{ "uniprot_canonical_ac": "Q07079-1", "uniprot_ac": "Q07079", "uniprot_id": "IBP5_MOUSE", "mass": { "chemical_mass": 30372.0, "monoisotopic_mass": 30372.0 }, "refseq": { "ac": "NP_034648", "name": "insulin-like growth factor-binding protein 5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034648" }, "gene_names": [ { "name": "Igfbp5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q07079", "id": "Q07079" }, { "name": "IGFBP-5; IGFBP-5P", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034648", "id": "NP_034648" }, { "name": "Igfbp-5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q07079", "id": "Q07079" }, { "name": "Igfbp5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034648", "id": "NP_034648" } ], "protein_names": [ { "name": "Insulin-like growth factor-binding protein 5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q07079" }, { "name": "IBP-5; IGF-binding protein 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034648", "id": "NP_034648" }, { "name": "IBP-5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q07079" }, { "name": "IGF-binding protein 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q07079" }, { "name": "IGFBP-5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q07079" }, { "name": "insulin-like growth factor-binding protein 5 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034648", "id": "NP_034648" } ], "function": [ { "annotation": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. 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"NP_034648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034648" } ], "reference": [ { "type": "PubMed", "id": "37078747", "url": "https://glygen.org/publication/PubMed/37078747" } ] }, { "title": "Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene.", "journal": "Genomics", "date": "1994", "authors": "Kou K, Jenkins NA, Gilbert DJ, Copeland NG, Rotwein P", "evidence": [ { "database": "UniProtKB", "id": "Q07079", "url": "https://www.uniprot.org/uniprot/Q07079" } ], "reference": [ { "type": "PubMed", "id": "7518410", "url": "https://glygen.org/publication/PubMed/7518410" } ] }, { "title": "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins.", "journal": "Mol. Cell. Endocrinol.", "date": "1994", "authors": "Drop S.L.S., van Neck J.W., Zwarthoff E.C., Schuller A.G.P., Groffen C.", "evidence": [ { "database": "UniProtKB", "id": "Q07079", "url": "https://www.uniprot.org/uniprot/Q07079" } ], "reference": [ { "type": "PubMed", "id": "7529732", "url": "https://glygen.org/publication/PubMed/7529732" } ] }, { "title": "A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation.", "journal": "J. Biol. Chem.", "date": "1993", "authors": "Rotwein P., James P.L., Clemmons D.R., Busby W.H. Jr., Jones S.B.", "evidence": [ { "database": "UniProtKB", "id": "Q07079", "url": "https://www.uniprot.org/uniprot/Q07079" } ], "reference": [ { "type": "PubMed", "id": "7693664", "url": "https://glygen.org/publication/PubMed/7693664" } ] } ], "pathway": [ { "id": "mmu:16011", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16011", "resource": "KEGG Pathway" }, { "id": "R-MMU-381426", "name": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-MMU-8957275", "name": "Post-translational protein phosphorylation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8957275", "resource": "Reactome", "description": "Post-translational protein 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