{
    "uniprot_canonical_ac": "P62509-1",
    "uniprot_ac": "P62509",
    "uniprot_id": "ERR3_MOUSE",
    "mass": {
        "chemical_mass": 51306.0,
        "monoisotopic_mass": 51306.0
    },
    "refseq": {
        "ac": "NP_001230721",
        "name": "estrogen-related receptor gamma isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721"
    },
    "gene_names": [
        {
            "name": "Esrrg",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P62509",
            "id": "P62509"
        },
        {
            "name": "ERR3; Errg; mKIAA0832; NR3B3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721",
            "id": "NP_001230721"
        },
        {
            "name": "Err3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P62509",
            "id": "P62509"
        },
        {
            "name": "Esrrg",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721",
            "id": "NP_001230721"
        },
        {
            "name": "Kiaa0832",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P62509",
            "id": "P62509"
        },
        {
            "name": "Nr3b3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P62509",
            "id": "P62509"
        }
    ],
    "protein_names": [
        {
            "name": "Estrogen-related receptor gamma",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P62509"
        },
        {
            "name": "Estrogen receptor-related protein 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P62509"
        },
        {
            "name": "Nuclear receptor subfamily 3 group B member 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P62509"
        },
        {
            "name": "estrogen receptor-related protein 3; nuclear receptor subfamily 3 group B member 3; estrogen-related receptor 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721",
            "id": "NP_001230721"
        },
        {
            "name": "estrogen-related receptor gamma isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721",
            "id": "NP_001230721"
        }
    ],
    "function": [
        {
            "annotation": "Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509#function"
                },
                {
                    "database": "PubMed",
                    "id": "10428842",
                    "url": "https://glygen.org/publication/PubMed/10428842"
                }
            ]
        },
        {
            "annotation": "Transcriptional activation by ERR3 can be ligand-independent.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001230721",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721"
                },
                {
                    "database": "PubMed",
                    "id": "11864604",
                    "url": "https://glygen.org/publication/PubMed/11864604"
                }
            ]
        },
        {
            "annotation": "Upregulation of the ERRgamma-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001230721",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721"
                },
                {
                    "database": "PubMed",
                    "id": "37155882",
                    "url": "https://glygen.org/publication/PubMed/37155882"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:14227",
            "recommended_name": {
                "id": "DOID:14227",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:14227",
                "name": "azoospermia",
                "description": "A male infertility disease characterized by the absence of any measurable level of sperm in semen."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "14227",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:14227"
                }
            ]
        },
        {
            "disease_id": "DOID:162",
            "recommended_name": {
                "id": "DOID:162",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:162",
                "name": "cancer",
                "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis."
            },
            "synonyms": [
                {
                    "id": "DOID:162",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:162",
                    "name": "malignant neoplasm",
                    "description": ""
                },
                {
                    "id": "DOID:162",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:162",
                    "name": "malignant tumor",
                    "description": ""
                },
                {
                    "id": "DOID:162",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:162",
                    "name": "primary cancer",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "162",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:162"
                }
            ]
        }
    ],
    "snv": [
        {
            "evidence": [
                {
                    "id": "rs3388521561",
                    "database": "dbSNP",
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388521561"
                }
            ],
            "glycoeffect": [
                "n-glyco-sequon-gain",
                "o-glyco-site-loss"
            ],
            "start_pos": 65,
            "end_pos": 65,
            "sequence_org": "S",
            "sequence_mut": "N",
            "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SGS->NGS).",
            "chr_id": "1",
            "chr_pos": "187775668",
            "ref_nt": "A",
            "alt_nt": "null",
            "minor_allelic_frequency": "",
            "site_lbl": "S65",
            "keywords": [
                "ebi",
                "germline"
            ]
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 449,
            "end_pos": 449,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Loss of transcriptional activation; when associated with A-450.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                },
                {
                    "database": "PubMed",
                    "id": "10428842",
                    "url": "https://glygen.org/publication/PubMed/10428842"
                }
            ]
        },
        {
            "start_pos": 450,
            "end_pos": 450,
            "sequence_org": "F",
            "sequence_mut": "A",
            "comment": "Loss of transcriptional activation; when associated with A-449.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                },
                {
                    "database": "PubMed",
                    "id": "10428842",
                    "url": "https://glygen.org/publication/PubMed/10428842"
                }
            ]
        },
        {
            "start_pos": 453,
            "end_pos": 453,
            "sequence_org": "M",
            "sequence_mut": "A",
            "comment": "Loss of transcriptional activation; when associated with A-454.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                },
                {
                    "database": "PubMed",
                    "id": "10428842",
                    "url": "https://glygen.org/publication/PubMed/10428842"
                }
            ]
        },
        {
            "start_pos": 454,
            "end_pos": 454,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Loss of transcriptional activation; when associated with A-453.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                },
                {
                    "database": "PubMed",
                    "id": "10428842",
                    "url": "https://glygen.org/publication/PubMed/10428842"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Esrrg",
            "url": "https://www.uniprot.org/uniprot/P62509",
            "locus": {
