{ "uniprot_canonical_ac": "Q03734-1", "uniprot_ac": "Q03734", "uniprot_id": "SPA3M_MOUSE", "mass": { "chemical_mass": 47064.0, "monoisotopic_mass": 47064.0 }, "refseq": { "ac": "NP_033279", "name": "serine protease inhibitor A3M isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033279" }, "gene_names": [ { "name": "Serpina3m", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q03734", "id": "Q03734" }, { "name": "3e46; MMCM7; MMSPi2.4; Spi-2l; Spi-2rs1; spi2; Spi2-rs1; Spi2.4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033279", "id": "NP_033279" }, { "name": "Serpina3m", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033279", "id": "NP_033279" } ], "protein_names": [ { "name": "Serine protease inhibitor A3M", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q03734" }, { "name": "Serpin A3M", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03734" }, { "name": "serine (or cysteine) proteinase inhibitor, clade A, member 3M; serine protease inhibitor A3M; serpin A3M; serine protease inhibitor-2 related sequence 1; antitrypsin; alpha-1 antiproteinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033279", "id": "NP_033279" }, { "name": "serine protease inhibitor A3M isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033279", "id": "NP_033279" } ], "function": [], "disease": [ { "disease_id": "DOID:11394", "recommended_name": { "id": "DOID:11394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11394", "name": "adult respiratory distress syndrome", "description": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia." }, "synonyms": [ { "id": "DOID:11394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11394", "name": "ARDS", "description": "" }, { "id": "DOID:11394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11394", "name": "Non-cardiogenic pulmonary edema", "description": "" }, { "id": "DOID:11394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11394", "name": "Shock lung", "description": "" }, { "id": "DOID:11394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11394", "name": "adult RDS", "description": "" }, { "id": "DOID:11394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11394", "name": "acute respiratory distress syndrome", "description": "" } ], "evidence": [ { "id": "11394", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11394" } ] }, { "disease_id": "DOID:11949", "recommended_name": { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Creutzfeldt-Jakob disease", "description": "" }, "synonyms": [ { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "CJD", "description": "" }, { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Creutzfeldt Jacob syndrome", "description": "" }, { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Creutzfeldt Jakob disease", "description": "" }, { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Creutzfeldt-Jacob disease", "description": "" }, { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Jakob-Creutzfeldt disease", "description": "" }, { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Subacute spongiform encephalopathy", "description": "" }, { "id": "DOID:11949", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11949", "name": "Transmissible virus dementia", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "inherited Creutzfeldt-Jakob disease", "description": "Inherited or familial Creutzfeldt-Jakob disease (fCJD) is a very rare form of genetic prion disease characterized by typical CJD features (rapidly progressive dementia, personality/behavioral changes, psychiatric disorders, myoclonus, and ataxia) with a genetic cause and sometimes a family history of dementia." }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "Creutzfeldt-Jakob disease, variant, resistance to", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "hereditary Creutzfeldt Jacob disease", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "inherited CJD", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "CJD", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "Creutzfeldt-Jakob disease", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "Creutzfeldt-Jakob disease, Heidenhain variant", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "Creutzfeldt-Jakob disease, familial", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "Creutzfeldt-Jakob disease, sporadic", "description": "" }, { "id": "MONDO:0007403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007403", "name": "Creutzfeldt-Jakob disease, variant", "description": "" }, { "id": "MIM:123400", "resource": "MIM", "url": "https://www.omim.org/entry/123400", "name": "Creutzfeldt-Jakob disease", "description": "Creutzfeldt-Jakob disease" } ], "evidence": [ { "id": "11949", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11949" } ] }, { "disease_id": "DOID:1485", "recommended_name": { "id": "DOID:1485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1485", "name": "cystic