{ "uniprot_canonical_ac": "Q05BC3-1", "uniprot_ac": "Q05BC3", "uniprot_id": "EMAL1_MOUSE", "mass": { "chemical_mass": 89680.0, "monoisotopic_mass": 89680.0 }, "refseq": { "ac": "NP_001036800", "name": "echinoderm microtubule-associated protein-like 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800" }, "gene_names": [ { "name": "Eml1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q05BC3", "id": "Q05BC3" }, { "name": "1110008N23Rik; A930030P13Rik; ELP79; EMAP; EMAP-1; EMAPL; heco", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276", "id": "NP_001273276" }, { "name": "Eml1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276", "id": "NP_001273276" } ], "protein_names": [ { "name": "Echinoderm microtubule-associated protein-like 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q05BC3" }, { "name": "EMAP-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q05BC3" }, { "name": "echinoderm microtubule associated protein-like protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800", "id": "NP_001036800" }, { "name": "echinoderm microtubule-associated protein-like 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800", "id": "NP_001036800" }, { "name": "echinoderm microtubule-associated protein-like 1 isoform 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276", "id": "NP_001273276" } ], "function": [ { "annotation": "Disruption in murine Eml1 perturbs retinal lamination during early development. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800" }, { "database": "PubMed", "id": "32221352", "url": "https://glygen.org/publication/PubMed/32221352" }, { "database": "RefSeq", "id": "NP_001273276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276" } ] }, { "annotation": "EML1 is essential for retinal photoreceptor migration and survival. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800" }, { "database": "PubMed", "id": "35190581", "url": "https://glygen.org/publication/PubMed/35190581" }, { "database": "RefSeq", "id": "NP_001273276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276" } ] }, { "annotation": "Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3#function" }, { "database": "PubMed", "id": "24859200", "url": "https://glygen.org/publication/PubMed/24859200" } ] } ], "disease": [ { "disease_id": "DOID:0111169", "recommended_name": { "id": "DOID:0111169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111169", "name": "subcortical band heterotopia", "description": "A congenital nervous system abnormality characterized by migration of neurons to ectopic locations in the brain where the neurons form areas that appear as band-like clusters of white tissue underneath the gray tissue of the cerebral cortex." }, "synonyms": [ { "id": "DOID:0111169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111169", "name": "HeCo", "description": "" }, { "id": "DOID:0111169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111169", "name": "band heterotopia", "description": "" }, { "id": "DOID:0111169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111169", "name": "double cortex syndrome", "description": "" }, { "id": "DOID:0111169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111169", "name": "heterotopic cortex", "description": "" }, { "id": "DOID:0111169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111169", "name": "subcortical laminar heterotopia", "description": "" }, { "id": "MONDO:0010873", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010873", "name": "band heterotopia of brain", "description": "" }, { "id": "MONDO:0010873", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010873", "name": "band heterotopia of brain", "description": "" }, { "id": "MONDO:0010873", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010873", "name": "BH", "description": "" }, { "id": "MONDO:0010873", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010873", "name": "band heterotopia", "description": "" }, { "id": "MIM:600348", "resource": "MIM", "url": "https://www.omim.org/entry/600348", "name": "Band heterotopia", "description": "Band heterotopia" } ], "evidence": [ { "id": "0111169", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111169" } ] }, { "disease_id": "DOID:11723", "recommended_name": { "id": "DOID:11723", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11723", "name": "Duchenne muscular dystrophy", "description": "A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy." }, "synonyms": [ { "id": "DOID:11723", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11723", "name": "Muscular dystrophy, Duchenne", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "Duchenne muscular dystrophy", "description": "Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by rapidly progressive muscle weakness and wasting due to degeneration of skeletal, smooth and cardiac muscle." }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "DMD", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "Duchenne muscular dystrophy", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "Duchenne muscular dystrophy, X-linked recessive", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "muscular dystrophy, Duchenne", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "severe dystrophinopathy, Duchenne type", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "muscular dystrophy, Duchenne type", "description": "" }, { "id": "MONDO:0010679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010679", "name": "muscular dystrophy, pseudohypertrophic progressive, Duchenne type", "description": "" }, { "id": "MIM:310200", "resource": "MIM", "url": "https://www.omim.org/entry/310200", "name": "Duchenne muscular dystrophy", "description": "Duchenne muscular dystrophy" } ], "evidence": [ { "id": "11723", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11723" } ] }, { "disease_id": "DOID:2490", "recommended_name": { "id": "DOID:2490", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2490", "name": "congenital nervous system abnormality", "description": "" }, "synonyms": [ { "id": "DOID:2490", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2490", "name": "congenital neurologic anomaly", "description": "" } ], "evidence": [ { "id": "2490", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2490" } ] } ], "snv": [ { "evidence": [ { "id": "rs3389260879", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389260879" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 533, "end_pos": 533, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DFT->NFT).", "chr_id": "12", "chr_pos": "108487680", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D533", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 242, "end_pos": 242, "sequence_org": "T", "sequence_mut": "A", "comment": "Impairs tubulin