{ "uniprot_canonical_ac": "P97562-1", "uniprot_ac": "P97562", "uniprot_id": "ACOX2_RAT", "mass": { "chemical_mass": 76799.0, "monoisotopic_mass": 76799.0 }, "refseq": { "ac": "NP_665713", "name": "peroxisomal acyl-coenzyme A oxidase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713" }, "gene_names": [ { "name": "Acox2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P97562", "id": "P97562" }, { "name": "Acox2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713", "id": "NP_665713" }, { "name": "THCCox", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713", "id": "NP_665713" }, { "name": "Thcox", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P97562", "id": "P97562" } ], "protein_names": [ { "name": "Peroxisomal acyl-coenzyme A oxidase 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P97562" }, { "name": "1.17.99.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97562" }, { "name": "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97562" }, { "name": "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97562" }, { "name": "THCA-CoA oxidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97562" }, { "name": "THCCox", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97562" }, { "name": "Trihydroxycoprostanoyl-CoA oxidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97562" }, { "name": "acyl-Coenzyme A oxidase 2, branched chain; THCA-CoA oxidase; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; acyl-CoA oxidase 2, branched chain; 3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713", "id": "NP_665713" }, { "name": "peroxisomal acyl-coenzyme A oxidase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713", "id": "NP_665713" } ], "function": [ { "annotation": "Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (PubMed:8947475, PubMed:1400324). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (PubMed:1400324).", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562#function" }, { "database": "PubMed", "id": "1400324", "url": "https://glygen.org/publication/PubMed/1400324" }, { "database": "PubMed", "id": "8947475", "url": "https://glygen.org/publication/PubMed/8947475" } ] }, { "annotation": "The overall dimeric structure and the folding pattern of each subunit are essentially superimposable on those of uncomplexed acyl-CoA oxidase-II structure.", "evidence": [ { "database": "RefSeq", "id": "NP_665713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713" }, { "database": "PubMed", "id": "16672280", "url": "https://glygen.org/publication/PubMed/16672280" } ] } ], "disease": [ { "disease_id": "DOID:0111067", "recommended_name": { "id": "DOID:0111067", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111067", "name": "congenital bile acid synthesis defect 6", "description": "A congenital bile acid synthesis defect characterized by increased liver enzymes, decreased cholesterol, and increased serum and urine levels of bile acid intermediates that has_material_basis_in homozygous mutation in the ACOX2 gene on chromosome 3p14." }, "synonyms": [ { "id": "DOID:0111067", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111067", "name": "CBAS6", "description": "" }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "congenital bile acid synthesis defect 6", "description": "Any congenital bile acid synthesis defect in which the cause of the disease is a mutation in the ACOX2 gene." }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "ACOX2 congenital bile acid synthesis defect", "description": "" }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "CBAS6", "description": "" }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "bile acid synthesis defect, congenital, 6", "description": "" }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "bile acid synthesis defect, congenital, type 6", "description": "" }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "congenital bile acid synthesis defect caused by mutation in ACOX2", "description": "" }, { "id": "MONDO:0015015", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015015", "name": "congenital bile acid synthesis defect type 6", "description": "" }, { "id": "MIM:617308", "resource": "MIM", "url": "https://www.omim.org/entry/617308", "name": "Congenital bile acid synthesis defect 6", "description": "Congenital bile acid synthesis defect 6" } ], "evidence": [ { "id": "0111067", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111067" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "common_name": "Rat" } ], "gene": [ { "name": "Acox2", "url": "https://www.uniprot.org/uniprot/P97562", "locus": { "chromosome": "15", "start_pos": 16692160, "end_pos": 16660272, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000007378", "url": "https://www.ensembl.org/id/ENSRNOG00000007378" } ] } } ], "crossref": [ { "id": "ENSRNOG00000007378", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007378", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.17.99.3", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.17.99.3&UniProtAcc=P97562", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01150", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01150", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "252898", "url": "https://www.ncbi.nlm.nih.gov/gene/252898", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:252898", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:252898", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYYISVK", "url": "https://omabrowser.org/oma/group/CYYISVK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5777at2759", "url": "http://www.orthodb.org/?query=5777at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10909:SF344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10909:SF344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01756", "url": "http://pfam.xfam.org/family/PF01756", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02770", "url": "http://pfam.xfam.org/family/PF02770", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14749", "url": "http://pfam.xfam.org/family/PF14749", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P97562", "url": "http://purl.obolibrary.org/obo/PR_P97562", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-193368", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193368", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-389887", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389887", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033241", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "628684", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=628684", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "15733", "url": "https://www.rhea-db.org/rhea/15733", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46728", "url": "https://www.rhea-db.org/rhea/46728", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6AM11", "url": "https://www.uniprot.org/uniprot/A0A8I6AM11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AM11-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AM11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LNW3", "url": "https://www.uniprot.org/uniprot/F1LNW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LNW3-1", "url": "https://www.uniprot.org/uniprot/F1LNW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97562-1", "url": "https://www.uniprot.org/uniprot/P97562-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSPMHRVSLGDHWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQELVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAHCYFITVKNFKEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKYPANTQENPAYKKYIRPLMLGWRHKM", "length": 681, "header": "sp|P97562-1|ACOX2_RAT Isoform 1 of Peroxisomal acyl-coenzyme A oxidase 2 OS=Rattus norvegicus OX=10116 GN=Acox2 PE=1 SV=1 CANONICAL=P97562-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AM11-1", "url": "", "sequence": { "sequence": "MWTTGSSHEDTGWECVVIQLAKKGPWMTPALSNAFRTQVLGTSQCSEQTLKETSRSRMGSPMHRVSLGDTWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQEFVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAYCYFITVKNFKEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKSPANTQENPAYKKYIRPLMLGWRHKM", "length": 738, "header": "tr|A0A8I6AM11-1|ACOX2_RAT Computationally mapped isoform of Peroxisomal acyl-coenzyme A oxidase 2 OS=Rattus norvegicus OX=10116 GN=Acox2 PE=1 SV=1 CANONICAL=P97562-1" }, "locus": { "chromosome": "15", "start_pos": 16691896, "end_pos": 16662606, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000101610.1", "url": "https://www.ensembl.org/id/ENSRNOT00000101610.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095724.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095724.1" } ] } }, { "isoform_ac": "F1LNW3-1", "url": "", "sequence": { "sequence": "MGSPMHRVSLGDTWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQEFVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAYCYFITVKNFKEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKSPANTQENPAYKKYIRPLMLGWRHKM", "length": 681, "header": "tr|F1LNW3-1|ACOX2_RAT Computationally mapped isoform of Peroxisomal acyl-coenzyme A oxidase 2 OS=Rattus norvegicus OX=10116 GN=Acox2 PE=1 SV=1 CANONICAL=P97562-1" }, "locus": { "chromosome": "15", "start_pos": 16691896, "end_pos": 16662777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000010260.5", "url": "https://www.ensembl.org/id/ENSRNOT00000010260.