{ "uniprot_canonical_ac": "P70507-1", "uniprot_ac": "P70507", "uniprot_id": "GRK4_RAT", "mass": { "chemical_mass": 66788.0, "monoisotopic_mass": 66788.0 }, "refseq": { "ac": "NP_075217", "name": "G protein-coupled receptor kinase 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" }, "gene_names": [ { "name": "Grk4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P70507", "id": "P70507" }, { "name": "Gprk2l", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251422", "id": "XP_006251422" }, { "name": "Gprk2l", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P70507", "id": "P70507" }, { "name": "Grk4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251422", "id": "XP_006251422" } ], "protein_names": [ { "name": "G protein-coupled receptor kinase 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P70507" }, { "name": "2.7.11.16", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P70507" }, { "name": "G protein-coupled receptor kinase 4 isoform X9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251422", "id": "XP_006251422" }, { "name": "G protein-coupled receptor kinase 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217", "id": "NP_075217" }, { "name": "G protein-coupled receptor kinase GRK4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P70507" }, { "name": "g protein-coupled receptor kinase GRK4; G protein-coupled receptor kinase 2, groucho gene related", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217", "id": "NP_075217" } ], "function": [ { "annotation": "Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase", "evidence": [ { "database": "RefSeq", "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" }, { "database": "PubMed", "id": "23839509", "url": "https://glygen.org/publication/PubMed/23839509" } ] }, { "annotation": "GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.", "evidence": [ { "database": "RefSeq", "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" }, { "database": "PubMed", "id": "32940654", "url": "https://glygen.org/publication/PubMed/32940654" } ] }, { "annotation": "Role of GRK4 in the regulation of the renal ETB receptor in hypertension. Erratum:[FASEB J. 2021 Apr;35(4):e21429. PMID: 33734484]", "evidence": [ { "database": "RefSeq", "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" }, { "database": "PubMed", "id": "32687659", "url": "https://glygen.org/publication/PubMed/32687659" } ] }, { "annotation": "Specifically phosphorylates the activated forms of G protein-coupled receptors. Plays an important role in the regulation of renal sodium handling and blood pressure.", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507#function" }, { "database": "PubMed", "id": "16636192", "url": "https://glygen.org/publication/PubMed/16636192" } ] } ], "disease": [ { "disease_id": "DOID:10825", "recommended_name": { "id": "DOID:10825", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10825", "name": "essential hypertension", "description": "A hypertension with no known cause. It is the most common type of hypertension." }, "synonyms": [ { "id": "DOID:10825", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10825", "name": "idiopathic hypertension", "description": "" }, { "id": "DOID:10825", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10825", "name": "primary hypertension", "description": "" }, { "id": "MONDO:0011384", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011384", "name": "hypertension, essential, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011384", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011384", "name": "hypertension, essential, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011384", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011384", "name": "hypertension, essential, susceptibility to, type 1", "description": "" }, { "id": "MONDO:0011384", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011384", "name": "Hyt1", "description": "" }, { "id": "MONDO:0011815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011815", "name": "hypertension, essential, susceptibility to, 3", "description": "" }, { "id": "MONDO:0011815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011815", "name": "hypertension, essential, susceptibility to, 3", "description": "" }, { "id": "MONDO:0011815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011815", "name": "hypertension, essential, susceptibility to, type 3", "description": "" }, { "id": "MONDO:0011815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011815", "name": "Hyt3", "description": "" }, { "id": "MONDO:0011440", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011440", "name": "hypertension, essential, susceptibility to, 2", "description": "" }, { "id": "MONDO:0011440", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011440", "name": "hypertension, essential, susceptibility to, 2", "description": "" }, { "id": "MONDO:0011440", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011440", "name": "hypertension, essential, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0011440", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011440", "name": "Hyt2", "description": "" }, { "id": "MONDO:0012458", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012458", "name": "hypertension, essential, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012458", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012458", "name": "hypertension, essential, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012458", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012458", "name": "hypertension, essential, susceptibility to, type 