{ "uniprot_canonical_ac": "Q01755-1", "uniprot_ac": "Q01755", "uniprot_id": "TCP11_MOUSE", "mass": { "chemical_mass": 61970.0, "monoisotopic_mass": 61970.0 }, "refseq": { "ac": "NP_038715", "name": "T-complex protein 11 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038715" }, "gene_names": [ { "name": "Tcp11", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q01755", "id": "Q01755" }, { "name": "D17Ken1; Tcp-11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079024", "id": "NP_001079024" }, { "name": "Tcp-11", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q01755", "id": "Q01755" }, { "name": "Tcp11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079024", "id": "NP_001079024" } ], "protein_names": [ { "name": "T-complex protein 11", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q01755" }, { "name": "T-complex protein 11 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038715", "id": "NP_038715" }, { "name": "T-complex protein 11 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079024", "id": "NP_001079024" }, { "name": "Testis-specific protein PBS13", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q01755" }, { "name": "testis-specific protein PBS13", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038715", "id": "NP_038715" } ], "function": [ { "annotation": "Mouse t-complex protein 11 is important for progressive motility in spermdagger.", "evidence": [ { "database": "RefSeq", "id": "NP_038715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038715" }, { "database": "PubMed", "id": "31837139", "url": "https://glygen.org/publication/PubMed/31837139" }, { "database": "RefSeq", "id": "NP_001079024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079024" } ] }, { "annotation": "Plays a role in the process of sperm capacitation and acrosome reactions (PubMed:9322250, PubMed:9820206). Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway (PubMed:9322250, PubMed:9820206).", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755#function" }, { "database": "PubMed", "id": "9322250", "url": "https://glygen.org/publication/PubMed/9322250" }, { "database": "PubMed", "id": "9820206", "url": "https://glygen.org/publication/PubMed/9820206" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Tcp11", "url": "https://www.uniprot.org/uniprot/Q01755", "locus": { "chromosome": "17", "start_pos": 28285719, "end_pos": 28299613, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000062859", "url": "https://www.ensembl.org/id/ENSMUSG00000062859" } ] } } ], "crossref": [ { "id": "ENSMUSG00000062859", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000062859", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "21463", "url": "https://www.ncbi.nlm.nih.gov/gene/21463", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:21463", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21463", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "98544", "url": "http://www.informatics.jax.org/marker/MGI:98544", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "NQKVFGP", "url": "https://omabrowser.org/oma/group/NQKVFGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5353227at2759", "url": "http://www.orthodb.org/?query=5353227at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12832", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12832", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12832:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12832:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05794", "url": "http://pfam.xfam.org/family/PF05794", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q01755", "url": "http://purl.obolibrary.org/obo/PR_Q01755", "database": "PRO", "categories": [ "Protein" ] }, { "id": "A0A3B2W7H0", "url": "https://www.uniprot.org/uniprot/A0A3B2W7H0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2W7H0-1", "url": "https://www.uniprot.org/uniprot/A0A3B2W7H0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2W8A4", "url": "https://www.uniprot.org/uniprot/A0A3B2W8A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2W8A4-1", "url": "https://www.uniprot.org/uniprot/A0A3B2W8A4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WAQ3", "url": "https://www.uniprot.org/uniprot/A0A3B2WAQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WAQ3-1", "url": "https://www.uniprot.org/uniprot/A0A3B2WAQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WCV7", "url": "https://www.uniprot.org/uniprot/A0A3B2WCV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WCV7-1", "url": "https://www.uniprot.org/uniprot/A0A3B2WCV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WD36", "url": "https://www.uniprot.org/uniprot/A0A3B2WD36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WD36-1", "url": "https://www.uniprot.org/uniprot/A0A3B2WD36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WD68", "url": "https://www.uniprot.org/uniprot/A0A3B2WD68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B2WD68-1", "url": "https://www.uniprot.org/uniprot/A0A3B2WD68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B2KF24", "url": "https://www.uniprot.org/uniprot/B2KF24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B2KF24-1", "url": "https://www.uniprot.org/uniprot/B2KF24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q01755-1", "url": "https://www.uniprot.org/uniprot/Q01755-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5FWA2", "url": "https://www.uniprot.org/uniprot/Q5FWA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5FWA2-1", "url": "https://www.uniprot.org/uniprot/Q5FWA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPDVKERAARKEPGAAESASRESRGGNTRESASSARGTDRVGSTVARARPPSPQGPRRGAVKTAPRGPVGHGGLRTGPTSRCPQPSARAKLPSVTRGAPLPPSPGKGHLGGTPSSHRLGMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL", "length": 