{ "uniprot_canonical_ac": "Q06151-1", "uniprot_ac": "Q06151", "uniprot_id": "DCPS_YEAST", "mass": { "chemical_mass": 40770.0, "monoisotopic_mass": 40770.0 }, "refseq": { "ac": "NP_013372", "name": "5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013372" }, "gene_names": [ { "name": "DCS1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q06151", "id": "Q06151" }, { "name": "DCS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013372", "id": "NP_013372" } ], "protein_names": [ { "name": "m7GpppX diphosphatase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q06151" }, { "name": "3.6.1.59", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q06151" }, { "name": "5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013372", "id": "NP_013372" }, { "name": "DCS-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q06151" }, { "name": "Hint-related 7meGMP-directed hydrolase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q06151" }, { "name": "Protein Dcs1p", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q06151" }, { "name": "Scavenger mRNA-decapping enzyme DcpS", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q06151" } ], "function": [ { "annotation": "Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP) or tri-methyl guanosine nucleoside monophosphate (m3(2,2,7)GMP), respectively. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to (m(7)GMP) and m3(2,2,7)GMP, respectively (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCS1 to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. May also regulate the 5'->3' exoribonucleolytic mRNA decay pathway in a cap-independent manner. Negatively regulates trehalase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151#function" }, { "database": "PubMed", "id": "15240832", "url": "https://glygen.org/publication/PubMed/15240832" }, { "database": "PubMed", "id": "16963086", "url": "https://glygen.org/publication/PubMed/16963086" }, { "database": "PubMed", "id": "15273322", "url": "https://glygen.org/publication/PubMed/15273322" }, { "database": "PubMed", "id": "14523240", "url": "https://glygen.org/publication/PubMed/14523240" }, { "database": "PubMed", "id": "16260594", "url": "https://glygen.org/publication/PubMed/16260594" }, { "database": "PubMed", "id": "12198172", "url": "https://glygen.org/publication/PubMed/12198172" }, { "database": "PubMed", "id": "22985415", "url": "https://glygen.org/publication/PubMed/22985415" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 268, "end_pos": 268, "sequence_org": "H", "sequence_mut": "N", "comment": "Loss of function.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "12198172", "url": "https://glygen.org/publication/PubMed/12198172" } ] }, { "start_pos": 66, "end_pos": 66, "sequence_org": "T", "sequence_mut": "A", "comment": "Strongly reduces phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "15240832", "url": "https://glygen.org/publication/PubMed/15240832" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "common_name": "Yeast" } ], "gene": [ { "name": "DCS1", "url": "https://www.uniprot.org/uniprot/Q06151", "locus": {} } ], "crossref": [ { "id": "3.6.1.59", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.59&UniProtAcc=Q06151", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "850974", "url": "https://www.ncbi.nlm.nih.gov/gene/850974", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q06151", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q06151*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR008594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036265", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036265", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YLR270W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR270W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVYNCLE", "url": "https://omabrowser.org/oma/group/WVYNCLE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5490768at2759", "url": "http://www.orthodb.org/?query=5490768at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12978", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12978", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12978:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12978:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5BV3", "url": "https://www.rcsb.org/structure/5BV3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6TRQ", "url": "https://www.rcsb.org/structure/6TRQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF05652", "url": "http://pfam.xfam.org/family/PF05652", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11969", "url": "http://pfam.xfam.org/family/PF11969", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q06151", "url": "http://purl.obolibrary.org/obo/PR_Q06151", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