5", "description": "" }, { "id": "MONDO:0012458", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012458", "name": "Hyt5", "description": "" }, { "id": "MONDO:0012458", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012458", "name": "hypertension, essential, body Mass-related", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "essential hypertension, genetic", "description": "An instance of essential hypertension that is caused by a modification of the individual's genome." }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "blood pressure regulation QTL", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "genetic essential hypertension", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, salt-sensitive", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to, 2", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to, 3", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to, 4", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to, 5", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to, 6", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, susceptibility to", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "EHT", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, essential, susceptibility to, 1", "description": "" }, { "id": "MONDO:0007781", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007781", "name": "hypertension, salt-sensitive essential, susceptibility to", "description": "" }, { "id": "MONDO:0012587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012587", "name": "hypertension, essential, susceptibility to, 7", "description": "" }, { "id": "MONDO:0012587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012587", "name": "hypertension, essential, susceptibility to, 7", "description": "" }, { "id": "MONDO:0012587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012587", "name": "hypertension, essential, susceptibility to, type 7", "description": "" }, { "id": "MONDO:0012587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012587", "name": "Hyt7", "description": "" }, { "id": "MONDO:0012599", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012599", "name": "hypertension, essential, susceptibility to, 8", "description": "" }, { "id": "MONDO:0012599", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012599", "name": "HYT8", "description": "" }, { "id": "MONDO:0012599", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012599", "name": "hypertension, essential, susceptibility to, 8", "description": "" }, { "id": "MONDO:0012109", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012109", "name": "hypertension, essential, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012109", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012109", "name": "hypertension, essential, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012109", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012109", "name": "hypertension, essential, susceptibility to, type 4", "description": "" }, { "id": "MONDO:0012109", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012109", "name": "Hyt4", "description": "" }, { "id": "MONDO:0012459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012459", "name": "hypertension, essential, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012459", "name": "hypertension, essential, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012459", "name": "hypertension, essential, susceptibility to, type 6", "description": "" }, { "id": "MONDO:0012459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012459", "name": "Hyt6", "description": "" }, { "id": "MONDO:0012459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012459", "name": "hypertension, essential, kidney function-related", "description": "" }, { "id": "MIM:145500", "resource": "MIM", "url": "https://www.omim.org/entry/145500", "name": "Essential hypertension", "description": "Essential hypertension" } ], "evidence": [ { "id": "10825", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10825" } ] }, { "disease_id": "DOID:1574", "recommended_name": { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences." }, "synonyms": [ { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "Ethanol abuse", "description": "" }, { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol abuse", "description": "" } ], "evidence": [ { "id": "1574", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "common_name": "Rat" } ], "gene": [ { "name": "Grk4", "url": "https://www.uniprot.org/uniprot/P70507", "locus": { "chromosome": "14", "start_pos": 76006218, "end_pos": 76080693, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011847", "url": "https://www.ensembl.org/id/ENSRNOG00000011847" } ] } } ], "crossref": [ { "id": "ENSRNOG00000011847", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05605", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05605", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "59077", "url": "https://www.ncbi.nlm.nih.gov/gene/59077", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:59077", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:59077", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PFRPDPN", "url": "https://omabrowser.org/oma/group/PFRPDPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2906348at2759", "url": "http://www.orthodb.org/?query=2906348at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "http://pfam.xfam.org/family/PF00069", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "http://pfam.xfam.org/family/PF00615", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P70507", "url": "http://purl.obolibrary.org/obo/PR_P70507", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2514859", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "61858", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=61858", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "12008", "url": "https://www.rhea-db.org/rhea/12008", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZVP3", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZVP3-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A4S4", "url": "https://www.uniprot.org/uniprot/A0A8I6A4S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A4S4-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A4S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P70507-1", "url": "https://www.uniprot.org/uniprot/P70507-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P70507-2", "url": "https://www.uniprot.org/uniprot/P70507-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH", "length": 