{ "uniprot_canonical_ac": "Q03834-1", "uniprot_ac": "Q03834", "uniprot_id": "MSH6_YEAST", "mass": { "chemical_mass": 140080.0, "monoisotopic_mass": 140080.0 }, "refseq": { "ac": "NP_010382", "name": "mismatch repair ATPase MSH6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010382" }, "gene_names": [ { "name": "MSH6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q03834", "id": "Q03834" }, { "name": "MSH6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010382", "id": "NP_010382" }, { "name": "PMS3; PMS6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010382", "id": "NP_010382" }, { "name": "PMS3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q03834", "id": "Q03834" }, { "name": "YD8557.04C", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q03834", "id": "Q03834" } ], "protein_names": [ { "name": "DNA mismatch repair protein MSH6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q03834" }, { "name": "MutS protein homolog 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03834" }, { "name": "Postmeiotic segregation protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03834" }, { "name": "mismatch repair ATPase MSH6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010382", "id": "NP_010382" } ], "function": [ { "annotation": "Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. MSH6 provides substrate-binding and substrate specificity to the complex. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair base-base and single insertion-deletion mismatches that occur during replication, but can also repair longer insertion-deletion loops (IDLs), although with decreasing efficiency as the size of the extrahelical loop increases. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis by the MutS alpha complex is crucial for MMR. Both subunits bind ATP, but with differing affinities, and their ATPase kinetics are also very different. MSH6 binds and hydrolyzes ATP rapidly, whereas MSH2 catalyzes ATP at a substantially slower rate. Binding to a mismatched base pair suppresses MSH6-catalyzed ATP hydrolysis, but not the activity of MSH2. ATP binding to both subunits is necessary to trigger a change in MutS alpha interaction with mismatched DNA, converting MutS alpha into a sliding clamp capable of hydrolysis-independent movement along DNA, and also facilitates formation of ternary complexes containing MutS and MutL proteins and the mismatch. May also be involved in resolution of recombination intermediates.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834#function" }, { "database": "PubMed", "id": "8600025", "url": "https://glygen.org/publication/PubMed/8600025" }, { "database": "PubMed", "id": "15811858", "url": "https://glygen.org/publication/PubMed/15811858" }, { "database": "PubMed", "id": "9111357", "url": "https://glygen.org/publication/PubMed/9111357" }, { "database": "PubMed", "id": "16702432", "url": "https://glygen.org/publication/PubMed/16702432" }, { "database": "PubMed", "id": "9545323", "url": "https://glygen.org/publication/PubMed/9545323" }, { "database": "PubMed", "id": "12820877", "url": "https://glygen.org/publication/PubMed/12820877" }, { "database": "PubMed", "id": "17573527", "url": "https://glygen.org/publication/PubMed/17573527" }, { "database": "PubMed", "id": "17157869", "url": "https://glygen.org/publication/PubMed/17157869" }, { "database": "PubMed", "id": "11237611", "url": "https://glygen.org/publication/PubMed/11237611" }, { "database": "PubMed", "id": "9770499", "url": "https://glygen.org/publication/PubMed/9770499" }, { "database": "PubMed", "id": "10518225", "url": "https://glygen.org/publication/PubMed/10518225" }, { "database": "PubMed", "id": "17567610", "url": "https://glygen.org/publication/PubMed/17567610" }, { "database": "PubMed", "id": "16337600", "url": "https://glygen.org/publication/PubMed/16337600" }, { "database": "PubMed", "id": "12509278", "url": "https://glygen.org/publication/PubMed/12509278" }, { "database": "PubMed", "id": "16214425", "url": "https://glygen.org/publication/PubMed/16214425" }, { "database": "PubMed", "id": "10970737", "url": "https://glygen.org/publication/PubMed/10970737" }, { "database": "PubMed", "id": "16600868", "url": "https://glygen.org/publication/PubMed/16600868" }, { "database": "PubMed", "id": "17141577", "url": "https://glygen.org/publication/PubMed/17141577" }, { "database": "PubMed", "id": "16407100", "url": "https://glygen.org/publication/PubMed/16407100" } ] } ], "disease": [ { "disease_id": "DOID:0070272", "recommended_name": { "id": "DOID:0070272", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070272", "name": "hereditary nonpolyposis colorectal cancer type 5", "description": "A Lynch syndrome that has_material_basis_in heterozygous mutation in the MSH6 gene on chromosome 2p16." }, "synonyms": [ { "id": "DOID:0070272", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070272", "name": "HNPCC5", "description": "" }, { "id": "MONDO:0013710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013710", "name": "Lynch syndrome 5", "description": "Any hereditary nonpolyposis colon cancer in which the cause of the disease is a mutation in the MSH6 gene." }, { "id": "MONDO:0013710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013710", "name": "MSH6 hereditary nonpolyposis colon cancer", "description": "" }, { "id": "MONDO:0013710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013710", "name": "colorectal cancer, hereditary nonpolyposis, type 5", "description": "" }, { "id": "MONDO:0013710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013710", "name": "hereditary nonpolyposis colon cancer caused by mutation in MSH6", "description": "" }, { "id": "MONDO:0013710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013710", "name": "HNPCC5", "description": "" }, { "id": "MIM:614350", "resource": "MIM", "url": "https://www.omim.org/entry/614350", "name": "Lynch syndrome 5", "description": "Lynch syndrome 5" } ], "evidence": [ { "id": "0070272", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070272" } ] }, { "disease_id": "DOID:0080199", "recommended_name": { "id": "DOID:0080199", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080199", "name": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa." }, "synonyms": [], "evidence": [ { "id": "0080199", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080199" } ] }, { "disease_id": "DOID:0112182", "recommended_name": { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "mismatch repair cancer syndrome", "description": "A syndrome characterized by predisposition for development of a broad spectrum of malignancies during childhood, including mainly brain, hematological and gastrointestinal cancers that has_material_basis_in homozygous or compound heterozygous mutation in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2 on chromosomes 3p22.2, 2p21-p16, 2p16.3, and 7p22.1, respectively." }, "synonyms": [ { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "BTP1 syndrome", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "BTPS1", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "CMMRDS", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "MMR deficiency", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "Turcot syndrome", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "CMMR-D syndrome", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "brain tumor-polyposis syndrome 1", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "childhood cancer syndrome", "description": "" }, { "id": "DOID:0112182", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112182", "name": "constitutional mismatch repair deficiency syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "mismatch repair cancer syndrome 1", "description": "A rare childhood cancer predisposition syndrome caused by biallelic inheritance of mutations in MLH1, MSH2, MSH6, or PMS2 genes. It is characterized by the development of childhood cancers, usually hematological malignancies and/or brain tumors, and colorectal cancers with multiple intestinal polyps. The majority of patients show signs of neurofibromatosis type 1." }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "BTP1 syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "CMMR-D", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "CMMR-D syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "MMRCS1", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "brain tumor-polyposis syndrome 1", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "constitutional MIS-match repair deficiency syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "constitutional mismatch repair deficiency syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "mismatch repair cancer syndrome 1", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "CNS tumors with familial polyposis of the colon", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "CNS tumours with familial polyposis of the colon", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "MMR deficiency", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "MMRCS", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "Turcot syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "brain tumor-polyposis syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "childhood cancer syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "glioma-polyposis syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "malignant tumors of the central nervous system associated with familial polyposis of the colon", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "malignant tumours of the central nervous system associated with familial polyposis of the