{
    "uniprot_canonical_ac": "P97411-1",
    "uniprot_ac": "P97411",
    "uniprot_id": "ICA69_MOUSE",
    "mass": {
        "chemical_mass": 54324.0,
        "monoisotopic_mass": 54324.0
    },
    "refseq": {
        "ac": "NP_001239195",
        "name": "islet cell autoantigen 1 isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
    },
    "gene_names": [
        {
            "name": "Ica1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P97411",
            "id": "P97411"
        },
        {
            "name": "69kDa; ICA69",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195",
            "id": "NP_001239195"
        },
        {
            "name": "Ica1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195",
            "id": "NP_001239195"
        },
        {
            "name": "Icap69",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P97411",
            "id": "P97411"
        }
    ],
    "protein_names": [
        {
            "name": "Islet cell autoantigen 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P97411"
        },
        {
            "name": "69 kDa islet cell autoantigen",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P97411"
        },
        {
            "name": "ICA69",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P97411"
        },
        {
            "name": "ICAp69",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P97411"
        },
        {
            "name": "Islet cell autoantigen p69",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P97411"
        },
        {
            "name": "islet cell autoantigen 1 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195",
            "id": "NP_001239195"
        },
        {
            "name": "p69; ICAp69; islet cell autoantigen p69; 69 kDa islet cell autoantigen; islet cell autoantigen 1, 69 kDa",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195",
            "id": "NP_001239195"
        },
        {
            "name": "p69",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P97411"
        }
    ],
    "function": [
        {
            "annotation": "Direct link between compromised thymic ICA69 expression and autoimmunity against multiple ICA69-expressing organs, and identify a potential novel mechanism for the development of multi-organ autoimmune diseases.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                },
                {
                    "database": "PubMed",
                    "id": "25088457",
                    "url": "https://glygen.org/publication/PubMed/25088457"
                }
            ]
        },
        {
            "annotation": "ICA69 deficiency promoted formalin-induced long-lasting pain hypersensitivity.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                },
                {
                    "database": "PubMed",
                    "id": "25547463",
                    "url": "https://glygen.org/publication/PubMed/25547463"
                }
            ]
        },
        {
            "annotation": "Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfbeta signaling in mice.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                },
                {
                    "database": "PubMed",
                    "id": "32531799",
                    "url": "https://glygen.org/publication/PubMed/32531799"
                }
            ]
        },
        {
            "annotation": "May play a role in neurotransmitter secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P97411",
                    "url": "https://www.uniprot.org/uniprot/P97411#function"
                },
                {
                    "database": "PubMed",
                    "id": "11029035",
                    "url": "https://glygen.org/publication/PubMed/11029035"
                }
            ]
        },
        {
            "annotation": "The findings of this study indicated that ICA69 mediates the antihyperalgesic effects of EA on CFA-induced inflammatory pain by regulating spinal GluR2 through PICK1 in mice",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                },
                {
                    "database": "PubMed",
                    "id": "30699097",
                    "url": "https://glygen.org/publication/PubMed/30699097"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:9351",
            "recommended_name": {
                "id": "DOID:9351",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9351",
                "name": "diabetes mellitus",
                "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
            },
            "synonyms": [
                {
                    "id": "DOID:9351",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9351",
                    "name": "diabetes",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "9351",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9351"
                }
            ]
        },
        {
            "disease_id": "DOID:9744",
            "recommended_name": {
                "id": "DOID:9744",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9744",
                "name": "type 1 diabetes mellitus",
                "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production."
            },
            "synonyms": [
                {
                    "id": "DOID:9744",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9744",
                    "name": "IDDM",
                    "description": ""
                },
                {
                    "id": "DOID:9744",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9744",
                    "name": "insulin-dependent diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "DOID:9744",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9744",
                    "name": "type I diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "type 1 diabetes mellitus",
                    "description": "A chronic condition characterized by minimal or absent production of insulin by the pancreas."