566, "header": "sp|Q01755-1|TCP11_MOUSE Isoform 1 of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "isoforms": [ { "isoform_ac": "A0A3B2W7H0-1", "url": "", "sequence": { "sequence": "MAVASIGMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL", "length": 454, "header": "tr|A0A3B2W7H0-1|A0A3B2W7H0_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28298583, "end_pos": 28285913, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000233898.2", "url": "https://www.ensembl.org/id/ENSMUST00000233898.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156512.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156512.2" } ] } }, { "isoform_ac": "A0A3B2W8A4-1", "url": "", "sequence": { "sequence": "RLGICLRQGPPSAGTAGPDLPPPRFKCSRTSVAMDFL", "length": 37, "header": "tr|A0A3B2W8A4-1|TCP11_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28298902, "end_pos": 28298792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000233615.2", "url": "https://www.ensembl.org/id/ENSMUST00000233615.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156943.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156943.2" } ] } }, { "isoform_ac": "A0A3B2WAQ3-1", "url": "", "sequence": { "sequence": "XGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLQLGRPISQ", "length": 57, "header": "tr|A0A3B2WAQ3-1|A0A3B2WAQ3_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28289533, "end_pos": 28288530, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000233665.2", "url": "https://www.ensembl.org/id/ENSMUST00000233665.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156460.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156460.2" } ] } }, { "isoform_ac": "A0A3B2WCV7-1", "url": "", "sequence": { "sequence": "MAVASIGMTERVHDASKLDCQLEERSLSSSRSCCPCCCHGRAA", "length": 43, "header": "tr|A0A3B2WCV7-1|A0A3B2WCV7_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=4 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28298583, "end_pos": 28290769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000232728.2", "url": "https://www.ensembl.org/id/ENSMUST00000232728.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156714.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156714.2" } ] } }, { "isoform_ac": "A0A3B2WD36-1", "url": "", "sequence": { "sequence": "XAKLPSVTRGAPLPPSPGKGHLGGTPSSHRYDGESP", "length": 36, "header": "tr|A0A3B2WD36-1|A0A3B2WD36_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28298988, "end_pos": 28297013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000233009.2", "url": "https://www.ensembl.org/id/ENSMUST00000233009.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156820.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156820.2" } ] } }, { "isoform_ac": "A0A3B2WD68-1", "url": "", "sequence": { "sequence": "MTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL", "length": 447, "header": "tr|A0A3B2WD68-1|TCP11_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28297030, "end_pos": 28285913, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000232798.2", "url": "https://www.ensembl.org/id/ENSMUST00000232798.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156874.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156874.2" } ] } }, { "isoform_ac": "B2KF24-1", "url": "", "sequence": { "sequence": "MPDVKERAARKEPGAAESASRESRGGNTRESASSAQGHRSCRFNRRPSTAALTPGSAQGRGVKTAPRGPVGHGGLRTGPTSRCPQPSARAKLPSVTRGAPLPPSPGKGHLGGTPSSHRLGMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL", "length": 567, "header": "tr|B2KF24-1|B2KF24_MOUSE Computationally mapped isoform of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=2 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28299253, "end_pos": 28285913, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000042692.13", "url": "https://www.ensembl.org/id/ENSMUST00000042692.13" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000038590.6", "url": "https://www.ensembl.org/id/ENSMUSP00000038590.6" } ] } }, { "isoform_ac": "Q01755-1", "url": "", "sequence": { "sequence": "MPDVKERAARKEPGAAESASRESRGGNTRESASSARGTDRVGSTVARARPPSPQGPRRGAVKTAPRGPVGHGGLRTGPTSRCPQPSARAKLPSVTRGAPLPPSPGKGHLGGTPSSHRLGMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL", "length": 566, "header": "sp|Q01755-1|TCP11_MOUSE Isoform 1 of T-complex protein 11 OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": {} }, { "isoform_ac": "Q5FWA2-1", "url": "", "sequence": { "sequence": "MPDVKERAARKEPGAAESASRESRGGNTRESASSAQGHRSCMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL", "length": 488, "header": "tr|Q5FWA2-1|Q5FWA2_MOUSE Computationally mapped isoform of Tcp11 protein OS=Mus musculus OX=10090 GN=Tcp11 PE=1 SV=1 CANONICAL=Q01755-1" }, "locus": { "chromosome": "17", "start_pos": 28299253, "end_pos": 28285913, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114836.9", "url": "https://www.ensembl.org/id/ENSMUST00000114836.