colon", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "mismatch repair cancer syndrome", "description": "" }, { "id": "MONDO:0010159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010159", "name": "mismatch repair deficiency", "description": "" }, { "id": "MIM:276300", "resource": "MIM", "url": "https://www.omim.org/entry/276300", "name": "Mismatch repair cancer syndrome 1", "description": "Mismatch repair cancer syndrome 1" } ], "evidence": [ { "id": "0112182", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112182" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "evidence": [ { "id": "11054", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] }, { "disease_id": "DOID:1380", "recommended_name": { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus." }, "synonyms": [ { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "endometrial Ca", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "endometrial neoplasm", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "malignant endometrial neoplasm", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "malignant neoplasm of endometrium", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "neoplasm of endometrium", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "primary malignant neoplasm of endometrium", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "tumor of Endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial cancer", "description": "Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity)." }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial neoplasm", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "neoplasm of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "tumor of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "tumour of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "cancer of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial Ca", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial cancer", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial cancer, familial, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial carcinoma, somatic", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrium cancer", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "malignant endometrial neoplasm", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "malignant endometrium neoplasm", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "malignant neoplasm of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "primary malignant neoplasm of endometrium", "description": "" }, { "id": "MIM:608089", "resource": "MIM", "url": "https://www.omim.org/entry/608089", "name": "Endometrial cancer", "description": "Endometrial cancer" } ], "evidence": [ { "id": "1380", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "evidence": [ { "id": "1612", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "evidence": [ { "id": "162", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "evidence": [ { "id": "2394", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ] }, { "disease_id": "DOID:3347", "recommended_name": { "id": "DOID:3347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3347", "name": "osteosarcoma", "description": "A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin." }, "synonyms": [ { "id": "DOID:3347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3347", "name": "Osteogenic sarcoma", "description": "" }, { "id": "DOID:3347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3347", "name": "Skeletal sarcoma", "description": "" }, { "id": "DOID:3347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3347", "name": "bone tissue neoplasm", "description": "" }, { "id": "DOID:3347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3347", "name": "osteoid sarcoma", "description": "" }, { "id": "MONDO:0002629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002629", "name": "bone osteosarcoma", "description": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs." }, { "id": "MONDO:0002629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002629", "name": "bone osteosarcoma", "description": "" }, { "id": "MONDO:0002629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002629", "name": "osteosarcoma of bone", "description": "" }, { "id": "MONDO:0002629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002629", "name": "osteosarcoma, somatic", "description": "" }, { "id": "MONDO:0002629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002629", "name": "osteosarcoma, somatic mutation", "description": "" }, { "id": "MONDO:0002629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002629", "name": "primary osteosarcoma of bone", "description": "" }, { "id": "MIM:259500", "resource": "MIM", "url": "https://www.omim.org/entry/259500", "name": "Osteogenic sarcoma", "description": "Osteogenic sarcoma" } ], "evidence": [ { "id": "3347", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3347" } ] }, { "disease_id": "DOID:3459", "recommended_name": { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "Mammary carcinoma", "description": "" }, { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "carcinoma of breast", "description": "" } ], "evidence": [ { "id": "3459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3459" } ] }, { "disease_id": "DOID:3883", "recommended_name": { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Lynch syndrome", "description": "A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers." }, "synonyms": [ { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "COCA 1", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "HNPCC - hereditary nonpolyposis colon cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary Defective Mismatch Repair syndrome", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "hereditary nonpolyposis colorectal cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "hereditary nonpolyposis colorectal neoplasm", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary non-polyposis colon cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary non-polyposis colon cancer syndrome", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary non-polyposis colorectal cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary nonpolyposis colon cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary nonpolyposis colon cancer syndrome", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary nonpolyposis colorectal cancer syndrome", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary non-polyposis colorectal cancer syndrome", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome 1", "description": "Any Lynch syndrome in which the cause of the disease is a mutation in the MSH2 gene." }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "HNPCC1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Hereditary non-polyposis colon cancer type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch 1 syndrome", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "familial non-polyposis colon cancer type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "hereditary nonpolyposis colorectal cancer type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "COCA1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "LYNCH syndrome I", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome 2", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "colon cancer, familial nonpolyposis, type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "colorectal cancer, hereditary nonpolyposis, type 1", "description": "" }, { "id": "MIM:120435", "resource": "MIM", "url": "https://www.omim.org/entry/120435", "name": "Lynch syndrome 1", "description": "Lynch syndrome 1" } ], "evidence": [ { "id": "3883", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3883" } ] }, { "disease_id": "DOID:5426", "recommended_name": { "id": "DOID:5426", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5426", "name": "primary ovarian insufficiency", "description": "An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40." }, "synonyms": [ { "id": "DOID:5426", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5426", "name": "premature ovarian failure", "description": "" }, { "id": "DOID:5426", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5426", "name": "hypergonadotropic hypogonadism", "description": "" }, { "id": "DOID:5426", "resource": "Disease 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"id": "IPR017261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YDR097C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDR097C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPMMAQY", "url": "https://omabrowser.org/oma/group/TPMMAQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "168255at2759", "url": "http://www.orthodb.org/?query=168255at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361:SF148", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361:SF148", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00488", "url": "http://pfam.xfam.org/family/PF00488", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01624", "url": "http://pfam.xfam.org/family/PF01624", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05188", "url": "http://pfam.xfam.org/family/PF05188", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05190", "url": "http://pfam.xfam.org/family/PF05190", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05192", "url": "http://pfam.xfam.org/family/PF05192", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q03834", "url": "http://purl.obolibrary.org/obo/PR_Q03834", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_010382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010382", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