{ "uniprot_canonical_ac": "Q04857-1", "uniprot_ac": "Q04857", "uniprot_id": "CO6A1_MOUSE", "mass": { "chemical_mass": 108489.0, "monoisotopic_mass": 108489.0 }, "refseq": { "ac": "NP_034063", "name": "collagen alpha-1(VI) chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063" }, "gene_names": [ { "name": "Col6a1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q04857", "id": "Q04857" }, { "name": "Col6a-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063", "id": "NP_034063" }, { "name": "Col6a1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063", "id": "NP_034063" } ], "protein_names": [ { "name": "Collagen alpha-1(VI) chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q04857" }, { "name": "collagen alpha-1(VI) chain precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063", "id": "NP_034063" }, { "name": "collagen alpha-1(VI) chain; procollagen, type VI, alpha 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063", "id": "NP_034063" } ], "function": [ { "annotation": "Collagen VI acts as a cell-binding protein.", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857#function" } ] }, { "annotation": "Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells.", "evidence": [ { "database": "RefSeq", "id": "NP_034063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063" }, { "database": "PubMed", "id": "37272555", "url": "https://glygen.org/publication/PubMed/37272555" } ] }, { "annotation": "Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis.", "evidence": [ { "database": "RefSeq", "id": "NP_034063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063" }, { "database": "PubMed", "id": "35857791", "url": "https://glygen.org/publication/PubMed/35857791" } ] } ], "disease": [ { "disease_id": "DOID:0050557", "recommended_name": { "id": "DOID:0050557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050557", "name": "congenital muscular dystrophy", "description": "A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted." }, "synonyms": [ { "id": "MONDO:0009682", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009682", "name": "muscular dystrophy, congenital, with rapid progression", "description": "" }, { "id": "MONDO:0009682", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009682", "name": "muscular dystrophy, congenital, with rapid progression", "description": "" } ], "evidence": [ { "id": "0050557", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050557" } ] }, { "disease_id": "DOID:0050558", "recommended_name": { "id": "DOID:0050558", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050558", "name": "Ullrich congenital muscular dystrophy", "description": "A congenital muscular dystrophy that is characterized by muscle weakness and respiratory depression and has_material_basis_in mutation in the COL6A1, COL6A2 and COL6A3 that produce components of type VI collagen." }, "synonyms": [ { "id": "DOID:0050558", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050558", "name": "ULLRICH DISEASE", "description": "" }, { "id": "DOID:0050558", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050558", "name": "Ullrich scleroatonic muscular dystrophy", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "Ullrich congenital muscular dystrophy 1", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "Ullrich congenital muscular dystrophy 1", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "Ullrich congenital muscular dystrophy type 1", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "UCMD1", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "Ullrich Scleroatonic muscular dystrophy", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "Ullrich congenital muscular dystrophy", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "Ullrich disease", "description": "" }, { "id": "MONDO:0009681", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009681", "name": "muscular dystrophy, Scleroatonic", "description": "" }, { "id": "MIM:254090", "resource": "MIM", "url": "https://www.omim.org/entry/254090", "name": "Ullrich congenital muscular dystrophy 1", "description": "Ullrich congenital muscular dystrophy 1" } ], "evidence": [ { "id": "0050558", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050558" } ] }, { "disease_id": "DOID:0050663", "recommended_name": { "id": "DOID:0050663", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050663", "name": "Bethlem myopathy", "description": "A congenital muscular dystrophy that is characterized by myopathy and joint contractures that progresses slowly, has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the COL6A1 gene, the COL6A2 gene, or the COL6A3 gene." }, "synonyms": [ { "id": "DOID:0050663", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050663", "name": "benign congenital muscular dystrophy", "description": "" }, { "id": "MONDO:0024530", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024530", "name": "Bethlem myopathy 1", "description": "" }, { "id": "MONDO:0024530", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024530", "name": "Bethlem myopathy 1", "description": "" }, { "id": "MONDO:0024530", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024530", "name": "BTHLM1", "description": "" }, { "id": "MONDO:0024530", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024530", "name": "Bethlem myopathy", "description": "" }, { "id": "MONDO:0024530", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024530", "name": "muscular dystrophy, benign congenital", "description": "" }, { "id": "MONDO:0024530", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024530", "name": "myopathy, benign congenital, with contractures", "description": "" }, { "id": "MIM:158810", "resource": "MIM", "url": "https://www.omim.org/entry/158810", "name": "Bethlem myopathy 1", "description": "Bethlem myopathy 1" } ], "evidence": [ { "id": "0050663", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050663" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Col6a1", "url": "https://www.uniprot.org/uniprot/Q04857", "locus": { "chromosome": "10", "start_pos": 76544626, "end_pos": 76562002, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000001119", "url": "https://www.ensembl.org/id/ENSMUSG00000001119" } ] } } ], "crossref": [ { "id": "ENSMUSG00000001119", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000001119", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01480", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01480", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "12833", "url": "https://www.ncbi.nlm.nih.gov/gene/12833", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0003883", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003883", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "Q04857", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q04857*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:12833", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:12833", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "88459", "url": "http://www.informatics.jax.org/marker/MGI:88459", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q04857", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q04857", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "QEKKCPD", "url": "https://omabrowser.org/oma/group/QEKKCPD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2906665at2759", "url": "http://www.orthodb.org/?query=2906665at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "http://pfam.xfam.org/family/PF00092", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "http://pfam.xfam.org/family/PF01391", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q04857", "url": "http://purl.obolibrary.org/obo/PR_Q04857", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1442490", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1650814", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-186797", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186797", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2022090", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022090", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-419037", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8948216", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_034063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q04857-1", "url": "https://www.uniprot.org/uniprot/Q04857-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLAHALLPLLLQACWVATQDIQGSKAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEEVISQTIDTIVDMIKNNVEQVCCSFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGMKGEKGEAGADGEAGRPGNSGSPGDEGDPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDSGEAGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGLNGTKGYPGLKGDEGEVGDPGEDNNDISPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGADIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPADITILLDSSASVGSHNFETTKVFAKRLAERFLSAGRADPSQDVRVAVVQYSGQGQQQPGRAALQFLQNYTVLASSVDSMDFINDATDVNDALSYVTRFYREASSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG", "length": 1025, "header": "sp|Q04857-1|CO6A1_MOUSE Isoform 1 of Collagen alpha-1(VI) chain OS=Mus musculus OX=10090 GN=Col6a1 PE=1 SV=1 CANONICAL=Q04857-1" }, "isoforms": [ { "isoform_ac": "Q04857-1", "url": "", "sequence": { "sequence": "MRLAHALLPLLLQACWVATQDIQGSKAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEEVISQTIDTIVDMIKNNVEQVCCSFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGMKGEKGEAGADGEAGRPGNSGSPGDEGDPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDSGEAGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGLNGTKGYPGLKGDEGEVGDPGEDNNDISPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGADIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPADITILLDSSASVGSHNFETTKVFAKRLAERFLSAGRADPSQDVRVAVVQYSGQGQQQPGRAALQFLQNYTVLASSVDSMDFINDATDVNDALSYVTRFYREASSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG", "length": 1025, "header": "sp|Q04857-1|CO6A1_MOUSE Isoform 1 of Collagen alpha-1(VI) chain OS=Mus musculus OX=10090 GN=Col6a1 PE=1 SV=1 CANONICAL=Q04857-1" }, "locus": { "chromosome": "10", "start_pos": 76561747, "end_pos": 76545396, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000001147", "url": "https://www.ensembl.org/id/ENSMUST00000001147" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000001147", "url": "https://www.ensembl.org/id/ENSMUSP00000001147" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 211, "start_aa": "Asn", "end_pos": 211, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn211", "evidence": [ { "id": "Q04857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04857#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 515, "start_aa": "Asn", "end_pos": 515, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn515", "evidence": [ { "id": "Q04857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04857#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 536, "start_aa": "Asn", "end_pos": 536, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn536", "evidence": [ { "id": "Q04857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04857#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 801, "start_aa": "Asn", "end_pos": 801, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn801", "evidence": [ { "id": "Q04857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04857#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 893, "start_aa": "Asn", "end_pos": 893, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn893", "evidence": [ { "id": "Q04857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04857#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q04857", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q04857" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" }, { "id": "28135057", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28135057" }, { "id": "29187734", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29187734" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.", "journal": "ACS chemical biology", "date": "2017", "authors": "Zaro BW, Batt AR, Chuh KN, Navarro MX, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q04857", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q04857" } ], "reference": [ { "type": "PubMed", "id": "28135057", "url": "https://glygen.org/publication/PubMed/28135057" } ] }, { "title": "O-GlcNAcylation is required for B cell homeostasis and antibody responses.", "journal": "Nature