{ "uniprot_canonical_ac": "P97305-1", "uniprot_ac": "P97305", "uniprot_id": "NFAC3_MOUSE", "mass": { "chemical_mass": 115451.0, "monoisotopic_mass": 115451.0 }, "refseq": { "ac": "NP_035031", "name": "nuclear factor of activated T-cells, cytoplasmic 3 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031" }, "gene_names": [ { "name": "Nfatc3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P97305", "id": "P97305" }, { "name": "D8Ertd281e; NFAT4; NFATx", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031", "id": "NP_035031" }, { "name": "Nfat4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P97305", "id": "P97305" }, { "name": "Nfatc3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031", "id": "NP_035031" } ], "protein_names": [ { "name": "Nuclear factor of activated T-cells, cytoplasmic 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P97305" }, { "name": "NF-AT4; NF-ATc3; T-cell transcription factor NFAT4; nuclear factor of activated T-cells, cytoplasmic 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031", "id": "NP_035031" }, { "name": "NF-AT4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97305" }, { "name": "NF-ATc3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97305" }, { "name": "NFATc3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97305" }, { "name": "NFATx", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97305" }, { "name": "T-cell transcription factor NFAT4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P97305" }, { "name": "nuclear factor of activated T-cells, cytoplasmic 3 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031", "id": "NP_035031" } ], "function": [ { "annotation": "Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Along with NFATC4, involved in embryonic heart development (PubMed:12750314).", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305#function" }, { "database": "UniProtKB", "id": "Q12968", "url": "https://www.uniprot.org/uniprot/Q12968#function" }, { "database": "PubMed", "id": "12750314", "url": "https://glygen.org/publication/PubMed/12750314" } ] }, { "annotation": "Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors.", "evidence": [ { "database": "RefSeq", "id": "NP_035031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031" }, { "database": "PubMed", "id": "36317923", "url": "https://glygen.org/publication/PubMed/36317923" } ] }, { "annotation": "Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.", "evidence": [ { "database": "RefSeq", "id": "NP_035031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031" }, { "database": "PubMed", "id": "34570211", "url": "https://glygen.org/publication/PubMed/34570211" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Nfatc3", "url": "https://www.uniprot.org/uniprot/P97305", "locus": { "chromosome": "8", "start_pos": 106857169, "end_pos": 106785472, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031902", "url": "https://www.ensembl.org/id/ENSMUSG00000031902" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031902", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031902", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01178", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01178", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07881", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07881", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "18021", "url": "https://www.ncbi.nlm.nih.gov/gene/18021", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P97305", "url": "https://www.ebi.ac.uk/intact/interactors/id:P97305*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "103296", "url": "http://www.informatics.jax.org/marker/MGI:103296", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "QGHKSYE", "url": "https://omabrowser.org/oma/group/QGHKSYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5405363at2759", "url": "http://www.orthodb.org/?query=5405363at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12533:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00554", "url": "http://pfam.xfam.org/family/PF00554", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16179", "url": "http://pfam.xfam.org/family/PF16179", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P97305", "url": "http://purl.obolibrary.org/obo/PR_P97305", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-2025928", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2025928", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2871809", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871809", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5607763", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5607763", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "B5B2U1", "url": "https://www.uniprot.org/uniprot/B5B2U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B5B2U1-1", "url": "https://www.uniprot.org/uniprot/B5B2U1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B5B2U2", "url": "https://www.uniprot.org/uniprot/B5B2U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B5B2U2-1", "url": "https://www.uniprot.org/uniprot/B5B2U2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97305-1", "url": "https://www.uniprot.org/uniprot/P97305-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97305-2", "url": "https://www.uniprot.org/uniprot/P97305-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P97305-3", "url": "https://www.uniprot.org/uniprot/P97305-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UZ64", "url": "https://www.uniprot.org/uniprot/Q3UZ64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UZ64-1", "url": "https://www.uniprot.org/uniprot/Q3UZ64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQFTSISPNCQQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGGPHWEVEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGGLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAH", "length": 