fibrosis", "description": "A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs." }, "synonyms": [ { "id": "DOID:1485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1485", "name": "CF", "description": "" }, { "id": "DOID:1485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1485", "name": "mucoviscidosis", "description": "" }, { "id": "MONDO:0009061", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009061", "name": "cystic fibrosis", "description": "Cystic fibrosis (CF) is a genetic disorder characterized by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity." }, { "id": "MONDO:0009061", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009061", "name": "CF", "description": "" }, { "id": "MONDO:0009061", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009061", "name": "cystic fibrosis", "description": "" }, { "id": "MONDO:0009061", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009061", "name": "cystic fibrosis lung disease, modifier of", "description": "" }, { "id": "MONDO:0009061", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009061", "name": "mucoviscidosis", "description": "" }, { "id": "MONDO:0009061", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009061", "name": "pseudomonas aeruginosa, susceptibility to chronic infection by, in cystic fibrosis", "description": "" }, { "id": "MIM:219700", "resource": "MIM", "url": "https://www.omim.org/entry/219700", "name": "Cystic fibrosis", "description": "Cystic fibrosis" } ], "evidence": [ { "id": "1485", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1485" } ] }, { "disease_id": "DOID:2945", "recommended_name": { "id": "DOID:2945", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2945", "name": "severe acute respiratory syndrome", "description": "A Coronavirus infection that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia." }, "synonyms": [ { "id": "DOID:2945", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2945", "name": "SARS", "description": "" }, { "id": "DOID:2945", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2945", "name": "SARS-CoV infection", "description": "" }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "severe acute respiratory syndrome", "description": "A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death." }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "SARS", "description": "" }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "SARS coronavirus caused disease or disorder", "description": "" }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "SARS coronavirus disease or disorder", "description": "" }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "SARS coronavirus infectious disease", "description": "" }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "SARS-CoV infection", "description": "" }, { "id": "MONDO:0005091", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005091", "name": "acute respiratory coronavirus infection", "description": "" } ], "evidence": [ { "id": "2945", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2945" } ] }, { "disease_id": "DOID:3083", "recommended_name": { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both." }, "synonyms": [ { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "COLD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "COPD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive airway disease", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease", "description": "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema." }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD, chronic obstructive pulmonary disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airway disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airways disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease, (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold (chronic obstructive lung disease)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "disease (COPD), chronic obstructive", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive lung disease, chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive pulmonary disease (COPD), chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "pulmonary disease (COPD), chronic obstructive", "description": "" } ], "evidence": [ { "id": "3083", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ] }, { "disease_id": "DOID:3910", "recommended_name": { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "bronchogenic lung adenocarcinoma", "description": "" }, { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "nonsmall cell adenocarcinoma", "description": "" } ], "evidence": [ { "id": "3910", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ] }, { "disease_id": "DOID:865", "recommended_name": { "id": "DOID:865", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:865", "name": "vasculitis", "description": "A