communications", "date": "2017", "authors": "Wu JL, Chiang MF, Hsu PH, Tsai DY, Hung KH, Wang YH, Angata T, Lin KI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q04857", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q04857" } ], "reference": [ { "type": "PubMed", "id": "29187734", "url": "https://glygen.org/publication/PubMed/29187734" } ] }, { "title": "Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis.", "journal": "Autophagy", "date": "2022-07-20", "authors": "Abbonante Vittorio, Malara Alessandro, Chrisam Martina, Metti Samuele, Soprano Paolo, Semplicini Claudio, Bello Luca, Bozzi Valeria, Battiston Monica, Pecci Alessandro, Pegoraro Elena, De Marco Luigi, Braghetta Paola, Bonaldo Paolo, Balduini Alessandra", "evidence": [ { "database": "RefSeq", "id": "NP_034063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063" } ], "reference": [ { "type": "PubMed", "id": "35857791", "url": "https://glygen.org/publication/PubMed/35857791" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q04857", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q04857" } ], "reference": [ { "type": "PubMed", "id": "36288343", "url": "https://glygen.org/publication/PubMed/36288343" } ] }, { "title": "Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells.", "journal": "The Journal of pathology", "date": "2023-08", "authors": "Molon Sibilla, Brun Paola, Scarpa Melania, Bizzotto Dario, Zuccolotto Gaia, Scarpa Marco, Fassan Matteo, Angriman Imerio, Rosato Antonio, Braghetta Paola, Castagliuolo Ignazio, Bonaldo Paolo", "evidence": [ { "database": "RefSeq", "id": "NP_034063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063" } ], "reference": [ { "type": "PubMed", "id": "37272555", "url": "https://glygen.org/publication/PubMed/37272555" } ] }, { "title": "Murine alpha 1(VI) collagen chain. Complete amino acid sequence and identification of the gene promoter region.", "journal": "Matrix", "date": "1993", "authors": "Bonaldo P., Piccolo S., Bressan G.M., Volpin D., Marvulli D.", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "reference": [ { "type": "PubMed", "id": "8326912", "url": "https://glygen.org/publication/PubMed/8326912" } ] }, { "title": "Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI.", "journal": "Biochem. J.", "date": "1993", "authors": "Chu M.-L., Timpl R., Zhang R.Z., Pan T.C.", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "reference": [ { "type": "PubMed", "id": "8489506", "url": "https://glygen.org/publication/PubMed/8489506" } ] } ], "pathway": [ { "id": "mmu:12833", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:12833", "resource": "KEGG Pathway" }, { "id": "R-MMU-1442490", "name": "Collagen degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-MMU-1650814", "name": "Collagen biosynthesis and modifying enzymes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-MMU-186797", "name": "Signaling by PDGF", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186797", "resource": "Reactome", "description": "Signaling by PDGF" }, { "id": "R-MMU-2022090", "name": "Assembly of collagen fibrils and other multimeric structures", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022090", "resource": "Reactome", "description": "Assembly of collagen fibrils and other multimeric structures" }, { "id": "R-MMU-216083", "name": "Integrin cell surface interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-MMU-3000178", "name": "ECM proteoglycans", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "resource": "Reactome", "description": "ECM proteoglycans" }, { "id": "R-MMU-419037", "name": "NCAM1 interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-419037", "resource": "Reactome", "description": "NCAM1 interactions" }, { "id": "R-MMU-8948216", "name": "Collagen chain trimerization", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZUL3-1", "protein_name": "Collagen type VI alpha 1 chain", "gene_name": "Col6a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVTRRPAGNMRLAHTLLPLLLQACWVAAQDIQGSRAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLMRMPSGRDELKASIDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEETISQTIDTIVDMIKNNVEQVCCTFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGLKGEKGEAGAEGEAGRPGNSGPPGDEGEPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDPGESGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGINGTKGYPGLKGDEGEAGDPGEDNNDVSPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGSDIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQSRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPTDITILLDSSASVGSHNFETTKVFAKRLAERFLSAGREDPTQVVRVAVVQYSGQGQQQPGRASLQFQQNYTVLASSVDSMDFINDATDVNDALSYVTRFYRENSSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRGGIEIFVMVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG", "length": 1034 }, "evidence": [ { "id": "45229003", "url": "http://www.informatics.jax.org/homology/45229003", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P12109-1", "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "COL6A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1028 }, "evidence": [ { "id": "45229003", "url": "http://www.informatics.jax.org/homology/45229003", "database": "MGI" }, { "id": "Q04857", "url": "https://omabrowser.org/oma/group/Q04857/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "collagen trimer", "id": "GO:0005581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005581", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "endodermal cell differentiation", "id": "GO:0035987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035987", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" }, { "name": "platelet-derived growth factor binding", "id": "GO:0048407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048407", "evidence": [ { "database": "UniProtKB", "id": "Q04857", "url": "https://www.uniprot.org/uniprot/Q04857" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" }, { "start_pos": 801, "end_pos": 803, "annotation": "n_glycosylation_sequon" }, { "start_pos": 893, "end_pos": 895, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 5 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", 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