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"recommended", "url": "", "id": "P98192" }, { "name": "2.3.1.42", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P98192" }, { "name": "Acyl-CoA:dihydroxyacetonephosphateacyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P98192" }, { "name": "DAP-AT; DHAP-AT; glycerone-phosphate O-acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034452", "id": "NP_034452" }, { "name": "DAP-AT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P98192" }, { "name": "DHAP-AT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P98192" }, { "name": "Glycerone-phosphate O-acyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P98192" }, { "name": "dihydroxyacetone phosphate acyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034452", "id": "NP_034452" } ], 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}, { "id": "5478811at2759", "url": "http://www.orthodb.org/?query=5478811at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12563", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12563", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12563:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12563:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01553", "url": "http://pfam.xfam.org/family/PF01553", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19277", "url": "http://pfam.xfam.org/family/PF19277", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P98192", "url": "http://purl.obolibrary.org/obo/PR_P98192", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483166", "database": "Reactome", 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"Q05DV2", "url": "https://www.uniprot.org/uniprot/Q05DV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q05DV2-1", "url": "https://www.uniprot.org/uniprot/Q05DV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRHISDFKFAMKCYTPPLYRGITPCKPGDIKSIVLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNEEGIQKLQRAVQEHPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLNRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVTILLQNQLSMDFDALVEKTLWLKGVTQVFGGFLLWPDNKLPEEVVQSSILLHSNLASLVKDQVVLKMNSGSSQVVNGLVPEHIALLMCSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKAEAMQMAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHEEDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKNALAAFVRLGVVEKKKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL", "length": 678, "header": "sp|P98192-1|GNPAT_MOUSE Isoform 1 of Dihydroxyacetone phosphate acyltransferase OS=Mus musculus OX=10090 GN=Gnpat PE=1 SV=1 CANONICAL=P98192-1" }, "isoforms": [ { "isoform_ac": "P98192-1", "url": "", "sequence": { "sequence": "MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRHISDFKFAMKCYTPPLYRGITPCKPGDIKSIVLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNEEGIQKLQRAVQEHPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLNRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVTILLQNQLSMDFDALVEKTLWLKGVTQVFGGFLLWPDNKLPEEVVQSSILLHSNLASLVKDQVVLKMNSGSSQVVNGLVPEHIALLMCSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKAEAMQMAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHEEDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKNALAAFVRLGVVEKKKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL", "length": 678, "header": "sp|P98192-1|GNPAT_MOUSE Isoform 1 of Dihydroxyacetone phosphate acyltransferase OS=Mus musculus OX=10090 GN=Gnpat PE=1 SV=1 CANONICAL=P98192-1" }, "locus": { "chromosome": "8", "start_pos": 125616051, "end_pos": 125589977, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000034466", "url": "https://www.ensembl.org/id/ENSMUST00000034466" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000034466", "url": "https://www.ensembl.org/id/ENSMUSP00000034466" } ] } }, { "isoform_ac": "Q05DV2-1", "url": "", "sequence": { "sequence": "MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRHISDFKFAMKCYTPPLYRGITPCKPGDIKSIVLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKLQRAVQEHPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLNRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVTILLQNQLSMDFDALVEKTLWLKGVTQVFGGFLLWPDNKLPEEVVQSSILLHSNLASLVKDQVVLKMNSGSSQVVNGLVPEHIALLMCSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKAEAMQMAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHEEDYFGE", "length": 585, "header": "tr|Q05DV2-1|Q05DV2_MOUSE Computationally mapped isoform of Gnpat protein OS=Mus musculus OX=10090 GN=Gnpat PE=1 SV=1 CANONICAL=P98192-1" }, "locus": { "chromosome": "8", "start_pos": 125613466, "end_pos": 125589977, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000161986.2", "url": "https://www.ensembl.org/id/ENSMUST00000161986.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125323.2", "url": "https://www.ensembl.org/id/ENSMUSP00000125323.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P98192", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P98192" } ], "site_lbl": "Ser12" }, { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "site_lbl": "Ser17" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase.", "journal": "Biochim. Biophys. Acta", "date": "1999", "authors": "Ofman R, Hogenhout EM, Wanders RJ", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "reference": [ { "type": "PubMed", "id": "10395968", "url": "https://glygen.org/publication/PubMed/10395968" } ] }, { "title": "Synthesis of plasmalogens in eye lens epithelial cells.", "journal": "FEBS Lett.", "date": "1999", "authors": "Thai TP, Rodemer C, Worsch J, Hunziker A, Gorgas K, Just WW", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "reference": [ { "type": "PubMed", "id": "10456321", "url": "https://glygen.org/publication/PubMed/10456321" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" }, { "database": "iPTMnet", "id": "P98192", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P98192" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Gnpat does not play an essential role in systemic iron homeostasis in murine model.", "journal": "Journal of cellular and molecular medicine", "date": "2020", "authors": "An P, Wang J, Wang H, Jiang L, Wang J, Min J, Wang F", "evidence": [ { "database": "RefSeq", "id": "NP_034452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034452" } ], "reference": [ { "type": "PubMed", "id": "32108988", "url": "https://glygen.org/publication/PubMed/32108988" } ] }, { "title": "Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.", "journal": "Bioscience reports", "date": "2020", "authors": "Rishi G, Secondes ES, Asplett K, Wallace DF, Ostini L, Berger J, Subramaniam VN", "evidence": [ { "database": "RefSeq", "id": "NP_034452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034452" } ], "reference": [ { "type": "PubMed", "id": "32766721", "url": "https://glygen.org/publication/PubMed/32766721" } ] } ], "pathway": [ { "id": "mmu:14712", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14712", "resource": "KEGG Pathway" }, { "id": "R-MMU-1483166", "name": "Synthesis of PA", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483166", "resource": "Reactome", "description": "Synthesis of PA" }, { "id": "R-MMU-75896", "name": "Plasmalogen biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75896", "resource": "Reactome", "description": "Plasmalogen biosynthesis" }, { "id": "R-MMU-9033241", "name": "Peroxisomal protein import", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "O15228-1", "protein_name": "Dihydroxyacetone phosphate acyltransferase", "gene_name": "GNPAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESSSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSEDMHAFVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFLIWPDNKPAEEVVPASILLHSNIASLVKDQVILKVDSGDSEVVDGLMLQHITLLMCSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATTKLEEMLGCKTPIGKPATAKL", "length": 680 }, "evidence": [ { "id": "45226199", "url": "http://www.informatics.jax.org/homology/45226199", "database": "MGI" }, { "id": "P98192", "url": "https://omabrowser.org/oma/group/P98192/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ES71-1", "protein_name": "Dihydroxyacetone phosphate acyltransferase", "gene_name": "Gnpat", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRQVSDFKFAMKCYTPPLYRGITPCKPSDIKSIVLNSEEINYVIKQLSRESLTGVDVLREEANEILEEMSHKLRIGAIRFFAFVLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVILLPSHRSYIDFLMLSFVLYNYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRSGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYELLGIPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLSRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVAILLQNQLCMDFDALVEKTLWLKGLTQVFGGFLLWPDNKLPEEVVQSSILLHSNLATLVKDQVVLKVDSESSQMVNGLVPQHIAFLMCSAYRNQLLNVFARPSLVAVALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKTEVMQMTGKDIILTDKGNAVLQFLTGLFKPFVESYQILSKCLLHEEDYFSEKEYLVTARKFTRQLLDQDASQCYDALSSELQKNALAAFVRLGVVEKNKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL", "length": 678 }, "evidence": [ { "id": "45226199", "url": "http://www.informatics.jax.org/homology/45226199", "database": "MGI" }, { "id": "P98192", "url": "https://omabrowser.org/oma/group/P98192/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "glycerophospholipid metabolic process", "id": "GO:0006650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006650", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "ether lipid biosynthetic process", "id": "GO:0008611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008611", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "membrane organization", "id": "GO:0061024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061024", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "cerebellum morphogenesis", "id": "GO:0021587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021587", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "triglyceride biosynthetic process", "id": "GO:0019432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019432", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "paranodal junction assembly", "id": "GO:0030913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030913", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "response to fatty acid", "id": "GO:0070542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070542", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "glycerone-phosphate O-acyltransferase activity", "id": "GO:0016287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016287", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "glycerol-3-phosphate O-acyltransferase activity", "id": "GO:0004366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004366", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "peroxisomal matrix", "id": "GO:0005782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005782", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "P98192", "url": "https://www.uniprot.org/uniprot/P98192" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17657", "name": "", "equation": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES71-1", "O15228-1", "P98192-1", "P32784-1", "P36148-1" ], "evidence": [ { "id": "17657", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17657" } ] }, { "id": "40715", "name": "", "equation": "dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES71-1", "O15228-1", "P98192-1" ], "evidence": [ { "id": "40715", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40715" } ] }, { "id": "R-MMU-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, peroxisomal membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-75973" ], "enzyme_list": [ "P98192-1" ], "evidence": [ { "id": "R-MMU-1483002", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483002" } ] }, { "id": "R-MMU-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-390419", "R-ALL-390440" ], "output_participant_list": [ "R-ALL-390409", "R-ALL-390435" ], "enzyme_list": [ "P98192-1", "Q8C0I1-1" ], "evidence": [ { "id": "R-MMU-390427", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-390427" } ] }, { "id": "R-MMU-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-390404", "R-ALL-390426" ], "output_participant_list": [], "enzyme_list": [ "P98192-1", "Q8C0I1-1" ], "evidence": [ { "id": "R-MMU-75879", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75879" } ] }, { "id": "R-MMU-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P38060-1", "Q99LB2-1", "Q9JHR7-1", "O35423-1", "Q9WV68-1", "P55098-1", "P98192-1", "P58137-1", "Q8BWN8-1", "Q9QYR9-1", "Q9QXD1-1", "Q9R0H0-1", "O09174-1", "P24270-1", "Q9WU19-1", "Q9DC50-1", "Q99MZ7-1", "Q9D826-1", "O35459-1", "Q9WUR2-1", "P47934-1", "P29477-1", "P32020-1", "O35488-1", "Q91X34-1", "Q9NYQ2-1", "Q9DBN5-1", "Q922Z0-1", "Q99J39-1", "Q99P30-1", "O55137-1", "Q9EPL9-1", "P11930-1", "P18894-1", "Q9DCM2-1", "Q6Q2Z6-1", "O88844-1", "B1AUE5-1", "Q8C0L6-1", "Q9QXE0-1", "Q9QYR7-1", "Q9DBA6-1" ], "evidence": [ { "id": "R-MMU-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9033235" } ] }, { "id": "R-MMU-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P38060-1", "Q99LB2-1", "Q9JHR7-1", "O35423-1", "Q9WV68-1", "P55098-1", "P98192-1", "P58137-1", "Q8BWN8-1", "Q9QYR9-1", "Q9QXD1-1", "Q9R0H0-1", "O09174-1", "P24270-1", "Q9WU19-1", "Q9DC50-1", "Q99MZ7-1", "Q9D826-1", "O35459-1", "Q9WUR2-1", "P47934-1", "P29477-1", "P32020-1", "O35488-1", "Q91X34-1", "Q9NYQ2-1", "Q9DBN5-1", "Q922Z0-1", "Q99J39-1", "Q99P30-1", "O55137-1", "Q9EPL9-1", "P11930-1", "P18894-1", "Q9DCM2-1", "Q6Q2Z6-1", "O88844-1", "B1AUE5-1", "Q8C0L6-1", "Q9QXE0-1", "Q9QYR7-1", "Q9DBA6-1" ], "evidence": [ { "id": "R-MMU-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9033236" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-390404", "participant_name": "DHAP [peroxisomal matrix]", "crossref": [ { "id": "000024492326", "database": "ZINC", "url": "" }, { "id": "C00111", "database": "COMPOUND", "url": "" }, { "id": "57642", "database": "ChEBI", "url": "" }, { "id": "57642", "database": "ChEBI", "url": "" }, { "id": "C00111", "database": "COMPOUND", "url": "" }, { "id": "000024492326", "database": "ZINC", "url": "" }, { "id": "C00111", "database": "COMPOUND", "url": "" }, { "id": "57642", "database": "ChEBI", "url": "" }, { "id": "000024492326", "database": "ZINC", "url": "" }, { "id": "000024492326", "database": "ZINC", "url": "" }, { "id": "C00111", "database": "COMPOUND", "url": "" }, { "id": "57642", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-390409", "participant_name": "GO3P [peroxisomal matrix]", "crossref": [ { "id": "C03372", "database": "COMPOUND", "url": "" }, { "id": "73315", "database": "ChEBI", "url": "" }, { "id": "C03372", "database": "COMPOUND", "url": "" }, { "id": "73315", "database": "ChEBI", "url": "" }, { "id": "73315", "database": "ChEBI", "url": "" }, { "id": "C03372", "database": "COMPOUND", "url": "" }, { "id": "C03372", "database": "COMPOUND", "url": "" }, { "id": "73315", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-390419", "participant_name": "1-Palmitoyl dihydroxyacetone phosphate [peroxisomal matrix]", "crossref": [ { "id": "58303", "database": "ChEBI", "url": "" }, { "id": "000008216956", "database": "ZINC", "url": "" }, { "id": "58303", "database": "ChEBI", "url": "" }, { "id": "000008216956", "database": "ZINC", "url": "" }, { "id": "000008216956", "database": "ZINC", "url": "" }, { "id": "58303", "database": "ChEBI", "url": "" }, { "id": "58303", "database": "ChEBI", "url": "" }, { "id": "000008216956", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-390426", "participant_name": "PalmCoA [peroxisomal matrix]", "crossref": [ { "id": "57379", "database": "ChEBI", "url": "" }, { "id": "C00154", "database": "COMPOUND", "url": "" }, { "id": "57379", "database": "ChEBI", "url": "" }, { "id": "C00154", "database": "COMPOUND", "url": "" }, { "id": "C00154", "database": "COMPOUND", "url": "" }, { "id": "57379", "database": "ChEBI", "url": "" }, { "id": "C00154", "database": "COMPOUND", "url": "" }, { "id": "57379", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-390435", "participant_name": "PALM [peroxisomal matrix]", "crossref": [ { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", 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] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] } ] }, { "uniprot_ac": 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"activity": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "P98192", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98192" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "P98192", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98192" } ] } ] }, { "uniprot_ac": "Q6Q2Z6", "gene_name": "Acot5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] } ] }, { "uniprot_ac": "Q8BWN8", "gene_name": "Acot4", "activity": [ { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8BWN8", "database": "UniProtKB", 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