_013372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013372", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000004260", "url": "https://www.yeastgenome.org/locus/S000004260", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q06151-1", "url": "https://www.uniprot.org/uniprot/Q06151-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQLPTDFASLIKRFQFVSVLDSNPQTKVMSLLGTIDNKDAIITAEKTHFLFDETVRRPSQDGRSTPVLYNCENEYSCINGIQELKEITSNDIYYWGLSVIKQDMESNPTAKLNLIWPATPIHIKKYEQQNFHLVRETPEMYKRIVQPYIEEMCNNGRLKWVNNILYEGAESERVVYKDFSEENKDDGFLILPDMKWDGMNLDSLYLVAIVYRTDIKTIRDLRYSDRQWLINLNNKIRSIVPGCYNYAVHPDELRILVHYQPSYYHFHIHIVNIKHPGLGNSIAAGKAILLEDIIEMLNYLGPEGYMNKTITYAIGENHDLWKRGLEEELTKQLERDGIPKIPKIVNGFK", "length": 350, "header": "sp|Q06151-1|DCPS_YEAST Isoform 1 of m7GpppX diphosphatase OS=Saccharomyces cerevisiae S288C OX=559292 GN=DCS1 PE=1 SV=1 CANONICAL=Q06151-1" }, "isoforms": [ { "isoform_ac": "Q06151-1", "url": "", "sequence": { "sequence": "MSQLPTDFASLIKRFQFVSVLDSNPQTKVMSLLGTIDNKDAIITAEKTHFLFDETVRRPSQDGRSTPVLYNCENEYSCINGIQELKEITSNDIYYWGLSVIKQDMESNPTAKLNLIWPATPIHIKKYEQQNFHLVRETPEMYKRIVQPYIEEMCNNGRLKWVNNILYEGAESERVVYKDFSEENKDDGFLILPDMKWDGMNLDSLYLVAIVYRTDIKTIRDLRYSDRQWLINLNNKIRSIVPGCYNYAVHPDELRILVHYQPSYYHFHIHIVNIKHPGLGNSIAAGKAILLEDIIEMLNYLGPEGYMNKTITYAIGENHDLWKRGLEEELTKQLERDGIPKIPKIVNGFK", "length": 350, "header": "sp|Q06151-1|DCPS_YEAST Isoform 1 of m7GpppX diphosphatase OS=Saccharomyces cerevisiae S288C OX=559292 GN=DCS1 PE=1 SV=1 CANONICAL=Q06151-1" }, "locus": { "chromosome": "XII", "start_pos": 682235, "end_pos": 681186, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YLR270W_mRNA", "url": "https://www.ensembl.org/id/YLR270W_mRNA" }, { "database": "Ensembl Peptide", "id": "YLR270W", "url": "https://www.ensembl.org/id/YLR270W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 120, "end_pos": 120, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ], "site_lbl": "Thr120" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Ser2" }, { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" }, { "database": "SGD", "id": "Q06151", "url": "https://www.yeastgenome.org/locus/Q06151" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser60" }, { "start_pos": 65, "end_pos": 65, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q06151", "url": "https://www.yeastgenome.org/locus/Q06151" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser65" }, { "start_pos": 66, "end_pos": 66, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "15240832", "url": "https://glygen.org/publication/PubMed/15240832" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q06151", "url": "https://www.yeastgenome.org/locus/Q06151" } ], "site_lbl": "Thr66" }, { "start_pos": 70, "end_pos": 70, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" }, { "database": "SGD", "id": "Q06151", "url": "https://www.yeastgenome.org/locus/Q06151" } ], "site_lbl": "Tyr70" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.", "journal": "EMBO J.", "date": "2002", "authors": "Liu H, Rodgers ND, Jiao X, Kiledjian M", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "12198172", "url": "https://glygen.org/publication/PubMed/12198172" } ] }, { "title": "DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "van Dijk E, Le Hir H, Seraphin B", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "14523240", "url": "https://glygen.org/publication/PubMed/14523240" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast.", "journal": "Nucleic acids research", "date": "2004", "authors": "Malys Naglis, Carroll Kathleen, Miyan Jaleel, Tollervey David, McCarthy John E G", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "15240832", "url": "https://glygen.org/publication/PubMed/15240832" } ] }, { "title": "Functional analysis of mRNA scavenger decapping enzymes.", "journal": "RNA", "date": "2004", "authors": "Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "15273322", "url": "https://glygen.org/publication/PubMed/15273322" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.", "journal": "Mol. Biol. Cell", "date": "2005", "authors": "Davis R.E., Piano F., Lall S.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "16207815", "url": "https://glygen.org/publication/PubMed/16207815" } ] }, { "title": "Scavenger decapping activity facilitates 5' to 3' mRNA decay.", "journal": "Mol. Cell. Biol.", "date": "2005", "authors": "Liu H., Kiledjian M.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "16260594", "url": "https://glygen.org/publication/PubMed/16260594" } ] }, { "title": "Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Malys N., McCarthy J.E.