1075, "header": "sp|P97305-1|NFAC3_MOUSE Isoform 1 of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "isoforms": [ { "isoform_ac": "B5B2U1-1", "url": "", "sequence": { "sequence": "MQRPRRVLFSVSAQLPSRTRPGPSDLDLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGYKNYEGTGDISESKYSPLGGPKPFECPSIQITSISPNCHQGTDAHEDDLHINDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGSLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDDQFISDLEHQPSGSTEKWPNHSEFSCPVPFWRI", "length": 1060, "header": "tr|B5B2U1-1|NFAC3_MOUSE Computationally mapped isoform of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "locus": { "chromosome": "8", "start_pos": 106846051, "end_pos": 106785472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000211991.2", "url": "https://www.ensembl.org/id/ENSMUST00000211991.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000148556.2", "url": "https://www.ensembl.org/id/ENSMUSP00000148556.2" } ] } }, { "isoform_ac": "B5B2U2-1", "url": "", "sequence": { "sequence": "MQRPRRVLFSVSAQLPSRTRPGPSDLDLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGYKNYEGTGDISESKYSPLGGPKPFECPSIQITSISPNCHQGTDAHEDDLHINDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGSLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAQ", "length": 1068, "header": "tr|B5B2U2-1|NFAC3_MOUSE Computationally mapped isoform of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "locus": { "chromosome": "8", "start_pos": 106854671, "end_pos": 106785472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000212742.2", "url": "https://www.ensembl.org/id/ENSMUST00000212742.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000148551.2", "url": "https://www.ensembl.org/id/ENSMUSP00000148551.2" } ] } }, { "isoform_ac": "P97305-1", "url": "", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQFTSISPNCQQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGGPHWEVEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGGLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAH", "length": 1075, "header": "sp|P97305-1|NFAC3_MOUSE Isoform 1 of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "locus": {} }, { "isoform_ac": "P97305-2", "url": "", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQFTSISPNCQQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGGPHWEVEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGGLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDDQLISDLEHQPSGSTEKWSNHSEFSCPVPFWRI", "length": 1067, "header": "sp|P97305-2|NFAC3_MOUSE Isoform 2 of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "locus": {} }, { "isoform_ac": "P97305-3", "url": "", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQFTSISPNCQQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGGPHWEVEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGGLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAH", "length": 1045, "header": "sp|P97305-3|NFAC3_MOUSE Isoform 3 of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "locus": {} }, { "isoform_ac": "Q3UZ64-1", "url": "", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGYKNYEGTGDISESKYSPLGGPKPFECPSIQITSISPNCHQGTDAHEDDLHINDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGSLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAQ", "length": 1076, "header": "tr|Q3UZ64-1|Q3UZ64_MOUSE Computationally mapped isoform of Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 OS=Mus musculus OX=10090 GN=Nfatc3 PE=1 SV=1 CANONICAL=P97305-1" }, "locus": { "chromosome": "8", "start_pos": 106854671, "end_pos": 106786523, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000109308.3", "url": "https://www.ensembl.org/id/ENSMUST00000109308.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000104931.2", "url": "https://www.ensembl.org/id/ENSMUSP00000104931.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1065, "end_pos": 1065, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "site_lbl": "Ser1065" }, { "start_pos": 344, "end_pos": 344, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P97305", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P97305" } ], "site_lbl": "Ser344" }, { "start_pos": 372, "end_pos": 372, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "site_lbl": "Ser372" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.", "journal": "Cell", "date": "1999", "authors": "Crabtree G.R.", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "10089876", "url": "https://glygen.org/publication/PubMed/10089876" } ] }, { "title": "Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.", "journal": "Mol. Cell. Biol.", "date": "2002", "authors": "Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "12370307", "url": "https://glygen.org/publication/PubMed/12370307" } ] }, { "title": "NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.", "journal": "Circ. Res.", "date": "2003", "authors": "Bushdid