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "IDDM",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "diabetes mellitis type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "diabetes mellitis type I",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "immune mediated diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "insulin dependent diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "insulin-dependent diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "juvenile diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "type 1 diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "type I diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005147",
                    "name": "type I diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MIM:222100",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/222100",
                    "name": "Type 1 diabetes mellitus",
                    "description": "Type 1 diabetes mellitus"
                }
            ],
            "evidence": [
                {
                    "id": "9744",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9744"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P97411",
                    "url": "https://www.uniprot.org/uniprot/P97411"
                }
            ],
            "common_name": "Mouse"
        }
    ],
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            "name": "Ica1",
            "url": "https://www.uniprot.org/uniprot/P97411",
            "locus": {
                "chromosome": "6",
                "start_pos": 8630527,
                "end_pos": 8778488,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000062995",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000062995"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000062995",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000062995",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd07661",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07661",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "15893",
            "url": "https://www.ncbi.nlm.nih.gov/gene/15893",
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            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P97411",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P97411*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR006723",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006723",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010504",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010504",
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                "Protein Classification"
            ]
        },
        {
            "id": "IPR024114",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027267",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:15893",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15893",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
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        },
        {
            "id": "96391",
            "url": "http://www.informatics.jax.org/marker/MGI:96391",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "THNACSE",
            "url": "https://omabrowser.org/oma/group/THNACSE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5317533at2759",
            "url": "http://www.orthodb.org/?query=5317533at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10164",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10164",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10164:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10164:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04629",
            "url": "http://pfam.xfam.org/family/PF04629",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF06456",
            "url": "http://pfam.xfam.org/family/PF06456",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P97411",
            "url": "http://purl.obolibrary.org/obo/PR_P97411",
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            "categories": [
                "Protein"
            ]
        },
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            "id": "NP_001239195",
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                "Protein"
            ]
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        },
        {
            "id": "D3Z118",
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            "id": "D3Z118-1",
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            ]
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            "id": "D3Z376-1",
            "url": "https://www.uniprot.org/uniprot/D3Z376-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z699",
            "url": "https://www.uniprot.org/uniprot/D3Z699",
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            "categories": [
                "Protein"
            ]
        },
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            "id": "D3Z699-1",
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            ]
        },
        {
            "id": "F6UY19",
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            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6UY19-1",
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            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7BG11",
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            ]
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            "id": "F7BG11-1",
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            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P97411",
            "url": "https://www.uniprot.org/uniprot/P97411",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P97411-1",
            "url": "https://www.uniprot.org/uniprot/P97411-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P97411-2",
            "url": "https://www.uniprot.org/uniprot/P97411-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S4R217",
            "url": "https://www.uniprot.org/uniprot/S4R217",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S4R217-1",
            "url": "https://www.uniprot.org/uniprot/S4R217-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA",
        "length": 478,
        "header": "sp|P97411-1|ICA69_MOUSE Isoform 1 of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=3 CANONICAL=P97411-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3Z020-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLS",
                "length": 73,
                "header": "tr|D3Z020-1|D3Z020_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8749729,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000126039.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000126039.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000118010.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000118010.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3Z118-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA",
                "length": 465,
                "header": "tr|D3Z118-1|D3Z118_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8630679,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000115519.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000115519.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000111181.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000111181.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3Z119-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKDITYTLLHGSRAGDSHRGVKWLFPGSATVPFASTAIPSLSGSW",
                "length": 310,
                "header": "tr|D3Z119-1|D3Z119_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8667235,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000115518.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000115518.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000111180.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000111180.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3Z376-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLV",
                "length": 277,
                "header": "tr|D3Z376-1|D3Z376_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8658285,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000153390.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000153390.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000117734.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000117734.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3Z699-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKED",
                "length": 45,
                "header": "tr|D3Z699-1|D3Z699_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=4 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8754634,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000151758.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000151758.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000117112.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000117112.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6UY19-1",
            "url": "",
            "sequence": {
                "sequence": "XMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKVSATGVQFVRSCSFITTTTKKLSLNV",
                "length": 66,
                "header": "tr|F6UY19-1|F6UY19_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8672317,