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000010260.3", "url": "https://www.ensembl.org/id/ENSRNOP00000010260.3" } ] } }, { "isoform_ac": "P97562-1", "url": "", "sequence": { "sequence": "MGSPMHRVSLGDHWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQELVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAHCYFITVKNFKEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKYPANTQENPAYKKYIRPLMLGWRHKM", "length": 681, "header": "sp|P97562-1|ACOX2_RAT Isoform 1 of Peroxisomal acyl-coenzyme A oxidase 2 OS=Rattus norvegicus OX=10116 GN=Acox2 PE=1 SV=1 CANONICAL=P97562-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" }, { "database": "PubMed", "id": "16396499", "url": "https://glygen.org/publication/PubMed/16396499" }, { "database": "phospho.ELM", "id": "P97562", "url": "http://phospho.elm.eu.org/byAccession/P97562.html" }, { "database": "iPTMnet", "id": "P97562", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P97562" } ], "site_lbl": "Ser3" }, { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "site_lbl": "Ser9" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase.", "journal": "J. Biol. Chem.", "date": "1992", "authors": "Van Veldhoven PP, Vanhove G, Assselberghs S, Eyssen HJ, Mannaerts GP", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "reference": [ { "type": "PubMed", "id": "1400324", "url": "https://glygen.org/publication/PubMed/1400324" } ] }, { "title": "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.", "journal": "Journal of proteome research", "date": "2006", "authors": "Moser K, White FM", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" }, { "database": "UniProtKB", "id": "F1LNW3", "url": "https://www.uniprot.org/uniprot/F1LNW3" }, { "database": "iPTMnet", "id": "P97562", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P97562" } ], "reference": [ { "type": "PubMed", "id": "16396499", "url": "https://glygen.org/publication/PubMed/16396499" } ] }, { "title": "Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: insights into substrate-recognition and reactivity toward molecular oxygen.", "journal": "Journal of biochemistry", "date": "2006", "authors": "Tokuoka K, Nakajima Y, Hirotsu K, Miyahara I, Nishina Y, Shiga K, Tamaoki H, Setoyama C, Tojo H, Miura R", "evidence": [ { "database": "RefSeq", "id": "NP_665713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665713" } ], "reference": [ { "type": "PubMed", "id": "16672280", "url": "https://glygen.org/publication/PubMed/16672280" } ] }, { "title": "Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase.", "journal": "Biochem. J.", "date": "1996", "authors": "Van Veldhoven P.P., Mannaerts G.P., Vanhooren J.C.T., Baumgart E., Fahimi H.D., Fransen M., Van Leuven F.", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "reference": [ { "type": "PubMed", "id": "8947475", "url": "https://glygen.org/publication/PubMed/8947475" } ] } ], "pathway": [ { "id": "rno:252898", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:252898", "resource": "KEGG Pathway" }, { "id": "R-RNO-193368", "name": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193368", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" }, { "id": "R-RNO-389887", "name": "Beta-oxidation of pristanoyl-CoA", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389887", "resource": "Reactome", "description": "Beta-oxidation of pristanoyl-CoA" }, { "id": "R-RNO-9033241", "name": "Peroxisomal protein import", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "Q99424-1", "protein_name": "Peroxisomal acyl-coenzyme A oxidase 2", "gene_name": "ACOX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSPVHRVSLGDTWSRQMHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSYPEFSCKDNYFMTQNERYKAAMRRAFHIRLIARRLGWLEDGRELGYAYRALSGDVALNIHRVFVRALRSLGSEEQIAKWDPLCKNIQIIATYAQTELGHGTYLQGLETEATYDAATQEFVIHSPTLTATKWWPGDLGRSATHALVQAQLICSGARRGMHAFIVPIRSLQDHTPLPGIIIGDIGPKMDFDQTDNGFLQLNHVRVPRENMLSRFAQVLPDGTYVKLGTAQSNYLPMVVVRVELLSGEILPILQKACVIAMRYSVIRRQSRLRPSDPEAKVLDYQTQQQKLFPQLAISYAFHFLAVSLLEFFQHSYTAILNQDFSFLPELHALSTGMKAMMSEFCTQGAEMCRRACGGHGYSKLSGLPSLVTKLSASCTYEGENTVLYLQVARFLVKSYLQTQMSPGSTPQRSLSPSVAYLTAPDLARCPAQRAADFLCPELYTTAWAHVAVRLIKDSVQHLQTLTQSGADQHEAWNQTTVIHLQAAKVHCYYVTVKGFTEALEKLENEPAIQQVLKRLCDLHAIHGILTNSGDFLHDAFLSGAQVDMARTAYLDLLRLIRKDAILLTDAFDFTDQCLNSALGCYDGNVYERLFQWAQKSPTNTQENPAYEEYIRPLLQSWRSKL", "length": 681 }, "evidence": [ { "id": "45240257", "url": "http://www.informatics.jax.org/homology/45240257", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QXD1-1", "protein_name": "Peroxisomal acyl-coenzyme A oxidase 2", "gene_name": "Acox2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNPGDRVSLGETWSREVHPDIDSERHSPSFSVERLTNILDGGIPNTELRRRVESLIQRDPVFNLKHLYFMTRDELYEDAVQKRFHLEKLAWSLGWSEDGPERIYADRVLAGYNNLNLHGIAMNAIRSLGSDEQIAKWGQLGKNFQIITTYAQTELGHGTYLQGLETEATYDATTQEFVIHSPTMTSIKWWPGDLGRTVTHAVVLAHLICLGARHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGFLRLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLYKGFLPTLQKACTIAVRYAVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYALHFMTTSLLQFFHSSYSDILKRDFSLLPELHALSTGMKAMSSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGENTVLYLQVARFLMKSYLQAQVSPGSIPQKPLPQSVMYLATPRPARCPAQTAADFRCPEVYTTAWAYVSARLIRDATQHTQTLMRSGVDQYDAWNQTSVIHLQAAKAHCYFLTVRNFKEAVEKLDNEPEIQRVLQNLCDLYALNGILTNSGDFLHDGFLSGAQVDMARTAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYQRLFEWAQKSPANTQENPAYKKYIRPLMQSWKPKL", "length": 