{ "uniprot_canonical_ac": "P98149-1", "uniprot_ac": "P98149", "uniprot_id": "DIF_DROME", "mass": { "chemical_mass": 73935.0, "monoisotopic_mass": 73935.0 }, "refseq": { "ac": "NP_001162998", "name": "Dorsal-related immunity factor, isoform C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162998" }, "gene_names": [ { "name": "Dif", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "6794; CG6794; dif; DIF; Dif2; Dmel\\CG6794; NF-kappaB; NF-KB; NFkappaB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162999", "id": "NP_001162999" }, { "name": "6794", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "CG6794", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "DIF", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "Dif2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "Dif", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162999", "id": "NP_001162999" }, { "name": "Dmel\\CG6794", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "Dmel_CG6794", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "NF-KB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "NF-kappaB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "NFkappaB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" }, { "name": "dif", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P98149", "id": "P98149" } ], "protein_names": [ { "name": "Dorsal-related immunity factor Dif", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P98149" }, { "name": "CG6794-PC; Dif-PC; Dorsal-related transcription factor; dorsal related immunity factor; Dorsal-like immunity factor; dorsal-related immunity factor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162998", "id": "NP_001162998" }, { "name": "CG6794-PD; Dif-PD; Dorsal-related transcription factor; dorsal related immunity factor; Dorsal-like immunity factor; dorsal-related immunity factor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162999", "id": "NP_001162999" }, { "name": "Dorsal-related immunity factor, isoform C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162998", "id": "NP_001162998" }, { "name": "Dorsal-related immunity factor, isoform D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162999", "id": "NP_001162999" } ], "function": [ { "annotation": "Mediates an immune response in larvae (PubMed:8242747). DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1 (PubMed:8242747). Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that down-regulates Spn27A in response to infection (PubMed:12456640). Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549).", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149#function" }, { "database": "PubMed", "id": "25477468", "url": "https://glygen.org/publication/PubMed/25477468" }, { "database": "PubMed", "id": "8242747", "url": "https://glygen.org/publication/PubMed/8242747" }, { "database": "PubMed", "id": "18000549", "url": "https://glygen.org/publication/PubMed/18000549" }, { "database": "PubMed", "id": "12456640", "url": "https://glygen.org/publication/PubMed/12456640" } ] } ], "disease": [ { "disease_id": "DOID:0050848", "recommended_name": { "id": "DOID:0050848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050848", "name": "obstructive sleep apnea", "description": "A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep." }, "synonyms": [ { "id": "DOID:0050848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050848", "name": "obstructive sleep apnea syndrome", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "obstructive sleep apnea syndrome", "description": "Cessation of air flow during sleep due to upper airway obstruction." }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "obstructive sleep apnea", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "obstructive sleep apnea syndrome", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "Apneas, obstructive sleep", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "OSAHS", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "Osa", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "apnea, obstructive sleep", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "obstructive sleep Apneas", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "sleep Apneas, obstructive", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "sleep apnea hypopnea syndrome", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "sleep apnea syndrome, obstructive", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "sleep apnea/hypopnea syndrome", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "syndrome, obstructive sleep apnea", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "syndrome, sleep apnea, obstructive", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "syndrome, upper airway resistance, sleep apnea", "description": "" }, { "id": "MONDO:0007147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007147", "name": "upper airway resistance sleep apnea syndrome", "description": "" } ], "evidence": [ { "id": "0050848", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050848" } ] }, { "disease_id": "DOID:0050866", "recommended_name": { "id": "DOID:0050866", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050866", "name": "oral squamous cell carcinoma", "description": "An oral cavity cancer that has_material_basis_in squamous cells." }, "synonyms": [ { "id": "DOID:0050866", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050866", "name": "mouth squamous cell carcinoma", "description": "" } ], "evidence": [ { "id": "0050866", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050866" } ] }, { "disease_id": "DOID:0060058", "recommended_name": { "id": "DOID:0060058", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060058", "name": "lymphoma", "description": "A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs." }, "synonyms": [ { "id": "DOID:0060058", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060058", "name": "lymphoid cancer", "description": "" } ], "evidence": [ { "id": "0060058", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060058" } ] }, { "disease_id": "DOID:0060074", "recommended_name": { "id": "DOID:0060074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells." }, "synonyms": [], "evidence": [ { "id": "0060074", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ] }, { "disease_id": "DOID:0060180", "recommended_name": { "id": "DOID:0060180", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060180", "name": "colitis", "description": "An inflammatory bowel disease that involves inflammation located_in colon." }, "synonyms": [], "evidence": [ { "id": "0060180", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060180" } ] }, { "disease_id": "DOID:0060322", "recommended_name": { "id": "DOID:0060322", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060322", "name": "mastoiditis", "description": "A middle ear disease characterized by an inflammation of the mucosal lining of the mastoid antrum and the mastoid air cell system inside the mastoid process." }, "synonyms": [], "evidence": [ { "id": "0060322", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060322" } ] }, { "disease_id": "DOID:0080855", "recommended_name": { "id": "DOID:0080855", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080855", "name": "Parkinsonism", "description": "A movement disorder that is characterized by disturbances of balance, gait and posture." }, "synonyms": [], "evidence": [ { "id": "0080855", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080855" } ] }, { "disease_id": "DOID:0080998", "recommended_name": { "id": "DOID:0080998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080998", "name": "acute necrotizing pancreatitis", "description": "An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems." }, "synonyms": [], "evidence": [ { "id": "0080998", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080998" } ] }, { "disease_id": "DOID:0111992", "recommended_name": { "id": "DOID:0111992", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111992", "name": "immunodeficiency 53", "description": "A combined T cell and B cell immunodeficiency characterized by recurrent upper and lower respiratory infections, increase in the CD4+ T cell to CD8+ T cell ratio, impaired T-cell proliferative responses to multiple antigens, and impaired ability to produce specific immunoglobulins that has_material_basis_in homozygous or compound heterozygous mutation in the RELB gene on chromosome 19q13.32." }, "synonyms": [ { "id": "DOID:0111992", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111992", "name": "IMD53", "description": "" }, { "id": "MONDO:0054696", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054696", "name": "immunodeficiency 53", "description": "" }, { "id": "MONDO:0054696", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054696", "name": "immunodeficiency 53", "description": "" }, { "id": "MONDO:0054696", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054696", "name": "IMD53", "description": "" }, { "id": "MIM:617585", "resource": "MIM", "url": "https://www.omim.org/entry/617585", "name": "Immunodeficiency 53", "description": "Immunodeficiency 53" } ], "evidence": [ { "id": "0111992", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111992" } ] }, { "disease_id": "DOID:104", "recommended_name": { "id": "DOID:104", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:104", "name": "bacterial infectious disease", "description": "A disease by infectious agent that results_in infection, has_material_basis_in Bacteria." }, "synonyms": [], "evidence": [ { "id": "104", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:104" } ] }, { "disease_id": "DOID:10754", "recommended_name": { "id": "DOID:10754", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10754", "name": "otitis media", "description": "A otitis which involves inflammation of the middle ear." }, "synonyms": [], "evidence": [ { "id": "10754", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10754" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:10964", "recommended_name": { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "cholesteatoma