                "end_pos": 8659019,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000127398.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000127398.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000118194.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000118194.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F7BG11-1",
            "url": "",
            "sequence": {
                "sequence": "RGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKELCCYKVSIKRHTLIGLLTQLGVRRTFLNLECPVKLCRK",
                "length": 141,
                "header": "tr|F7BG11-1|F7BG11_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8737097,
                "end_pos": 8659872,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000126430.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000126430.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000116861.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000116861.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P97411-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA",
                "length": 478,
                "header": "sp|P97411-1|ICA69_MOUSE Isoform 1 of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=3 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8630679,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000115520",
                        "url": "https://www.ensembl.org/id/ENSMUST00000115520"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000111182",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000111182"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P97411-2",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKRPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA",
                "length": 457,
                "header": "sp|P97411-2|ICA69_MOUSE Isoform 2 of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=3 CANONICAL=P97411-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "S4R217-1",
            "url": "",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQTHR",
                "length": 302,
                "header": "tr|S4R217-1|ICA69_MOUSE Computationally mapped isoform of Islet cell autoantigen 1  OS=Mus musculus OX=10090 GN=Ica1 PE=1 SV=1 CANONICAL=P97411-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 8758382,
                "end_pos": 8653526,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000156695.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000156695.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000138459.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000138459.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion.",
            "journal": "Mol. Biol. Cell",
            "date": "2000",
            "authors": "Pilon M, Peng XR, Spence AM, Plasterk RH, Dosch HM",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P97411",
                    "url": "https://www.uniprot.org/uniprot/P97411"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11029035",
                    "url": "https://glygen.org/publication/PubMed/11029035"
                }
            ]
        },
        {
            "title": "ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.",
            "journal": "J. Immunol.",
            "date": "2002",
            "authors": "Singh B., Gaedigk R., Karges W., Dosch H.-M., Arpaia E., Song A., McKerlie C., Astsaturov I., Hammond-McKibben D., Kubiak V., Pilon M., Winer S., Zucker P.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P97411",
                    "url": "https://www.uniprot.org/uniprot/P97411"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11751995",
                    "url": "https://glygen.org/publication/PubMed/11751995"
                }
            ]
        },
        {
            "title": "Compromised central tolerance of ICA69 induces multiple organ autoimmunity.",
            "journal": "Journal of autoimmunity",
            "date": "2014",
            "authors": "Fan Y, Gualtierotti G, Tajima A, Grupillo M, Coppola A, He J, Bertera S, Owens G, Pietropaolo M, Rudert WA, Trucco M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25088457",
                    "url": "https://glygen.org/publication/PubMed/25088457"
                }
            ]
        },
        {
            "title": "Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw.",
            "journal": "Neurochemical research",
            "date": "2015",
            "authors": "Li QJ, Wang Z, Yao YX, Jin SH, Qian MZ, Li NN, Wang YN, Zhang YW, Chen BY, Jia DY, Shen Y, Wang JL",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25547463",
                    "url": "https://glygen.org/publication/PubMed/25547463"
                }
            ]
        },
        {
            "title": "Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice.",
            "journal": "Pain",
            "date": "2019",
            "authors": "Han K, Zhang A, Mo Y, Mao T, Ji B, Li D, Zhuang X, Qian M, Chen S, Wang Z, Wang J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30699097",
                    "url": "https://glygen.org/publication/PubMed/30699097"
                }
            ]
        },
        {
            "title": "Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfbeta signaling in mice.",
            "journal": "FEBS letters",
            "date": "2020",
            "authors": "Chen L, Tao F, Zhang Y, Shu C, Xiang W, Yang L, Chen X, Hong Y, Chen B, Li K, Zhang W, Hao K, Ge F, Wang Z, Lyu J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001239195",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239195"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32531799",
                    "url": "https://glygen.org/publication/PubMed/32531799"
                }
            ]
        },
        {
            "title": "Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity.",
            "journal": "Genomics",
            "date": "1996",
            "authors": "Scherer S.W., Gaedigk R., Karges W., Dosch H.-M., Hui M.F.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P97411",
                    "url": "https://www.uniprot.org/uniprot/P97411"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8975715",
                    "url": "https://glygen.org/publication/PubMed/8975715"
                }
            ]
        },
        {
            "title": "Molecular cloning of murine ICA69: diabetes-prone mice recognize the human autoimmune-epitope, Tep69, conserved in splice variants from both species.",
            "journal": "Biochim. Biophys. Acta",
            "date": "1997",
            "authors": "Gaedigk R., Cheung R.K., Dosch H.-M., Hui M.F., Karges W.J.P.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P97411",
                    "url": "https://www.uniprot.org/uniprot/P97411"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9128175",
                    "url": "https://glygen.org/publication/PubMed/9128175"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:15893",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15893",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q05084-1",
            "protein_name": "Islet cell autoantigen 1",
            "gene_name": "ICA1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLEEENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA",
                "length": 483
            },
            "evidence": [
                {
                    "id": "45236173",
                    "url": "http://www.informatics.jax.org/homology/45236173",
                    "database": "MGI"
                },
                {
                    "id": "P97411",
                    "url": "https://omabrowser.org/oma/group/P97411/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q63054-1",
            "protein_name": "Islet cell autoantigen 1",
            "gene_name": "Ica1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEKKKSSRRENREAVAQEPRQLISLEEENQHKESSTCQKEEGKSVPSSVDKSSADDACSGPIDELLDVKPEEACLGPMAGTPEPESGDKDDLLLLNEIFSTSSLDEGEFSREWAAVFGDDRLKEPAPMGAQGEPDPKPQIGSAFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAIGKTDKEHELLNA",
                "length": 480
            },
            "evidence": [
                {
                    "id": "45236173",
                    "url": "http://www.informatics.jax.org/homology/45236173",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 11,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular membrane-bounded organelle",
                        "id": "GO:0043231",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endomembrane system",
                        "id": "GO:0012505",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "perinuclear region of cytoplasm",
                        "id": "GO:0048471",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "secretory granule membrane",
                        "id": "GO:0030667",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030667",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle membrane",
                        "id": "GO:0030672",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P97411",
                                "url": "https://www.uniprot.org/uniprot/P97411"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi stack",
                        "id": "GO:0005795",
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