{ "uniprot_canonical_ac": "P62874-1", "uniprot_ac": "P62874", "uniprot_id": "GBB1_MOUSE", "mass": { "chemical_mass": 37377.0, "monoisotopic_mass": 37377.0 }, "refseq": { "ac": "NP_001153488", "name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" }, "gene_names": [ { "name": "Gnb1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P62874", "id": "P62874" }, { "name": "Gnb-1; Hg2a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488", "id": "NP_001153488" }, { "name": "Gnb1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488", "id": "NP_001153488" } ], "protein_names": [ { "name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P62874" }, { "name": "Transducin beta chain 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P62874" }, { "name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488", "id": "NP_001153488" }, { "name": "transducin beta chain 1; guanine nucleotide binding protein, beta 1; heterotrimeric guanine nucleotide-binding protein 2a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488", "id": "NP_001153488" } ], "function": [ { "annotation": "Data show that synaptosome associated protein 25 (SNAP25)Delta3 mutation has a twofold reduction in GTP-binding protein beta/gamma (Gbetagamma) binding. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" }, { "database": "PubMed", "id": "30783011", "url": "https://glygen.org/publication/PubMed/30783011" } ] }, { "annotation": "Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in quiescent platelets; then, Ppp1ca and Plcb3 interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G protein-coupled receptor signaling. (Ppp1ca = protein phosphatase 1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3)", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" }, { "database": "PubMed", "id": "28615442", "url": "https://glygen.org/publication/PubMed/28615442" } ] }, { "annotation": "G protein subunit beta1 is an important mediator of the late stage of endochondral ossification.", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" }, { "database": "PubMed", "id": "32928505", "url": "https://glygen.org/publication/PubMed/32928505" } ] }, { "annotation": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P62874", "url": "https://www.uniprot.org/uniprot/P62874#function" } ] }, { "annotation": "This study indicates that GNB1 negatively regulates NLRP3 inflammasome activation", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" }, { "database": "PubMed", "id": "30777924", "url": "https://glygen.org/publication/PubMed/30777924" } ] } ], "disease": [ { "disease_id": "DOID:0050908", "recommended_name": { "id": "DOID:0050908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050908", "name": "myelodysplastic syndrome", "description": "A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets." }, "synonyms": [ { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome", "description": "A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "MDS", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "MDS, unclassifiable", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "MDS-U", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "dysmyelopoietic syndrome", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "hematopoeitic - myelodysplastic syndrome (MDS)", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplasia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic neoplasm", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome, somatic", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome, unclassifiable", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome/neoplasm", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndromes", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "oligoblastic leukaemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "oligoblastic leukemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "preleukemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "smoldering leukemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "smouldering leukaemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome, susceptibility to", "description": "" }, { "id": "MIM:614286", "resource": "MIM", "url": "https://www.omim.org/entry/614286", "name": "Myelodysplastic syndrome", "description": "Myelodysplastic syndrome" } ], "evidence": [ { "id": "0050908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050908" } ] }, { "disease_id": "DOID:0070072", "recommended_name": { "id": "DOID:0070072", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070072", "name": "autosomal dominant intellectual developmental disorder 42", "description": "An autosomal dominant intellectual developmental disorder that has_material_basis_in an autosomal dominant mutation of the GNB1 gene on chromosome 1p36.33." }, "synonyms": [ { "id": "DOID:0070072", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070072", "name": "autosomal dominant non-syndromic intellectual disability 42", "description": "" }, { "id": "DOID:0070072", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070072", "name": "MRD42", "description": "" }, { "id": "DOID:0070072", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070072", "name": "autosomal dominant mental retardation 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "intellectual disability, autosomal dominant 42", "description": "Any autosomal dominant non-syndromic intellectual disability in which the cause of the disease is a mutation in the GNB1 gene." }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "GNB1 autosomal dominant non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "Gnb1 autosomal dominant non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "MRD42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "autosomal dominant intellectual disability 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "autosomal dominant mental retardation 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "autosomal dominant non-syndromic intellectual disability caused by mutation in GNB1", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "autosomal dominant non-syndromic intellectual disability caused by mutation in Gnb1", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "intellectual developmental disorder, autosomal dominant 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "intellectual disability, autosomal dominant 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "intellectual disability, autosomal dominant type 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "mental retardation, autosomal dominant 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "mental retardation, autosomal dominant type 42", "description": "" }, { "id": "MONDO:0014855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014855", "name": "autosomal dominant non-syndromic intellectual disability 42", "description": "" }, { "id": "MIM:616973", "resource": "MIM", "url": "https://www.omim.org/entry/616973", "name": "Intellectual developmental disorder, autosomal dominant 42", "description": "Intellectual developmental disorder, autosomal dominant 42" } ], "evidence": [ { "id": "0070072", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070072" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "evidence": [ { "id": "6000", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:9952", "recommended_name": { "id": "DOID:9952", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9952", "name": "acute lymphoblastic leukemia", "description": "A acute leukemia that is characterized by over production of lymphoblasts." }, "synonyms": [ { "id": "DOID:9952", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9952", "name": "ALL", "description": "" }, { "id": "DOID:9952", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9952", "name": "precursor lymphoblastic lymphoma/leukemia", "description": "" }, { "id": "DOID:9952", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9952", "name": "acute lymphoblastic leukaemia", "description": "" }, { "id": "DOID:9952", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9952", "name": "acute lymphocytic leukaemia", "description": "" }, { "id": "MONDO:0009539", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009539", "name": "lymphoblastic leukemia, acute, with lymphomatous features", "description": "" }, { "id": "MONDO:0009539", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009539", "name": "leukemia, acute lymphoblastic", "description": "" }, { "id": "MONDO:0009539", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009539", "name": "lymphoblastic leukemia, acute, with lymphomatous features", "description": "" }, { "id": "MONDO:0009539", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009539", "name": "lall", "description": "" }, { "id": "MONDO:0009539", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009539", "name": "lymphomatous All", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "leukemia, acute lymphocytic, susceptibility to, 1", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "T-cell acute lymphoblastic leukemia, somatic", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "leukemia, T-cell acute lymphoblastic, somatic", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "leukemia, T-cell acute lymphocytic, somatic", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "leukemia, acute lymphoblastic, somatic", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "leukemia, acute lymphocytic, Philadelphia chromosome positive, somatic", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "name": "leukemia, acute lymphocytic, susceptibility to, 1", "description": "" }, { "id": "MONDO:0013108", "resource": "MONDO", "url": 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nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Mus musculus OX=10090 GN=Gnb1 PE=1 SV=8 CANONICAL=P62874-1" }, "locus": { "chromosome": "4", "start_pos": 155639591, "end_pos": 155611910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000177094.8", "url": "https://www.ensembl.org/id/ENSMUST00000177094.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000135492.2", "url": "https://www.ensembl.org/id/ENSMUSP00000135492.2" } ] } }, { "isoform_ac": "H3BLF7-1", "url": "", "sequence": { "sequence": "MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS", "length": 108, "header": "tr|H3BLF7-1|GBB1_MOUSE Computationally mapped isoform of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Mus musculus OX=10090 GN=Gnb1 PE=1 SV=1 CANONICAL=P62874-1" }, "locus": { "chromosome": "4", "start_pos": 155627544, "end_pos": 155611910, "strand": "-", "evidence": [ { "database": 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"ENSMUST00000165335", "url": "https://www.ensembl.org/id/ENSMUST00000165335" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000130123", "url": "https://www.ensembl.org/id/ENSMUSP00000130123" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 136, "start_aa": "Ser", "end_pos": 136, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser136", "evidence": [ { "id": "P62874", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P62874" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P62874", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P62874" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] } ], "phosphorylation": [ { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "His", "comment": "Phosphohistidine", "evidence": [ { "database": "UniProtKB", "id": "P62874", "url": "https://www.uniprot.org/uniprot/P62874" } ], "site_lbl": "His266" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P62874", "url": "https://www.uniprot.org/uniprot/P62874" } ], "site_lbl": "Ser2" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes.", "journal": "DNA Seq.", "date": "2001", "authors": "Wang X., Uhl G.R., Hembree C.M., Kitanaka J., Kitanaka N.", "evidence": [ { "database": "UniProtKB", "id": "P62874", "url": "https://www.uniprot.org/uniprot/P62874" } ], "reference": [ { "type": "PubMed", "id": "11913780", "url": "https://glygen.org/publication/PubMed/11913780" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "P62874", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P62874" }, { "database": "O-GlcNAc Atlas", "id": "P62874", "url": "https://oglcnac.org/atlas/detail/P62874" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "The heterotrimeric G protein Gbeta1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Pradhan S, Khatlani T, Nairn AC, Vijayan KV", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" } ], "reference": [ { "type": "PubMed", "id": "28615442", "url": "https://glygen.org/publication/PubMed/28615442" } ] }, { "title": "Cutting Edge: G Protein Subunit beta 1 Negatively Regulates NLRP3 Inflammasome Activation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2019", "authors": "Murakami T, Ruengsinpinya L, Nakamura E, Takahata Y, Hata K, Okae H, Taniguchi S, Takahashi M, Nishimura R", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" } ], "reference": [ { "type": "PubMed", "id": "30777924", "url": "https://glygen.org/publication/PubMed/30777924" } ] }, { "title": "Disabling the Gbetagamma-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.", "journal": "Science signaling", "date": "2019", "authors": "Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" } ], "reference": [ { "type": "PubMed", "id": "30783011", "url": "https://glygen.org/publication/PubMed/30783011" } ] }, { "title": "G protein subunit beta1 is an important mediator of the late stage of endochondral ossification.", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Ruengsinpinya L, Murakami T, Nakamura E, Takahata Y, Hata K, Nakaminami Y, Okae H, Nishimura R", "evidence": [ { "database": "RefSeq", "id": "NP_001153488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153488" } ], "reference": [ { "type": "PubMed", "id": "32928505", "url": "https://glygen.org/publication/PubMed/32928505" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "P62874", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P62874" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] } ], "pathway": [ { "id": "mmu:14688", "name": "", "url": 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