575, "header": "sp|P70507-1|GRK4_RAT Isoform 1 of G protein-coupled receptor kinase 4 OS=Rattus norvegicus OX=10116 GN=Grk4 PE=1 SV=1 CANONICAL=P70507-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZVP3-1", "url": "", "sequence": { "sequence": "MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH", "length": 529, "header": "tr|A0A8I5ZVP3-1|A0A8I5ZVP3_RAT Computationally mapped isoform of G protein-coupled receptor kinase OS=Rattus norvegicus OX=10116 GN=Grk4 PE=3 SV=1 CANONICAL=P70507-1" }, "locus": { "chromosome": "14", "start_pos": 76080505, "end_pos": 76006302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098753.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098753.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083618.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083618.1" } ] } }, { "isoform_ac": "A0A8I6A4S4-1", "url": "", "sequence": { "sequence": "LELRLQTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRASLSEEKEEEKKRIKRRQINKDRRKDTHTHTHTHTHTHTHTHTRFI", "length": 588, "header": "tr|A0A8I6A4S4-1|GRK4_RAT Computationally mapped isoform of G protein-coupled receptor kinase 4 OS=Rattus norvegicus OX=10116 GN=Grk4 PE=1 SV=1 CANONICAL=P70507-1" }, "locus": { "chromosome": "14", "start_pos": 76075325, "end_pos": 76007905, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000103702.1", "url": "https://www.ensembl.org/id/ENSRNOT00000103702.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000086910.1", "url": "https://www.ensembl.org/id/ENSRNOP00000086910.1" } ] } }, { "isoform_ac": "P70507-1", "url": "", "sequence": { "sequence": "MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH", "length": 575, "header": "sp|P70507-1|GRK4_RAT Isoform 1 of G protein-coupled receptor kinase 4 OS=Rattus norvegicus OX=10116 GN=Grk4 PE=1 SV=1 CANONICAL=P70507-1" }, "locus": { "chromosome": "14", "start_pos": 76080505, "end_pos": 76006302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000015894", "url": "https://www.ensembl.org/id/ENSRNOT00000015894" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000015894", "url": "https://www.ensembl.org/id/ENSRNOP00000015894" } ] } }, { "isoform_ac": "P70507-2", "url": "", "sequence": { "sequence": "MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH", "length": 544, "header": "sp|P70507-2|GRK4_RAT Isoform 2 of G protein-coupled receptor kinase 4 OS=Rattus norvegicus OX=10116 GN=Grk4 PE=1 SV=1 CANONICAL=P70507-1" }, "locus": { "chromosome": "14", "start_pos": 76080505, "end_pos": 76006302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094171", "url": "https://www.ensembl.org/id/ENSRNOT00000094171" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088283", "url": "https://www.ensembl.org/id/ENSRNOP00000088283" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 484, "end_pos": 484, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P70507", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P70507" } ], "site_lbl": "Ser484" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression.", "journal": "Hypertension", "date": "2006", "authors": "Sanada H, Yatabe J, Midorikawa S, Katoh T, Hashimoto S, Watanabe T, Xu J, Luo Y, Wang X, Zeng C, Armando I, Felder RA, Jose PA", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "reference": [ { "type": "PubMed", "id": "16636192", "url": "https://glygen.org/publication/PubMed/16636192" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" }, { "database": "iPTMnet", "id": "P70507", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P70507" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase.", "journal": "Applied biochemistry and biotechnology", "date": "2013", "authors": "Chougule RA, P S, Salimath BP, Sosalegowda AH", "evidence": [ { "database": "RefSeq", "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" } ], "reference": [ { "type": "PubMed", "id": "23839509", "url": "https://glygen.org/publication/PubMed/23839509" } ] }, { "title": "Role of GRK4 in the regulation of the renal ETB receptor in hypertension.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2020", "authors": "Yang Y, Li M, Zou X, Chen C, Zheng S, Fu C, Chen K, Jose PA, Lan C, Liu Y", "evidence": [ { "database": "RefSeq", "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" } ], "reference": [ { "type": "PubMed", "id": "32687659", "url": "https://glygen.org/publication/PubMed/32687659" } ] }, { "title": "GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.", "journal": "Clinical science (London, England : 1979)", "date": "2020", "authors": "Zhang Y, Wang S, Huang H, Zeng A, Han Y, Zeng C, Zheng S, Ren H, Wang Y, Huang Y, Jose PA, Ma XL, Zeng C, Chen K", "evidence": [ { "database": "RefSeq", "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217" } ], "reference": [ { "type": "PubMed", "id": "32940654", "url": "https://glygen.org/publication/PubMed/32940654" } ] }, { "title": "Rat G protein-coupled receptor kinase GRK4: identification, functional expression, and differential tissue distribution of two splice