{
    "uniprot_canonical_ac": "P70213-1",
    "uniprot_ac": "P70213",
    "uniprot_id": "FV1_MOUSE",
    "mass": {
        "chemical_mass": 51997.0,
        "monoisotopic_mass": 51997.0
    },
    "refseq": {
        "ac": "NP_034374",
        "name": "Friend virus susceptibility protein 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374"
    },
    "gene_names": [
        {
            "name": "Fv1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P70213",
            "id": "P70213"
        },
        {
            "name": "Fv-1; Fv1d; Rv-1; Rv1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374",
            "id": "NP_034374"
        },
        {
            "name": "Fv1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374",
            "id": "NP_034374"
        }
    ],
    "protein_names": [
        {
            "name": "Friend virus susceptibility protein 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P70213"
        },
        {
            "name": "Friend virus susceptibility protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374",
            "id": "NP_034374"
        },
        {
            "name": "Rauscher leukemia virus susceptibility 1; retrovirus restriction protein; Fv1 gammaretrovirus restriction factor; Fv1 restriction factor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374",
            "id": "NP_034374"
        }
    ],
    "function": [
        {
            "annotation": "Data indicate that for some but not all Fv1 proteins, gain of restriction activities could be achieved by increasing the expression level of Fv1; however such a concentration dependent effect is not seen with most Fv1s and cannot explain the recently reported activities against non-MLVs Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034374",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374"
                },
                {
                    "database": "PubMed",
                    "id": "27342974",
                    "url": "https://glygen.org/publication/PubMed/27342974"
                }
            ]
        },
        {
            "annotation": "Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034374",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374"
                },
                {
                    "database": "PubMed",
                    "id": "34578445",
                    "url": "https://glygen.org/publication/PubMed/34578445"
                }
            ]
        },
        {
            "annotation": "Regions of Fv1 adapt cooperatively, highlighting its preference for repeated structures and suggesting that this functionally constrained aspect of the retroviral capsid lattice presents a common target in the evolution of intrinsic immunity.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034374",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374"
                },
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                    "id": "30224488",
                    "url": "https://glygen.org/publication/PubMed/30224488"
                }
            ]
        },
        {
            "annotation": "Retroviral restriction factor that prevents infection by gammaretroviruses. Acts by interacting with the capsid protein ca after entry of the virus into the cell. This interaction presumably disrupt the capsid thereby inactivating the viral genome, making it unable to enter host nucleus and integrate into host genome.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P70213",
                    "url": "https://www.uniprot.org/uniprot/P70213#function"
                },
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                    "database": "PubMed",
                    "id": "16474118",
                    "url": "https://glygen.org/publication/PubMed/16474118"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P70213",
                    "url": "https://www.uniprot.org/uniprot/P70213"
                }
            ],
            "common_name": "Mouse"
        }
    ],
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        {
            "name": "Fv1",
            "url": "https://www.uniprot.org/uniprot/P70213",
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                "start_pos": 147954815,
                "end_pos": 147953436,
                "strand": "-",
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                        "id": "ENSMUSG00000070583",
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                    }
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            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000070583",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070583",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "14349",
            "url": "https://www.ncbi.nlm.nih.gov/gene/14349",
            "database": "GeneID",
            "categories": [
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            ]
        },
        {
            "id": "mmu:14349",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14349",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
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        },
        {
            "id": "95595",
            "url": "http://www.informatics.jax.org/marker/MGI:95595",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "TWDGDVW",
            "url": "https://omabrowser.org/oma/group/TWDGDVW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4761307at2759",
            "url": "http://www.orthodb.org/?query=4761307at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48195",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48195",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48195:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48195:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P70213",
            "url": "http://purl.obolibrary.org/obo/PR_P70213",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_034374",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P70213",
            "url": "https://www.uniprot.org/uniprot/P70213",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P70213-1",
            "url": "https://www.uniprot.org/uniprot/P70213-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNFPRALAGFSSWLFKPELAEDSPDNDSPDNDTVNPWRELLQKINVADLPDSSFSSGKELNDSVYHTFEHFCKIRDYDAVGELLLAFLDKVTKERDQFRDEISQLRMHINDLKASKCVLGETLLSYRHRIEVGEKQTEALIVRLADVQSQVMCQPARKVSADKVRALIGKEWDPVTWDGDVWEDIDSEGSEEAELPTVLASPSLSEESGYALSKERTQQDKADAPQIQSSTSLVTSEPVTRPKSLSDLTSQKHRHTNHELNSLAHSNRQKAKEHARKWILRVWDNGGRLTILDQIEFLSLGPLSLDSEFNVIARTVEDNGVKSLFDWLAEAWVQRWPTTRELQSPDTLEWYSIEDGIERLRELGMIEWLCVKATCPQWRGPEDVPITRAMRITFVRETRETWKSFVFSLLCIKDITVGSVAAQLHDLIELSLKPTAAGLTSVGSVGVLSLSPWKHQSNS",
        "length": 459,
        "header": "sp|P70213-1|FV1_MOUSE Isoform 1 of Friend virus susceptibility protein 1  OS=Mus musculus OX=10090 GN=Fv1 PE=4 SV=1 CANONICAL=P70213-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P70213-1",
            "url": "",
            "sequence": {
                "sequence": "MNFPRALAGFSSWLFKPELAEDSPDNDSPDNDTVNPWRELLQKINVADLPDSSFSSGKELNDSVYHTFEHFCKIRDYDAVGELLLAFLDKVTKERDQFRDEISQLRMHINDLKASKCVLGETLLSYRHRIEVGEKQTEALIVRLADVQSQVMCQPARKVSADKVRALIGKEWDPVTWDGDVWEDIDSEGSEEAELPTVLASPSLSEESGYALSKERTQQDKADAPQIQSSTSLVTSEPVTRPKSLSDLTSQKHRHTNHELNSLAHSNRQKAKEHARKWILRVWDNGGRLTILDQIEFLSLGPLSLDSEFNVIARTVEDNGVKSLFDWLAEAWVQRWPTTRELQSPDTLEWYSIEDGIERLRELGMIEWLCVKATCPQWRGPEDVPITRAMRITFVRETRETWKSFVFSLLCIKDITVGSVAAQLHDLIELSLKPTAAGLTSVGSVGVLSLSPWKHQSNS",
                "length": 459,
                "header": "sp|P70213-1|FV1_MOUSE Isoform 1 of Friend virus susceptibility protein 1  OS=Mus musculus OX=10090 GN=Fv1 PE=4 SV=1 CANONICAL=P70213-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 147954812,
                "end_pos": 147953436,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000094481",
                        "url": "https://www.ensembl.org/id/ENSMUST00000094481"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000092054",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000092054"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.",
            "journal": "J. Virol.",
            "date": "2006",
            "authors": "Towers G.J., Keckesova Z., Passerini L.D.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P70213",
                    "url": "https://www.uniprot.org/uniprot/P70213"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16474118",
                    "url": "https://glygen.org/publication/PubMed/16474118"
                }
            ]
        },
        {
            "title": "Expression levels of Fv1: effects on retroviral restriction specificities.",
            "journal": "Retrovirology",
            "date": "2016",
            "authors": "Li W, Yap MW, Voss V, Stoye JP",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034374",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27342974",
                    "url": "https://glygen.org/publication/PubMed/27342974"
                }
            ]
        },
        {
            "title": "Evolutionary journey of the retroviral restriction gene Fv1.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2018",
            "authors": "Young GR, Yap MW, Michaux JR, Steppan SJ, Stoye JP",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034374",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034374"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30224488",
                    "url": "https://glygen.org/publication/PubMed/30224488"
                }
            ]
        },
        {
            "title": "Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.",
            "journal": "Viruses",
            "date": "2021",
            "authors": "Boso G, Lam O, Bamunusinghe D, Oler AJ, Wollenberg K, Liu Q, Shaffer E, Kozak CA",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_034374",
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                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34578445",
                    "url": "https://glygen.org/publication/PubMed/34578445"
                }
            ]
        },
        {
            "title": "Positional cloning of the mouse retrovirus restriction gene Fv1.",
            "journal": "Nature",
            "date": "1996",
            "authors": "Best S., Stoye J.P., le Tissier P., Towers G.",
            "evidence": [
                {
                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/P70213"
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                    "type": "PubMed",
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            ]
        }
    ],
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        {
            "id": "mmu:14349",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14349",
            "resource": "KEGG Pathway"
        }
    ],
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                "name": "Cellular Component",
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                    {
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