{
    "uniprot_canonical_ac": "Q02739-1",
    "uniprot_ac": "Q02739",
    "uniprot_id": "CXB5_MOUSE",
    "mass": {
        "chemical_mass": 31195.0,
        "monoisotopic_mass": 31195.0
    },
    "refseq": {
        "ac": "NP_034421",
        "name": "gap junction beta-5 protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421"
    },
    "gene_names": [
        {
            "name": "Gjb5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q02739",
            "id": "Q02739"
        },
        {
            "name": "Cnx31.1; Cx31.1; Cxna; Gjb-5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421",
            "id": "NP_034421"
        },
        {
            "name": "Cxn-31.1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q02739",
            "id": "Q02739"
        },
        {
            "name": "Gjb5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421",
            "id": "NP_034421"
        }
    ],
    "protein_names": [
        {
            "name": "Gap junction beta-5 protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q02739"
        },
        {
            "name": "Connexin-31.1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q02739"
        },
        {
            "name": "Cx31.1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q02739"
        },
        {
            "name": "connexin-31.1; gap junction membrane channel protein beta 5; connexin a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421",
            "id": "NP_034421"
        },
        {
            "name": "gap junction beta-5 protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421",
            "id": "NP_034421"
        }
    ],
    "function": [
        {
            "annotation": "Findings show delayed differentiation of connexin31.1 (Gjb5)-deficient trophoblast stem cell.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034421",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421"
                },
                {
                    "database": "PubMed",
                    "id": "24866916",
                    "url": "https://glygen.org/publication/PubMed/24866916"
                }
            ]
        },
        {
            "annotation": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q02739",
                    "url": "https://www.uniprot.org/uniprot/Q02739#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q02739",
                    "url": "https://www.uniprot.org/uniprot/Q02739"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Gjb5",
            "url": "https://www.uniprot.org/uniprot/Q02739",
            "locus": {
                "chromosome": "4",
                "start_pos": 127248602,
                "end_pos": 127251974,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000042357",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000042357"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000042357",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000042357",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "14622",
            "url": "https://www.ncbi.nlm.nih.gov/gene/14622",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000500",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002271",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002271",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013092",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019570",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038359",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:14622",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14622",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "95723",
            "url": "http://www.informatics.jax.org/marker/MGI:95723",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "HSFYPKY",
            "url": "https://omabrowser.org/oma/group/HSFYPKY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5301774at2759",
            "url": "http://www.orthodb.org/?query=5301774at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11984",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11984:SF29",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF29",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00029",
            "url": "http://pfam.xfam.org/family/PF00029",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q02739",
            "url": "http://purl.obolibrary.org/obo/PR_Q02739",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-190861",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-190861",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_034421",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q02739",
            "url": "https://www.uniprot.org/uniprot/Q02739",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q02739-1",
            "url": "https://www.uniprot.org/uniprot/Q02739-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQEKIGEGYLYPNPGKKRGGLWWTYVFSLSFKATIDIIFLYLFHAFYPRYTLPSMVKCHAEPCPNTVDCFIAKPSEKNIFIVFMVVTAVICILLNLVELIYLVIKRCSECAQLRRPPTAHAKNDPNWANSPSKEKDFLSCDLIFLGSDAHPPLLPDRPRAHVKKTIL",
        "length": 271,
        "header": "sp|Q02739-1|CXB5_MOUSE Isoform 1 of Gap junction beta-5 protein  OS=Mus musculus OX=10090 GN=Gjb5 PE=2 SV=1 CANONICAL=Q02739-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q02739-1",
            "url": "",
            "sequence": {
                "sequence": "MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQEKIGEGYLYPNPGKKRGGLWWTYVFSLSFKATIDIIFLYLFHAFYPRYTLPSMVKCHAEPCPNTVDCFIAKPSEKNIFIVFMVVTAVICILLNLVELIYLVIKRCSECAQLRRPPTAHAKNDPNWANSPSKEKDFLSCDLIFLGSDAHPPLLPDRPRAHVKKTIL",
                "length": 271,
                "header": "sp|Q02739-1|CXB5_MOUSE Isoform 1 of Gap junction beta-5 protein  OS=Mus musculus OX=10090 GN=Gjb5 PE=2 SV=1 CANONICAL=Q02739-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 127250142,
                "end_pos": 127249330,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000046498",
                        "url": "https://www.ensembl.org/id/ENSMUST00000046498"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000045325",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000045325"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin.",
            "journal": "J. Biol. Chem.",
            "date": "1992",
            "authors": "Hennemann H, Dahl E, White JB, Schwarz HJ, Lalley PA, Chang S, Nicholson BJ, Willecke K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q02739",
                    "url": "https://www.uniprot.org/uniprot/Q02739"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1512260",
                    "url": "https://glygen.org/publication/PubMed/1512260"
                }
            ]
        },
        {
            "title": "Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development.",
            "journal": "Stem cells and development",
            "date": "2014",
            "authors": "Kibschull M, Colaco K, Matysiak-Zablocki E, Winterhager E, Lye SJ",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034421",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034421"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24866916",
                    "url": "https://glygen.org/publication/PubMed/24866916"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:14622",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14622",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-190861",
            "name": "Gap junction assembly",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-190861",
            "resource": "Reactome",
            "description": "Gap junction assembly"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O95377-1",
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            "sequence": {
                "sequence": "MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL",
                "length": 273
            },
            "evidence": [
                {
                    "id": "45225741",
                    "url": "http://www.informatics.jax.org/homology/45225741",
                    "database": "MGI"
                },
                {
                    "id": "Q02739",
                    "url": "https://omabrowser.org/oma/group/Q02739/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P28232-1",
            "protein_name": "Gap junction beta-5 protein",
            "gene_name": "Gjb5",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQQEVGKGYLYPNPGKKRGGLWWTYVCSLLFKATIDIIFLYLFHAFYPRYTLPSMVKCHSAPCPNTVDCFIAKPSEKNIFIVFMLVTAIVCILLNLVELLYLVIKRCSECAPAKRPPTAHAKNDPNWANPSSKEKDFLSSDLIFLGSDTHPPLLPDRPRAHVKKTIL",
                "length": 271
            },
            "evidence": [
                {
                    "id": "45225741",
                    "url": "http://www.informatics.jax.org/homology/45225741",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cell-cell signaling",
                        "id": "GO:0007267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267",
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                                "id": "Q02739",
                                "url": "https://www.uniprot.org/uniprot/Q02739"
                            }
                        ],
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                    },
                    {
                        "name": "spongiotrophoblast differentiation",
                        "id": "GO:0060708",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060708",
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                                "id": "Q02739",
                                "url": "https://www.uniprot.org/uniprot/Q02739"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "trophoblast giant cell differentiation",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060707",
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                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "labyrinthine layer morphogenesis",
                        "id": "GO:0060713",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060713",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q02739",
                                "url": "https://www.uniprot.org/uniprot/Q02739"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "epididymis development",
                        "id": "GO:1905867",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905867",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q02739",
                                "url": "https://www.uniprot.org/uniprot/Q02739"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
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                    {
                        "name": "connexin complex",
                        "id": "GO:0005922",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922",
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                            {
                                "database": "UniProtKB",
                                "id": "Q02739",
                                "url": "https://www.uniprot.org/uniprot/Q02739"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "gap junction channel activity",
                        "id": "GO:0005243",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q02739",
                                "url": "https://www.uniprot.org/uniprot/Q02739"
                            }
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                        "pmid": ""
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                ]
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        ]
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    "site_annotation": [
        {
            "start_pos": 2,
            "end_pos": 4,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
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