{ "uniprot_canonical_ac": "Q03148-1", "uniprot_ac": "Q03148", "uniprot_id": "SNZ1_YEAST", "mass": { "chemical_mass": 31817.0, "monoisotopic_mass": 31817.0 }, "refseq": { "ac": "NP_013814", "name": "pyridoxine biosynthesis protein SNZ1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013814" }, "gene_names": [ { "name": "SNZ1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q03148", "id": "Q03148" }, { "name": "SNZ1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013814", "id": "NP_013814" }, { "name": "YM6543.03", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q03148", "id": "Q03148" } ], "protein_names": [ { "name": "Pyridoxal 5'-phosphate synthase subunit SNZ1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q03148" }, { "name": "4.3.3.6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03148" }, { "name": "PDX1 homolog 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03148" }, { "name": "PLP synthase subunit SNZ1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03148" }, { "name": "Pdx1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03148" }, { "name": "p35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q03148" }, { "name": "pyridoxine biosynthesis protein SNZ1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013814", "id": "NP_013814" } ], "function": [ { "annotation": "Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148#function" }, { "database": "PubMed", "id": "19523954", "url": "https://glygen.org/publication/PubMed/19523954" }, { "database": "PubMed", "id": "12271461", "url": "https://glygen.org/publication/PubMed/12271461" }, { "database": "PubMed", "id": "12649274", "url": "https://glygen.org/publication/PubMed/12649274" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 116, "end_pos": 116, "sequence_org": "E", "sequence_mut": "A", "comment": "No effect.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" }, { "database": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] }, { "start_pos": 117, "end_pos": 117, "sequence_org": "K", "sequence_mut": "A", "comment": "No activity.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" }, { "database": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] }, { "start_pos": 136, "end_pos": 137, "sequence_org": "RR", "sequence_mut": "AA", "comment": "No pyridoxal 5'-phosphate synthesis activity. Retains ability to isomerize dihydroxyacetone phosphate to glyceraldehyde 3-phosphate.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" }, { "database": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] }, { "start_pos": 148, "end_pos": 148, "sequence_org": "K", "sequence_mut": "A", "comment": "No activity.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" }, { "database": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] }, { "start_pos": 164, "end_pos": 164, "sequence_org": "R", "sequence_mut": "A", "comment": "No pyridoxal 5'-phosphate synthesis activity. Retains ability to isomerize dihydroxyacetone phosphate to glyceraldehyde 3-phosphate.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" }, { "database": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] }, { "start_pos": 240, "end_pos": 240, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" }, { "database": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SNZ1", "url": "https://www.uniprot.org/uniprot/Q03148", "locus": {} } ], "crossref": [ { "id": "4.3.3.6", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.3.3.6&UniProtAcc=Q03148", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd04727", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04727", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "855121", "url": "https://www.ncbi.nlm.nih.gov/gene/855121", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q03148", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q03148*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YMR096W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YMR096W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TVIQRIM", "url": "https://omabrowser.org/oma/group/TVIQRIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "275220at2759", "url": "http://www.orthodb.org/?query=275220at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31829:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31829:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3FEM", "url": "https://www.rcsb.org/structure/3FEM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3O05", "url": "https://www.rcsb.org/structure/3O05", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3O06", "url": "https://www.rcsb.org/structure/3O06", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3O07", "url": "https://www.rcsb.org/structure/3O07", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01680", "url": "http://pfam.xfam.org/family/PF01680", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q03148", "url": "http://purl.obolibrary.org/obo/PR_Q03148", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_013814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013814", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000004702", "url": "https://www.yeastgenome.org/locus/S000004702", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q03148-1", "url": "https://www.uniprot.org/uniprot/Q03148-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGEDFKIKSGLAQMLKGGVIMDVVTPEQAKIAEKSGACAVMALESIPADMRKSGKVCRMSDPKMIKDIMNSVSIPVMAKVRIGHFVEAQIIEALEVDYIDESEVLTPADWTHHIEKDKFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHIRRITEEIKACQQLKSEDDIAKVAEEMRVPVSLLKDVLEKGKLPVVNFAAGGVATPADAALLMQLGCDGVFVGSGIFKSSNPVRLATAVVEATTHFDNPSKLLEVSSDLGELMGGVSIESISHASNGVRLSEIGW", "length": 297, "header": "sp|Q03148-1|SNZ1_YEAST Isoform 1 of Pyridoxal 5'-phosphate synthase subunit SNZ1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SNZ1 PE=1 SV=1 CANONICAL=Q03148-1" }, "isoforms": [ { "isoform_ac": "Q03148-1", "url": "", "sequence": { "sequence": "MTGEDFKIKSGLAQMLKGGVIMDVVTPEQAKIAEKSGACAVMALESIPADMRKSGKVCRMSDPKMIKDIMNSVSIPVMAKVRIGHFVEAQIIEALEVDYIDESEVLTPADWTHHIEKDKFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHIRRITEEIKACQQLKSEDDIAKVAEEMRVPVSLLKDVLEKGKLPVVNFAAGGVATPADAALLMQLGCDGVFVGSGIFKSSNPVRLATAVVEATTHFDNPSKLLEVSSDLGELMGGVSIESISHASNGVRLSEIGW", "length": 297, "header": "sp|Q03148-1|SNZ1_YEAST Isoform 1 of Pyridoxal 5'-phosphate synthase subunit SNZ1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SNZ1 PE=1 SV=1 CANONICAL=Q03148-1" }, "locus": { "chromosome": "XIII", "start_pos": 459298, "end_pos": 458408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YMR096W_mRNA", "url": "https://www.ensembl.org/id/YMR096W_mRNA" }, { "database": "Ensembl Peptide", "id": "YMR096W", "url": "https://www.ensembl.org/id/YMR096W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6.", "journal": "Yeast", "date": "2002", "authors": "Herrero E., Sunnerhagen P., Llorente B., Rodriguez-Navarro S., Rodriguez-Manzaneque M.T., Marchesan D., Dujon B., Perez-Ortin J.E., Ramne A., Uber G.