                "chromosome": "1",
                "start_pos": 187947082,
                "end_pos": 187340988,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000026610",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000026610"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000026610",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026610",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd06946",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06946",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd07170",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07170",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "CHEMBL3585238",
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3585238",
            "database": "ChEMBL",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "26381",
            "url": "https://www.ncbi.nlm.nih.gov/gene/26381",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P62509",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P62509*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000536",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001628",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001723",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003078",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003078",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013088",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR024178",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024178",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027289",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027289",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035500",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:26381",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26381",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1347056",
            "url": "http://www.informatics.jax.org/marker/MGI:1347056",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P62509",
            "url": "https://oglcnac.org/atlas/detail/P62509",
            "database": "O-GlcNAc Atlas",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "P62509",
            "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P62509",
            "database": "O-GlcNAc Database",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "MDPVELC",
            "url": "https://omabrowser.org/oma/group/MDPVELC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5387678at2759",
            "url": "http://www.orthodb.org/?query=5387678at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48092",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48092",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48092:SF10",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48092:SF10",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1S9P",
            "url": "https://www.rcsb.org/structure/1S9P",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "1S9Q",
            "url": "https://www.rcsb.org/structure/1S9Q",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00104",
            "url": "http://pfam.xfam.org/family/PF00104",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00105",
            "url": "http://pfam.xfam.org/family/PF00105",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P62509",
            "url": "http://purl.obolibrary.org/obo/PR_P62509",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-383280",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-383280",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001230721",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z2J0",
            "url": "https://www.uniprot.org/uniprot/D3Z2J0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z2J0-1",
            "url": "https://www.uniprot.org/uniprot/D3Z2J0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P62509",
            "url": "https://www.uniprot.org/uniprot/P62509",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P62509-1",
            "url": "https://www.uniprot.org/uniprot/P62509-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P62509-2",
            "url": "https://www.uniprot.org/uniprot/P62509-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV",
        "length": 458,
        "header": "sp|P62509-1|ERR3_MOUSE Isoform 1 of Estrogen-related receptor gamma  OS=Mus musculus OX=10090 GN=Esrrg PE=1 SV=1 CANONICAL=P62509-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3Z2J0-1",
            "url": "",
            "sequence": {
                "sequence": "MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGH",
                "length": 52,
                "header": "tr|D3Z2J0-1|ERR3_MOUSE Computationally mapped isoform of Estrogen-related receptor gamma  OS=Mus musculus OX=10090 GN=Esrrg PE=1 SV=1 CANONICAL=P62509-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 187775699,
                "end_pos": 187775544,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000127489.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000127489.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000119286.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119286.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P62509-1",
            "url": "",
            "sequence": {
                "sequence": "MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV",
                "length": 458,
                "header": "sp|P62509-1|ERR3_MOUSE Isoform 1 of Estrogen-related receptor gamma  OS=Mus musculus OX=10090 GN=Esrrg PE=1 SV=1 CANONICAL=P62509-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 187943333,
                "end_pos": 187730194,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000027906",
                        "url": "https://www.ensembl.org/id/ENSMUST00000027906"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000027906",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000027906"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P62509-2",
            "url": "",
            "sequence": {
                "sequence": "MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV",
                "length": 435,
                "header": "sp|P62509-2|ERR3_MOUSE Isoform 2 of Estrogen-related receptor gamma  OS=Mus musculus OX=10090 GN=Esrrg PE=1 SV=1 CANONICAL=P62509-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 187943333,
                "end_pos": 187775544,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000110938",
                        "url": "https://www.ensembl.org/id/ENSMUST00000110938"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000106563",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000106563"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "S",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
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            "end_aa": "Ser",
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                    "id": "P62509",
                    "database": "O-GlcNAc Database",
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                {
                    "id": "27335230",
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                {
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                    "url": "https://oglcnac.org/atlas/detail/P62509"
                }
            ]
        },
        {
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            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
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            "relation": "attached",
            "comment": "O-GlcNAcylation",
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            "start_aa": "Ser",
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            "end_aa": "Ser",
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                {