PB, Osinska H, Waclaw RR, Molkentin JD, Yutzey KE", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "12750314", "url": "https://glygen.org/publication/PubMed/12750314" } ] }, { "title": "Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.", "journal": "Dev. Biol.", "date": "2007", "authors": "Yang XY, Yang TT, Schubert W, Factor SM, Chow CW", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "17198697", "url": "https://glygen.org/publication/PubMed/17198697" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" }, { "database": "iPTMnet", "id": "P97305", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P97305" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.", "journal": "Cell Death Differ.", "date": "2015", "authors": "Mojsa B, Mora S, Bossowski JP, Lassot I, Desagher S", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "25215946", "url": "https://glygen.org/publication/PubMed/25215946" } ] }, { "title": "Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.", "journal": "European heart journal", "date": "2021", "authors": "Liu X, Guo JW, Lin XC, Tuo YH, Peng WL, He SY, Li ZQ, Ye YC, Yu J, Zhang FR, Ma MM, Shang JY, Lv XF, Zhou AD, Ouyang Y, Wang C, Pang RP, Sun JX, Ou JS, Zhou JG, Liang SJ", "evidence": [ { "database": "RefSeq", "id": "NP_035031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031" } ], "reference": [ { "type": "PubMed", "id": "34570211", "url": "https://glygen.org/publication/PubMed/34570211" } ] }, { "title": "Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors.", "journal": "Molecular and cellular biology", "date": "2022-11-17", "authors": "Pal Debosree, Dutta Sangeeta, Iyer Dhanur P, Shriram Deepika, Bhaduri Utsa, Rao M R S", "evidence": [ { "database": "RefSeq", "id": "NP_035031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035031" } ], "reference": [ { "type": "PubMed", "id": "36317923", "url": "https://glygen.org/publication/PubMed/36317923" } ] }, { "title": "NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.", "journal": "J. Biol. Chem.", "date": "1995", "authors": "Crabtree G.R., Francke U., Li X., Ho S.N., Thomas D.J., Timmerman L.A.", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "7650004", "url": "https://glygen.org/publication/PubMed/7650004" } ] }, { "title": "Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.", "journal": "Mol. Biol. Cell", "date": "1997", "authors": "Liu J., Arai K., Yokota T., Ikeuchi T., Saito-Ohara F., Takano T., Arai N., Imai S., Koyano-Nakagawa N., Amasaki Y.", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "reference": [ { "type": "PubMed", "id": "9017603", "url": "https://glygen.org/publication/PubMed/9017603" } ] } ], "pathway": [ { "id": "R-MMU-2025928", "name": "Calcineurin activates NFAT", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2025928", "resource": "Reactome", "description": "Calcineurin activates NFAT" }, { "id": "R-MMU-2871809", "name": "FCERI mediated Ca+2 mobilization", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871809", "resource": "Reactome", "description": "FCERI mediated Ca+2 mobilization" }, { "id": "R-MMU-5607763", "name": "CLEC7A (Dectin-1) induces NFAT activation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5607763", "resource": "Reactome", "description": "CLEC7A (Dectin-1) induces NFAT activation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTY4-1", "protein_name": "Nuclear factor of activated T-cells 3", "gene_name": "Nfatc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ", "length": 1076 }, "evidence": [ { "id": "45234943", "url": "http://www.informatics.jax.org/homology/45234943", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q12968-1", "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 3", "gene_name": "NFATC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL", "length": 1075 }, "evidence": [ { "id": "45234943", "url": "http://www.informatics.jax.org/homology/45234943", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "negative regulation of vascular associated smooth muscle cell differentiation", "id": "GO:1905064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905064", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "myotube cell development", "id": "GO:0014904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014904", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell differentiation", "id": "GO:0035886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035886", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "blood vessel remodeling", "id": "GO:0001974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "cardiac muscle hypertrophy in response to stress", "id": "GO:0014898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014898", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell development", "id": "GO:0097084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097084", "evidence": [ { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305" } ], "pmid": "" }, { "name": "regulation of store-operated calcium entry", "id": "GO:2001256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001256", "evidence": [ { 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