{ "uniprot_canonical_ac": "P97574-1", "uniprot_ac": "P97574", "uniprot_id": "STC1_RAT", "mass": { "chemical_mass": 27507.0, "monoisotopic_mass": 27507.0 }, "refseq": { "ac": "NP_112385", "name": "stanniocalcin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" }, "gene_names": [ { "name": "Stc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P97574", "id": "P97574" }, { "name": "Stc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385", "id": "NP_112385" }, { "name": "Stc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P97574", "id": "P97574" } ], "protein_names": [ { "name": "Stanniocalcin-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P97574" }, { "name": "STC-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385", "id": "NP_112385" }, { "name": "STC-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97574" }, { "name": "stanniocalcin-1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385", "id": "NP_112385" } ], "function": [ { "annotation": "AVP-mediated elevations in STC-1 gene expression are wholly dependent on functional COX-2 activity.", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" }, { "database": "PubMed", "id": "23877023", "url": "https://glygen.org/publication/PubMed/23877023" } ] }, { "annotation": "In this study, we have found that several HIF target genes including STC1 are upregulated in AECs by a submerged condition, that STC1 is regulated by hypoxia and HIF.", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" }, { "database": "PubMed", "id": "25251473", "url": "https://glygen.org/publication/PubMed/25251473" } ] }, { "annotation": "Results show that STC1 have an important role in the carbohydrate metabolism regulation, in particular gluconeogenesis from glutamine in the kidney, across the vertebrates.", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" }, { "database": "PubMed", "id": "26187698", "url": "https://glygen.org/publication/PubMed/26187698" } ] }, { "annotation": "Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy.", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" }, { "database": "PubMed", "id": "33025358", "url": "https://glygen.org/publication/PubMed/33025358" } ] }, { "annotation": "Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" }, { "database": "PubMed", "id": "31314602", "url": "https://glygen.org/publication/PubMed/31314602" } ] }, { "annotation": "Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "common_name": "Rat" } ], "gene": [ { "name": "Stc1", "url": "https://www.uniprot.org/uniprot/P97574", "locus": { "chromosome": "15", "start_pos": 44310264, "end_pos": 44299621, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000015075", "url": "https://www.ensembl.org/id/ENSRNOG00000015075" } ] } } ], "crossref": [ { "id": "ENSRNOG00000015075", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015075", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "81801", "url": "https://www.ncbi.nlm.nih.gov/gene/81801", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:81801", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:81801", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RMITEVQ", "url": "https://omabrowser.org/oma/group/RMITEVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4573585at2759", "url": "http://www.orthodb.org/?query=4573585at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11245:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11245:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03298", "url": "http://pfam.xfam.org/family/PF03298", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P97574", "url": "http://purl.obolibrary.org/obo/PR_P97574", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621776", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621776", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97574-1", "url": "https://www.uniprot.org/uniprot/P97574-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSQENA", "length": 247, "header": "sp|P97574-1|STC1_RAT Isoform 1 of Stanniocalcin-1 OS=Rattus norvegicus OX=10116 GN=Stc1 PE=2 SV=1 CANONICAL=P97574-1" }, "isoforms": [ { "isoform_ac": "P97574-1", "url": "", "sequence": { "sequence": "MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSQENA", "length": 247, "header": "sp|P97574-1|STC1_RAT Isoform 1 of Stanniocalcin-1 OS=Rattus norvegicus OX=10116 GN=Stc1 PE=2 SV=1 CANONICAL=P97574-1" }, "locus": { "chromosome": "15", "start_pos": 44308828, "end_pos": 44299878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000020728", "url": "https://www.ensembl.org/id/ENSRNOT00000020728" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000020728", "url": "https://www.ensembl.org/id/ENSRNOP00000020728" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 62, "start_aa": "Asn", "end_pos": 62, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn62", "evidence": [ { "id": "P97574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97574#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine vasopressin.", "journal": "Molecular and cellular endocrinology", "date": "2013", "authors": "Law AY, Hebert RL, Nasrallah R, Langenbach R, Wong CK, Wagner GF", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" } ], "reference": [ { "type": "PubMed", "id": "23877023", "url": "https://glygen.org/publication/PubMed/23877023" } ] }, { "title": "Stanniocalcin-1 is induced by hypoxia inducible factor in rat alveolar epithelial cells.", "journal": "Biochemical and biophysical research communications", "date": "2014", "authors": "Ito Y, Zemans R, Correll K, Yang IV, Ahmad A, Gao B, Mason RJ", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" } ], "reference": [ { "type": "PubMed", "id": "25251473", "url": "https://glygen.org/publication/PubMed/25251473" } ] }, { "title": "Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish.", "journal": "Molecular and cellular endocrinology", "date": "2015", "authors": "Schein V, Kucharski LC, Guerreiro PM, Martins TL, Morgado I, Power DM, Canario AV, da Silva RS", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" } ], "reference": [ { "type": "PubMed", "id": "26187698", "url": "https://glygen.org/publication/PubMed/26187698" } ] }, { "title": "Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.", "journal": "Current eye research", "date": "2020", "authors": "Dalvin LA, Hartnett ME, Bretz CA, Hann CR, Cui RZ, Marmorstein AD, Sheikh-Hamad D, Fautsch MP, Roddy GW", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" } ], "reference": [ { "type": "PubMed", "id": "31314602", "url": "https://glygen.org/publication/PubMed/31314602" } ] }, { "title": "Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy.", "journal": "Neurotoxicity research", "date": "2021", "authors": "Bonfante S, Joaquim L, Fileti ME, Giustina AD, de Souza Goldim MP, Danielski LG, Cittadin E, De Carli RJ, de Farias BX, Engel NA, da Rosa N, Fortunato JJ, Giridharan V, Scaini G, Rezin GT, Generoso J, de Bitencourt RM, Terra S, Barichello T, Petronilho F", "evidence": [ { "database": "RefSeq", "id": "NP_112385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112385" } ], "reference": [ { "type": "PubMed", "id": "33025358", "url": "https://glygen.org/publication/PubMed/33025358" } ] } ], "pathway": [ { "id": "rno:81801", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:81801", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O55183-1", "protein_name": "Stanniocalcin-1", "gene_name": "Stc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEGDSPSHIKRTSQESA", "length": 247 }, "evidence": [ { "id": "45232214", "url": "http://www.informatics.jax.org/homology/45232214", "database": "MGI" }, { "id": "P97574", "url": "https://omabrowser.org/oma/group/P97574/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P52823-1", "protein_name": "Stanniocalcin-1", "gene_name": "STC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEEDSPSHIKRTSHESA", "length": 247 }, "evidence": [ { "id": "45232214", "url": "http://www.informatics.jax.org/homology/45232214", "database": "MGI" }, { "id": "P97574", "url": "https://omabrowser.org/oma/group/P97574/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "negative regulation of calcium ion transport", "id": "GO:0051926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051926", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell migration", "id": "GO:0010596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010596", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "regulation of cardiac muscle cell contraction", "id": "GO:0086004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086004", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "cellular response to glucocorticoid stimulus", "id": "GO:0071385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071385", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "response to vitamin D", "id": "GO:0033280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033280", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": "https://www.uniprot.org/uniprot/P97574" } ], "pmid": "" }, { "name": "endothelial cell morphogenesis", "id": "GO:0001886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001886", "evidence": [ { "database": "UniProtKB", "id": "P97574", "url": 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