{ "uniprot_canonical_ac": "Q04233-1", "uniprot_ac": "Q04233", "uniprot_id": "GIS4_YEAST", "mass": { "chemical_mass": 87140.0, "monoisotopic_mass": 87140.0 }, "refseq": { "ac": "NP_013708", "name": "Gis4p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013708" }, "gene_names": [ { "name": "GIS4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q04233", "id": "Q04233" }, { "name": "GIS4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013708", "id": "NP_013708" }, { "name": "YM9571.13C", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q04233", "id": "Q04233" } ], "protein_names": [ { "name": "Protein GIS4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q04233" }, { "name": "Gis4p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013708", "id": "NP_013708" } ], "function": [ { "annotation": "May be involved in the Ras/cAMP signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233#function" }, { "database": "PubMed", "id": "10628841", "url": "https://glygen.org/publication/PubMed/10628841" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" } ], "common_name": "Yeast" } ], "gene": [ { "name": "GIS4", "url": "https://www.uniprot.org/uniprot/Q04233", "locus": {} } ], "crossref": [ { "id": "855006", "url": "https://www.ncbi.nlm.nih.gov/gene/855006", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q04233", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q04233*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "sce:YML006C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YML006C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NHENHYL", "url": "https://omabrowser.org/oma/group/NHENHYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1968846at2759", "url": "http://www.orthodb.org/?query=1968846at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PR_Q04233", "url": "http://purl.obolibrary.org/obo/PR_Q04233", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_013708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013708", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000004465", "url": "https://www.yeastgenome.org/locus/S000004465", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q04233-1", "url": "https://www.uniprot.org/uniprot/Q04233-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKSVRVGDYFDNDDNGLWSWYLTNLRLGDFEELIGNQLKYTLLKRFLNSHFYGDNNISARPNKKILLVSIPENVHEDISILEIFLKDYFHLEKLEHIQISKLTHSHCYNHENHYLLTDNLNNFQDPTFLEFASTSWQVQKNSKALNNNNRNSIPPPTISSSKASNGKLESNVSDDQWSNINTQTSTATRTNTNTRTLTSPDTVDINVTSVNSQSNNNDTPQDNENEVDEEDATSSIVLNFSHSRTVDSKPNRLPKIFPSYTNEDYTPSHSEIMSIDSFAGEDVSSTYPGQDLSLTTARREDESGQDEVEDHYSRVSHDLGDESIDQASYSMESSVSYTSYSSSSNSSSAHYSLSSSSRGNPKRENIDHTNATYVSELSSITSSIDNLTTSTTPEEEDNLIHHNYDAQGYGSGEDDGEEVYDDEDLSSSDYSVLSILPSISICDSLGYFRLVLQSILIQDPDTKEIFTAIRQSNNKPTMASVTDDWLLYDSNFSMNNLQILTLQDLLDIKRSFPKILFYTMVIVTNSGKQVEEEFKNPNYDNREGISKEQPLDSELSLTNDPQQYFPTAYNNGYNDYIDDEDDEDDGDDASLSEQSGPQMYIPTRMESNVTTAHRSIRTVNSIGEWAFNRHNSVTKIDKSNSNELDNSKTGESTVLSSEPHPMTQLSNSNTTSSNFSHSLKTKNSHKPNSKGNNESNSKNELKKIKSSINAMSAVERSKSLPLPTLLKSLSGIDNPTHATNKDRKRWKFQMNRFKNHKNSGSAGTDKSQRCAIM", "length": 774, "header": "sp|Q04233-1|GIS4_YEAST Isoform 1 of Protein GIS4 OS=Saccharomyces cerevisiae S288C OX=559292 GN=GIS4 PE=1 SV=1 CANONICAL=Q04233-1" }, "isoforms": [ { "isoform_ac": "Q04233-1", "url": "", "sequence": { "sequence": "MQKSVRVGDYFDNDDNGLWSWYLTNLRLGDFEELIGNQLKYTLLKRFLNSHFYGDNNISARPNKKILLVSIPENVHEDISILEIFLKDYFHLEKLEHIQISKLTHSHCYNHENHYLLTDNLNNFQDPTFLEFASTSWQVQKNSKALNNNNRNSIPPPTISSSKASNGKLESNVSDDQWSNINTQTSTATRTNTNTRTLTSPDTVDINVTSVNSQSNNNDTPQDNENEVDEEDATSSIVLNFSHSRTVDSKPNRLPKIFPSYTNEDYTPSHSEIMSIDSFAGEDVSSTYPGQDLSLTTARREDESGQDEVEDHYSRVSHDLGDESIDQASYSMESSVSYTSYSSSSNSSSAHYSLSSSSRGNPKRENIDHTNATYVSELSSITSSIDNLTTSTTPEEEDNLIHHNYDAQGYGSGEDDGEEVYDDEDLSSSDYSVLSILPSISICDSLGYFRLVLQSILIQDPDTKEIFTAIRQSNNKPTMASVTDDWLLYDSNFSMNNLQILTLQDLLDIKRSFPKILFYTMVIVTNSGKQVEEEFKNPNYDNREGISKEQPLDSELSLTNDPQQYFPTAYNNGYNDYIDDEDDEDDGDDASLSEQSGPQMYIPTRMESNVTTAHRSIRTVNSIGEWAFNRHNSVTKIDKSNSNELDNSKTGESTVLSSEPHPMTQLSNSNTTSSNFSHSLKTKNSHKPNSKGNNESNSKNELKKIKSSINAMSAVERSKSLPLPTLLKSLSGIDNPTHATNKDRKRWKFQMNRFKNHKNSGSAGTDKSQRCAIM", "length": 