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110485.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110485.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 103, "end_pos": 103, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "site_lbl": "Ser103" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse T-complex.", "journal": "Development", "date": "1991", "authors": "Freemont P., Lyon M.F., Dudley K., Ruddy S., Evans E.P., Mazarakis N.D., Nelki D.", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "reference": [ { "type": "PubMed", "id": "1893875", "url": "https://glygen.org/publication/PubMed/1893875" } ] }, { "title": "A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.", "journal": "FASEB J.", "date": "2016", "authors": "Stanger SJ, Law EA, Jamsai D, O'Bryan MK, Nixon B, McLaughlin EA, Aitken RJ, Roman SD", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "reference": [ { "type": "PubMed", "id": "27105888", "url": "https://glygen.org/publication/PubMed/27105888" } ] }, { "title": "Mouse t-complex protein 11 is important for progressive motility in spermdagger.", "journal": "Biology of reproduction", "date": "2020", "authors": "Castaneda JM, Miyata H, Archambeault DR, Satouh Y, Yu Z, Ikawa M, Matzuk MM", "evidence": [ { "database": "RefSeq", "id": "NP_038715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038715" }, { "database": "RefSeq", "id": "NP_001079024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079024" } ], "reference": [ { "type": "PubMed", "id": "31837139", "url": "https://glygen.org/publication/PubMed/31837139" } ] }, { "title": "TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction.", "journal": "Mol. Reprod. Dev.", "date": "1997", "authors": "Dudley R.K., Fraser L.R., Hanyalogou A., Hosseini R., Talmor A.", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "reference": [ { "type": "PubMed", "id": "9322250", "url": "https://glygen.org/publication/PubMed/9322250" } ] }, { "title": "FPP modulates mammalian sperm function via TCP-11 and the adenylyl cyclase/cAMP pathway.", "journal": "Mol. Reprod. Dev.", "date": "1998", "authors": "Adeoya-Osiguwa SA, Dudley RK, Hosseini R, Fraser LR", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "reference": [ { "type": "PubMed", "id": "9820206", "url": "https://glygen.org/publication/PubMed/9820206" } ] } ], "pathway": [ { "id": "mmu:21463", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21463", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5XI00-1", "protein_name": "T-complex protein 11 homolog", "gene_name": "Tcp11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPDLKERAARKEPGAAESASRESRGGNTRESASSAQGHRSRRFNRRSSTAALTPGSAQGRGVQTAPRAPVGHGGLRTGLTSRCPQPSARAKLPSVTRGAPLPPSPGKGHFGATPISHRLGLTERVHDASKLDCHLEDRKSASSLESRGKEVMPSDFWDHLKEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLRNEIEEALDMEFLHQQADRGDLNVSYLSKYILNMMVLLCAPVRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSIQFERAQFQERLNKDPSLLNHTTKWLTQAATQLIAPSGSCYDIQDPSSSSGPSPSDIAIPEPLSPAMVLSQGFLNLLTWDPENEEFPETLLADRSRLQELESQQNQLTILASVLLVASSFSGSVLFGSPQFVDRLKRITKSLVEDFNSRPEEVMQTVSDQVTEEIHQSLKNMGLSPLSSENTDSLIGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLSLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLINPVQTLTTKVGSL", "length": 566 }, "evidence": [ { "id": "45243959", "url": "http://www.informatics.jax.org/homology/45243959", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WWU5-1", "protein_name": "T-complex protein 11 homolog", "gene_name": "TCP11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLSVTGLTETVNEVSKLSNKIGMNCDYYMEEKVLPPSSLEGKVKETVHNAFWDHLKEQLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAEHGALKVLYLSKYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQYERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLCQGFLNLLLWDLENEEFPETLLMDRTRLQELKSQLHQLTVMASVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEEAILTVSEQVSQEIHQSLKNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV", "length": 503 }, "evidence": [ { "id": "45243959", "url": "http://www.informatics.jax.org/homology/45243959", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein kinase A signaling", "id": "GO:0010737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010737", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "negative regulation of exocytosis", "id": "GO:0045920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045920", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "regulation of sperm capacitation", "id": "GO:1902490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902490", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "germ cell development", "id": "GO:0007281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007281", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa (PubMed:27105888). Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway (PubMed:27105888).", "evidence": [ { "database": "UniProtKB", "id": "Q01755", "url": "https://www.uniprot.org/uniprot/Q01755" }, { "database": "PubMed", "id": "27105888", "url": "https://glygen.org/publication/PubMed/27105888" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }