{ "uniprot_canonical_ac": "P97677-1", "uniprot_ac": "P97677", "uniprot_id": "DLL1_RAT", "mass": { "chemical_mass": 77379.0, "monoisotopic_mass": 77379.0 }, "refseq": { "ac": "NP_114452", "name": "delta-like protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452" }, "gene_names": [ { "name": "Dll1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P97677", "id": "P97677" }, { "name": "Dll1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452", "id": "NP_114452" } ], "protein_names": [ { "name": "Delta-like protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P97677" }, { "name": "Delta1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97677" }, { "name": "Drosophila Delta homolog 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97677" }, { "name": "delta-like protein 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452", "id": "NP_114452" }, { "name": "delta-like protein 1; delta1; drosophila Delta homolog 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452", "id": "NP_114452" } ], "function": [ { "annotation": "Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats.", "evidence": [ { "database": "RefSeq", "id": "NP_114452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452" }, { "database": "PubMed", "id": "32703409", "url": "https://glygen.org/publication/PubMed/32703409" } ] }, { "annotation": "Putative Notch ligand involved in the mediation of Notch signaling.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A9U8", "url": "https://www.uniprot.org/uniprot/A0A8I6A9U8#function" }, { "database": "UniProtKB", "id": "RU280815", "url": "https://www.uniprot.org/uniprot/RU280815#function" }, { "database": "UniProtKB", "id": "G3V7W6", "url": "https://www.uniprot.org/uniprot/G3V7W6#function" } ] }, { "annotation": "These results showed that Dll1 enhanced RBL-2H3 cell degranulation and cytokine production via a novel Notch/downstream of tyrosine kinases 1 (Dok-1)/MAPKs pathway, suggesting Notch signaling was a key mediator in the effect phase of food allergy", "evidence": [ { "database": "RefSeq", "id": "NP_114452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452" }, { "database": "PubMed", "id": "29181775", "url": "https://glygen.org/publication/PubMed/29181775" } ] }, { "annotation": "Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (By similarity). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:22658936). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (By similarity). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (By similarity). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation through regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677#function" }, { "database": "UniProtKB", "id": "Q61483", "url": "https://www.uniprot.org/uniprot/Q61483#function" }, { "database": "PubMed", "id": "22658936", "url": "https://glygen.org/publication/PubMed/22658936" }, { "database": "UniProtKB", "id": "O00548", "url": "https://www.uniprot.org/uniprot/O00548#function" } ] } ], "disease": [ { "disease_id": "DOID:12930", "recommended_name": { "id": "DOID:12930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently." }, "synonyms": [ { "id": "DOID:12930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12930", "name": "primary dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "Familial dilated cardiomyopathy with conduction defect due to LMNA mutation is a rare familial dilated cardiomyopathy characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy and elevated serum creatine kinase." }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "CDCD1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "LMNA familial isolated dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy dilated with conduction defect type 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial dilated cardiomyopathy with conduction defect due to LMNA mutation", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial isolated dilated cardiomyopathy caused by mutation in LMNA", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, congestive", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, familial idiopathic", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, idiopathic dilated", "description": "" }, { "id": "MIM:115200", "resource": "MIM", "url": "https://www.omim.org/entry/115200", "name": "Cardiomyopathy, dilated, 1A", "description": "Cardiomyopathy, dilated, 1A" } ], "evidence": [ { "id": "12930", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ] }, { "disease_id": "DOID:13375", "recommended_name": { "id": "DOID:13375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13375", "name": "temporal arteritis", "description": "A central nervous system vasculitis that is characterized by inflammation of the lining of arteries, often arteries in the head." }, "synonyms": [ { "id": "DOID:13375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13375", "name": "Horton's disease", "description": "" }, { "id": "DOID:13375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13375", "name": "giant cell arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "temporal arteritis", "description": "A large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries." }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Horton disease", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Horton's disease", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "giant cell arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "inflammation of temporal artery", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "temporal arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "temporal artery inflammation", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "GCA", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Horton's arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Horton's giant cell arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Horton's temporal arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Hortons disease", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "Hortons syndrome", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "arteritis cranialis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "arteritis temporalis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "cranial arteritis", "description": "" }, { "id": "MONDO:0008538", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008538", "name": "polymyalgia rheumatica", "description": "" } ], "evidence": [ { "id": "13375", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13375" } ] }, { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "evidence": [ { "id": "162", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "common_name": "Rat" } ], "gene": [ { "name": "Dll1", "url": "https://www.uniprot.org/uniprot/P97677", "locus": { "chromosome": "1", "start_pos": 56312066, "end_pos": 56320179, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000059984", "url": "https://www.ensembl.org/id/ENSRNOG00000059984" } ] } } ], "crossref": [ { "id": "ENSRNOG00000059984", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000059984", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "84010", "url": "https://www.ncbi.nlm.nih.gov/gene/84010", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P97677", "url": "https://www.ebi.ac.uk/intact/interactors/id:P97677*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:84010", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:84010", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHYTCSE", "url": "https://omabrowser.org/oma/group/GHYTCSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5475408at2759", "url": "http://www.orthodb.org/?query=5475408at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12916", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12916:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "http://pfam.xfam.org/family/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01414", "url": "http://pfam.xfam.org/family/PF01414", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07645", "url": "http://pfam.xfam.org/family/PF07645", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07657", "url": "http://pfam.xfam.org/family/PF07657", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P97677", "url": "http://purl.obolibrary.org/obo/PR_P97677", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-9013507", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013507", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_114452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "70949", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=70949", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I6A9U8", "url": "https://www.uniprot.org/uniprot/A0A8I6A9U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A9U8-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A9U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V7W6", "url": "https://www.uniprot.org/uniprot/G3V7W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V7W6-1", "url": "https://www.uniprot.org/uniprot/G3V7W6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97677-1", "url": "https://www.uniprot.org/uniprot/P97677-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTAVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGANCQFLLPEPPPDLIVAAQGGSFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPDPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGADKSSFKARYPTVDYNLIRDLKGDEATVRDAHSKRDTKCQSQGSVGEEKSTSTLRGGEVPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEV", "length": 714, "header": "sp|P97677-1|DLL1_RAT Isoform 1 of Delta-like protein 1 OS=Rattus norvegicus OX=10116 GN=Dll1 PE=1 SV=1 CANONICAL=P97677-1" }, "isoforms": [ { "isoform_ac": "A0A8I6A9U8-1", "url": "", "sequence": { "sequence": "MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDRCLHGTCQQPWQCNCQEGWGGLFCNQGKPLLYDYLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGANCQFLLPEPPPDLIVAAQGGSFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPDPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGADKSSFKARYPTVDYNLIRDLKGDEATVRDAHSKRDTKCQSQGSVGEEKSTSTLRGGEVPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEVSVWPPCHGRE", "length": 693, "header": "tr|A0A8I6A9U8-1|DLL1_RAT Computationally mapped isoform of Delta-like protein 1 OS=Rattus norvegicus OX=10116 GN=Dll1 PE=1 SV=1 CANONICAL=P97677-1" }, "locus": { "chromosome": "1", "start_pos": 56319893, "end_pos": 56312819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000113128.1", "url": "https://www.ensembl.org/id/ENSRNOT00000113128.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000089438.1", "url": "https://www.ensembl.org/id/ENSRNOP00000089438.1" } ] } }, { "isoform_ac": "G3V7W6-1", "url": "", "sequence": { "sequence": "MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGANCQFLLPEPPPDLIVAAQGGSFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPDPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGADKSSFKARYPTVDYNLIRDLKGDEATVRDAHSKRDTKCQSQGSVGEEKSTSTLRGGEVPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEV", "length": 714, "header": "tr|G3V7W6-1|DLL1_RAT Computationally mapped isoform of Delta-like protein 1 OS=Rattus norvegicus OX=10116 GN=Dll1 PE=1 SV=1 CANONICAL=P97677-1" }, "locus": { "chromosome": "1", "start_pos": 56319893, "end_pos": 56312753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080429.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080429.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073159.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073159.1" } ] } }, { "isoform_ac": "P97677-1", "url": "", "sequence": { "sequence": "MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTAVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGANCQFLLPEPPPDLIVAAQGGSFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPDPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGADKSSFKARYPTVDYNLIRDLKGDEATVRDAHSKRDTKCQSQGSVGEEKSTSTLRGGEVPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEV", "length": 714, "header": "sp|P97677-1|DLL1_RAT Isoform 1 of Delta-like protein 1 OS=Rattus norvegicus OX=10116 GN=Dll1 PE=1 SV=1 CANONICAL=P97677-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 476, "start_aa": "Asn", "end_pos": 476, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn476", "evidence": [ { "id": "P97677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97677#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 630, "end_pos": 630, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "site_lbl": "Thr630" }, { "start_pos": 685, "end_pos": 685, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKB", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "site_lbl": "Ser685" }, { "start_pos": 688, "end_pos": 688, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "site_lbl": "Ser688" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "reference": [ { "type": "PubMed", "id": "12036964", "url": "https://glygen.org/publication/PubMed/12036964" } ] }, { "title": "Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.", "journal": "Dev. Cell", "date": "2012", "authors": "Meloty-Kapella L, Shergill B, Kuon J, Botvinick E, Weinmaster G", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "reference": [ { "type": "PubMed", "id": "22658936", "url": "https://glygen.org/publication/PubMed/22658936" } ] }, { "title": "Deciphering the fringe-mediated notch code: identification of activating and inhibiting sites allowing discrimination between ligands.", "journal": "Dev. Cell", "date": "2017", "authors": "Kakuda S, Haltiwanger RS", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "reference": [ { "type": "PubMed", "id": "28089369", "url": "https://glygen.org/publication/PubMed/28089369" } ] }, { "title": "Notch ligand Delta-like1 enhances degranulation and cytokine production through a novel Notch/Dok-1/MAPKs pathway in vitro.", "journal": "Immunologic research", "date": "2018", "authors": "Jiang S, Da Y, Han S, He Y, Che H", "evidence": [ { "database": "RefSeq", "id": "NP_114452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452" } ], "reference": [ { "type": "PubMed", "id": "29181775", "url": "https://glygen.org/publication/PubMed/29181775" } ] }, { "title": "Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats.", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Kohara Y, Kitazawa S, Kitazawa R, Haraguchi R, Arai K, Amasaki H, Soeta S", "evidence": [ { "database": "RefSeq", "id": "NP_114452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452" } ], "reference": [ { "type": "PubMed", "id": "32703409", "url": "https://glygen.org/publication/PubMed/32703409" } ] } ], "pathway": [ { "id": "rno:84010", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:84010", "resource": "KEGG Pathway" }, { "id": "R-RNO-9013507", "name": "NOTCH3 Activation and Transmission of Signal to the Nucleus", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013507", "resource": "Reactome", "description": "NOTCH3 Activation and Transmission of Signal to the Nucleus" } ], "orthologs": [ { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV", "length": 723 }, "evidence": [ { "id": "45224946", "url": "http://www.informatics.jax.org/homology/45224946", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q61483-1", "protein_name": "Delta-like protein 1", "gene_name": "Dll1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGDRGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCKNGASCTDLEDSFSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPLGFSGFNCEKKMDLCGSSPCSNGAKCVDLGNSYLCRCQAGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGKNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGPNCQFLLPEPPPGPMVVDLSERHMESQGGPFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPEPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGAEKSSFKVRYPTVDYNLVRDLKGDEATVRDTHSKRDTKCQSQSSAGEEKIAPTLRGGEIPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEV", "length": 722 }, "evidence": [ { "id": "45224946", "url": "http://www.informatics.jax.org/homology/45224946", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 69, "go_terms": [ { "name": "inner ear auditory receptor cell differentiation", "id": "GO:0042491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042491", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "cerebellar molecular layer formation", "id": "GO:0021688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021688", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "cerebellar Purkinje cell layer structural organization", "id": "GO:0021693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021693", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "negative regulation of interleukin-10 production", "id": "GO:0032693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032693", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "negative regulation of inner ear auditory receptor cell differentiation", "id": "GO:0045608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045608", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "lateral inhibition", "id": "GO:0046331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046331", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "retina morphogenesis in camera-type eye", "id": "GO:0060042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060042", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "Notch signaling pathway involved in arterial endothelial cell fate commitment", "id": "GO:0060853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060853", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "loop of Henle development", "id": "GO:0072070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072070", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "endothelial tip cell fate specification", "id": "GO:0097102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097102", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "skin epidermis development", "id": "GO:0098773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098773", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of sprouting angiogenesis", "id": "GO:1903672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903672", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "spinal cord development", "id": "GO:0021510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021510", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "skeletal muscle tissue growth", "id": "GO:0048630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048630", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "regulation of blood pressure", "id": "GO:0008217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008217", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "energy homeostasis", "id": "GO:0097009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097009", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of Notch signaling pathway", "id": "GO:0045747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045747", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "proximal/distal pattern formation", "id": "GO:0009954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009954", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "neuroepithelial cell differentiation", "id": "GO:0060563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060563", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of skeletal muscle tissue growth", "id": "GO:0048633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048633", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "left/right axis specification", "id": "GO:0070986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070986", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "organ growth", "id": "GO:0035265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035265", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "positive regulation of endocytosis", "id": "GO:0045807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045807", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "negative regulation of myoblast differentiation", "id": "GO:0045662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045662", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "proximal tubule development", "id": "GO:0072014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072014", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "neuron fate specification", "id": "GO:0048665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048665", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "neuronal stem cell population maintenance", "id": "GO:0097150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097150", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "astrocyte development", "id": "GO:0014002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014002", "evidence": [ { "database": "UniProtKB", "id": "P97677", "url": "https://www.uniprot.org/uniprot/P97677" } ], "pmid": "" }, { "name": "somite specification", "id": "GO:0001757", "url": 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