{
    "uniprot_canonical_ac": "P91659-1",
    "uniprot_ac": "P91659",
    "uniprot_id": "P91659_DROME",
    "mass": {
        "chemical_mass": 68727.0,
        "monoisotopic_mass": 68727.0
    },
    "refseq": {
        "ac": "NP_001189331",
        "name": "uncharacterized protein, isoform B",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189331"
    },
    "gene_names": [
        {
            "name": "Dmel\\CG2187",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "id": "P91659"
        },
        {
            "name": "CG2187",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189331",
            "id": "NP_001189331"
        },
        {
            "name": "CG2187",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "id": "P91659"
        },
        {
            "name": "D3-100EF",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "id": "P91659"
        },
        {
            "name": "Dmel_CG2187",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "id": "P91659"
        },
        {
            "name": "anon-100EF-D3; D3-100EF; Dmel\\CG2187; dSLC5A6",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189331",
            "id": "NP_001189331"
        },
        {
            "name": "anon-100EF-D3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "id": "P91659"
        },
        {
            "name": "dSLC5A6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "id": "P91659"
        }
    ],
    "protein_names": [
        {
            "name": "CG2187-PB",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189331",
            "id": "NP_001189331"
        },
        {
            "name": "Uncharacterized protein D3-100EF",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P91659"
        },
        {
            "name": "Uncharacterized protein, isoform A",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P91659"
        },
        {
            "name": "Uncharacterized protein, isoform B",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P91659"
        },
        {
            "name": "uncharacterized protein, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189331",
            "id": "NP_001189331"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050328",
            "recommended_name": {
                "id": "DOID:0050328",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050328",
                "name": "congenital hypothyroidism",
                "description": "A hypothyroidism that is present at birth."
            },
            "synonyms": [
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism due to TSH receptor mutations",
                    "description": "Hypothyroidism due to thyroid-stimulating hormone (TSH) receptor mutations is a type of primary congenital hypothyroidism, a permanent thyroid hormone deficiency that is present from birth due to thyroid resistance to TSH."
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "CHNG1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "TSH resistance",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, congenital, nongoitrous, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "congenital nongoitrous hypothryoidism 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "congenital nongoitrous hypothyroidism 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism due to unresponsiveness to thyrotropin",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, Nonautoimmune",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, congenital, due to TSH resistance",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, congenital, nongoitrous, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "thyroid-stimulating hormone, resistance to",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "thyrotropin resistance",
                    "description": ""
                },
                {
                    "id": "MIM:275200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/275200",
                    "name": "Hypothyroidism, congenital, non-goitrous, 1",
                    "description": "Hypothyroidism, congenital, non-goitrous, 1"
                }
            ],
            "evidence": [
                {
                    "id": "0050328",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050328"
                }
            ]
        },
        {
            "disease_id": "DOID:0112185",
            "recommended_name": {
                "id": "DOID:0112185",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112185",
                "name": "thyroid dyshormonogenesis 1",
                "description": "A familial thyroid dyshormonogenesis that has_material_basis_in homozygous or compound heterozygous mutation in SLC5A5 on chromosome 19p13.11."
            },
            "synonyms": [
                {
                    "id": "DOID:0112185",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112185",
                    "name": "TDH1",
                    "description": ""
                },
                {
                    "id": "DOID:0112185",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112185",
                    "name": "genetic defect in thyroid hormonogenesis 1",
                    "description": ""
                },
                {
                    "id": "DOID:0112185",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112185",
                    "name": "iodide accumulation, transport, or trapping defect",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "familial thyroid dyshormonogenesis 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "TDH1",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "hypothyroidism, congenital, due to dyshormonogenesis, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "iodine accumulation, transport, or trapping defect",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "thyroid dyshormonogenesis 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "thyroid dyshormonogenesis type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0020716",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020716",
                    "name": "thyroid hormonogenesis, genetic defect in, 1",
                    "description": ""
                },
                {
                    "id": "MIM:274400",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/274400",
                    "name": "Thyroid dyshormonogenesis 1",
                    "description": "Thyroid dyshormonogenesis 1"
                }
            ],
            "evidence": [
                {
                    "id": "0112185",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112185"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P91659",
                    "url": "https://www.uniprot.org/uniprot/P91659"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "Dmel\\CG2187",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "locus": {
                "chromosome": "3R",
                "start_pos": 31755356,
                "end_pos": 31758637,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0017448",
                        "url": "https://www.ensembl.org/id/FBgn0017448"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0017448",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0017448",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd11492",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11492",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FBgn0017448",
            "url": "https://flybase.org/reports/FBgn0017448",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "43743",
            "url": "https://www.ncbi.nlm.nih.gov/gene/43743",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P91659",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P91659*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001734",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001734",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038377",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038377",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG2187",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG2187",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "TDFVVFT",
            "url": "https://omabrowser.org/oma/group/TDFVVFT/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2970519at2759",
            "url": "http://www.orthodb.org/?query=2970519at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR42985",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42985",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR42985:SF21",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42985:SF21",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00474",
            "url": "http://pfam.xfam.org/family/PF00474",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-197264",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-197264",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-209968",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-209968",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DME-428643",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-428643",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001189331",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189331",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P91659",
            "url": "https://www.uniprot.org/uniprot/P91659",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P91659-1",
            "url": "https://www.uniprot.org/uniprot/P91659-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSTTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVGVLGTIRSGGMFTVMERASDGGRFNFDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIVVVMGGYCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLPVTDQDLEEVPLRGSKVAATPDLRIEPTEKEKQTVTEP",
        "length": 623,
        "header": "tr|P91659-1|P91659_DROME Isoform 1 of Uncharacterized protein D3-100EF  OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG2187 PE=2 SV=1 CANONICAL=P91659-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P91659-1",
            "url": "",
            "sequence": {
                "sequence": "MSTTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVGVLGTIRSGGMFTVMERASDGGRFNFDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIVVVMGGYCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLPVTDQDLEEVPLRGSKVAATPDLRIEPTEKEKQTVTEP",
                "length": 623,
                "header": "tr|P91659-1|P91659_DROME Isoform 1 of Uncharacterized protein D3-100EF  OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG2187 PE=2 SV=1 CANONICAL=P91659-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 31758007,
                "end_pos": 31755437,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0303376",
                        "url": "https://www.ensembl.org/id/FBtr0303376"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0292438",
                        "url": "https://www.ensembl.org/id/FBpp0292438"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The genome sequence of Drosophila melanogaster.",
            "journal": "Science",
            "date": "2000",
            "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P91659",
                    "url": "https://www.uniprot.org/uniprot/P91659"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10731132",
                    "url": "https://glygen.org/publication/PubMed/10731132"
                }
            ]
        },
        {
            "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P91659",
                    "url": "https://www.uniprot.org/uniprot/P91659"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537568",
                    "url": "https://glygen.org/publication/PubMed/12537568"
                }
            ]
        },
        {
            "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.",
            "journal": "Genome Biol.",
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