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "16963086", "url": "https://glygen.org/publication/PubMed/16963086" } ] }, { "title": "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.", "journal": "Genome Res.", "date": "2007", "authors": "Hu Y., LaBaer J., Moreira D., Raphael J., Rolfs A., Zuo D., Richardson A., Simpson A.J.G., Zhu C., Harlow E., Camargo A.A., Jepson D., Kelley F., McCarron S., Taycher E., Kolodner R.D., Kane M.F., Williamson J., Berger M.F., Bulyk M.L., Bhullar B., Mohr S., Marsischky G., Murthy T.V.S.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "17322287", "url": "https://glygen.org/publication/PubMed/17322287" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.", "journal": "BMC genomics", "date": "2010-12-02", "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R", "evidence": [ { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ] }, { "title": "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2012", "authors": "Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "22814378", "url": "https://glygen.org/publication/PubMed/22814378" } ] }, { "title": "7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity.", "journal": "Biochemistry", "date": "2012", "authors": "Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "22985415", "url": "https://glygen.org/publication/PubMed/22985415" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "Q06151", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06151" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Duesterhoeft A., Hillier L.W., Mewes H.-W., Obermaier B., Scharfe M., Wambutt R., Wedler H., Verhasselt P., Rose M., Benes V., Brueckner M., Rieger M., Portetelle D., Delius H., Schwarz S., Kleine K., Floeth M., Schwager C., Voss H., Hoheisel J.D., Dubois E., Volckaert G., Andre B., Koetter P., Entian K.-D., Louis E.J., Vandenbol M., Johnston M., Pohl T.M., Goffeau A., Hani J., Hilger F., Messenguy F., Miosga T., Mueller-Auer S., Scherens B., Zimmermann F.K., Zollner A., Purnelle B., Urrestarazu L.A., Vierendeels F., Voet M., Albermann K., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Moestl D., Nentwich U., Piravandi E., Rechmann S., Riles L., Rinke M., Scholler P., Underwood A.P., Wedler E.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "reference": [ { "type": "PubMed", "id": "9169871", "url": "https://glygen.org/publication/PubMed/9169871" } ] } ], "pathway": [ { "id": "sce:YLR270W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR270W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "id": "GO:0000290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, deadenylation-independent decay", "id": "GO:0031086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031086", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "response to osmotic stress", "id": "GO:0006970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006970", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "cellular response to starvation", "id": "GO:0009267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process", "id": "GO:0000956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000956", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "response to heat", "id": "GO:0009408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009408", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "id": "GO:0000288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000288", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "m7G(5')pppN diphosphatase complex", "id": "GO:0106095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106095", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "RNA 7-methylguanosine cap binding", "id": "GO:0000340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000340", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "id": "GO:0016818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016818", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "exoribonuclease activator activity", "id": "GO:0044692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044692", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" }, { "name": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "id": "GO:0140932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140932", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated. Phosphorylation occurs upon glucose deprivation.", "evidence": [ { "database": "UniProtKB", "id": "Q06151", "url": "https://www.uniprot.org/uniprot/Q06151" }, { "database": "PubMed", "id": "15240832", "url": "https://glygen.org/publication/PubMed/15240832" } ] } ], "interactions": [], "reactions": [ { "id": "65388", "name": "", "equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F7-1", "P61131-1", "Q566C7-1", "Q96C86-1", "O95989-1", "Q9DAR7-1", "Q9JI46-1", "Q06151-1", "Q9VNH5-1" ], "evidence": [ { "id": "65388", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65388" } ] }, { "id": "R-SCE-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-429925", "R-ALL-430042" ], "enzyme_list": [ "Q06151-1" ], "evidence": [ { "id": "R-SCE-429961", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-429961" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-429925", "participant_name": "oligoribonucleotide with a 5'-diphosphate [cytosol]", "crossref": [ { "id": "33697", "database": "ChEBI", "url": "" }, { "id": "33697", "database": "ChEBI", "url": "" }, { "id": "33697", "database": "ChEBI", "url": "" }, { "id": "33697", "database": "ChEBI", "url": "" }, { "id": "33697", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-430042", "participant_name": "7MGMP [cytosol]", "crossref": [ { "id": "HMDB0059612", "database": "HMDB Metabolite", "url": "" }, { "id": "17825", "database": "ChEBI", "url": "" }, { "id": "C03998", "database": "COMPOUND", "url": "" }, { "id": "000004096273", "database": "ZINC", "url": "" }, { "id": "17825", "database": "ChEBI", "url": "" }, { "id": "000004096273", "database": "ZINC", "url": "" }, { "id": "HMDB0059612", "database": "HMDB Metabolite", "url": "" }, { "id": "C03998", "database": "COMPOUND", "url": "" }, { "id": "17825", "database": "ChEBI", "url": "" }, { "id": "000004096273", "database": "ZINC", "url": "" }, { "id": "HMDB0059612", "database": "HMDB Metabolite", "url": "" }, { "id": "C03998", "database": "COMPOUND", "url": "" }, { "id": "17825", "database": "ChEBI", "url": "" }, { "id": "000004096273", "database": "ZINC", "url": "" }, { "id": "HMDB0059612", "database": "HMDB Metabolite", "url": "" }, { "id": "C03998", "database": "COMPOUND", "url": "" }, { "id": "17825", "database": "ChEBI", "url": "" }, { "id": "000004096273", "database": "ZINC", "url": "" }, { "id": "HMDB0059612", "database": "HMDB Metabolite", "url": "" }, { "id": "C03998", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O95989", "gene_name": "NUDT3", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "O95989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95989" } ] }, { "ec_number": "3.6.1.52", "activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.", "evidence": [ { "id": "O95989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95989" } ] }, { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.", "evidence": [ { "id": "O95989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95989" } ] }, { "ec_number": "3.6.1.10", "activity": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate.", "evidence": [ { "id": "O95989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95989" } ] }, { "ec_number": "3.6.1.61", "activity": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+).", "evidence": [ { "id": "O95989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95989" } ] }, { "ec_number": "3.6.1.52", "activity": "", "evidence": [ { "id": "O95989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95989" } ] } ] }, { "uniprot_ac": "P61131", "gene_name": "St3gal4", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "3.6.1.59", "activity": "", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.2", "activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.2", "activity": "", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "P61131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61131" } ] } ] }, { "uniprot_ac": "Q06151", "gene_name": "DCS1", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "Q06151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06151" } ] }, { "ec_number": "3.6.1.59", "activity": "", "evidence": [ { "id": "Q06151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06151" } ] } ] }, { "uniprot_ac": "Q566C7", "gene_name": "Nudt3", "activity": [ { "ec_number": "3.6.1.52", "activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.", "evidence": [ { "id": "Q566C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566C7" } ] }, { "ec_number": "3.6.1.52", "activity": "", "evidence": [ { "id": "Q566C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566C7" } ] }, { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "Q566C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566C7" } ] }, { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.", "evidence": [ { "id": "Q566C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566C7" } ] }, { "ec_number": "3.6.1.10", "activity": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate.", "evidence": [ { "id": "Q566C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566C7" } ] }, { "ec_number": "3.6.1.61", "activity": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+).", "evidence": [ { "id": "Q566C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566C7" } ] } ] }, { "uniprot_ac": "Q8K4F7", "gene_name": "Dcps", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "Q8K4F7", "database": 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