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "12271461", "url": "https://glygen.org/publication/PubMed/12271461" } ] }, { "title": "Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Stolz J., Vielreicher M.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "12649274", "url": "https://glygen.org/publication/PubMed/12649274" } ] }, { "title": "Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae.", "journal": "Eur. J. Biochem.", "date": "2004", "authors": "Kondo H., Nikawa J., Dong Y.X., Sueda S.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "14764090", "url": "https://glygen.org/publication/PubMed/14764090" } ] }, { "title": "X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases.", "journal": "FEBS Lett.", "date": "2009", "authors": "Sinning I., Macheroux P., Tews I., Wallner S., Rippe K., Deller S., Neuwirth M., Strohmeier M., Windeisen V.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "19523954", "url": "https://glygen.org/publication/PubMed/19523954" } ] }, { "title": "Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1.", "journal": "Biochem. J.", "date": "2010", "authors": "Zhang Xuan, Teng Yan-Bin, Liu Jian-Ping, He Yong-Xing, Zhou Kang, Chen Yuxing, Zhou Cong-Zhao", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "20919991", "url": "https://glygen.org/publication/PubMed/20919991" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family.", "journal": "J. Bacteriol.", "date": "1996", "authors": "Werner-Washburne M., Braun E.L., Fuge E.K., Padilla P.A.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "8955308", "url": "https://glygen.org/publication/PubMed/8955308" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.", "journal": "Nature", "date": "1997", "authors": "Connor R., Gentles S., Pearson D., Bowman S., Hunt S., Barrell B.G., Skelton J., Brown D., Rice P., Odell C., Whitehead S., Badcock K., Chillingworth T., Churcher C.M., Dedman K., Devlin K., Hamlin N., Jagels K., Lye G., Moule S., Rajandream M.A., Walsh S.V.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "9169872", "url": "https://glygen.org/publication/PubMed/9169872" } ] }, { "title": "The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation.", "journal": "J. Bacteriol.", "date": "1998", "authors": "Werner-Washburne M., Crawford M.E., Errett A., Fuge E.K., Padilla P.A.", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "reference": [ { "type": "PubMed", "id": "9791124", "url": "https://glygen.org/publication/PubMed/9791124" } ] } ], "pathway": [ { "id": "sce:YMR096W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YMR096W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" }, { "name": "pyridoxine biosynthetic process", "id": "GO:0008615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008615", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" }, { "name": "glutamine catabolic process", "id": "GO:0006543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006543", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" }, { "name": "pyridoxal phosphate biosynthetic process", "id": "GO:0042823", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042823", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" }, { "name": "vitamin B6 biosynthetic process", "id": "GO:0042819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042819", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "amine-lyase activity", "id": "GO:0016843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016843", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" }, { "name": "pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "id": "GO:0036381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036381", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "glutaminase complex", "id": "GO:1903600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903600", "evidence": [ { "database": "UniProtKB", "id": "Q03148", "url": "https://www.uniprot.org/uniprot/Q03148" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "31507", "name": "", "equation": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q03144-1", "Q03148-1", "P43544-1", "P43545-1", "P53823-1", "P53824-1", "Q54J47-1", "Q54J48-1" ], "evidence": [ { "id": "31507", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31507" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P43544", "gene_name": "SNO3", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P43544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43544" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "P43544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43544" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "P43544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43544" } ] } ] }, { "uniprot_ac": "P43545", "gene_name": "SNZ3", "activity": [ { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "P43545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43545" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "P43545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43545" } ] } ] }, { "uniprot_ac": "P53823", "gene_name": "SNO2", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P53823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53823" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "P53823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53823" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "P53823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53823" } ] } ] }, { "uniprot_ac": "P53824", "gene_name": "SNZ2", "activity": [ { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "P53824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53824" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "P53824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53824" } ] } ] }, { "uniprot_ac": "Q03144", "gene_name": "SNO1", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q03144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03144" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q03144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03144" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "Q03144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03144" } ] } ] }, { "uniprot_ac": "Q03148", "gene_name": "SNZ1", "activity": [ { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q03148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03148" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ 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