of middle ear", "description": "" }, "synonyms": [ { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "Cholesteatoma of middle ear and mastoid", "description": "" }, { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "Cholesteatoma of middle ear and/or mastoid", "description": "" }, { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "Cholesteatoma of the middle ear", "description": "" }, { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "Epidermosis of ear", "description": "" }, { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "Epidermosis of middle ear", "description": "" }, { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "cholesteatoma", "description": "" }, { "id": "DOID:10964", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10964", "name": "middle ear cholesteatoma", "description": "" } ], "evidence": [ { "id": "10964", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10964" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "evidence": [ { "id": "11054", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] }, { "disease_id": "DOID:11132", "recommended_name": { "id": "DOID:11132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11132", "name": "prostatic hypertrophy", "description": "" }, "synonyms": [ { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostatic hyperplasia", "description": "A non-cancerous nodular enlargement of the prostate gland. It is characterized by the presence of epithelial cell nodules, and stromal nodules containing fibrous and smooth muscle elements. It is the most common urologic disorder in men, causing blockage of urine flow." }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "prostate hypertrophy", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "prostatic hypertrophy", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign hyperplasia of prostate", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign hyperplasia of the prostate", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostate hyperplasia", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostatic Hypertrophy", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostatic hyperplasia", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostatic hyperplasia (disease)", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostatic hyperplasia - BPH", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "benign prostatic hypertrophy", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "BPH", "description": "" }, { "id": "MONDO:0010811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010811", "name": "prostatic hyperplasia, benign", "description": "" } ], "evidence": [ { "id": "11132", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11132" } ] }, { "disease_id": "DOID:11716", "recommended_name": { "id": "DOID:11716", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11716", "name": "prediabetes syndrome", "description": "A glucose metabolism disease that is characterized by blood glucose levels are high, but not high enough to be classified as type 2 diabetes." }, "synonyms": [ { "id": "DOID:11716", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11716", "name": "Prediabetes", "description": "" }, { "id": "DOID:11716", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11716", "name": "prediabetic state", "description": "" }, { "id": "DOID:11716", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11716", "name": "impaired glucose tolerance", "description": "" } ], "evidence": [ { "id": "11716", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11716" } ] }, { "disease_id": "DOID:13141", "recommended_name": { "id": "DOID:13141", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid." }, "synonyms": [], "evidence": [ { "id": "13141", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ] }, { "disease_id": "DOID:1591", "recommended_name": { "id": "DOID:1591", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1591", "name": "renovascular hypertension", "description": "" }, "synonyms": [], "evidence": [ { "id": "1591", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1591" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "evidence": [ { "id": "1612", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:1824", "recommended_name": { "id": "DOID:1824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1824", "name": "status epilepticus", "description": "" }, "synonyms": [ { "id": "DOID:1824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1824", "name": "Grand mal status", "description": "" } ], "evidence": [ { "id": "1824", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:2349", "recommended_name": { "id": "DOID:2349", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries." }, "synonyms": [ { "id": "DOID:2349", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2349", "name": "Arteriosclerotic vascular disease", "description": "" } ], "evidence": [ { "id": "2349", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ] }, { "disease_id": "DOID:2526", "recommended_name": { "id": "DOID:2526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2526", "name": "prostate adenocarcinoma", "description": "A prostate carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [], "evidence": [ { "id": "2526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2526" } ] }, { "disease_id": "DOID:2671", "recommended_name": { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells." }, "synonyms": [ { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional carcinoma", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell tumor", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "urothelial cell carcinoma", "description": "" } ], "evidence": [ { "id": "2671", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ] }, { "disease_id": "DOID:2876", "recommended_name": { "id": "DOID:2876", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2876", "name": "laryngeal squamous cell carcinoma", "description": "A laryngeal carcinoma that has_material_basis_in squamous cells." }, "synonyms": [ { "id": "DOID:2876", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2876", "name": "Epidermoid carcinoma of the Larynx", "description": "" }, { "id": "DOID:2876", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2876", "name": "squamous cell carcinoma of larynx", "description": "" } ], "evidence": [ { "id": "2876", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2876" } ] }, { "disease_id": "DOID:3310", "recommended_name": { "id": "DOID:3310", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3310", "name": "atopic dermatitis", "description": "An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking." }, "synonyms": [ { "id": "DOID:3310", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3310", "name": "Atopic neurodermatitis", "description": "" }, { "id": "DOID:3310", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3310", "name": "Besnier's prurigo", "description": "" }, { "id": "DOID:3310", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3310", "name": "allergic dermatitis", "description": "" }, { "id": "DOID:3310", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3310", "name": "atopic eczema", "description": "" }, { "id": "MONDO:0011292", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011292", "name": "dermatitis, atopic", "description": "" }, { "id": "MONDO:0011292", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011292", "name": "ATOD", "description": "" }, { "id": "MONDO:0011292", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011292", "name": "dermatitis, atopic", "description": "" }, { "id": "MONDO:0011292", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011292", "name": "eczema, atopic", "description": "" } ], "evidence": [ { "id": "3310", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3310" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "evidence": [ { "id": "3908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:4450", "recommended_name": { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney." }, "synonyms": [ { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "RCC", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "adenocarcinoma of kidney", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "hypernephroma", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, papillary, 1", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "RCCX1", "description": "" } ], "evidence": [ { "id": "4450", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ] }, { "disease_id": "DOID:5199", "recommended_name": { "id": "DOID:5199", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5199", "name": "ureteral obstruction", "description": "" }, "synonyms": [], "evidence": [ { "id": "5199", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5199" } ] }, { "disease_id": "DOID:557", "recommended_name": { "id": "DOID:557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:557", "name": "kidney disease", "description": "A urinary system disease that is located_in the kidney." }, "synonyms": [ { "id": "DOID:557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:557", "name": "impaired renal function disease", "description": "" }, { "id": "DOID:557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:557", "name": "nephropathy", "description": "" } ], "evidence": [ { "id": "557", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:557" } ] }, { "disease_id": "DOID:6432", "recommended_name": { "id": "DOID:6432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries." }, "synonyms": [], "evidence": [ { "id": "6432", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ] }, { "disease_id": "DOID:767", "recommended_name": { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "muscular atrophy", "description": "" }, "synonyms": [ { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "Amyotrophia", "description": "" }, { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "Muscle wasting", "description": "" }, { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "Wasting - muscle", "description": "" } ], "evidence": [ { "id": "767", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:767" } ] }, { "disease_id": "DOID:783", "recommended_name": { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease." }, "synonyms": [ { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal failure", "description": "" }, { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end-stage kidney disease", "description": "" } ], "evidence": [ { "id": "783", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:783" } ] }, { "disease_id": "DOID:8634", "recommended_name": { "id": "DOID:8634", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8634", "name": "prostate carcinoma in situ", "description": "An in situ carcinoma that is located_in the prostate." }, "synonyms": [ { 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"DOID:9452", "recommended_name": { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes." }, "synonyms": [ { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "SLD", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "fatty liver disease", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Fatty change of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Steatosis of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease 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"Protein" ] } ], "sequence": { "sequence": "MFEEAFGDIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYELRLCYQAFITVGNSKVPLDPIVSSPIYGKSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPELLTKHNRRVAQKTVESLKRSLMSTNLHPSKQVKTSSQYTIFSKPQIATTTPQTQVSPGMPLMFPGGSPNFVQDIKMENGFMDVDSQSSQCPSVERNFASPRSNCSTVDSIPPMQMGQNQTHLYLPDATNFTFNGNFASPSSNCSTVDSIPPFQIGQRNNHMYLPENSNFPVNGCSPTHFSGGSMTPINNNNNVLINNNNNDFLSQKMSAISIPPQGNFGIKQVYQQTQQFLPQLQPESIPYLAQSHPEQSQYQQQQQPQEQQPPADEPTQSFSDLISSSIGMAPIDTSELIQDIEAELNSLGIQPFK", "length": 667, "header": "sp|P98149-1|DIF_DROME Isoform 1 of Dorsal-related immunity factor Dif OS=Drosophila melanogaster OX=7227 GN=Dif PE=1 SV=2 CANONICAL=P98149-1" }, "isoforms": [ { "isoform_ac": "E1JHK1-1", "url": "", "sequence": { "sequence": "MFEEAFGDIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYELRLCYQAFITVGNSKVPLDPIVSSPIYGKSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPELLTKHNRRVAQKTVESLKRSLMSTNLHPSKQVKTSSQYTIFSKPQIATTTPQTQVSPGMPLMFPGGSPNFVQDIKMENGFMDVDSQSSQCPSVERNFASPRSNCSTVDSIPPMQMGQNQTHLYLPDATNFTFNGNFASPSSNCSTVDSIPPFQIGQRNNHMYLPENSNFPVNGCSPTHFSGGSMTPINNNNNVLINNNNNDFLSQKMSAISIPPQGNFGIKQVYQQTQQFLPQLQPESIPYLAQSHPEQSQYQQQQQPQEQQPPADEPTQSFSDLISSSIGMAPIDTSELIQDIEAELNSLGIQPFK", "length": 667, "header": "tr|E1JHK1-1|E1JHK1_DROME Computationally mapped isoform of Dorsal-related immunity factor, isoform D OS=Drosophila melanogaster OX=7227 GN=Dif PE=1 SV=1 CANONICAL=P98149-1" }, "locus": { "chromosome": "2L", "start_pos": 17420093, "end_pos": 17413518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0081008", "url": "https://www.ensembl.org/id/FBtr0081008" }, { "database": "Ensembl Peptide", "id": "FBpp0080561", "url": "https://www.ensembl.org/id/FBpp0080561" } ] } }, { "isoform_ac": "E1JHK2-1", "url": "", "sequence": { "sequence": "MFEEAFGDIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYELRLCYQAFITVGNSKVPLDPIVSSPIYGKSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKYSCPPMDLEEDNNTVSSDDQQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPMEEILQHPQLQSRPLSNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLTANTTITNQLDEEAHGLLANGSRRDTLENPAVKELPENEKEPEMVSASAQASMDLDENFDETATYTSLQIAFNNPIDIGLPKESKQAAPIYPPTNPFGQLDDDELVVLTNPPAPRIKVNAAQTPATPPASPPLPLPPRTPSPVSDQRLPPLPPKPQRNSQDLSAVSDSISVSRSRNGSLSSNRTTPSPIIIMRTPDQSPTKRQPTPSASPKKRQGFFSRFFSRRRSKTDDEESLTPGGSPNKQLPGGSKATTPTGSREPSVAHFSLGDPNRSSTRSMQPLGKSEGRNGKPVGRSSSSVSGKRPAHLDADVIHIPLKGGDSENSLLRPESYSNASTLSYGRPLDRKTLSTLQLADIPISDGNMELIAIADRQSIKNLCEGAYGVVLDPSVDLSEAEHFALYTSKSPEPPFGGECGEGGAATGGVDTTDFLSADEIARRLAEANGLE", "length": 987, "header": "tr|E1JHK2-1|E1JHK2_DROME Computationally mapped isoform of Dorsal-related immunity factor, isoform C OS=Drosophila melanogaster OX=7227 GN=Dif PE=4 SV=1 CANONICAL=P98149-1" }, "locus": { "chromosome": "2L", "start_pos": 17420093, "end_pos": 17415688, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0301577", "url": "https://www.ensembl.org/id/FBtr0301577" }, { "database": "Ensembl Peptide", "id": "FBpp0290792", "url": "https://www.ensembl.org/id/FBpp0290792" } ] } }, { "isoform_ac": "P98149-1", "url": "", "sequence": { "sequence": "MFEEAFGDIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYELRLCYQAFITVGNSKVPLDPIVSSPIYGKSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPELLTKHNRRVAQKTVESLKRSLMSTNLHPSKQVKTSSQYTIFSKPQIATTTPQTQVSPGMPLMFPGGSPNFVQDIKMENGFMDVDSQSSQCPSVERNFASPRSNCSTVDSIPPMQMGQNQTHLYLPDATNFTFNGNFASPSSNCSTVDSIPPFQIGQRNNHMYLPENSNFPVNGCSPTHFSGGSMTPINNNNNVLINNNNNDFLSQKMSAISIPPQGNFGIKQVYQQTQQFLPQLQPESIPYLAQSHPEQSQYQQQQQPQEQQPPADEPTQSFSDLISSSIGMAPIDTSELIQDIEAELNSLGIQPFK", "length": 667, "header": "sp|P98149-1|DIF_DROME Isoform 1 of Dorsal-related immunity factor Dif OS=Drosophila