681 }, "evidence": [ { "id": "45240257", "url": "http://www.informatics.jax.org/homology/45240257", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "fatty acid binding", "id": "GO:0005504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005504", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "acyl-CoA oxidase activity", "id": "GO:0003997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003997", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "id": "GO:0033791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033791", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "palmitoyl-CoA oxidase activity", "id": "GO:0016401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016401", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "fatty acid beta-oxidation using acyl-CoA oxidase", "id": "GO:0033540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033540", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "bile acid biosynthetic process", "id": "GO:0006699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006699", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "very long-chain fatty acid metabolic process", "id": "GO:0000038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000038", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "P97562", "url": "https://www.uniprot.org/uniprot/P97562" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 533, "end_pos": 535, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15733", "name": "", "equation": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97562-1", "Q99424-1", "Q9QXD1-1" ], "evidence": [ { "id": "15733", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15733" } ] }, { "id": "46728", "name": "", "equation": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97562-1", "Q99424-1", "Q9QXD1-1" ], "evidence": [ { "id": "46728", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46728" } ] }, { "id": "R-RNO-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-192316" ], "output_participant_list": [ "R-ALL-192342" ], "enzyme_list": [ "P97562-1" ], "evidence": [ { "id": "R-RNO-192335", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-192335" } ] }, { "id": "R-RNO-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-193442" ], "output_participant_list": [ "R-ALL-193459" ], "enzyme_list": [ "P97562-1" ], "evidence": [ { "id": "R-RNO-193369", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193369" } ] }, { "id": "R-RNO-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-389893" ], "output_participant_list": [ "R-ALL-389894" ], "enzyme_list": [ "P97562-1" ], "evidence": [ { "id": "R-RNO-389889", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389889" } ] }, { "id": "R-RNO-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES71-1", "P07872-1", "P97562-1", "Q62651-1", "P11915-1", "Q06518-1", "Q8CHM7-1", "Q63276-1", "Q63448-1", "O88267-1", "Q5XIC0-1", "P09139-1", "Q3MIB4-1", "Q5I0K1-1", "P04762-1", "Q704S8-1", "Q920F5-1", "Q9Z2M4-1", "P24392-1", "P41562-1", "P97519-1", "B0BNF9-1", "B1H261-1", "O55171-1", "P70473-1", "Q8VHK0-1", "P97524-1", "Q6AYD9-1", "Q9WVK3-1", "O35078-1", "P11466-1", "P24473-1", "Q07523-1", "Q8VID1-1", "P35559-1", "D3ZDM7-1" ], "evidence": [ { "id": "R-RNO-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033235" } ] }, { "id": "R-RNO-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES71-1", "P07872-1", "P97562-1", "Q62651-1", "P11915-1", "Q06518-1", "Q8CHM7-1", "Q63276-1", "Q63448-1", "O88267-1", "Q5XIC0-1", "P09139-1", "Q3MIB4-1", "Q5I0K1-1", "P04762-1", "Q704S8-1", "Q920F5-1", "Q9Z2M4-1", "P24392-1", "P41562-1", "P97519-1", "B0BNF9-1", "B1H261-1", "O55171-1", "P70473-1", "Q8VHK0-1", "P97524-1", "Q6AYD9-1", "Q9WVK3-1", "O35078-1", "P11466-1", "P24473-1", "Q07523-1", "Q8VID1-1", "P35559-1", "D3ZDM7-1" ], "evidence": [ { "id": "R-RNO-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033236" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-192316", "participant_name": "25(S) THCA-CoA [peroxisomal matrix]", "crossref": [ { "id": "C04760", "database": "COMPOUND", "url": "" }, { "id": "37643", "database": "ChEBI", "url": "" }, { "id": "C04760", "database": "COMPOUND", "url": "" }, { "id": "37643", "database": "ChEBI", "url": "" }, { "id": "C04760", "database": "COMPOUND", "url": "" }, { "id": "37643", "database": "ChEBI", "url": "" }, { "id": "C04760", "database": "COMPOUND", "url": "" }, { "id": "37643", "database": "ChEBI", "url": "" }, { "id": "C04760", "database": "COMPOUND", "url": "" }, { "id": "37643", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-192342", "participant_name": "THCA-CoA [peroxisomal matrix]", "crossref": [ { "id": "HMDB0006889", "database": "HMDB Metabolite", "url": "" }, { "id": "C05460", "database": "COMPOUND", "url": "" }, { "id": "27505", "database": "ChEBI", "url": "" }, { "id": "C05460", "database": "COMPOUND", "url": "" }, { "id": "27505", "database": "ChEBI", "url": "" }, { "id": "HMDB0006889", "database": "HMDB Metabolite", "url": "" }, { "id": "C05460", "database": "COMPOUND", "url": "" }, { "id": "27505", "database": "ChEBI", "url": "" }, { "id": "HMDB0006889", "database": "HMDB Metabolite", "url": "" }, { "id": "C05460", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006889", "database": "HMDB Metabolite", "url": "" }, { "id": "27505", "database": "ChEBI", "url": "" }, { "id": "C05460", "database": "COMPOUND", "url": "" }, { "id": "27505", "database": "ChEBI", "url": "" }, { "id": "HMDB0006889", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-193442", "participant_name": "25(S) DHCA-CoA [peroxisomal matrix]", "crossref": [ { "id": "C04644", "database": "COMPOUND", "url": "" }, { "id": "15494", "database": "ChEBI", "url": "" }, { "id": "C04644", "database": "COMPOUND", "url": "" }, { "id": "15494", "database": "ChEBI", "url": "" }, { "id": "15494", "database": "ChEBI", "url": "" }, { "id": "C04644", "database": "COMPOUND", "url": "" }, { "id": "15494", "database": "ChEBI", "url": "" }, { "id": "C04644", "database": "COMPOUND", "url": "" }, { "id": "C04644", "database": "COMPOUND", "url": "" }, { "id": "15494", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-193459", "participant_name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA [peroxisomal matrix]", "crossref": [ { "id": "HMDB0006895", "database": "HMDB Metabolite", "url": "" }, { "id": "27393", "database": "ChEBI", "url": "" }, { "id": "27393", "database": "ChEBI", "url": "" }, { "id": "HMDB0006895", "database": "HMDB Metabolite", "url": "" }, { "id": "27393", "database": "ChEBI", "url": "" }, { "id": "HMDB0006895", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0006895", "database": "HMDB Metabolite", "url": "" }, { "id": "27393", "database": "ChEBI", "url": "" }, { "id": "27393", "database": "ChEBI", "url": "" }, { "id": "HMDB0006895", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-389893", "participant_name": "(2S) Pristanoyl-CoA [peroxisomal matrix]", "crossref": [ { "id": "64039", "database": "ChEBI", "url": "" }, { "id": "64039", "database": "ChEBI", "url": "" }, { "id": "64039", "database": "ChEBI", "url": "" }, { "id": "64039", "database": "ChEBI", "url": "" }, { "id": "64039", "database": "ChEBI", "url": "" }, { "id": "64039", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-389894", "participant_name": "trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]", "crossref": [ { "id": "63803", "database": "ChEBI", "url": "" }, { "id": "HMDB0062535", "database": "HMDB Metabolite", "url": "" }, { "id": "63803", "database": "ChEBI", "url": "" }, { "id": "HMDB0062535", "database": "HMDB Metabolite", "url": "" }, { "id": "63803", "database": "ChEBI", "url": "" }, { "id": "HMDB0062535", "database": "HMDB Metabolite", "url": "" }, { "id": "63803", "database": "ChEBI", "url": "" }, { "id": "HMDB0062535", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0062535", "database": "HMDB Metabolite", "url": "" }, { "id": "63803", "database": "ChEBI", "url": "" }, { "id": "63803", "database": "ChEBI", "url": "" }, { "id": "HMDB0062535", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "B0BNF9", "gene_name": "Hao1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "B0BNF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0BNF9" } ] }, { "ec_number": "1.2.3.5", "activity": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate.", "evidence": [ { "id": "B0BNF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0BNF9" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "B0BNF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0BNF9" } ] } ] }, { "uniprot_ac": "B1H261", "gene_name": "Tysnd1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "B1H261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H261" } ] } ] }, { "uniprot_ac": "D3ZDM7", "gene_name": "Ddo", "activity": [ { "ec_number": "1.4.3.1", "activity": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate.", "evidence": [ { "id": "D3ZDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDM7" } ] } ] }, { "uniprot_ac": "O35078", "gene_name": "Dao", "activity": [ { "ec_number": "1.4.3.3", "activity": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+).", "evidence": [ { "id": "O35078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35078" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "O35078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35078" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "P04762", "gene_name": "Cat", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "P04762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04762" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P04762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04762" } ] } ] }, { "uniprot_ac": "P07872", "gene_name": "Acox1", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "P07872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07872" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "P07872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07872" } ] } ] }, { "uniprot_ac": "P09139", "gene_name": "Agxt", "activity": [ { "ec_number": "2.6.1.51", "activity": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.", "evidence": [ { "id": "P09139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09139" } ] }, { "ec_number": "2.6.1.44", "activity": "glyoxylate + L-alanine = glycine + pyruvate.", "evidence": [ { "id": "P09139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09139" } ] }, { "ec_number": "2.6.1.44", "activity": "", "evidence": [ { "id": "P09139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09139" } ] } ] }, { "uniprot_ac": "P11466", "gene_name": "Crot", "activity": [ { "ec_number": "2.3.1.137", "activity": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine.", "evidence": [ { "id": "P11466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11466" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "P11466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11466" } ] } ] }, { "uniprot_ac": "P11915", "gene_name": "Scp2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.155", "activity": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] } ] }, { "uniprot_ac": "P24392", "gene_name": "Pex2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] } ] }, { "uniprot_ac": "P24473", "gene_name": "Gstk1", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "P24473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24473" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "P24473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24473" } ] } ] }, { "uniprot_ac": "P35559", "gene_name": "Ide", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "P35559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35559" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "P35559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35559" } ] } ] }, { "uniprot_ac": "P41562", "gene_name": "Idh1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "P41562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41562" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "P41562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41562" } ] } ] }, { "uniprot_ac": "P70473", "gene_name": "Amacr", "activity": [ { "ec_number": "5.1.99.4", "activity": "a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA.", "evidence": [ { "id": "P70473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70473" } ] }, { "ec_number": "5.1.99.4", "activity": "", "evidence": [ { "id": "P70473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70473" } ] } ] }, { "uniprot_ac": "P97519", "gene_name": "Hmgcl", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "P97519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97519" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "P97519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97519" } ] } ] }, { "uniprot_ac": "P97524", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] } ] }, { "uniprot_ac": "P97562", "gene_name": "Acox2", "activity": [ { "ec_number": "1.17.99.3", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2.", "evidence": [ { "id": "P97562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97562" } ] }, { "ec_number": "1.17.99.3", "activity": "", "evidence": [ { "id": "P97562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97562" } ] } ] }, { "uniprot_ac": "Q06518", "gene_name": "Nos2", "activity": [ { "ec_number": "1.14.13.39", "activity": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide.", "evidence": [ { "id": "Q06518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06518" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "Q06518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06518" } ] } ] }, { "uniprot_ac": "Q07523", "gene_name": "Hao2", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q07523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07523" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q07523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07523" } ] } ] }, { "uniprot_ac": "Q3MIB4", "gene_name": "Lonp2", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q3MIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ] }, { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q3MIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q3MIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ] } ] }, { "uniprot_ac": "Q5I0K1", "gene_name": "Pipox", "activity": [ { "ec_number": "1.5.3.1", "activity": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q5I0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K1" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q5I0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K1" } ] } ] }, { "uniprot_ac": "Q5XIC0", "gene_name": "Eci2", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "Q5XIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIC0" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "Q5XIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIC0" } ] } ] }, { "uniprot_ac": "Q62651", "gene_name": "Ech1", "activity": [ { "ec_number": "5.3.3.-", "activity": "", "evidence": [ { "id": "Q62651", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62651" } ] } ] }, { "uniprot_ac": "Q63276", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] } ] }, { "uniprot_ac": "Q63448", "gene_name": "Acox3", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "Q63448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63448" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "Q63448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63448" } ] } ] }, { "uniprot_ac": "Q6AYD9", "gene_name": "Nudt19", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q6AYD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYD9" } ] } ] }, { "uniprot_ac": "Q704S8", "gene_name": "Crat", "activity": [ { "ec_number": "2.3.1.137", "activity": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine.", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine.", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] } ] }, { "uniprot_ac": "Q8CHM7", "gene_name": "Hacl1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "Q8CHM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHM7" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "Q8CHM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHM7" } ] } ] }, { "uniprot_ac": "Q8VHK0", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] } ] }, { "uniprot_ac": "Q8VID1", "gene_name": "Dhrs4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] } ] }, { "uniprot_ac": "Q920F5", "gene_name": "Mlycd", "activity": [ { "ec_number": "4.1.1.9", "activity": "H(+) + malonyl-CoA = acetyl-CoA + CO2.", "evidence": [ { "id": "Q920F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920F5" } ] }, { "ec_number": "4.1.1.9", "activity": "", "evidence": [ { "id": "Q920F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920F5" } ] } ] }, { "uniprot_ac": "Q99424", "gene_name": "ACOX2", "activity": [ { "ec_number": "1.17.99.3", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2.", "evidence": [ { "id": "Q99424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99424" } ] }, { "ec_number": "1.17.99.3", "activity": "", "evidence": [ { "id": "Q99424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99424" } ] } ] }, { "uniprot_ac": "Q9ES71", "gene_name": "Gnpat", "activity": [ { "ec_number": "2.3.1.42", "activity": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "Q9ES71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES71" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "Q9ES71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES71" } ] } ] }, { "uniprot_ac": "Q9QXD1", "gene_name": "Acox2", "activity": [ { "ec_number": "1.17.99.3", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2.", "evidence": [ { "id": "Q9QXD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXD1" } ] }, { "ec_number": "1.17.99.3", "activity": "", "evidence": [ { "id": "Q9QXD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXD1" } ] } ] }, { "uniprot_ac": "Q9WVK3", "gene_name": "Pecr", "activity": [ { "ec_number": "1.3.1.38", "activity": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+).", "evidence": [ { "id": "Q9WVK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVK3" } ] }, { "ec_number": "1.3.1.38", "activity": "", "evidence": [ { "id": "Q9WVK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVK3" } ] } ] }, { "uniprot_ac": "Q9Z2M4", "gene_name": "Decr2", "activity": [ { "ec_number": "1.3.1.124", "activity": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+).", "evidence": [ { "id": "Q9Z2M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z2M4" } ] }, { "ec_number": "1.3.1.124", "activity": "", "evidence": [ { "id": "Q9Z2M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z2M4" } ] }, { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "Q9Z2M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z2M4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q9Z2M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z2M4" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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