{ "uniprot_canonical_ac": "P84444-1", "uniprot_ac": "P84444", "uniprot_id": "CC21A_MOUSE", "mass": { "chemical_mass": 14558.0, "monoisotopic_mass": 14558.0 }, "refseq": {}, "gene_names": [ { "name": "Ccl21a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P84444", "id": "P84444" }, { "name": "Scya21a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P84444", "id": "P84444" }, { "name": "Scya21", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P84444", "id": "P84444" } ], "protein_names": [ { "name": "C-C motif chemokine 21a", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P84444" }, { "name": "6Ckine", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P84444" }, { "name": "Beta-chemokine exodus-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P84444" }, { "name": "Small-inducible cytokine A21a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P84444" }, { "name": "TCA4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P84444" }, { "name": "Thymus-derived chemotactic agent 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P84444" } ], "function": [ { "annotation": "Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444#function" } ] } ], "disease": [ { "disease_id": "DOID:3770", "recommended_name": { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation." }, "synonyms": [ { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "Fibrosis of lung", "description": "" } ], "evidence": [ { "id": "3770", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ccl21a", "url": "https://www.uniprot.org/uniprot/P84444", "locus": { "chromosome": "4", "start_pos": 42772860, "end_pos": 42773993, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000094686", "url": "https://www.ensembl.org/id/ENSMUSG00000094686" } ] } } ], "crossref": [ { "id": "ENSMUSG00000094686", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000094686", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "18829", "url": "https://www.ncbi.nlm.nih.gov/gene/18829", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:18829", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18829", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1349183", "url": "http://www.informatics.jax.org/marker/MGI:1349183", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CKRTEQP", "url": "https://omabrowser.org/oma/group/CKRTEQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5265378at2759", "url": "http://www.orthodb.org/?query=5265378at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "http://pfam.xfam.org/family/PF00048", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P84444", "url": "http://purl.obolibrary.org/obo/PR_P84444", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-380108", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380108", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001180596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P84444-1", "url": "https://www.uniprot.org/uniprot/P84444-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFSPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPGCRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG", "length": 133, "header": "sp|P84444-1|CC21A_MOUSE Isoform 1 of C-C motif chemokine 21a OS=Mus musculus OX=10090 GN=Ccl21a PE=1 SV=1 CANONICAL=P84444-1" }, "isoforms": [ { "isoform_ac": "P84444-1", "url": "", "sequence": { "sequence": "MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFSPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPGCRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG", "length": 133, "header": "sp|P84444-1|CC21A_MOUSE Isoform 1 of C-C motif chemokine 21a OS=Mus musculus OX=10090 GN=Ccl21a PE=1 SV=1 CANONICAL=P84444-1" }, "locus": { "chromosome": "4", "start_pos": 42773918, "end_pos": 42773256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000095114", "url": "https://www.ensembl.org/id/ENSMUST00000095114" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000092732", "url": "https://www.ensembl.org/id/ENSMUSP00000092732" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes.", "journal": "J. Exp. Med.", "date": "1999", "authors": "Zlotnik A., Kakiuchi T., Nakano H., Soto H., Hedrick J.A., Vassileva G., Lira S.A.", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "reference": [ { "type": "PubMed", "id": "10523616", "url": "https://glygen.org/publication/PubMed/10523616" } ] }, { "title": "Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.", "journal": "J. Immunol.", "date": "2001", "authors": "Nakano H, Gunn MD", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "reference": [ { "type": "PubMed", "id": "11123313", "url": "https://glygen.org/publication/PubMed/11123313" } ] }, { "title": "Identification and characterization of a novel beta chemokine containing six conserved cysteines.", "journal": "J. Immunol.", "date": "1997", "authors": "Zlotnik A., Hedrick J.A.", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "reference": [ { "type": "PubMed", "id": "9257816", "url": "https://glygen.org/publication/PubMed/9257816" } ] }, { "title": "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1998", "authors": "Williams L.T., Tam C., Cyster J.G., Gunn M.D., Rosen S.D., Tangemann K.", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "reference": [ { "type": "PubMed", "id": "9419363", "url": "https://glygen.org/publication/PubMed/9419363" } ] }, { "title": "Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.", "journal": "J. Immunol.", "date": "1997", "authors": "Tanabe S, Lu Z, Luo Y, Quackenbush EJ, Berman MA, Collins-Racie LA, Mi S, Reilly C, Lo D, Jacobs KA, Dorf ME", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "reference": [ { "type": "PubMed", "id": "9548511", "url": "https://glygen.org/publication/PubMed/9548511" } ] } ], "pathway": [ { "id": "mmu:18829", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18829", "resource": "KEGG Pathway" }, { "id": "R-MMU-380108", "name": "Chemokine receptors bind chemokines", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380108", "resource": "Reactome", "description": "Chemokine receptors bind chemokines" }, { "id": "R-MMU-418594", "name": "G alpha (i) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A6IIY7-1", "protein_name": "Chemokine (C-C motif) ligand 21b (Serine)", "gene_name": "Ccl21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQMLALSLLSLVLVLCVPWTQGSDGGGQDCCLRYSQKKIPYNIVRGYRKQEPSLGCPIPAILFAPRKQSQPELCANPEEAWVQKLMRRLDQPPAPGKQNCRKNRGTSKSGKKGRGSKGCKGTEQTDSKRVSQ", "length": 133 }, "evidence": [ { "id": "45230712", "url": "http://www.informatics.jax.org/homology/45230712", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O00585-1", "protein_name": "C-C motif chemokine 21", "gene_name": "CCL21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP", "length": 134 }, "evidence": [ { "id": "45230712", "url": "http://www.informatics.jax.org/homology/45230712", "database": "MGI" }, { "id": "P84444", "url": "https://omabrowser.org/oma/group/P84444/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 52, "go_terms": [ { "name": "cellular response to chemokine", "id": "GO:1990869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990869", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "negative regulation of dendritic cell apoptotic process", "id": "GO:2000669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000669", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of T cell chemotaxis", "id": "GO:0010820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010820", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of protein kinase B signaling", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "id": "GO:0061844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "chemokine-mediated signaling pathway", "id": "GO:0070098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070098", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of T cell migration", "id": "GO:2000406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000406", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of protein kinase activity", "id": "GO:0045860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045860", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of cell adhesion mediated by integrin", "id": "GO:0033630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033630", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "lymphocyte chemotaxis", "id": "GO:0048247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048247", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of I-kappaB kinase/NF-kappaB signaling", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "release of sequestered calcium ion into cytosol", "id": "GO:0051209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051209", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "cell chemotaxis", "id": "GO:0060326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of pseudopodium assembly", "id": "GO:0031274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031274", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "ruffle organization", "id": "GO:0031529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031529", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of receptor-mediated endocytosis", "id": "GO:0048260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048260", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "activation of GTPase activity", "id": "GO:0090630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "dendritic cell chemotaxis", "id": "GO:0002407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002407", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of cell motility", "id": "GO:2000147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000147", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "killing of cells of another organism", "id": "GO:0031640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of filopodium assembly", "id": "GO:0051491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "monocyte chemotaxis", "id": "GO:0002548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002548", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase activity", "id": "GO:0043552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043552", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "cell maturation", "id": "GO:0048469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048469", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "induction of positive chemotaxis", "id": "GO:0050930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050930", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { "name": "cellular response to interleukin-1", "id": "GO:0071347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071347", "evidence": [ { "database": "UniProtKB", "id": "P84444", "url": "https://www.uniprot.org/uniprot/P84444" } ], "pmid": "" }, { 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