binding.", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" }, { "database": "PubMed", "id": "24859200", "url": "https://glygen.org/publication/PubMed/24859200" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Eml1", "url": "https://www.uniprot.org/uniprot/Q05BC3", "locus": { "chromosome": "12", "start_pos": 108505876, "end_pos": 108337216, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000058070", "url": "https://www.ensembl.org/id/ENSMUSG00000058070" } ] } } ], "crossref": [ { "id": "ENSMUSG00000058070", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000058070", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "68519", "url": "https://www.ncbi.nlm.nih.gov/gene/68519", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0002220", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002220", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0002290", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002290", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003900", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003900", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003901", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003901", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003902", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003902", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "Q05BC3", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q05BC3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:68519", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68519", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1915769", "url": "http://www.informatics.jax.org/marker/MGI:1915769", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q05BC3", "url": "https://oglcnac.org/atlas/detail/Q05BC3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q05BC3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q05BC3", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "ICCADFH", "url": "https://omabrowser.org/oma/group/ICCADFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2959353at2759", "url": "http://www.orthodb.org/?query=2959353at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03451", "url": "http://pfam.xfam.org/family/PF03451", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q05BC3", "url": "http://purl.obolibrary.org/obo/PR_Q05BC3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D3Z4J9", "url": "https://www.uniprot.org/uniprot/D3Z4J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z4J9-1", "url": "https://www.uniprot.org/uniprot/D3Z4J9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RII3", "url": "https://www.uniprot.org/uniprot/D6RII3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RII3-1", "url": "https://www.uniprot.org/uniprot/D6RII3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q05BC3-1", "url": "https://www.uniprot.org/uniprot/Q05BC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q05BC3-2", "url": "https://www.uniprot.org/uniprot/Q05BC3-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q05BC3-3", "url": "https://www.uniprot.org/uniprot/Q05BC3-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPAPSGARKEVVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGGHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVTDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHERKLLCTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 814, "header": "sp|Q05BC3-1|EMAL1_MOUSE Isoform 1 of Echinoderm microtubule-associated protein-like 1 OS=Mus musculus OX=10090 GN=Eml1 PE=1 SV=1 CANONICAL=Q05BC3-1" }, "isoforms": [ { "isoform_ac": "D3Z4J9-1", "url": "", "sequence": { "sequence": "MEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPAPSGARKEVVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPALQSPKPQGKRRVTHCKEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGGHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVTDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHERKLLCTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 800, "header": "tr|D3Z4J9-1|EMAL1_MOUSE Computationally mapped isoform of Echinoderm microtubule-associated protein-like 1 OS=Mus musculus OX=10090 GN=Eml1 PE=1 SV=1 CANONICAL=Q05BC3-1" }, "locus": { "chromosome": "12", "start_pos": 108504484, "end_pos": 108429812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000109857.8", "url": "https://www.ensembl.org/id/ENSMUST00000109857.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000105483.2", "url": "https://www.ensembl.org/id/ENSMUSP00000105483.2" } ] } }, { "isoform_ac": "D6RII3-1", "url": "", "sequence": { "sequence": "MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPAPSGARKEVVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGGHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVTDNGRKYTRVGPFQLHHPLGLVRELTIPGVKFRGLRDPLLGSVCL", "length": 699, "header": "tr|D6RII3-1|EMAL1_MOUSE Computationally mapped isoform of Echinoderm microtubule-associated protein-like 1 OS=Mus musculus OX=10090 GN=Eml1 PE=1 SV=1 CANONICAL=Q05BC3-1" }, "locus": { "chromosome": "12", "start_pos": 108502501, "end_pos": 108389454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000130999.2", "url": "https://www.ensembl.org/id/ENSMUST00000130999.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118325.2", "url": "https://www.ensembl.org/id/ENSMUSP00000118325.2" } ] } }, { "isoform_ac": "Q05BC3-1", "url": "", "sequence": { "sequence": "MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPAPSGARKEVVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGGHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVTDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHERKLLCTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 814, "header": "sp|Q05BC3-1|EMAL1_MOUSE Isoform 1 of Echinoderm microtubule-associated protein-like 1 OS=Mus musculus OX=10090 GN=Eml1 PE=1 SV=1 CANONICAL=Q05BC3-1" }, "locus": { "chromosome": "12", "start_pos": 108504484, "end_pos": 108389454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000109860", "url": "https://www.ensembl.org/id/ENSMUST00000109860" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000105486", "url": "https://www.ensembl.org/id/ENSMUSP00000105486" } ] } }, { "isoform_ac": "Q05BC3-2", "url": "", "sequence": { "sequence": "MEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPAPSGARKEVVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGGHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVTDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHERKLLCTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 783, "header": "sp|Q05BC3-2|EMAL1_MOUSE Isoform 2 of Echinoderm microtubule-associated protein-like 1 OS=Mus musculus OX=10090 GN=Eml1 PE=1 SV=1 CANONICAL=Q05BC3-1" }, "locus": { "chromosome": "12", "start_pos": 108504484, "end_pos": 