{ "uniprot_canonical_ac": "P70208-1", "uniprot_ac": "P70208", "uniprot_id": "PLXA3_MOUSE", "mass": { "chemical_mass": 207958.0, "monoisotopic_mass": 207958.0 }, "refseq": { "ac": "NP_032909", "name": "plexin-A3 isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909" }, "gene_names": [ { "name": "Plxna3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P70208", "id": "P70208" }, { "name": "Plxna3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909", "id": "NP_032909" }, { "name": "mKIAA4078; PlexA3; Plxa3; Plxn3; Plxn4; SEX", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909", "id": "NP_032909" } ], "protein_names": [ { "name": "Plexin-A3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P70208" }, { "name": "plexin 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909", "id": "NP_032909" }, { "name": "plexin-A3 isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909", "id": "NP_032909" } ], "function": [ { "annotation": "Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208#function" }, { "database": "PubMed", "id": "18262512", "url": "https://glygen.org/publication/PubMed/18262512" }, { "database": "PubMed", "id": "18804103", "url": "https://glygen.org/publication/PubMed/18804103" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" }, { "database": "PubMed", "id": "20010807", "url": "https://glygen.org/publication/PubMed/20010807" }, { "database": "PubMed", "id": "19020035", "url": "https://glygen.org/publication/PubMed/19020035" }, { "database": "PubMed", "id": "11683995", "url": "https://glygen.org/publication/PubMed/11683995" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3389567242", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389567242" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1064, "end_pos": 1064, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IET->NET).", "chr_id": "X", "chr_pos": "73381092", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1064", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389561620", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389561620" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 1076, "end_pos": 1076, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NDT->NDA).", "chr_id": "X", "chr_pos": "73381208", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1076", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3410891662", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3410891662" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1153, "end_pos": 1153, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLI->NLT).", "chr_id": "X", "chr_pos": "73381530", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1153", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 1279, "end_pos": 1279, "sequence_org": "L", "sequence_mut": "R", "comment": "Strongly reduced response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1300, "end_pos": 1300, "sequence_org": "Y", "sequence_mut": "A", "comment": "Almost abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1309, "end_pos": 1309, "sequence_org": "F", "sequence_mut": "A", "comment": "Almost abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1407, "end_pos": 1408, "sequence_org": "RR", "sequence_mut": "AA", "comment": "Abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1453, "end_pos": 1453, "sequence_org": "I", "sequence_mut": "R", "comment": "Abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1464, "end_pos": 1464, "sequence_org": "L", "sequence_mut": "G", "comment": "Almost abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1506, "end_pos": 1506, "sequence_org": "Q", "sequence_mut": "A", "comment": "Abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "start_pos": 1631, "end_pos": 1632, "sequence_org": "HL", "sequence_mut": "AA", "comment": "Abolishes response to semaphorin.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" }, { "database": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Plxna3", "url": "https://www.uniprot.org/uniprot/P70208", "locus": { "chromosome": "X", "start_pos": 73388295, "end_pos": 73372672, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031398", "url": "https://www.ensembl.org/id/ENSMUSG00000031398" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031398", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031398", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00603", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00603", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01179", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01179", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01180", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01180", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01181", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01181", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11273", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11273", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12790", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12790", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "18846", "url": "https://www.ncbi.nlm.nih.gov/gene/18846", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2591", "url": "https://glyconnect.expasy.org/browser/proteins/2591", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "GPDB0003762", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003762", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003763", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003763", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:18846", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18846", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "107683", "url": "http://www.informatics.jax.org/marker/MGI:107683", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P70208", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P70208", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "CPEILPR", "url": "https://omabrowser.org/oma/group/CPEILPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1387371at2759", "url": "http://www.orthodb.org/?query=1387371at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22625:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22625:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3IG3", "url": "https://www.rcsb.org/structure/3IG3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01403", "url": "http://pfam.xfam.org/family/PF01403", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01437", "url": "http://pfam.xfam.org/family/PF01437", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01833", "url": "http://pfam.xfam.org/family/PF01833", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08337", "url": "http://pfam.xfam.org/family/PF08337", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17960", "url": "http://pfam.xfam.org/family/PF17960", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18020", "url": "http://pfam.xfam.org/family/PF18020", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20170", "url": "http://pfam.xfam.org/family/PF20170", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P70208", "url": "http://purl.obolibrary.org/obo/PR_P70208", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399954", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399955", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_032909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P70208-1", "url": "https://www.uniprot.org/uniprot/P70208-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P70208-2", "url": "https://www.uniprot.org/uniprot/P70208-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTVCLLPLLFFTIGGCLGSSRPFRTFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQVQGPSKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELSKCIQVRVRPNNVSVTSSGVQLTVAMRNVPDLSVGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQLLSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILPQGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGHPQPRAQGEHPDEFGFLLDHVQAARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRAASSPDSLRSRAPMLTPDQEAGTKLWHLVRNHDHTDHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSSSS", "length": 1872, "header": "sp|P70208-1|PLXA3_MOUSE Isoform 1 of Plexin-A3 OS=Mus musculus OX=10090 GN=Plxna3 PE=1 SV=2 CANONICAL=P70208-1" }, "isoforms": [ { "isoform_ac": "P70208-1", "url": "", "sequence": { "sequence": "MPTVCLLPLLFFTIGGCLGSSRPFRTFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQVQGPSKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELSKCIQVRVRPNNVSVTSSGVQLTVAMRNVPDLSVGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQLLSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILPQGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGHPQPRAQGEHPDEFGFLLDHVQAARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRAASSPDSLRSRAPMLTPDQEAGTKLWHLVRNHDHTDHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSSSS", "length": 1872, "header": "sp|P70208-1|PLXA3_MOUSE Isoform 1 of Plexin-A3 OS=Mus musculus OX=10090 GN=Plxna3 PE=1 SV=2 CANONICAL=P70208-1" }, "locus": { "chromosome": "X", "start_pos": 73387145, "end_pos": 73374602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000004326", "url": "https://www.ensembl.org/id/ENSMUST00000004326" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000004326", "url": "https://www.ensembl.org/id/ENSMUSP00000004326" } ] } }, { "isoform_ac": "P70208-2", "url": "", "sequence": { "sequence": "MPTVCLLPLLFFTIGGCLGSSRPFRTFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQVQGPSKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELSKCIQVRVRPNNVSVTSSGVQLTVAMRNVPDLSVGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQLLSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILPQGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQGKNLIPAAAGSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRAASSPDSLRSRAPMLTPDQEAGTKLWHLVRNHDHTDHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSSSS", "length": 1795, "header": "sp|P70208-2|PLXA3_MOUSE Isoform 2 of Plexin-A3 OS=Mus musculus OX=10090 GN=Plxna3 PE=1 SV=2 CANONICAL=P70208-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1074, "start_aa": "Asn", "end_pos": 1074, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1074", "evidence": [ { "id": "2591", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2591" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1163, "start_aa": "Asn", "end_pos": 1163, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1163", "evidence": [ { "id": "P70208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70208#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 549, "start_aa": "Asn", "end_pos": 549, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn549", "evidence": [ { "id": "P70208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70208#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 60, "start_aa": "Asn", "end_pos": 60, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn60", "evidence": [ { "id": "P70208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70208#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P70208", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P70208" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" } ] } ], "phosphorylation": [ { "start_pos": 1597, "end_pos": 1597, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "site_lbl": "Ser1597" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.", "journal": "Neuron", "date": "2001", "authors": "Cheng HJ, Bagri A, Yaron A, Stein E, Pleasure SJ, Tessier-Lavigne M", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "11683995", "url": "https://glygen.org/publication/PubMed/11683995" } ] }, { "title": "Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors.", "journal": "Dev. Biol.", "date": "2008", "authors": "Chen M., Cheng H.J., Huang P.H., Waimey K.E.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "18262512", "url": "https://glygen.org/publication/PubMed/18262512" } ] }, { "title": "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.", "journal": "Dev. Biol.", "date": "2008", "authors": "Schwarz Q, Waimey KE, Golding M, Takamatsu H, Kumanogoh A, Fujisawa H, Cheng HJ, Ruhrberg C", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "18804103", "url": "https://glygen.org/publication/PubMed/18804103" } ] }, { "title": "The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development.", "journal": "J. Neurosci.", "date": "2008", "authors": "Ben-Zvi A., Tessier-Lavigne M., Schachner M., Yaron A., Behar O., Manor O.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "19020035", "url": "https://glygen.org/publication/PubMed/19020035" } ] }, { "title": "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2009", "authors": "He H, Yang T, Terman JR, Zhang X", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "19717441", "url": "https://glygen.org/publication/PubMed/19717441" } ] }, { "title": "Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.", "journal": "Nature", "date": "2009", "authors": "Johnson D., Tessier-Lavigne M., Huganir R.L., Rubio M.E., Kolodkin A.L., Clem R.L., Ginty D.D., Case L., Tran T.S.", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "20010807", "url": "https://glygen.org/publication/PubMed/20010807" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2591", "url": "https://glyconnect.expasy.org/browser/proteins/2591" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "P70208", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P70208" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Identification of plexin family molecules in mice.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1996", "authors": "Kameyama T, Murakami Y, Suto F, Kawakami A, Takagi S, Hirata T, Fujisawa H", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "reference": [ { "type": "PubMed", "id": "8806646", "url": "https://glygen.org/publication/PubMed/8806646" } ] } ], "pathway": [ { "id": "mmu:18846", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18846", "resource": "KEGG Pathway" }, { "id": "R-MMU-399954", "name": "Sema3A PAK dependent Axon repulsion", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399954", "resource": "Reactome", "description": "Sema3A PAK dependent Axon repulsion" }, { "id": "R-MMU-399955", "name": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399955", "resource": "Reactome", "description": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" }, { "id": "R-MMU-399956", "name": "CRMPs in Sema3A signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399956", "resource": "Reactome", "description": "CRMPs in Sema3A signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZPX4-1", "protein_name": "Plexin-A3", "gene_name": "Plxna3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHTVCLLPLLFFTIGGCLGSSRPFRTFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLASNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGTPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELNKCIQVRVRPNNVSVTSSGVQLTVAMRNVPDLSLGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQLLSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILPRGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRVHCPAPKSNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTLDRVSPTRGPASGGTRLTISGTSLDAGSRVTVIIRDGECQFVRRDAEAIVCISPISTLGPSQAPIILAIDHANISSTGVIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGHPQPRAQGEHPDEFGFLLDHVQAARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECDWKRINSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRAASSPDSLRSRAPMLTPDQEAGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSSSS", "length": 1872 }, "evidence": [ { "id": "45229047", "url": "http://www.informatics.jax.org/homology/45229047", "database": "MGI" }, { "id": "P70208", "url": "https://omabrowser.org/oma/group/P70208/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P51805-1", "protein_name": "Plexin-A3", "gene_name": "PLXNA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1871 }, "evidence": [ { "id": "45229047", "url": "http://www.informatics.jax.org/homology/45229047", "database": "MGI" }, { "id": "P70208", "url": "https://omabrowser.org/oma/group/P70208/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "neuron projection guidance", "id": "GO:0097485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097485", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "pmid": "" }, { "name": "positive regulation of cytoskeleton organization", "id": "GO:0051495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051495", "evidence": [ { "database": "UniProtKB", "id": "P70208", "url": "https://www.uniprot.org/uniprot/P70208" } ], "pmid": "" }, { "name": "negative regulation of cell adhesion", "id": "GO:0007162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007162", "evidence": [ { 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