000002504", "url": "https://www.yeastgenome.org/locus/S000002504", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q03834-1", "url": "https://www.uniprot.org/uniprot/Q03834-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPATPKTSKTAHFENGSTSSQKKMKQSSLLSFFSKQVPSGTPSKKVQKPTPATLENTATDKITKNPQGGKTGKLFVDVDEDNDLTIAEETVSTVRSDIMHSQEPQSDTMLNSNTTEPKSTTTDEDLSSSQSRRNHKRRVNYAESDDDDSDTTFTAKRKKGKVVDSESDEDEYLPDKNDGDEDDDIADDKEDIKGELAEDSGDDDDLISLAETTSKKKFSYNTSHSSSPFTRNISRDNSKKKSRPNQAPSRSYNPSHSQPSATSKSSKFNKQNEERYQWLVDERDAQRRPKSDPEYDPRTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYEKDALLANALFDLKIAGGGRANMQLAGIPEMSFEYWAAQFIQMGYKVAKVDQRESMLAKEMREGSKGIVKRELQCILTSGTLTDGDMLHSDLATFCLAIREEPGNFYNETQLDSSTIVQKLNTKIFGAAFIDTATGELQMLEFEDDSECTKLDTLMSQVRPMEVVMERNNLSTLANKIVKFNSAPNAIFNEVKAGEEFYDCDKTYAEIISSEYFSTEEDWPEVLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKNLISMKNIKEYDFVKSQHSMVLDGITLQNLEIFSNSFDGSDKGTLFKLFNRAITPMGKRMMKKWLMHPLLRKNDIESRLDSVDSLLQDITLREQLEITFSKLPDLERMLARIHSRTIKVKDFEKVITAFETIIELQDSLKNNDLKGDVSKYISSFPEGLVEAVKSWTNAFERQKAINENIIVPQRGFDIEFDKSMDRIQELEDELMEILMTYRKQFKCSNIQYKDSGKEIYTIEIPISATKNVPSNWVQMAANKTYKRYYSDEVRALARSMAEAKEIHKTLEEDLKNRLCQKFDAHYNTIWMPTIQAISNIDCLLAITRTSEYLGAPSCRPTIVDEVDSKTNTQLNGFLKFKSLRHPCFNLGATTAKDFIPNDIELGKEQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAVLTPIDRIMTRLGANDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIAESVLHHVATHIQSLGFFATHYGTLASSFKHHPQVRPLKMSILVDEATRNVTFLYKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNLEHTSRLVKERDLAANNLNGEVVSVPGGLQSDFVRIAYGDGLKNTKLGSGEGVLNYDWNIKRNVLKSLFSIIDDLQS", "length": 1242, "header": "sp|Q03834-1|MSH6_YEAST Isoform 1 of DNA mismatch repair protein MSH6 OS=Saccharomyces cerevisiae S288C OX=559292 GN=MSH6 PE=1 SV=1 CANONICAL=Q03834-1" }, "isoforms": [ { "isoform_ac": "Q03834-1", "url": "", "sequence": { "sequence": "MAPATPKTSKTAHFENGSTSSQKKMKQSSLLSFFSKQVPSGTPSKKVQKPTPATLENTATDKITKNPQGGKTGKLFVDVDEDNDLTIAEETVSTVRSDIMHSQEPQSDTMLNSNTTEPKSTTTDEDLSSSQSRRNHKRRVNYAESDDDDSDTTFTAKRKKGKVVDSESDEDEYLPDKNDGDEDDDIADDKEDIKGELAEDSGDDDDLISLAETTSKKKFSYNTSHSSSPFTRNISRDNSKKKSRPNQAPSRSYNPSHSQPSATSKSSKFNKQNEERYQWLVDERDAQRRPKSDPEYDPRTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYEKDALLANALFDLKIAGGGRANMQLAGIPEMSFEYWAAQFIQMGYKVAKVDQRESMLAKEMREGSKGIVKRELQCILTSGTLTDGDMLHSDLATFCLAIREEPGNFYNETQLDSSTIVQKLNTKIFGAAFIDTATGELQMLEFEDDSECTKLDTLMSQVRPMEVVMERNNLSTLANKIVKFNSAPNAIFNEVKAGEEFYDCDKTYAEIISSEYFSTEEDWPEVLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKNLISMKNIKEYDFVKSQHSMVLDGITLQNLEIFSNSFDGSDKGTLFKLFNRAITPMGKRMMKKWLMHPLLRKNDIESRLDSVDSLLQDITLREQLEITFSKLPDLERMLARIHSRTIKVKDFEKVITAFETIIELQDSLKNNDLKGDVSKYISSFPEGLVEAVKSWTNAFERQKAINENIIVPQRGFDIEFDKSMDRIQELEDELMEILMTYRKQFKCSNIQYKDSGKEIYTIEIPISATKNVPSNWVQMAANKTYKRYYSDEVRALARSMAEAKEIHKTLEEDLKNRLCQKFDAHYNTIWMPTIQAISNIDCLLAITRTSEYLGAPSCRPTIVDEVDSKTNTQLNGFLKFKSLRHPCFNLGATTAKDFIPNDIELGKEQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAVLTPIDRIMTRLGANDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIAESVLHHVATHIQSLGFFATHYGTLASSFKHHPQVRPLKMSILVDEATRNVTFLYKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNLEHTSRLVKERDLAANNLNGEVVSVPGGLQSDFVRIAYGDGLKNTKLGSGEGVLNYDWNIKRNVLKSLFSIIDDLQS", "length": 1242, "header": "sp|Q03834-1|MSH6_YEAST Isoform 1 of DNA mismatch repair protein MSH6 OS=Saccharomyces cerevisiae S288C OX=559292 GN=MSH6 PE=1 SV=1 CANONICAL=Q03834-1" }, "locus": { "chromosome": "IV", "start_pos": 643837, "end_pos": 640112, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YDR097C_mRNA", "url": "https://www.ensembl.org/id/YDR097C_mRNA" }, { "database": "Ensembl Peptide", "id": "YDR097C", "url": "https://www.ensembl.org/id/YDR097C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 102, "end_pos": 102, "kinase_uniprot_canonical_ac": "P38110-1", "kinase_gene_name": "TEL1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" } ], "site_lbl": "Ser102" }, { "start_pos": 102, "end_pos": 102, "kinase_uniprot_canonical_ac": "P38111-1", "kinase_gene_name": "MEC1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" } ], "site_lbl": "Ser102" }, { "start_pos": 102, "end_pos": 102, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser102" }, { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser107" }, { "start_pos": 1137, "end_pos": 1137, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "22031224", "url": "https://glygen.org/publication/PubMed/22031224" } ], "site_lbl": "Ser1137" }, { "start_pos": 120, "end_pos": 120, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Ser120" }, { "start_pos": 128, "end_pos": 128, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser128" }, { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser129" }, { "start_pos": 130, "end_pos": 130, "kinase_uniprot_canonical_ac": "P38110-1", "kinase_gene_name": "TEL1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" } ], "site_lbl": "Ser130" }, { "start_pos": 130, "end_pos": 130, "kinase_uniprot_canonical_ac": "P38111-1", "kinase_gene_name": "MEC1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" } ], "site_lbl": "Ser130" }, { "start_pos": 130, "end_pos": 130, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser130" }, { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser132" }, { "start_pos": 145, "end_pos": 145, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser145" }, { "start_pos": 150, "end_pos": 150, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser150" }, { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr152" }, { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" } ], "site_lbl": "Thr153" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "Q03834", "url": "https://www.yeastgenome.org/locus/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" }, { 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Chem.", "date": "2000", "authors": "Clark AB, Valle F, Drotschmann K, Gary RK, Kunkel TA", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "11005803", "url": "https://glygen.org/publication/PubMed/11005803" } ] }, { "title": "Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex.", "journal": "Nat. Genet.", "date": "2000", "authors": "Flores-Rozas H, Clark D, Kolodner R D", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "11062484", "url": "https://glygen.org/publication/PubMed/11062484" } ] }, { "title": "MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp.", "journal": "J. Mol. 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Chem.", "date": "2002", "authors": "Hess Martin T, Gupta Ruchira Das, Kolodner Richard D", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "11986324", "url": "https://glygen.org/publication/PubMed/11986324" } ] }, { "title": "Transfer of the MSH2.MSH6 complex from proliferating cell nuclear antigen to mispaired bases in DNA.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Kolodner R.D., Lau P.J.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "12435741", "url": "https://glygen.org/publication/PubMed/12435741" } ] }, { "title": "Evidence for sequential action of two ATPase active sites in yeast Msh2-Msh6.", "journal": "DNA Repair", "date": "2002", "authors": "Drotschmann Karin, Yang Wei, Kunkel Thomas A", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "12509278", "url": "https://glygen.org/publication/PubMed/12509278" } ] }, { "title": "Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.", "journal": "Biochemistry", "date": "2003", "authors": "Antony E., Hingorani M.M.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "12820877", "url": "https://glygen.org/publication/PubMed/12820877" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Cadmium inhibits the functions of eukaryotic MutS complexes.", "journal": "J. 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Chem.", "date": "2005", "authors": "Kolodner R.D., Mazur D.J., Mendillo M.L.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "15811858", "url": "https://glygen.org/publication/PubMed/15811858" } ] }, { "title": "Contribution of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiae Msh2-Msh6 mismatch repair protein.", "journal": "DNA Repair", "date": "2006", "authors": "Antony Edwin, Khubchandani Sapna, Chen Siying, Hingorani Manju M", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "16214425", "url": "https://glygen.org/publication/PubMed/16214425" } ] }, { "title": "Detection of high-affinity and sliding clamp modes for MSH2-MSH6 by single-molecule unzipping force analysis.", "journal": "Mol. Cell", "date": "2005", "authors": "Jiang J., Bai L., Alani E., Gemici Z., Surtees J.A., Wang M.D.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "16337600", "url": "https://glygen.org/publication/PubMed/16337600" } ] }, { "title": "Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Hess Martin T, Mendillo Marc L, Mazur Dan J, Kolodner Richard D", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "16407100", "url": "https://glygen.org/publication/PubMed/16407100" } ] }, { "title": "Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2(ATP)-Msh6(ATP) state capable of hydrolysis-independent movement along DNA.", "journal": "Mol. Cell", "date": "2006", "authors": "Mazur Dan J, Mendillo Marc L, Kolodner Richard D", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "16600868", "url": "https://glygen.org/publication/PubMed/16600868" } ] }, { "title": "Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae.", "journal": "Genetics", "date": "2006", "authors": "Petes T.D., Stone J.E.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "16702432", "url": "https://glygen.org/publication/PubMed/16702432" } ] }, { "title": "Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6.", "journal": "DNA Repair", "date": "2007", "authors": "Holmes Shannon F, Scarpinato Karin Drotschmann, McCulloch Scott D, Schaaper Roel M, Kunkel Thomas A", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17141577", "url": "https://glygen.org/publication/PubMed/17141577" } ] }, { "title": "Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.", "journal": "J. Mol. Biol.", "date": "2007", "authors": "Lee Susan D, Surtees Jennifer A, Alani Eric", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17157869", "url": "https://glygen.org/publication/PubMed/17157869" } ] }, { "title": "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Chi An, Huttenhower Curtis, Geer Lewis Y, Coon Joshua J, Syka John E P, Bai Dina L, Shabanowitz Jeffrey, Burke Daniel J, Troyanskaya Olga G, Hunt Donald F", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "Multiple functions for the N-terminal region of Msh6.", "journal": "Nucleic Acids Res.", "date": "2007", "authors": "Kunkel T.A., Tomer K.B., Clark A.B., Deterding L.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17567610", "url": "https://glygen.org/publication/PubMed/17567610" } ] }, { "title": "Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Putnam C.D., Kolodner R.D., Shell S.S.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "17573527", "url": "https://glygen.org/publication/PubMed/17573527" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Systematic identification of cell cycle-dependent yeast 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"type": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" }, { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "A proteome-wide analysis of kinase-substrate network in the DNA damage response.", "journal": "The Journal of biological chemistry", "date": "2010-04-23", "authors": "Chen Sheng-hong, Albuquerque Claudio P, Liang Jason, Suhandynata Raymond T, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "20190278", "url": "https://glygen.org/publication/PubMed/20190278" } ] }, { "title": "The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.", "journal": "Molecular biology of the cell", "date": "2010-10-01", "authors": "Soulard Alexandre, Cremonesi Alessio, Moes Suzette, Sch\u00fctz Fr\u00e9d\u00e9ric, Jen\u00f6 Paul, Hall Michael N", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" } ] }, { "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.", "journal": "BMC genomics", "date": "2010-12-02", "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ] }, { "title": "Cell cycle phosphorylation of mitotic exit network (MEN) proteins.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2011-10-15", "authors": "Jones Michele H, Keck Jamie M, Wong Catherine C L, Xu Tao, Yates John R, Winey Mark", "evidence": [ { "database": "iPTMnet", "id": "Q03834", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q03834" } ], "reference": [ { "type": "PubMed", "id": "22031224", "url": "https://glygen.org/publication/PubMed/22031224" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", 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"https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.", "journal": "Genes Dev.", "date": "1996", "authors": "Marsischky G T, Filosi N, Kane M F, Kolodner R", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "8600025", "url": "https://glygen.org/publication/PubMed/8600025" } ] }, { "title": "MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2.", "journal": "Curr. Biol.", "date": "1996", "authors": "Hsuan J.J., Totty N.F., Jiricny J., Modrich P., Palombo F., Iaccarino I., Drummond J.T.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "8723353", "url": "https://glygen.org/publication/PubMed/8723353" } ] }, { "title": "The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs.", "journal": "Mol. Cell. Biol.", "date": "1996", "authors": "Alani E.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "8816473", "url": "https://glygen.org/publication/PubMed/8816473" } ] }, { "title": "Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes.", "journal": "Mol. Cell. Biol.", "date": "1997", "authors": "Petes T.D., Sia E.A., Dominska M., Greenwell P., Kokoska R.J.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "9111357", "url": "https://glygen.org/publication/PubMed/9111357" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.", "journal": "Nature", "date": "1997", "authors": "Andrews S., Bahr A., Bloecker H., Brandt P., Connor R., Du Z., Fulton L., Gentles S., Hawkins J., Hillier L.W., Johnson D., Latreille P., Mardis E., Mewes H.