108429812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000054955", "url": "https://www.ensembl.org/id/ENSMUST00000054955" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000057209", "url": "https://www.ensembl.org/id/ENSMUSP00000057209" } ] } }, { "isoform_ac": "Q05BC3-3", "url": "", "sequence": { "sequence": "MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPAPSGARKEVVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPALQSPKPQGKRRVTHCKEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGGHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVTDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHERKLLCTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 831, "header": "sp|Q05BC3-3|EMAL1_MOUSE Isoform 3 of Echinoderm microtubule-associated protein-like 1 OS=Mus musculus OX=10090 GN=Eml1 PE=1 SV=1 CANONICAL=Q05BC3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 126, "start_aa": "Thr", "end_pos": 126, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr126", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 15, "start_aa": "Ser", "end_pos": 15, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser15", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 16, "start_aa": "Ser", "end_pos": 16, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser16", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 25, "start_aa": "Ser", "end_pos": 25, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser25", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 27, "start_aa": "Ser", "end_pos": 27, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser27", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 30, "start_aa": "Ser", "end_pos": 30, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser30", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 31, "start_aa": "Ser", "end_pos": 31, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser31", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q05BC3" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q05BC3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q05BC3" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q05BC3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q05BC3" }, { "database": "O-GlcNAc Atlas", "id": "Q05BC3", "url": "https://oglcnac.org/atlas/detail/Q05BC3" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human.", "journal": "Nat. Neurosci.", "date": "2014", "authors": "Kielar M, Tuy FP, Bizzotto S, Lebrand C, de Juan Romero C, Poirier K, Oegema R, Mancini GM, Bahi-Buisson N, Olaso R, Le Moing AG, Boutourlinsky K, Boucher D, Carpentier W, Berquin P, Deleuze JF, Belvindrah R, Borrell V, Welker E, Chelly J, Croquelois A, Francis F", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "reference": [ { "type": "PubMed", "id": "24859200", "url": "https://glygen.org/publication/PubMed/24859200" } ] }, { "title": "Fam208a orchestrates interaction protein network essential for early embryonic development and cell division.", "journal": "Exp. Cell Res.", "date": "2019", "authors": "Gresakova V, Novosadova V, Prochazkova M, Bhargava S, Jenickova I, Prochazka J, Sedlacek R", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "reference": [ { "type": "PubMed", "id": "31112734", "url": "https://glygen.org/publication/PubMed/31112734" } ] }, { "title": "Disruption in murine Eml1 perturbs retinal lamination during early development.", "journal": "Scientific reports", "date": "2020", "authors": "Collin GB, Won J, Krebs MP, Hicks WJ, Charette JR, Naggert JK, Nishina PM", "evidence": [ { "database": "RefSeq", "id": "NP_001273276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276" }, { "database": "RefSeq", "id": "NP_001036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800" } ], "reference": [ { "type": "PubMed", "id": "32221352", "url": "https://glygen.org/publication/PubMed/32221352" } ] }, { "title": "EML1 is essential for retinal photoreceptor migration and survival.", "journal": "Scientific reports", "date": "2022", "authors": "Poria D, Sun C, Santeford A, Kielar M, Apte RS, Kisselev OG, Chen S, Kefalov VJ", "evidence": [ { "database": "RefSeq", "id": "NP_001273276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273276" }, { "database": "RefSeq", "id": "NP_001036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800" } ], "reference": [ { "type": "PubMed", "id": "35190581", "url": "https://glygen.org/publication/PubMed/35190581" } ] }, { "title": "Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.", "journal": "Frontiers in aging", "date": "2021", "authors": "Huynh Van N, Wang Sheng, Ouyang Xiaosen, Wani Willayat Y, Johnson Michelle S, Chacko Balu K, Jegga Anil G, Qian Wei-Jun, Chatham John C, Darley-Usmar Victor M, Zhang Jianhua", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q05BC3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q05BC3" } ], "reference": [ { "type": "PubMed", "id": "35822049", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q05BC3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q05BC3" } ], "reference": [ { "type": "PubMed", "id": "36288343", "url": "https://glygen.org/publication/PubMed/36288343" } ] } ], "pathway": [ { "id": "mmu:68519", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68519", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O00423-1", "protein_name": "Echinoderm microtubule-associated protein-like 1", "gene_name": "EML1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 815 }, "evidence": [ { "id": "45234188", "url": "http://www.informatics.jax.org/homology/45234188", "database": "MGI" }, { "id": "Q05BC3", "url": "https://omabrowser.org/oma/group/Q05BC3/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q4V8C3-1", "protein_name": "Echinoderm microtubule-associated protein-like 1", "gene_name": "Eml1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEISDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPSPSGSRKEMVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPTFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGSHLCAVDDSNDHVLSVWDWQREERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKAEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLTGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYSGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI", "length": 814 }, "evidence": [ { "id": "45234188", "url": "http://www.informatics.jax.org/homology/45234188", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "neuroblast proliferation", "id": "GO:0007405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007405", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "Q05BC3", "url": "https://www.uniprot.org/uniprot/Q05BC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 8 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 8 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }