF19055", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q08409", "url": "http://purl.obolibrary.org/obo/PR_Q08409", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014654", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005537", "url": "https://www.yeastgenome.org/locus/S000005537", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q08409-1", "url": "https://www.uniprot.org/uniprot/Q08409-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSISKYFTPVADGSLTFNGANIQFGADAQGESKKSYDAEDSMPNPANQLNDITFQAEAGEMVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKCPHQIIYNNEQDVHFPFLTVEQTIDFALSCKFDIPKGERDQIRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASVLKTATGEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQLLFCTKRAFQRSLGDKAYMTAQFISVVIQSLVIGSLFYEIPLTTIGSYSRGSLTFFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSIILYFLAHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLAIAMYASYVIYLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDVPFSHKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQYIKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCAYCTYTVGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKIITKVIPHRGKKPVQN", "length": 1394, "header": "sp|Q08409-1|AUS1_YEAST Isoform 1 of ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=AUS1 PE=3 SV=1 CANONICAL=Q08409-1" }, "isoforms": [ { "isoform_ac": "Q08409-1", "url": "", "sequence": { "sequence": "MSISKYFTPVADGSLTFNGANIQFGADAQGESKKSYDAEDSMPNPANQLNDITFQAEAGEMVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKCPHQIIYNNEQDVHFPFLTVEQTIDFALSCKFDIPKGERDQIRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASVLKTATGEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQLLFCTKRAFQRSLGDKAYMTAQFISVVIQSLVIGSLFYEIPLTTIGSYSRGSLTFFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSIILYFLAHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLAIAMYASYVIYLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDVPFSHKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQYIKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCAYCTYTVGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKIITKVIPHRGKKPVQN", "length": 1394, "header": "sp|Q08409-1|AUS1_YEAST Isoform 1 of ATP-dependent permease AUS1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=AUS1 PE=3 SV=1 CANONICAL=Q08409-1" }, "locus": { "chromosome": "XV", "start_pos": 353860, "end_pos": 349679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR011W_mRNA", "url": "https://www.ensembl.org/id/YOR011W_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR011W", "url": "https://www.ensembl.org/id/YOR011W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Sturley S.L., Tinkelenberg A.H., Wilcox L.J., Rao G., Balderes D.A., Wharton B.", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "reference": [ { "type": "PubMed", "id": "12077145", "url": "https://glygen.org/publication/PubMed/12077145" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Mewes H.-W., Wambutt R., Wedler H., Wiemann S., Pujol A., Uhlen M., Camasses A., Poch O., Benes V., Durand P., Vlcek C., Winsor B., Landt O., Portetelle D., Casas C., Lafuente M.J., Paces V., Delius H., Michaux G., Schweizer M., Feldmann H., Kleine K., Martin R.P., Hofmann B., Schwager C., Voss H., Cziepluch C., Jauniaux J.-C., Hughes B., Galisson F., Volckaert G., Hattenhorst U., Cheret G., Sor F., Herrero E., Arino J., Vetter I., Casamayor A., Bordonne R., Perrin A., Thierry A., Kordes E., Louis E.J., Hollenberg C.P., Maarse A.C., Marck C., Vandenbol M., Pohl T.M., Tobiasch E., Pearson B.M., Poirey R., Hand N.J., Goulding S.E., Daignan-Fornier B., Dujon B., Goffeau A., Grivell L.A., Hani J., Hernando Y., Hilger F., Madania A., Mannhaupt G., Zollner A., Aldea M., Alexandraki D., Bolotin-Fukuhara M., Fairhead C., Gancedo C., Purnelle B., Ramezani Rad M., Tarassov I.A., Tzermia M., Voet M., Albermann K., Bohn C., Boyer J., Dang V.-D., Gaillon L., Gamo F.-J., Habbig B., Hebling U., Heumann K., Hiesel R., Kalogeropoulos A., Katsoulou C., Parle-McDermott A.G., Pettersson B., Rechmann S., Sterky F., Teodoru C., Tettelin H., Unseld M., Valens M., Wolfe K.H., Zumstein E., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "reference": [ { "type": "PubMed", "id": "9169874", "url": "https://glygen.org/publication/PubMed/9169874" } ] } ], "pathway": [ { "id": "sce:YOR011W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR011W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" }, { "name": "ABC-type sterol transporter activity", "id": "GO:0034041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034041", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sterol import", "id": "GO:0035376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035376", "evidence": [ { "database": "UniProtKB", "id": "Q08409", "url": "https://www.uniprot.org/uniprot/Q08409" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1336, "end_pos": 1338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": 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[] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": 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