-W., Miller N., Niblett D., Oliver K., Schaefer M., Scharfe M., Vaudin M., Wambutt R., Waterston R., Wedler H., Wilson R., Chen E., Le T., Verhasselt P., Bowman S., Hunt S., Wagner G., Chung E., Nakahara K., Botstein D., Brueckner M., Davis R.W., Lin D., Hankeln T., Schneider C., Schmidt E.R., Duncan M., Favello A., Kucaba T., Rifkin L., Trevaskis E., Wohldman P., Barrell B.G., Rieger M., Berno A., Schroeder M., Ding H., Oh C., Oefner P., Schwarz S., Woelfl S., Kleine K., Becker A., Prydz H., Cooper J., Arnold W., Eide L.G., Kraemer C., Lashkari D., Allen E., Jimenez A., Kuester H., Hoheisel J.D., Pauley A., Paulin L., Brown D., Jaeger W., Volckaert G., Hyman R.W., Andre B., Perez-Alonso M., Araujo R., Komp C., Lew H., Namath A., Roberts D., Paricio N., Boskovic J., Louis E.J., Mulligan J.T., Delaveau T., Greco T., Johnston L., Nhan M., Jones L., Odell C., Menezes S., Johnston M., Pohl T.M., Harris D.E., Schramm S., McDonald S., Salom D., Bargues M., Cherry J.M., Ballesta J.P.G., Churcher C.M., Dedman K., Dietrich F.S., Dujon B., Goffeau A., Hamlin N., Hani J., Jacq C., Mueller-Auer S., Perea J., Perez-Ortin J.E., Rajandream M.A., Remacha M.A., Revuelta J.L., Vissers S., Walsh S.V., Zollner A., del Rey F., Jonniaux J.-L., Purnelle B., Saiz J.E., Urrestarazu L.A., Voet M., Wilcox L., Albermann K., Alt-Moerbe J., Aviles E., Baron L., Biteau N., Blugeon C., Brinkman R., Buitrago M.J., Carpenter J., Coster F., Garcia-Cantalejo J.M., Gattung S., Gomez-Peris A., Granotier C., Hallsworth K., Hanemann V., Heumann K., Hunicke-Smith S., Jier M., Kirsten J., Laamanen P., Langston Y., Legros Y., Moeller-Rieker S., Monnet A., Moro M., Mosedale D., Murphy L.D., Nussbaumer B., Peluso D., Petel F.X., Rasmussen S.W., Richards C., Riles L., Saluz H.P., Saren A.-M., Scholler P., Shogren T., Shore L., Shroff N., Soler-Mira A., Taich A., Vignati D., Wedler E., Winant A., Yelton M.A., Zaccaria P.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "9169867", "url": "https://glygen.org/publication/PubMed/9169867" } ] }, { "title": "ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Sung P., Prakash L., Prakash S., Habraken Y.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "9545323", "url": "https://glygen.org/publication/PubMed/9545323" } ] }, { "title": "The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1998", "authors": "Flores-Rozas H., Kolodner R.D.", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "9770499", "url": "https://glygen.org/publication/PubMed/9770499" } ] }, { "title": "Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair.", "journal": "Mol. Cell. Biol.", "date": "1998", "authors": "Studamire B, Quach T, Alani E", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "reference": [ { "type": "PubMed", "id": "9819445", "url": "https://glygen.org/publication/PubMed/9819445" } ] } ], "pathway": [ { "id": "sce:YDR097C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDR097C", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P52701-1", "protein_name": "DNA mismatch repair protein Msh6", "gene_name": "MSH6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL", "length": 1360 }, "evidence": [ { "id": "Q03834", "url": "https://omabrowser.org/oma/group/Q03834/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P54276-1", "protein_name": "DNA mismatch repair protein Msh6", "gene_name": "Msh6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 1358 }, "evidence": [ { "id": "Q03834", "url": "https://omabrowser.org/oma/group/Q03834/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VUM0-1", "protein_name": "Probable DNA mismatch repair protein Msh6", "gene_name": "Msh6", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKKLNTSVGGTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRIIGEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQLKMCQV", "length": 1190 }, "evidence": [ { "id": "Q03834", "url": "https://omabrowser.org/oma/group/Q03834/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "MutSalpha complex", "id": "GO:0032301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032301", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "meiotic mismatch repair", "id": "GO:0000710", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000710", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "mismatch repair", "id": "GO:0006298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "replication fork arrest", "id": "GO:0043111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043111", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "mismatched DNA binding", "id": "GO:0030983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030983", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" }, { "name": "ATP-dependent DNA damage sensor activity", "id": "GO:0140664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140664", "evidence": [ { "database": "UniProtKB", "id": "Q03834", "url": "https://www.uniprot.org/uniprot/Q03834" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1054, "end_pos": 1056, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1125, "end_pos": 1127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": 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"authors" ] } ] }