variants.", "journal": "Endocrinology", "date": "1998", "authors": "Virlon B, Firsov D, Cheval L, Reiter E, Troispoux C, Guillou F, Elalouf JM", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "reference": [ { "type": "PubMed", "id": "9607785", "url": "https://glygen.org/publication/PubMed/9607785" } ] } ], "pathway": [ { "id": "rno:59077", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:59077", "resource": "KEGG Pathway" }, { "id": "R-RNO-2514859", "name": "Inactivation, recovery and regulation of the phototransduction cascade", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2514859", "resource": "Reactome", "description": "Inactivation, recovery and regulation of the phototransduction cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "O70291-1", "protein_name": "G protein-coupled receptor kinase 4", "gene_name": "Grk4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLSSLEKYKMCSSILRPKRNFFRRLFRRTGCLNIALSEEREPTEH", "length": 574 }, "evidence": [ { "id": "45238897", "url": "http://www.informatics.jax.org/homology/45238897", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P32298-1", "protein_name": "G protein-coupled receptor kinase 4", "gene_name": "GRK4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC", "length": 578 }, "evidence": [ { "id": "45238897", "url": "http://www.informatics.jax.org/homology/45238897", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "G protein-coupled receptor kinase activity", "id": "GO:0004703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004703", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "rhodopsin kinase activity", "id": "GO:0050254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050254", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "receptor internalization", "id": "GO:0031623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031623", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "G protein-coupled receptor internalization", "id": "GO:0002031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002031", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" }, { "name": "desensitization of G protein-coupled receptor signaling pathway", "id": "GO:0002029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002029", "evidence": [ { "database": "UniProtKB", "id": "P70507", "url": "https://www.uniprot.org/uniprot/P70507" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 452, "end_pos": 454, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12008", "name": "", "equation": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62833-1", "P97711-1", "P70507-1", "P32298-1", "P43250-1", "P34947-1", "O70291-1", "O70293-1", "Q8VEB1-1", "P32865-1", "P32866-1" ], "evidence": [ { "id": "12008", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12008" } ] }, { "id": "R-RNO-2581474", "name": "GRK1,4,7 phosphorylate MII to p-MII", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, photoreceptor disc membrane", "input_participant_list": [], "output_participant_list": [ "R-RNO-5205903" ], "enzyme_list": [ "P70507-1", "Q63651-1" ], "evidence": [ { "id": "R-RNO-2581474", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2581474" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-5205903", "participant_name": "phospho-p-S334,338,343-at-retinyl-RHO [photoreceptor disc membrane]", "crossref": [ { "id": "P51489", "database": "UniProt", "url": "" }, { "id": "NP_254276.1", "database": "RefSeq", "url": "" }, { "id": "P51489", "database": "PRO", "url": "" }, { "id": "3573", "database": "RGD", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O70291", "gene_name": "Grk4", "activity": [ { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "O70291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70291" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "O70291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70291" } ] } ] }, { "uniprot_ac": "O70293", "gene_name": "Grk6", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "O70293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70293" } ] }, { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "O70293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70293" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "O70293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70293" } ] } ] }, { "uniprot_ac": "P32298", "gene_name": "GRK4", "activity": [ { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P32298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32298" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "P32298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32298" } ] } ] }, { "uniprot_ac": "P32865", "gene_name": "Gprk1", "activity": [ { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P32865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32865" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "P32865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32865" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P32865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32865" } ] } ] }, { "uniprot_ac": "P32866", "gene_name": "Gprk2", "activity": [ { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P32866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32866" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "P32866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32866" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P32866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32866" } ] } ] }, { "uniprot_ac": "P34947", "gene_name": "GRK5", "activity": [ { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P34947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34947" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": 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