774, "header": "sp|Q04233-1|GIS4_YEAST Isoform 1 of Protein GIS4 OS=Saccharomyces cerevisiae S288C OX=559292 GN=GIS4 PE=1 SV=1 CANONICAL=Q04233-1" }, "locus": { "chromosome": "XIII", "start_pos": 258416, "end_pos": 256095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YML006C_mRNA", "url": "https://www.ensembl.org/id/YML006C_mRNA" }, { "database": "Ensembl Peptide", "id": "YML006C", "url": "https://www.ensembl.org/id/YML006C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser153" }, { "start_pos": 165, "end_pos": 165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser165" }, { "start_pos": 174, "end_pos": 174, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser174" }, { "start_pos": 179, "end_pos": 179, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser179" }, { "start_pos": 304, "end_pos": 304, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20489023", "url": "https://glygen.org/publication/PubMed/20489023" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" } ], "site_lbl": "Ser304" }, { "start_pos": 608, "end_pos": 608, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser608" }, { "start_pos": 612, "end_pos": 612, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" } ], "site_lbl": "Thr612" }, { "start_pos": 616, "end_pos": 616, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" } ], "site_lbl": "Ser616" }, { "start_pos": 619, "end_pos": 619, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" } ], "site_lbl": "Thr619" }, { "start_pos": 622, "end_pos": 622, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { 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"url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser642" }, { "start_pos": 707, "end_pos": 707, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser707" }, { "start_pos": 708, "end_pos": 708, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" } ], "site_lbl": "Ser708" }, { "start_pos": 720, "end_pos": 720, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" } ], "site_lbl": "Ser720" }, { "start_pos": 729, "end_pos": 729, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { 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"id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "Q04233", "url": "https://www.yeastgenome.org/locus/Q04233" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser731" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells.", "journal": "Mol. Gen. Genet.", "date": "1999", "authors": "Ronne H., Balciunas D.", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" } ], "reference": [ { "type": "PubMed", "id": "10628841", "url": "https://glygen.org/publication/PubMed/10628841" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "Q04233", "url": "https://www.uniprot.org/uniprot/Q04233" }, { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.", "journal": "Genes & development", "date": "2009-08-15", "authors": "Huber Alexandre, Bodenmiller Bernd, Uotila Aino, Stahl Michael, Wanka Stefanie, Gerrits Bertran, Aebersold Ruedi, Loewith Robbie", "evidence": [ { "database": "iPTMnet", "id": "Q04233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04233" } ], "reference": [ { "type": "PubMed", "id": "19684113", 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