vascular disease that is characterized by inflammation of the blood vessels." }, "synonyms": [ { "id": "DOID:865", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:865", "name": "Angiitis", "description": "" } ], "evidence": [ { "id": "865", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:865" } ] } ], "snv": [ { "evidence": [ { "id": "rs250671280", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs250671280" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 269, "end_pos": 269, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAS->DAS).", "chr_id": "12", "chr_pos": "104357882", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N269", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3403588747", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3403588747" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 349, "end_pos": 349, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "12", "chr_pos": "104359034", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D349", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Serpina3m", "url": "https://www.uniprot.org/uniprot/Q03734", "locus": { "chromosome": "12", "start_pos": 104360516, "end_pos": 104304745, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000079012", "url": "https://www.ensembl.org/id/ENSMUSG00000079012" } ] } } ], "crossref": [ { "id": "ENSMUSG00000079012", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079012", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19551", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19551", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "20717", "url": "https://www.ncbi.nlm.nih.gov/gene/20717", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0003878", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003878", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:20717", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20717", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "98378", "url": "http://www.informatics.jax.org/marker/MGI:98378", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "AYACGVW", "url": "https://omabrowser.org/oma/group/AYACGVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3218836at2759", "url": "http://www.orthodb.org/?query=3218836at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "http://pfam.xfam.org/family/PF00079", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q03734", "url": "http://purl.obolibrary.org/obo/PR_Q03734", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_033279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033279", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q03734-1", "url": "https://www.uniprot.org/uniprot/Q03734-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFIAALGILMAGICPTVLCFSDDTWGIDILLHKNQESGTPDDSLTLASINTDFAFSLYKKMALKNPDKNIVFSPLSISAALALVSLGAKGNTLEEILEGLKFNLTETSEADIHQGFGHLLQRLSQPEDQDQINIGNAMFIEKDLQILAEFHEKTRALYQTEAFTADFQQPTEATKLINDYVSNQTQGMIKKLISELDDRTLMVLVNYIYFKGKWKISFDPQDTFESEFYLDEKRSVKVPMMKMKFLTTRHFRDEELSCSVLELKYTGNASALFILPDQGRMQQVEASLQPETLRKWWKSLKTRKIGELYLPKFSISTDYNLKDILPELGIKEIFSKQADLSGITGTKDLSVSQVVHKAVLDVAETGTEAAAATGFIFGFRSRRLQTMTVQFNRPFLMVISHTGVQTTLFMAKVTNPK", "length": 418, "header": "sp|Q03734-1|SPA3M_MOUSE Isoform 1 of Serine protease inhibitor A3M OS=Mus musculus OX=10090 GN=Serpina3m PE=1 SV=2 CANONICAL=Q03734-1" }, "isoforms": [ { "isoform_ac": "Q03734-1", "url": "", "sequence": { "sequence": "MAFIAALGILMAGICPTVLCFSDDTWGIDILLHKNQESGTPDDSLTLASINTDFAFSLYKKMALKNPDKNIVFSPLSISAALALVSLGAKGNTLEEILEGLKFNLTETSEADIHQGFGHLLQRLSQPEDQDQINIGNAMFIEKDLQILAEFHEKTRALYQTEAFTADFQQPTEATKLINDYVSNQTQGMIKKLISELDDRTLMVLVNYIYFKGKWKISFDPQDTFESEFYLDEKRSVKVPMMKMKFLTTRHFRDEELSCSVLELKYTGNASALFILPDQGRMQQVEASLQPETLRKWWKSLKTRKIGELYLPKFSISTDYNLKDILPELGIKEIFSKQADLSGITGTKDLSVSQVVHKAVLDVAETGTEAAAATGFIFGFRSRRLQTMTVQFNRPFLMVISHTGVQTTLFMAKVTNPK", "length": 418, "header": "sp|Q03734-1|SPA3M_MOUSE Isoform 1 of Serine protease inhibitor A3M OS=Mus musculus OX=10090 GN=Serpina3m PE=1 SV=2 CANONICAL=Q03734-1" }, "locus": { "chromosome": "12", "start_pos": 104360183, "end_pos": 104355335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000101078", "url": "https://www.ensembl.org/id/ENSMUST00000101078" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000098639", "url": "https://www.ensembl.org/id/ENSMUSP00000098639" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 104, "start_aa": "Asn", "end_pos": 104, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn104", "evidence": [ { "id": "Q03734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03734#ptm_processing" }, { "id": "16944957", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16944957" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "Q03734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03734#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 269, "start_aa": "Asn", "end_pos": 269, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn269", "evidence": [ { "id": "Q03734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03734#ptm_processing" }, { "id": "16944957", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16944957" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported" ], "publication": [ { "title": "A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.", "journal": "Genomics", "date": "2003", "authors": "Forsyth S, Horvath A, Coughlin P", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "reference": [ { "type": "PubMed", "id": "12659817", "url": "https://glygen.org/publication/PubMed/12659817" } ] }, { "title": "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.", "journal": "J. Mol. Evol.", "date": "2004", "authors": "Horvath AJ, Forsyth SL, Coughlin PB", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "reference": [ { "type": "PubMed", "id": "15638460", "url": "https://glygen.org/publication/PubMed/15638460" } ] }, { "title": "Proteome-wide characterization of N-glycosylation events by diagonal chromatography.", "journal": "Journal of proteome research", "date": "2006", "authors": "Ghesquiere B, Van Damme J, Martens L, Vandekerckhove J, Gevaert K", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734#ptm_processing" }, { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "reference": [ { "type": "PubMed", "id": "16944957", "url": "https://glygen.org/publication/PubMed/16944957" } ] }, { "title": "Cloning, structure and expression of cDNA for mouse contrapsin and a related protein.", "journal": "Biochem. J.", "date": "1991", "authors": "Ohkubo K, Ogata S, Misumi Y, Takami N, Sinohara H, Ikehara Y", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "reference": [ { "type": "PubMed", "id": "2049065", "url": "https://glygen.org/publication/PubMed/2049065" } ] } ], "pathway": [ { "id": "mmu:20717", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20717", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JSK1-1", "protein_name": "Serine (or cysteine) proteinase inhibitor, clade A, member 3C", "gene_name": "Serpina3c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFIAALGLLMAGICPAVLCDGILGRDTLPHEDQGKGRQLHSLTLASINTDFTLSLYKKLALRNPDKNVVFSPLSISAALAILSLGAKDSTMEEILEGLKFNLTEITEEEIHQGFGHLLQRLSQPEDQAEINTGSALFIDKEQPILSEFQEKTRALYQAEAFVADFKQCNEAKKFINDYVSNQTQGKIAELFSDLDERTSMVLVNYLLFKGKWKVPFNPNDTFESEFYLDEKRSVKVPMMKIKDLTTPYVRDEELSCSVLELKYTGNASALFILPDQGKMQQVESSLQPETLKKWKDSLRPRIISELRMPKFSISTDYNLEEVLPELGIRKIFSQQADLSRITGTKNLHVSQVVHKAVLDVDETGTEGAAATAVTAALKSLPQTVPLLNFNRPFMLVITDNNGQSVFFMGKVTNPM", "length": 416 }, "evidence": [ { "id": "45228160", "url": "http://www.informatics.jax.org/homology/45228160", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P01011-1", "protein_name": "Alpha-1-antichymotrypsin", "gene_name": "SERPINA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA", "length": 423 }, "evidence": [ { "id": "45228160", "url": "http://www.informatics.jax.org/homology/45228160", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P05544-1", "protein_name": "Serine protease inhibitor A3L", "gene_name": "Serpina3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFIAALGLLMAGICPAVLCDGTLGRDTLSHEDHGKGRQLHSLTLASSNTDFALSLYKKLALRNPDKNVVFSPLSISAALTILSLGAKDSTMEEILEGLKFNLTEITEEEIHQGFGHLLQRLSQPEDQVEINTGSALFIDKEQPILSEFQEKTRALYQAEAFIADFKQPNEAKKLINDYVSNQTQGKIAELFSDLEERTSMVLVNYLLFKGKWKVPFNPNDTFESEFYLDEKRSVKVPMMKIKEVTTPYVRDEELSCSVLELKYTGNASALFILPDQGKMQQVESSLQPETLKKWKDSLIPRIINDLRMPKFSISTDYSLKEVLPELGIKKVFSQQADLSRITGTKDLYVSQVVHKAVLDVDETGTEATAATGVATVIRRQPRTLNFNRPFMVVITDMDSQSILFVAKITNPK", "length": 413 }, "evidence": [ { "id": "Q03734", "url": "https://omabrowser.org/oma/group/Q03734/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q63556-1", "protein_name": "Serine protease inhibitor A3M", "gene_name": "Serpina3m", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "FLLMAGICPAVLGFPDGTLGNDTLLHKDQDKGTQLDSLTLESINTDFAFSLYKMLALKNPDKNVVFSPLSISAALAIVSLGAKGNTLEEILEVLRFNLTESYETDIHQGFGHLLQRLSQPGDQVKIITGNALFIDKNLQVLAEFQEKTRALYQVEAFTASFQQPRVTEKLINDSVRNQTQGKIQELVSGLKERTSMVLVNILLFRGKWKVPFDPDYTFESEFYVDEKRSVKVSMMKIEELTTPYFRDEELSCSVLELKYTGNSSALFILPDKGRMQQVEASLQPETLKKWKDSLRPRKIDELYLPRLSISTDYSLEEVLPELGIRDVFSQQADLSRITGAKDLSVSQVVHKVVLDVNETGTEAAAATGANLVPRSGRPPMIVWFNRPFLIAVSHTHGQHILFMAKVINPVGA", "length": 412 }, "evidence": [ { "id": "45228160", "url": "http://www.informatics.jax.org/homology/45228160", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "pmid": "" }, { "name": "response to peptide hormone", "id": "GO:0043434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043434", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "pmid": "" }, { "name": "negative regulation of endopeptidase activity", "id": "GO:0010951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010951", "evidence": [ { "database": "UniProtKB", "id": "Q03734", "url": "https://www.uniprot.org/uniprot/Q03734" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }