{ "uniprot_canonical_ac": "P78329-1", "uniprot_ac": "P78329", "uniprot_id": "CP4F2_HUMAN", "mass": { "chemical_mass": 59853.0, "monoisotopic_mass": 59853.0 }, "refseq": { "ac": "NP_001073", "name": "cytochrome P450 4F2 precursor", "summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" }, "gene_names": [ { "name": "CYP4F2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P78329", "id": "P78329" }, { "name": "CPF2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073", "id": "NP_001073" }, { "name": "CYP4F2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073", "id": "NP_001073" }, { "name": "hCG_1788543", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P78329", "id": "P78329" } ], "protein_names": [ { "name": "Cytochrome P450 4F2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P78329" }, { "name": "1.14.14.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "1.14.14.78", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "1.14.14.79", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "1.14.14.94", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "20-HETE synthase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "20-hydroxyeicosatetraenoic acid synthase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "Arachidonic acid omega-hydroxylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "CYPIVF2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "Cytochrome P450-LTB-omega", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "Docosahexaenoic acid omega-hydroxylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "Leukotriene-B(4) 20-monooxygenase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "Leukotriene-B(4) omega-hydroxylase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "Phylloquinone omega-hydroxylase CYP4F2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P78329" }, { "name": "cytochrome P450 4F2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073", "id": "NP_001073" }, { "name": "cytochrome P450, subfamily IVF, polypeptide 2; leukotriene-B(4) omega-hydroxylase 1; CYPIVF2; cytochrome P450 4F2; cytochrome P450-LTB-omega; leukotriene-B(4) 20-monooxygenase 1; 20-HETE synthase; arachidonic acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; phylloquinone omega-hydroxylase CYP4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; docosahexaenoic acid omega-hydroxylase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073", "id": "NP_001073" } ], "function": [ { "annotation": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531).", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329#function" }, { "database": "PubMed", "id": "24138531", "url": "https://glygen.org/publication/PubMed/24138531" }, { "database": "PubMed", "id": "8026587", "url": "https://glygen.org/publication/PubMed/8026587" }, { "database": "PubMed", "id": "17341693", "url": "https://glygen.org/publication/PubMed/17341693" }, { "database": "PubMed", "id": "19297519", "url": "https://glygen.org/publication/PubMed/19297519" }, { "database": "PubMed", "id": "9799565", "url": "https://glygen.org/publication/PubMed/9799565" }, { "database": "PubMed", "id": "10833273", "url": "https://glygen.org/publication/PubMed/10833273" }, { "database": "PubMed", "id": "10660572", "url": "https://glygen.org/publication/PubMed/10660572" }, { "database": "PubMed", "id": "15145985", "url": "https://glygen.org/publication/PubMed/15145985" }, { "database": "PubMed", "id": "18182499", "url": "https://glygen.org/publication/PubMed/18182499" }, { "database": "PubMed", "id": "18065749", "url": "https://glygen.org/publication/PubMed/18065749" }, { "database": "PubMed", "id": "18574070", "url": "https://glygen.org/publication/PubMed/18574070" }, { "database": "PubMed", "id": "16547005", "url": "https://glygen.org/publication/PubMed/16547005" }, { "database": "PubMed", "id": "18577768", "url": "https://glygen.org/publication/PubMed/18577768" }, { "database": "PubMed", "id": "11997390", "url": "https://glygen.org/publication/PubMed/11997390" } ] }, { "annotation": "CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.", "evidence": [ { "database": "RefSeq", "id": "NP_001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" }, { "database": "PubMed", "id": "37121548", "url": "https://glygen.org/publication/PubMed/37121548" } ] }, { "annotation": "Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" }, { "database": "PubMed", "id": "37161313", "url": "https://glygen.org/publication/PubMed/37161313" } ] }, { "annotation": "Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.", "evidence": [ { "database": "RefSeq", "id": "NP_001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" }, { "database": "PubMed", "id": "37505171", "url": "https://glygen.org/publication/PubMed/37505171" } ] }, { "annotation": "Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" }, { "database": "PubMed", "id": "36634101", "url": "https://glygen.org/publication/PubMed/36634101" } ] }, { "annotation": "The frequency of cytochrome 4F2 rs2108622 genetic variant and its effects on the lipid profile and complications of type II diabetes among a sample of patients in Jordan: A pilot study.", "evidence": [ { "database": "RefSeq", "id": "NP_001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" }, { "database": "PubMed", "id": "36758722", "url": "https://glygen.org/publication/PubMed/36758722" } ] }, { "annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073" } ] } ], "disease": [ { "disease_id": "DOID:0080665", "recommended_name": { "id": "DOID:0080665", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080665", "name": "warfarin resistance", "description": "An inherited metabolic disorder that is characterized by a high tolerance for the drug warfarin." }, "synonyms": [ { "id": "MONDO:0007390", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007390", "name": "coumarin resistance", "description": "" }, { "id": "MONDO:0007390", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007390", "name": "coumarin resistance", "description": "" }, { "id": "MONDO:0007390", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007390", "name": "coumarin sensitivity", "description": "" }, { "id": "MONDO:0007390", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007390", "name": "coumarin, poor metabolism of", "description": "" }, { "id": "MONDO:0007390", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007390", "name": "warfarin resistance", "description": "" }, { "id": "MONDO:0007390", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007390", "name": "warfarin sensitivity", "description": "" }, { "id": "MIM:122700", "resource": "MIM", "url": "https://www.omim.org/entry/122700", "name": "Coumarin resistance", "description": "Coumarin resistance" } ], "evidence": [ { "id": "122700", "database": "MIM", "url": "https://www.omim.org/entry/122700" } ] } ], "snv": [ { "evidence": [ { "id": "P78329", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P78329" } ], "glycoeffect": [], "start_pos": 224, "end_pos": 224, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", "chr_id": "19", "chr_pos": "15889671", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A224", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P78329", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P78329" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P78329", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P78329" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "common_name": "Human" } ], "gene": [ { "name": "CYP4F2", "url": "https://www.uniprot.org/uniprot/P78329", "locus": { "chromosome": "19", "start_pos": 15878023, "end_pos": 15898077, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000186115", "url": "https://www.ensembl.org/id/ENSG00000186115" } ] } } ], "crossref": [ { "id": "ENSG00000186115", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186115", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P78329", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P78329", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "1.14.14.94", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.14.94&UniProtAcc=P78329", "database": 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"A0A0A0MQR0-1", "url": "https://www.uniprot.org/uniprot/A0A0A0MQR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EK90", "url": "https://www.uniprot.org/uniprot/K7EK90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EK90-1", "url": "https://www.uniprot.org/uniprot/K7EK90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EPM0", "url": "https://www.uniprot.org/uniprot/K7EPM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EPM0-1", "url": "https://www.uniprot.org/uniprot/K7EPM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EQI8", "url": "https://www.uniprot.org/uniprot/K7EQI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EQI8-1", "url": "https://www.uniprot.org/uniprot/K7EQI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P78329-1", "url": "https://www.uniprot.org/uniprot/P78329-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P78329-2", "url": "https://www.uniprot.org/uniprot/P78329-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS", "length": 520, "header": "sp|P78329-1|CP4F2_HUMAN Isoform 1 of Cytochrome P450 4F2 OS=Homo sapiens OX=9606 GN=CYP4F2 PE=1 SV=1 CANONICAL=P78329-1" }, "isoforms": [ { "isoform_ac": "A0A0A0MQR0-1", "url": "", "sequence": { "sequence": "MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMIHSSEEGLLYTQSLACTFGDMGCWWVGPWQAVIHIFLPTCIKPVLFAPAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS", "length": 520, "header": "tr|A0A0A0MQR0-1|A0A0A0MQR0_HUMAN Computationally mapped isoform of Cytochrome P450, family 4, subfamily F, polypeptide 2, isoform CRA_a OS=Homo sapiens OX=9606 GN=CYP4F2 PE=1 SV=1 CANONICAL=P78329-1" }, "locus": { "chromosome": "19", "start_pos": 15897611, "end_pos": 15878774, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000011989.11", "url": "https://www.ensembl.org/id/ENST00000011989.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000011989.8", "url": "https://www.ensembl.org/id/ENSP00000011989.8" } ] } }, { "isoform_ac": "K7EK90-1", "url": "", "sequence": { "sequence": "MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTP", "length": 153, "header": "tr|K7EK90-1|K7EK90_HUMAN Computationally mapped isoform of Cytochrome P450 family 4 subfamily F member 2 OS=Homo sapiens OX=9606 GN=CYP4F2 PE=1 SV=8 CANONICAL=P78329-1" }, "locus": { "chromosome": "19", "start_pos": 15897611, "end_pos": 15892375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586927.2", "url": "https://www.ensembl.org/id/ENST00000586927.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000465514.1", "url": "https://www.ensembl.org/id/ENSP00000465514.1" } ] } }, { "isoform_ac": "K7EPM0-1", "url": "", "sequence": { "sequence": "MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMLPLHQRTSSSTASWSPGWGMGSC", "length": 89, "header": "tr|K7EPM0-1|K7EPM0_HUMAN Computationally mapped isoform of Cytochrome P450 family 4 subfamily F member 2 OS=Homo sapiens OX=9606 GN=CYP4F2 PE=4 SV=2 CANONICAL=P78329-1" }, "locus": { "chromosome": "19", "start_pos": 15897611, "end_pos": 15892422, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587671.2", "url": "https://www.ensembl.org/id/ENST00000587671.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000467443.2", "url": "https://www.ensembl.org/id/ENSP00000467443.2" } ] } }, { "isoform_ac": "K7EQI8-1", "url": "", "sequence": { "sequence": "XWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWSTTPFALTQRTSRRGHLWLLFPSRQGPGTASGRRSRWRR", "length": 74, "header": "tr|K7EQI8-1|K7EQI8_HUMAN Computationally mapped isoform of Cytochrome P450 family 4 subfamily F member 2 OS=Homo sapiens OX=9606 GN=CYP4F2 PE=3 SV=1 CANONICAL=P78329-1" }, "locus": { "chromosome": "19", "start_pos": 15886025, "end_pos": 15878900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000589654.2", "url": "https://www.ensembl.org/id/ENST00000589654.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000467846.1", "url": "https://www.ensembl.org/id/ENSP00000467846.1" } ] } }, { "isoform_ac": "P78329-1", "url": "", "sequence": { "sequence": "MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS", "length": 520, "header": "sp|P78329-1|CP4F2_HUMAN Isoform 1 of Cytochrome P450 4F2 OS=Homo sapiens OX=9606 GN=CYP4F2 PE=1 SV=1 CANONICAL=P78329-1" }, "locus": { "chromosome": "19", "start_pos": 15897611, "end_pos": 15878774, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000221700.11", "url": "https://www.ensembl.org/id/ENST00000221700.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000221700.3", "url": "https://www.ensembl.org/id/ENSP00000221700.3" } ] } }, { "isoform_ac": "P78329-2", "url": "", "sequence": { "sequence": "MLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKAMTPRPVVSPGSCTTLQSTQNTRSAAGRRCKNF", "length": 190, "header": "sp|P78329-2|CP4F2_HUMAN Isoform 2 of Cytochrome P450 4F2 OS=Homo sapiens OX=9606 GN=CYP4F2 PE=1 SV=1 CANONICAL=P78329-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.", "journal": "Journal of lipid research", "date": "1999", "authors": "Sjolinder M, Tornhamre S, Claesson HE, Hydman J, Lindgren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142691" } ], "reference": [ { "type": "PubMed", "id": "10064732", "url": "https://glygen.org/publication/PubMed/10064732" } ] }, { "title": "Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Bylund J, Finnstrom N, Oliw EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-211979", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211979" } ], "reference": [ { "type": "PubMed", "id": "10405341", "url": "https://glygen.org/publication/PubMed/10405341" } ] }, { "title": "Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.", "journal": "DNA Cell Biol.", "date": "1999", "authors": "Kikuta Y., Kusunose E., Kusunose M., Miyauchi Y.", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "reference": [ { "type": "PubMed", "id": "10492403", "url": "https://glygen.org/publication/PubMed/10492403" } ] }, { "title": "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11.", "journal": "J. Biol. 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"MPQLDLSWLGLRLETSLPWLLLLLIGASWLLVRVLTQTYIFYRTYQHLCDFPQPPKWNWFLGHLGMITPTEQGLKQVTKLVATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHKACKLVHNFTDAVIQGRRRALPSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ", "length": 522 }, "evidence": [ { "id": "45234382", "url": "http://www.informatics.jax.org/homology/45234382", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P98187-1", "protein_name": "Cytochrome P450 4F8", "gene_name": "CYP4F8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG", "length": 520 }, "evidence": [ { "id": "45234382", "url": "http://www.informatics.jax.org/homology/45234382", "database": "MGI" }, { "id": "45234381", "url": "http://www.informatics.jax.org/homology/45234381", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q08477-1", "protein_name": "Cytochrome P450 4F3", "gene_name": "CYP4F3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS", "length": 520 }, "evidence": [ { "id": "45234384", "url": "http://www.informatics.jax.org/homology/45234384", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q3MID2-1", "protein_name": "Cytochrome P450 4F3", "gene_name": "Cyp4f3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLLSLSWLGLGHTAASPWLLLLLVGASCLLAYILPQVYAVFENSRRLRRFPQPPPRNWLFGHLGLIQSSEEGLLYIQSLSRTFRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLRPWLGDGLLLSTGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQSLLLHVDLFYHLTRDGMRFRKACRLVHDFTDAVIRERRCTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSAGAH", "length": 524 }, "evidence": [ { "id": "45234384", "url": "http://www.informatics.jax.org/homology/45234384", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99N16-1", "protein_name": "Cytochrome P450 4F3", "gene_name": "Cyp4f3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDAVIRERRRTLLDQGGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDPFRFDADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLKVEPLSAGAQ", "length": 524 }, "evidence": [ { "id": "45234384", "url": "http://www.informatics.jax.org/homology/45234384", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99N18-1", "protein_name": "Cytochrome P450, family 4, subfamily f, polypeptide 15", "gene_name": "Cyp4f15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFFRMPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGMITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFDSNCQENPSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHSFTDAVIQDRRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ", "length": 534 }, "evidence": [ { "id": "45234382", "url": "http://www.informatics.jax.org/homology/45234382", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9EP75-1", "protein_name": "Leukotriene-B4 omega-hydroxylase 3", "gene_name": "Cyp4f14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLSAGAH", "length": 524 }, "evidence": [ { "id": "45234381", "url": "http://www.informatics.jax.org/homology/45234381", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HBI6-1", "protein_name": "Cytochrome P450 4F11", "gene_name": "CYP4F11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ", "length": 524 }, "evidence": [ { "id": "45234382", "url": "http://www.informatics.jax.org/homology/45234382", "database": "MGI" }, { "id": "45234381", "url": "http://www.informatics.jax.org/homology/45234381", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9HCS2-1", "protein_name": "Cytochrome P450 4F12", "gene_name": "CYP4F12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ", "length": 524 }, "evidence": [ { "id": "45234381", "url": "http://www.informatics.jax.org/homology/45234381", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 15, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "id": "GO:0016709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016709", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "aromatase activity", "id": "GO:0070330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "arachidonic acid epoxygenase activity", "id": "GO:0008392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "leukotriene-B4 20-monooxygenase activity", "id": "GO:0050051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050051", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "arachidonic acid omega-hydroxylase activity", "id": "GO:0052869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052869", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "alpha-tocopherol omega-hydroxylase activity", "id": "GO:0052871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052871", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "tocotrienol omega-hydroxylase activity", "id": "GO:0052872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052872", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "20-hydroxy-leukotriene B4 omega oxidase activity", "id": "GO:0097258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097258", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "20-aldehyde-leukotriene B4 20-monooxygenase activity", "id": "GO:0097259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097259", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "alkane 1-monooxygenase activity", "id": "GO:0018685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018685", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "long-chain fatty acid omega-hydroxylase activity", "id": "GO:0102033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102033", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "icosanoid metabolic process", "id": "GO:0006690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006690", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "omega-hydroxylase P450 pathway", "id": "GO:0097267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097267", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "very long-chain fatty acid metabolic process", "id": "GO:0000038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000038", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "long-chain fatty acid metabolic process", "id": "GO:0001676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "renal water homeostasis", "id": "GO:0003091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003091", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "regulation of blood pressure", "id": "GO:0008217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008217", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "fatty acid omega-oxidation", "id": "GO:0010430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010430", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "negative regulation of icosanoid secretion", "id": "GO:0032304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032304", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "leukotriene metabolic process", "id": "GO:0006691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006691", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "sodium ion homeostasis", "id": "GO:0055078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055078", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "phylloquinone catabolic process", "id": "GO:0042376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042376", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "arachidonic acid metabolic process", "id": "GO:0019369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019369", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "epoxygenase P450 pathway", "id": "GO:0019373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "pressure natriuresis", "id": "GO:0003095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003095", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "positive regulation of icosanoid secretion", "id": "GO:0032305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032305", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "leukotriene B4 catabolic process", "id": "GO:0036101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036101", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "vitamin E metabolic process", "id": "GO:0042360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042360", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "menaquinone catabolic process", "id": "GO:0042361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042361", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" }, { "name": "vitamin K catabolic process", "id": "GO:0042377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042377", "evidence": [ { "database": "UniProtKB", "id": "P78329", "url": "https://www.uniprot.org/uniprot/P78329" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17149", "name": "", "equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11711-1", "P05182-1", "A0A8I6A0P6-1", "P10633-1", "P51538-1", "P00176-1", "P05178-1", "P10610-1", "P13107-1", "P20812-1", "P33272-1", "P51870-1", "P00185-1", "Q64581-1", "P05179-1", "P51871-1", "P04167-1", "P04800-1", "P05183-1", "P10634-1", "P11510-1", "P12938-1", "P12939-1", "P15129-1", "P15149-1", "P20814-1", "P33273-1", "P51590-1", "Q64583-1", "Q64680-1", "P04799-1", "Q64678-1", "P08683-1", "P24464-1", "D4A820-1", "A0A0G2K5K4-1", "F1LT33-1", "G3V9D2-1", "Q9QXF7-1", "A0A8I5ZZ08-1", "P05181-1", "A0A087X1C5-1", "P08684-1", "P20853-1", "P04798-1", "P05177-1", "P33261-1", "Q86W10-1", "Q16678-1", "P98187-1", "P10632-1", "P11712-1", "P24462-1", "Q9HB55-1", "P13584-1", "Q16696-1", "Q9HCS2-1", "P33260-1", "Q02928-1", "Q08477-1", "Q9HBI6-1", "P78329-1", "P24903-1", "P20815-1", "Q6V0L0-1", "P20852-1", "O09158-1", "O55071-1", "Q64459-1", "Q64481-1", "O54749-1", "P11714-1", "P15392-1", "Q8CIM7-1", "P24456-1", "P56654-1", "P56655-1", "P56656-1", "P12791-1", "P56593-1", "O54750-1", "Q91WL5-1", "Q91X77-1", "Q64458-1", "P00186-1", "P00184-1", "Q05421-1", "Q6XVG2-1", "Q9D816-1", "P12790-1", "P24457-1", "Q9JMA7-1", "Q64462-1", "Q64464-1", "Q64429-1", "D3YYZ0-1", "D3Z2W7-1", "Q9WV19-1", "Q9DBX6-1", "B2RXZ2-1", "E9Q593-1", "A2A974-1", "A6H6J2-1", "Q9EQW4-1", "B2RXA7-1" ], "evidence": [ { "id": "17149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17149" } ] }, { "id": "22176", "name": "", "equation": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51869-1", "P33274-1", "Q08477-1", "P78329-1", "Q9EP75-1" ], "evidence": [ { "id": "22176", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22176" } ] }, { "id": "39043", "name": "", "equation": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q02928-1", "Q08477-1", "P78329-1" ], "evidence": [ { "id": "39043", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39043" } ] }, { "id": "39047", "name": "", "equation": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "39047", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39047" } ] }, { "id": "39055", "name": "", "equation": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q02928-1", "Q08477-1", "P78329-1" ], "evidence": [ { "id": "39055", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39055" } ] }, { "id": "39059", "name": "", "equation": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "39059", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39059" } ] }, { "id": "39719", "name": "", "equation": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "39719", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39719" } ] }, { "id": "39731", "name": "", "equation": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q02928-1", "Q08477-1", "Q9HBI6-1", "P78329-1" ], "evidence": [ { "id": "39731", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39731" } ] }, { "id": "39735", "name": "", "equation": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P78329-1" ], "evidence": [ { "id": "39735", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39735" } ] }, { "id": "39755", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51869-1", "P08516-1", "P33274-1", "Q4V8D1-1", "P24464-1", "Q02928-1", "Q08477-1", "Q9HBI6-1", "P78329-1", "Q7Z449-1", "Q91WL5-1", "O88833-1", "Q9CX98-1", "A2A974-1" ], "evidence": [ { "id": "39755", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39755" } ] }, { "id": "39791", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2RRT9-1", "Q08477-1", "P78329-1", "Q6ZWL3-1", "Q91WL5-1", "Q9DBW0-1", "A2A974-1" ], "evidence": [ { "id": "39791", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39791" } ] }, { "id": "40079", "name": "", "equation": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "40079", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40079" } ] }, { "id": "40083", "name": "", "equation": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "40083", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40083" } ] }, { "id": "40155", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2RRT9-1", "Q6ZWL3-1", "Q08477-1", "Q9HBI6-1", "P78329-1", "Q9DBW0-1" ], "evidence": [ { "id": "40155", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40155" } ] }, { "id": "41516", "name": "", "equation": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9HBI6-1", "P78329-1" ], "evidence": [ { "id": "41516", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41516" } ] }, { "id": "41520", "name": "", "equation": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9HBI6-1", "P78329-1" ], "evidence": [ { "id": "41520", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41520" } ] }, { "id": "45108", "name": "", "equation": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P78329-1" ], "evidence": [ { "id": "45108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45108" } ] }, { "id": "45112", "name": "", "equation": "gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P78329-1" ], "evidence": [ { "id": "45112", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45112" } ] }, { "id": "48648", "name": "", "equation": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P33274-1", "Q08477-1", "P78329-1" ], "evidence": [ { "id": "48648", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48648" } ] }, { "id": "48660", "name": "", "equation": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P33274-1", "Q08477-1", "Q9HBI6-1", "P78329-1" ], "evidence": [ { "id": "48660", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48660" } ] }, { "id": "48664", "name": "", "equation": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "48664", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48664" } ] }, { "id": "48676", "name": "", "equation": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51869-1", "P33274-1", "P78329-1" ], "evidence": [ { "id": "48676", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48676" } ] }, { "id": "49376", "name": "", "equation": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "49376", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49376" } ] }, { "id": "50164", "name": "", "equation": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "50164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50164" } ] }, { "id": "53552", "name": "", "equation": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P78329-1" ], "evidence": [ { "id": "53552", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53552" } ] }, { "id": "53556", "name": "", "equation": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q02928-1", "P78329-1" ], "evidence": [ { "id": "53556", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53556" } ] }, { "id": "53564", "name": "", "equation": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "53564", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53564" } ] }, { "id": "53568", "name": "", "equation": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "P78329-1" ], "evidence": [ { "id": "53568", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53568" } ] }, { "id": "53572", "name": "", "equation": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08516-1", "Q08477-1", "P78329-1", "O88833-1" ], "evidence": [ { "id": "53572", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53572" } ] }, { "id": "R-HSA-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "equation": "", "summary": "Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-266056" ], "output_participant_list": [ "R-ALL-2161636" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-211873", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211873" } ] }, { "id": "R-HSA-211904", "name": "CYP4F12 18-hydroxylates ARA", "equation": "", "summary": "Human CYP4F12 is involved in metabolism of endogenous compounds such as inflammatory mediators (arachidonic acid and prostaglandin H2) as well as xenobiotics like terfenadine (an antihistaminic drug) (Bylund et al. 2001). The omega-hydroxylation of arachidonic acid (ARA) is shown here to form 18-hydroxyarachidonic acid (18OH-ARA aka 18-HETE).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [], "output_participant_list": [ "R-ALL-352318" ], "enzyme_list": [ "Q9HCS2-1", "P78329-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-211904", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211904" } ] }, { "id": "R-HSA-211919", "name": "CYP4F8 19-hydroxylates PGH2", "equation": "", "summary": "19-hydroxyprostaglandins E1 and E2 (19OH-PGE1 and 2) are major components of human seminal fluid. The initial step in their formation is the 19-hydroxylation of prostaglandin H1 and H2 (PGH1 and 2). CYP4F8 performs this initial conversion (Bylund et al. 1999, 2000). The example of PGH2 is used here.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [], "output_participant_list": [ "R-ALL-215545" ], "enzyme_list": [ "Q9HCS2-1", "P78329-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-211919", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211919" } ] }, { "id": "R-HSA-211924", "name": "CYP4B1 12-hydroxylates ARA", "equation": "", "summary": "Injury to the eye's surface provokes an inflammatory response, mediated, in part, by 12-hydroxyeicosanoids. CYP4B1 catalyses the 12-hydroxylation of arachidonic acid (ARA) to 12-HETE and 12-HETrE (12-hydroxy-5,8,10,14-eicosatetraenoic acid and 12-hydroxy-5,8,14-eicosatrienoic acid respectively). Both these metabolites possess potent inflammatory and angiogenic properties (Ashkar et al. 2004). The example of 12-HETE formation only is shown here.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [], "output_participant_list": [ "R-ALL-215075" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-211924", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211924" } ] }, { "id": "R-HSA-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "equation": "", "summary": "Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-216621" ], "output_participant_list": [ "R-ALL-216612" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-211962", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211962" } ] }, { "id": "R-HSA-215526", "name": "CYP4F3 20-hydroxylates LTB4", "equation": "", "summary": "Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4). This deactivation can be carried out by CYP4F3 in addition to CYP4F2 (Kikuta et al. 1998).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-215557" ], "output_participant_list": [ "R-ALL-571314" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-215526", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-215526" } ] }, { "id": "R-HSA-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "equation": "", "summary": "The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-2161745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161745" } ] }, { "id": "R-HSA-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "equation": "", "summary": "The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise 20-aldehyde leukotriene B4 (20cho-LTB4) to form 20-carboxy leukotriene B4 (20cooh-LTB4) (Soberman et al. 1988).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-2142740" ], "output_participant_list": [ "R-ALL-2161582" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1", "P98187-1" ], "evidence": [ { "id": "R-HSA-2161792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161792" } ] }, { "id": "R-HSA-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "equation": "", "summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). The CYPs and their references are as follows: CYP4A11 (Gainer et al. 2005, Powell 1998); CYP4F2 (Powell et al. 1998, Kikuta et al. 2002); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2142780" ], "enzyme_list": [ "Q16678-1", "Q7Z449-1", "P04798-1", "P78329-1", "Q02928-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-2161940", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161940" } ] }, { "id": "R-HSA-76466", "name": "CYP4A11 12-hydroxylates DDCX", "equation": "", "summary": "Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-33549" ], "output_participant_list": [ "R-ALL-42373" ], "enzyme_list": [ "Q08477-1", "Q9HBI6-1", "P13584-1", "P78329-1", "Q02928-1", "Q5TCH4-1", "Q6NT55-1" ], "evidence": [ { "id": "R-HSA-76466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76466" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2142740", "participant_name": "20cho-LTB4 [cytosol]", "crossref": [ { "id": "HMDB0012641", "database": "HMDB Metabolite", "url": "" }, { "id": "000033985160", "database": "ZINC", "url": "" }, { "id": "63979", "database": "ChEBI", "url": "" }, { "id": "63979", "database": "ChEBI", "url": "" }, { "id": "HMDB0012641", "database": "HMDB Metabolite", "url": "" }, { "id": "000033985160", "database": "ZINC", "url": "" }, { "id": "63979", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] } ] }, { "uniprot_ac": "A2RRT9", "gene_name": "Cyp4v2", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A2RRT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RRT9" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A2RRT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RRT9" } ] } ] }, { "uniprot_ac": "A6H6J2", "gene_name": "Cyp2b13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] } ] }, { "uniprot_ac": "B2RXA7", "gene_name": "Cyp26c1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] } ] }, { 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"Cyp2s1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "D4A820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A820" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "D4A820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A820" } ] } ] }, { "uniprot_ac": "E9Q593", "gene_name": "Cyp2b23", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] } ] }, { "uniprot_ac": "F1LT33", "gene_name": "Cyp2b14", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "F1LT33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LT33" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "F1LT33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LT33" } ] } ] }, { "uniprot_ac": "G3V9D2", "gene_name": "Cyp2b21", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "G3V9D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "G3V9D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D2" } ] } ] }, { "uniprot_ac": "O09158", "gene_name": "Cyp3a25", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] } ] }, { "uniprot_ac": "O54749", "gene_name": "Cyp2j5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] } ] }, { "uniprot_ac": "O54750", "gene_name": "Cyp2j6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] } ] }, { "uniprot_ac": "O55071", "gene_name": "Cyp2b19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] } ] }, { "uniprot_ac": "O88833", "gene_name": "Cyp4a10", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O88833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88833" } ] } ] }, { "uniprot_ac": "P00176", "gene_name": "Cyp2b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00176" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00176" } ] } ] }, { "uniprot_ac": "P00184", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] } ] }, { "uniprot_ac": "P00185", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] } ] }, { "uniprot_ac": "P00186", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] } ] }, { "uniprot_ac": "P04167", "gene_name": "Cyp2b2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] } ] }, { "uniprot_ac": "P04798", "gene_name": "CYP1A1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] } ] }, { "uniprot_ac": "P04799", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] } ] }, { "uniprot_ac": "P04800", "gene_name": "Cyp3a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] } ] }, { "uniprot_ac": "P05177", "gene_name": "CYP1A2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] } ] }, { "uniprot_ac": "P05178", "gene_name": "Cyp2c6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] } ] }, { "uniprot_ac": "P05179", "gene_name": "Cyp2c7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] } ] }, { "uniprot_ac": "P05181", "gene_name": "CYP2E1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] } ] }, { "uniprot_ac": "P05182", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] } ] }, { "uniprot_ac": "P05183", "gene_name": "Cyp3a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] } ] }, { "uniprot_ac": "P08516", "gene_name": "Cyp4a10", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08516" } ] } ] }, { "uniprot_ac": "P08683", "gene_name": "Cyp2c11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] } ] }, { "uniprot_ac": "P08684", "gene_name": "CYP3A4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.55", "activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.56", "activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] } ] }, { "uniprot_ac": "P10610", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] } ] }, { "uniprot_ac": "P10632", "gene_name": "CYP2C8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] } ] }, { "uniprot_ac": "P10633", "gene_name": "Cyp2d1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] } ] }, { "uniprot_ac": "P10634", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] } ] }, { "uniprot_ac": "P11510", "gene_name": "Cyp2c12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] } ] }, { "uniprot_ac": "P11711", "gene_name": "Cyp2a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] } ] }, { "uniprot_ac": "P11712", "gene_name": "CYP2C9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] } ] }, { "uniprot_ac": "P11714", "gene_name": "Cyp2d9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] } ] }, { "uniprot_ac": "P12790", "gene_name": "Cyp2b9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] } ] }, { "uniprot_ac": "P12791", "gene_name": "Cyp2b10", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] } ] }, { "uniprot_ac": "P12938", "gene_name": "Cyp2d3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] } ] }, { "uniprot_ac": "P12939", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] } ] }, { "uniprot_ac": "P13107", "gene_name": "Cyp2b3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] } ] }, { "uniprot_ac": "P13584", "gene_name": "CYP4B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] } ] }, { "uniprot_ac": "P15129", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] } ] }, { "uniprot_ac": "P15149", "gene_name": "Cyp2a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] } ] }, { "uniprot_ac": "P15392", "gene_name": "Cyp2a4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] } ] }, { "uniprot_ac": "P20812", "gene_name": "Cyp2a3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] } ] }, { "uniprot_ac": "P20814", "gene_name": "Cyp2c13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] } ] }, { "uniprot_ac": "P20815", "gene_name": "CYP3A5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] } ] }, { "uniprot_ac": "P20852", "gene_name": "Cyp2a5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] } ] }, { "uniprot_ac": "P20853", "gene_name": "CYP2A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] } ] }, { "uniprot_ac": "P24456", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] } ] }, { "uniprot_ac": "P24457", "gene_name": "Cyp2d11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] } ] }, { "uniprot_ac": "P24462", "gene_name": "CYP3A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] } ] }, { "uniprot_ac": "P24464", "gene_name": "Cyp4a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] } ] }, { "uniprot_ac": "P24903", "gene_name": "CYP2F1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] } ] }, { "uniprot_ac": "P33260", "gene_name": "CYP2C18", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] } ] }, { "uniprot_ac": "P33261", "gene_name": "CYP2C19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.75", "activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] } ] }, { "uniprot_ac": "P33272", "gene_name": "Cyp2b12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] } ] }, { "uniprot_ac": "P33273", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] } ] }, { "uniprot_ac": "P33274", "gene_name": "Cyp4f1", "activity": [ { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33274" } ] } ] }, { "uniprot_ac": "P51538", "gene_name": "Cyp3a9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] } ] }, { "uniprot_ac": "P51590", "gene_name": "Cyp2j3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] } ] }, { "uniprot_ac": "P51869", "gene_name": "Cyp4f4", "activity": [ { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51869" } ] } ] }, { "uniprot_ac": "P51870", "gene_name": "Cyp4f5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] } ] }, { "uniprot_ac": "P51871", "gene_name": "Cyp4f6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] } ] }, { "uniprot_ac": "P56593", "gene_name": "Cyp2a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] } ] }, { "uniprot_ac": "P56654", "gene_name": "Cyp2c37", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] } ] }, { "uniprot_ac": "P56655", "gene_name": "Cyp2c38", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] } ] }, { "uniprot_ac": "P56656", "gene_name": "Cyp2c39", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] } ] }, { "uniprot_ac": "P78329", "gene_name": "CYP4F2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] } ] }, { "uniprot_ac": "P98187", "gene_name": "CYP4F8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] } ] }, { "uniprot_ac": "Q02928", "gene_name": "CYP4A11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] } ] }, { "uniprot_ac": "Q05421", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] } ] }, { "uniprot_ac": "Q08477", "gene_name": "CYP4F3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] } ] }, { "uniprot_ac": "Q16678", "gene_name": "CYP1B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] } ] }, { "uniprot_ac": "Q16696", "gene_name": "CYP2A13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] } ] }, { "uniprot_ac": "Q4V8D1", "gene_name": "Cyp2u1", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q4V8D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8D1" } ] } ] }, { "uniprot_ac": "Q5TCH4", "gene_name": "CYP4A22", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q5TCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TCH4" } ] } ] }, { "uniprot_ac": "Q64429", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] } ] }, { "uniprot_ac": "Q64458", "gene_name": "Cyp2c29", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] } ] }, { "uniprot_ac": "Q64459", "gene_name": "Cyp3a11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] } ] }, { "uniprot_ac": "Q64462", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] } ] }, { "uniprot_ac": "Q64464", "gene_name": "Cyp3a13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] } ] }, { "uniprot_ac": "Q64481", "gene_name": "Cyp3a16", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] } ] }, { "uniprot_ac": "Q64581", "gene_name": "Cyp3a18", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] } ] }, { "uniprot_ac": "Q64583", "gene_name": "Cyp2b15", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] } ] }, { "uniprot_ac": "Q64678", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] } ] }, { "uniprot_ac": "Q64680", "gene_name": "Cyp2d4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64680" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64680" } ] } ] }, { "uniprot_ac": "Q6NT55", "gene_name": "CYP4F22", "activity": [ { "ec_number": "1.14.14.177", "activity": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6NT55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT55" } ] }, { "ec_number": "1.14.14.177", "activity": "", "evidence": [ { "id": "Q6NT55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT55" } ] } ] }, { "uniprot_ac": "Q6V0L0", "gene_name": "CYP26C1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] } ] }, { "uniprot_ac": "Q6XVG2", "gene_name": "Cyp2c54", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6XVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XVG2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6XVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XVG2" } ] } ] }, { "uniprot_ac": "Q6ZWL3", "gene_name": "CYP4V2", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6ZWL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWL3" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6ZWL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWL3" } ] } ] }, { "uniprot_ac": "Q7Z449", "gene_name": "CYP2U1", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q7Z449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z449" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q7Z449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z449" } ] } ] }, { "uniprot_ac": "Q86W10", "gene_name": "CYP4Z1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] }, { "ec_number": "1.14.14.130", "activity": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] } ] }, { "uniprot_ac": "Q8CIM7", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] } ] }, { "uniprot_ac": "Q91WL5", "gene_name": "Cyp4a12a", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q91WL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WL5" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q91WL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WL5" } ] } ] }, { "uniprot_ac": "Q91X77", "gene_name": "Cyp2c50", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q91X77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X77" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q91X77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X77" } ] } ] }, { "uniprot_ac": "Q9CX98", "gene_name": "Cyp2u1", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9CX98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CX98" } ] } ] }, { "uniprot_ac": "Q9D816", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9D816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D816" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9D816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D816" } ] } ] }, { "uniprot_ac": "Q9DBW0", "gene_name": "Cyp4v2", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9DBW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBW0" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9DBW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBW0" } ] } ] }, { "uniprot_ac": "Q9DBX6", "gene_name": "Cyp2s1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] } ] }, { "uniprot_ac": "Q9EP75", "gene_name": "Cyp4f14", "activity": [ { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9EP75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EP75" } ] }, { "ec_number": "1.14.14.94", "activity": "", "evidence": [ { "id": "Q9EP75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EP75" } ] } ] }, { "uniprot_ac": "Q9EQW4", "gene_name": "Cyp3a44", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9EQW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQW4" } ] } ] }, { "uniprot_ac": "Q9HB55", "gene_name": "CYP3A43", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HB55" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HB55" } ] } ] }, { "uniprot_ac": "Q9HBI6", "gene_name": "CYP4F11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] } ] }, { "uniprot_ac": "Q9HCS2", "gene_name": "CYP4F12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HCS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCS2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HCS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCS2" } ] } ] }, { "uniprot_ac": "Q9JMA7", "gene_name": "Cyp3a41a", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9JMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9JMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMA7" } ] } ] }, { "uniprot_ac": "Q9QXF7", "gene_name": "CYP2J4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9QXF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXF7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9QXF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXF7" } ] } ] }, { "uniprot_ac": "Q9WV19", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9WV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV19" } ] }, { "ec_number": 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