{ "uniprot_canonical_ac": "P62947-1", "uniprot_ac": "P62947", "uniprot_id": "RL41_MOUSE", "mass": { "chemical_mass": 3456.0, "monoisotopic_mass": 3456.0 }, "refseq": { "ac": "NP_061348", "name": "large ribosomal subunit protein eL41", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061348" }, "gene_names": [ { "name": "Rpl41", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P62947", "id": "P62947" }, { "name": "1810055P16Rik; 2210411K19Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061348", "id": "NP_061348" }, { "name": "Rpl41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061348", "id": "NP_061348" } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL41", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P62947" }, { "name": "60S ribosomal protein L41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061348", "id": "NP_061348" }, { "name": "60S ribosomal protein L41", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P62947" }, { "name": "large ribosomal subunit protein eL41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061348", "id": "NP_061348" } ], "function": [ { "annotation": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947#function" }, { "database": "UniProtKB", "id": "P62945", "url": "https://www.uniprot.org/uniprot/P62945#function" }, { "database": "PubMed", "id": "36517592", "url": "https://glygen.org/publication/PubMed/36517592" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rpl41", "url": "https://www.uniprot.org/uniprot/P62947", "locus": { "chromosome": "10", "start_pos": 128383983, "end_pos": 128385174, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000093674", "url": "https://www.ensembl.org/id/ENSMUSG00000093674" } ] } } ], "crossref": [ { "id": "ENSMUSG00000093674", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000093674", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "67945", "url": "https://www.ncbi.nlm.nih.gov/gene/67945", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:67945", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67945", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1915195", "url": "http://www.informatics.jax.org/marker/MGI:1915195", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "6SWA", "url": "https://www.rcsb.org/structure/6SWA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7CPU", "url": "https://www.rcsb.org/structure/7CPU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7CPV", "url": "https://www.rcsb.org/structure/7CPV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7LS1", "url": "https://www.rcsb.org/structure/7LS1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7LS2", "url": "https://www.rcsb.org/structure/7LS2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF05162", "url": "http://pfam.xfam.org/family/PF05162", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P62947", "url": "http://purl.obolibrary.org/obo/PR_P62947", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_061348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061348", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "H3BK91", "url": "https://www.uniprot.org/uniprot/H3BK91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BK91-1", "url": "https://www.uniprot.org/uniprot/H3BK91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P62947-1", "url": "https://www.uniprot.org/uniprot/P62947-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAKWRKKRMRRLKRKRRKMRQRSK", "length": 25, "header": "sp|P62947-1|RL41_MOUSE Isoform 1 of Large ribosomal subunit protein eL41 OS=Mus musculus OX=10090 GN=Rpl41 PE=1 SV=1 CANONICAL=P62947-1" }, "isoforms": [ { "isoform_ac": "H3BK91-1", "url": "", "sequence": { "sequence": "MRAKWRKKRMRRFVCLPFQAEAQEKKDEAEVQVSQPVHLRRLQEQK", "length": 46, "header": "tr|H3BK91-1|H3BK91_MOUSE Computationally mapped isoform of Ribosomal protein L41 OS=Mus musculus OX=10090 GN=Rpl41 PE=4 SV=1 CANONICAL=P62947-1" }, "locus": { "chromosome": "10", "start_pos": 128384829, "end_pos": 128384218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000176906.2", "url": "https://www.ensembl.org/id/ENSMUST00000176906.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000135298.2", "url": "https://www.ensembl.org/id/ENSMUSP00000135298.2" } ] } }, { "isoform_ac": "P62947-1", "url": "", "sequence": { "sequence": "MRAKWRKKRMRRLKRKRRKMRQRSK", "length": 25, "header": "sp|P62947-1|RL41_MOUSE Isoform 1 of Large ribosomal subunit protein eL41 OS=Mus musculus OX=10090 GN=Rpl41 PE=1 SV=1 CANONICAL=P62947-1" }, "locus": { "chromosome": "10", "start_pos": 128384829, "end_pos": 128384259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000176010", "url": "https://www.ensembl.org/id/ENSMUST00000176010" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000135533", "url": "https://www.ensembl.org/id/ENSMUSP00000135533" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:67945", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67945", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "P62947", "url": "https://www.uniprot.org/uniprot/P62947" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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