melanogaster OX=7227 GN=Dif PE=1 SV=2 CANONICAL=P98149-1" }, "locus": { "chromosome": "2L", "start_pos": 17420093, "end_pos": 17413518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0081008", "url": "https://www.ensembl.org/id/FBtr0081008" }, { "database": "Ensembl Peptide", "id": "FBpp0080561", "url": "https://www.ensembl.org/id/FBpp0080561" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 343, "end_pos": 343, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" } ], "site_lbl": "Ser343" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation.", "journal": "Genes & development", "date": "1999", "authors": "Drier EA, Huang LH, Steward R", "evidence": [ { "database": "Reactome", "id": "R-DME-209400", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209400" } ], "reference": [ { "type": "PubMed", "id": "10072384", "url": "https://glygen.org/publication/PubMed/10072384" } ] }, { "title": "Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor.", "journal": "Genes & development", "date": "1999", "authors": "Meng X, Khanuja BS, Ip YT", "evidence": [ { "database": "Reactome", "id": "R-DME-209400", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209400" } ], "reference": [ { "type": "PubMed", "id": "10197979", "url": "https://glygen.org/publication/PubMed/10197979" } ] }, { "title": "A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.", "journal": "The EMBO journal", "date": "1999", "authors": "Manfruelli P, Reichhart JM, Steward R, Hoffmann JA, Lemaitre B", "evidence": [ { "database": "Reactome", "id": "R-DME-209400", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209400" } ], "reference": [ { "type": "PubMed", "id": "10369678", "url": "https://glygen.org/publication/PubMed/10369678" } ] }, { "title": "Cactus-independent regulation of Dorsal nuclear import by the ventral signal.", "journal": "Current biology : CB", "date": "2000", "authors": "Drier EA, Govind S, Steward R", "evidence": [ { "database": "Reactome", "id": "R-DME-209400", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209400" } ], "reference": [ { "type": "PubMed", "id": "10660298", "url": "https://glygen.org/publication/PubMed/10660298" } ] }, { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" }, { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila.", "journal": "Immunity", "date": "2000", "authors": "Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D", "evidence": [ { "database": "Reactome", "id": "R-DME-209400", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209400" } ], "reference": [ { "type": "PubMed", "id": "10843389", "url": "https://glygen.org/publication/PubMed/10843389" } ] }, { "title": "Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation.", "journal": "Development (Cambridge, England)", "date": "2001", "authors": "Fernandez NQ, Grosshans J, Goltz JS, Stein D", "evidence": [ { "database": "Reactome", "id": "R-DME-214844", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-214844" } ], "reference": [ { "type": "PubMed", "id": "11532919", "url": "https://glygen.org/publication/PubMed/11532919" } ] }, { "title": "A serpin mutant links Toll activation to melanization in the host defence of Drosophila.", "journal": "EMBO J.", "date": "2002", "authors": "Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" } ], "reference": [ { "type": "PubMed", "id": "12456640", "url": "https://glygen.org/publication/PubMed/12456640" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" }, { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses.", "journal": "EMBO reports", "date": "2003", "authors": "Leulier F, Marchal C, Miletich I, Limbourg-Bouchon B, Benarous R, Lemaitre B", "evidence": [ { "database": "Reactome", "id": "R-DME-209406", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209406" } ], "reference": [ { "type": "PubMed", "id": "12973300", "url": "https://glygen.org/publication/PubMed/12973300" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in Drosophila.", "journal": "J. Cell Sci.", "date": "2006", "authors": "Xylourgidis N, Roth P, Sabri N, Tsarouhas V, Samakovlis C", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" } ], "reference": [ { "type": "PubMed", "id": "17032737", "url": "https://glygen.org/publication/PubMed/17032737" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "E1JHK2", "url": "https://www.uniprot.org/uniprot/E1JHK2" }, { "database": "UniProtKB", "id": "E1JHK1", "url": "https://www.uniprot.org/uniprot/E1JHK1" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.", "journal": "PLoS ONE", "date": "2007", "authors": "Ayyar S, Pistillo D, Calleja M, Brookfield A, Gittins K, Goldstone C, Simpson P", "evidence": [ { "database": "UniProtKB", "id": "P98149", "url": "https://www.uniprot.org/uniprot/P98149" } ], "reference": [ { "type": "PubMed", "id": "18000549", "url": "https://glygen.org/publication/PubMed/18000549" } ] }, { "title": "Spn1 regulates the GNBP3-dependent Toll signaling pathway in Drosophila melanogaster.", "journal": "Mol. 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