{
    "uniprot_canonical_ac": "Q04632-1",
    "uniprot_ac": "Q04632",
    "uniprot_id": "COG8_YEAST",
    "mass": {
        "chemical_mass": 69829.0,
        "monoisotopic_mass": 69829.0
    },
    "refseq": {
        "ac": "NP_013640",
        "name": "Golgi transport complex subunit COG8",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013640"
    },
    "gene_names": [
        {
            "name": "COG8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q04632",
            "id": "Q04632"
        },
        {
            "name": "COG8",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013640",
            "id": "NP_013640"
        },
        {
            "name": "DOR1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013640",
            "id": "NP_013640"
        },
        {
            "name": "DOR1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q04632",
            "id": "Q04632"
        }
    ],
    "protein_names": [
        {
            "name": "Conserved oligomeric Golgi complex subunit 8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q04632"
        },
        {
            "name": "COG complex subunit 8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q04632"
        },
        {
            "name": "Component of oligomeric Golgi complex 8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q04632"
        },
        {
            "name": "Golgi transport complex subunit COG8",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013640",
            "id": "NP_013640"
        }
    ],
    "function": [
        {
            "annotation": "Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632#function"
                },
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                    "database": "PubMed",
                    "id": "11703943",
                    "url": "https://glygen.org/publication/PubMed/11703943"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070260",
            "recommended_name": {
                "id": "DOID:0070260",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070260",
                "name": "congenital disorder of glycosylation type IIh",
                "description": "A congenital disorder of glycosylation type II that has_material_basis_in a mutation of the COG8 gene on chromosome 16q22.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0070260",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070260",
                    "name": "CDG IIh",
                    "description": ""
                },
                {
                    "id": "DOID:0070260",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070260",
                    "name": "CDG2H",
                    "description": ""
                },
                {
                    "id": "DOID:0070260",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070260",
                    "name": "CDGIIdh",
                    "description": ""
                },
                {
                    "id": "DOID:0070260",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070260",
                    "name": "COG8-CDG",
                    "description": ""
                },
                {
                    "id": "DOID:0070260",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070260",
                    "name": "Congenital disorder of glycosylation type 2h",
                    "description": ""
                },
                {
                    "id": "DOID:0070260",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070260",
                    "name": "Carbohydrate deficient glycoprotein syndrome type IIh",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "COG8-congenital disorder of glycosylation",
                    "description": "The CDG (Congenital Disorders of Glycosylation) syndromes are a group of autosomal recessive disorders affecting glycoprotein synthesis. CDG syndrome type IIh is characterized by severe psychomotor retardation, failure to thrive and intolerance to wheat and dairy products."
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "CDG syndrome type IIh",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "CDG-IIh",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "CDG2H",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "COG8-CDG",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "COG8-congenital disorder of glycosylation",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "carbohydrate deficient glycoprotein syndrome type IIh",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "congenital disorder of glycosylation type 2h",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "congenital disorder of glycosylation type IIh",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "CDG IIh",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "COG8-CDG (CDG-IIh)",
                    "description": ""
                },
                {
                    "id": "MONDO:0012635",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012635",
                    "name": "congenital disorder of glycosylation, type IIh",
                    "description": ""
                },
                {
                    "id": "MIM:611182",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/611182",
                    "name": "Congenital disorder of glycosylation 2H",
                    "description": "Congenital disorder of glycosylation 2H"
                }
            ],
            "evidence": [
                {
                    "id": "0070260",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070260"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                }
            ],
            "common_name": "Yeast"
        }
    ],
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        {
            "name": "COG8",
            "url": "https://www.uniprot.org/uniprot/Q04632",
            "locus": {
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                "start_pos": 129749,
                "end_pos": 131572,
                "strand": "+",
                "evidence": [
                    {
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                        "id": "YML071C",
                        "url": "https://www.ensembl.org/id/YML071C"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "854904",
            "url": "https://www.ncbi.nlm.nih.gov/gene/854904",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q04632",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q04632*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR007255",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007255",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YML071C",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YML071C",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "CLQLVYC",
            "url": "https://omabrowser.org/oma/group/CLQLVYC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1442148at2759",
            "url": "http://www.orthodb.org/?query=1442148at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21311",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21311",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21311:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21311:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04124",
            "url": "http://pfam.xfam.org/family/PF04124",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q04632",
            "url": "http://purl.obolibrary.org/obo/PR_Q04632",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
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            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013640",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000004536",
            "url": "https://www.yeastgenome.org/locus/S000004536",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "Q04632",
            "url": "https://www.uniprot.org/uniprot/Q04632",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q04632-1",
            "url": "https://www.uniprot.org/uniprot/Q04632-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MELILNSLISDDLTEEQKRLSLDFLQDILQSNTKDYESYFSSRAVPGSITEDIAEIDAELSALDRKIRKTLLDNTSQIIGNILENDDRAQLDDIAKSLEQLWELDTNINKAADRNVTNDDINNESVSIDDFLEDDKEDNDTGRIMTTESNNLARKKKEDEFHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSITDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLLSTNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYPLDVESSNESLIEMMVKRKIEVLREHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGTNEEKEIEEKEKETKKEEYQKQDSVANNEEDVTENKSIEDVQEEVQGKVEGEDDGAERKTENEIENETVNKTEDKAEKEKEEEVNTKDNKAEKEEEEINKVEVTPEEPSKSIDNKAEKEEEEINKVEVTPEEPSKKIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRGLNSIKLSDSVCLQLVYCSFRLCDLNRNYHHLFLKKINDTSLFTTEQLARAIDKRAELASKYIYS",
        "length": 607,
        "header": "sp|Q04632-1|COG8_YEAST Isoform 1 of Conserved oligomeric Golgi complex subunit 8  OS=Saccharomyces cerevisiae S288C OX=559292 GN=COG8 PE=1 SV=1 CANONICAL=Q04632-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q04632-1",
            "url": "",
            "sequence": {
                "sequence": "MELILNSLISDDLTEEQKRLSLDFLQDILQSNTKDYESYFSSRAVPGSITEDIAEIDAELSALDRKIRKTLLDNTSQIIGNILENDDRAQLDDIAKSLEQLWELDTNINKAADRNVTNDDINNESVSIDDFLEDDKEDNDTGRIMTTESNNLARKKKEDEFHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSITDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLLSTNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYPLDVESSNESLIEMMVKRKIEVLREHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGTNEEKEIEEKEKETKKEEYQKQDSVANNEEDVTENKSIEDVQEEVQGKVEGEDDGAERKTENEIENETVNKTEDKAEKEKEEEVNTKDNKAEKEEEEINKVEVTPEEPSKSIDNKAEKEEEEINKVEVTPEEPSKKIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRGLNSIKLSDSVCLQLVYCSFRLCDLNRNYHHLFLKKINDTSLFTTEQLARAIDKRAELASKYIYS",
                "length": 607,
                "header": "sp|Q04632-1|COG8_YEAST Isoform 1 of Conserved oligomeric Golgi complex subunit 8  OS=Saccharomyces cerevisiae S288C OX=559292 GN=COG8 PE=1 SV=1 CANONICAL=Q04632-1"
            },
            "locus": {
                "chromosome": "XIII",
                "start_pos": 131572,
                "end_pos": 129752,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YML071C_mRNA",
                        "url": "https://www.ensembl.org/id/YML071C_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YML071C",
                        "url": "https://www.ensembl.org/id/YML071C"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 410,
            "end_pos": 410,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q04632",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04632"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                },
                {
                    "database": "SGD",
                    "id": "Q04632",
                    "url": "https://www.yeastgenome.org/locus/Q04632"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser410"
        },
        {
            "start_pos": 433,
            "end_pos": 433,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q04632",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04632"
                },
                {
                    "database": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                }
            ],
            "site_lbl": "Thr433"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.",
            "journal": "Dev. Cell",
            "date": "2001",
            "authors": "Munro S., Whyte J.R.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11703943",
                    "url": "https://glygen.org/publication/PubMed/11703943"
                }
            ]
        },
        {
            "title": "Global analysis of protein expression in yeast.",
            "journal": "Nature",
            "date": "2003",
            "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14562106",
                    "url": "https://glygen.org/publication/PubMed/14562106"
                }
            ]
        },
        {
            "title": "The binary interacting network of the conserved oligomeric Golgi tethering complex.",
            "journal": "J. Biol. Chem.",
            "date": "2004",
            "authors": "Loh E, Hong W",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15047703",
                    "url": "https://glygen.org/publication/PubMed/15047703"
                }
            ]
        },
        {
            "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2007-06-19",
            "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q04632",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                }
            ]
        },
        {
            "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.",
            "journal": "Science (New York, N.Y.)",
            "date": "2009-09-25",
            "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q04632",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                }
            ]
        },
        {
            "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.",
            "journal": "BMC genomics",
            "date": "2010-12-02",
            "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q04632",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                }
            ]
        },
        {
            "title": "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2012",
            "authors": "Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q04632",
                    "url": "https://www.uniprot.org/uniprot/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22814378",
                    "url": "https://glygen.org/publication/PubMed/22814378"
                }
            ]
        },
        {
            "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.",
            "journal": "Nature methods",
            "date": "2013-07",
            "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q04632",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04632"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ]
        },
        {
            "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.",
            "journal": "G3 (Bethesda)",
            "date": "2014",
            "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael",
            "evidence": [
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