{ "uniprot_canonical_ac": "P97844-1", "uniprot_ac": "P97844", "uniprot_id": "RGS1_RAT", "mass": { "chemical_mass": 24096.0, "monoisotopic_mass": 24096.0 }, "refseq": { "ac": "NP_062209", "name": "regulator of G-protein signaling 1 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062209" }, "gene_names": [ { "name": "Rgs1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P97844", "id": "P97844" }, { "name": "Rgs1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062209", "id": "NP_062209" } ], "protein_names": [ { "name": "Regulator of G-protein signaling 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P97844" }, { "name": "RGS1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97844" }, { "name": "regulator of G-protein signaling 1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062209", "id": "NP_062209" } ], "function": [ { "annotation": "Functional suppression of RGS1 inhibits the inflammatory response and angiogenesis by inactivating the TLR signaling pathway in rats", "evidence": [ { "database": "RefSeq", "id": "NP_062209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062209" }, { "database": "PubMed", "id": "31012109", "url": "https://glygen.org/publication/PubMed/31012109" } ] }, { "annotation": "Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. 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"id": "ENSRNOG00000003895", "url": "https://www.ensembl.org/id/ENSRNOG00000003895" } ] } } ], "crossref": [ { "id": "ENSRNOG00000003895", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003895", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "54289", "url": "https://www.ncbi.nlm.nih.gov/gene/54289", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": 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"sequence": { "sequence": "MRAAAISMPRLNKMPGMFFSASPKDSKEPSHSLLDDNKQKKRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDILSAEEVMQWSQSLEKLLANQMGQNVFGKFLKSEFSEENIEFWLACEDYKKTETDLLHNKAEHIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTCFDEAQKVIYALMEKDSYPRFLKSNIYLNLLNDLQANTLK", "length": 209, "header": "sp|P97844-1|RGS1_RAT Isoform 1 of Regulator of G-protein signaling 1 OS=Rattus norvegicus OX=10116 GN=Rgs1 PE=2 SV=3 CANONICAL=P97844-1" }, "isoforms": [ { "isoform_ac": "P97844-1", "url": "", "sequence": { "sequence": "MRAAAISMPRLNKMPGMFFSASPKDSKEPSHSLLDDNKQKKRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDILSAEEVMQWSQSLEKLLANQMGQNVFGKFLKSEFSEENIEFWLACEDYKKTETDLLHNKAEHIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTCFDEAQKVIYALMEKDSYPRFLKSNIYLNLLNDLQANTLK", "length": 209, "header": "sp|P97844-1|RGS1_RAT Isoform 1 of Regulator of G-protein signaling 1 OS=Rattus norvegicus OX=10116 GN=Rgs1 PE=2 SV=3 CANONICAL=P97844-1" }, "locus": { "chromosome": "13", "start_pos": 56022867, "end_pos": 56019160, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000005251", "url": "https://www.ensembl.org/id/ENSRNOT00000005251" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000005251", "url": "https://www.ensembl.org/id/ENSRNOP00000005251" } ] } }, { "isoform_ac": "P97844-2", "url": "", "sequence": { "sequence": "MDMKAYLRSMIPHLESGMKSSKSKDILSAEEVMQWSQSLEKLLANQMGQNVFGKFLKSEFSEENIEFWLACEDYKKTETDLLHNKAEHIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTCFDEAQKVIYALMEKDSYPRFLKSNIYLNLLNDLQANTLK", "length": 162, "header": "sp|P97844-2|RGS1_RAT Isoform 2 of Regulator of G-protein signaling 1 OS=Rattus norvegicus OX=10116 GN=Rgs1 PE=2 SV=3 CANONICAL=P97844-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll-like receptor signaling pathway.", "journal": "Journal of cellular physiology", "date": "2019", "authors": "Hu X, Tang J, Zeng G, Hu X, Bao P, Wu J, Liang Y, Deng W, Tang Y", "evidence": [ { "database": "RefSeq", "id": "NP_062209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062209" } ], "reference": [ { "type": "PubMed", "id": "31012109", "url": "https://glygen.org/publication/PubMed/31012109" } ] } ], "pathway": [ { "id": "rno:54289", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:54289", "resource": "KEGG Pathway" }, { "id": "R-RNO-416476", "name": "G alpha (q) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-RNO-418594", "name": "G alpha (i) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "Q08116-1", "protein_name": "Regulator of G-protein signaling 1", "gene_name": "RGS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK", "length": 209 }, "evidence": [ { "id": "45234452", "url": "http://www.informatics.jax.org/homology/45234452", "database": "MGI" }, { "id": "P97844", "url": "https://omabrowser.org/oma/group/P97844/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JL25-1", "protein_name": "Regulator of G-protein signaling 1", "gene_name": "Rgs1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRAAAISMPRLNKMPGMFFSASPKDSKEHSHSLLDDKKQKKRPKTFGMDVKTYLRSMIPHLESGMKSAKSKDILSAEEVMQWSQSLEKLLANQTGQNVFGRFLKSEFSEENIEFWLACEDYKKTETDLLHNKAENIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTSFDEAQKVIYSLMEKDSYPRFLKSNIYLNLLNDLQANTLK", "length": 209 }, "evidence": [ { "id": "45234452", "url": 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