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                }
            ]
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            "kinase_uniprot_canonical_ac": "",
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        "glycoprotein_reported_with_glycan"
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        {
            "title": "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3.",
            "journal": "J. Biol. Chem.",
            "date": "1999",
            "authors": "Hong H, Yang L, Stallcup MR",
            "evidence": [
                {
                    "database": "UniProtKB",
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            ],
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                {
                    "type": "PubMed",
                    "id": "10428842",
                    "url": "https://glygen.org/publication/PubMed/10428842"
                }
            ]
        },
        {
            "title": "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.",
            "journal": "Molecular cell",
            "date": "2002",
            "authors": "Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001230721",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "11864604",
                    "url": "https://glygen.org/publication/PubMed/11864604"
                }
            ]
        },
        {
            "title": "Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.",
            "journal": "J. Biol. Chem.",
            "date": "2004",
            "authors": "Moras D., Flaig R., Greschik H., Renaud J.-P.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15161930",
                    "url": "https://glygen.org/publication/PubMed/15161930"
                }
            ]
        },
        {
            "title": "O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor gamma Promotes Hepatic Gluconeogenesis.",
            "journal": "Diabetes",
            "date": "2016",
            "authors": "Misra J, Kim DK, Jung YS, Kim HB, Kim YH, Yoo EK, Kim BG, Kim S, Lee IK, Harris RA, Kim JS, Lee CH, Cho JW, Choi HS",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "P62509",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P62509"
                },
                {
                    "database": "O-GlcNAc Atlas",
                    "id": "P62509",
                    "url": "https://oglcnac.org/atlas/detail/P62509"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27335230",
                    "url": "https://glygen.org/publication/PubMed/27335230"
                }
            ]
        },
        {
            "title": "GDF15 is a heart-derived hormone that regulates body growth.",
            "journal": "EMBO Mol. Med.",
            "date": "2017",
            "authors": "Liu J., Hakonarson H., Wang T., Zhai X., Pei L., McDonald C., Wilkins B.J., Lupino K.",
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                {
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                    "id": "P62509",
                    "url": "https://www.uniprot.org/uniprot/P62509"
                }
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                    "type": "PubMed",
                    "id": "28572090",
                    "url": "https://glygen.org/publication/PubMed/28572090"
                }
            ]
        },
        {
            "title": "Upregulation of the ERR\u03b3-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2023-05-16",
            "authors": "Chanda Dipanjan, Thoudam Themis, Sinam Ibotombi Singh, Lim Chae Won, Kim Myeongjin, Wang Jiale, Lee Kyeong-Min, Ma Jing, Saxena Romil, Choi Jinhyuk, Oh Chang Joo, Lee Hoyul, Jeon Yong Hyun, Cho Sung Jin, Jung Hoe-Yune, Park Keun-Gyu, Choi Hueng-Sik, Suh Jae Myoung, Auwerx Johan, Ji Baoan, Liangpunsakul Suthat, Jeon Jae-Han, Lee In-Kyu",
            "evidence": [
                {
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                    "id": "NP_001230721",
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                    "id": "37155882",
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        }
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        {
            "id": "mmu:26381",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26381",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-383280",
            "name": "Nuclear Receptor transcription pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-383280",
            "resource": "Reactome",
            "description": "Nuclear Receptor transcription pathway"
        }
    ],
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                "length": 458
            },
            "evidence": [
                {
                    "id": "45225424",
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                }
            ],
            "common_name": "Human"
        },
        {
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            "tax_id": 10116,
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                "sequence": "MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV",
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            },
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                {
                    "id": "P62509",
                    "url": "https://omabrowser.org/oma/group/P62509/",
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                }
            ],
            "common_name": "Rat"
        }
    ],
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            {
                "name": "Molecular Function",
                "total": 11,
                "go_terms": [
                    {
                        "name": "estrogen response element binding",
                        "id": "GO:0034056",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034056",
                        "evidence": [
                            {
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                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
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                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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                        "id": "GO:0005516",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516",
                        "evidence": [
                            {
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                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear steroid receptor activity",
                        "id": "GO:0003707",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003707",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
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                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "steroid binding",
                        "id": "GO:0005496",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005496",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear receptor activity",
                        "id": "GO:0004879",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
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                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific double-stranded DNA binding",
                        "id": "GO:1990837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA-templated transcription",
                        "id": "GO:0006355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "retinoic acid receptor signaling pathway",
                        "id": "GO:0048384",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048384",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular steroid hormone receptor signaling pathway",
                        "id": "GO:0030518",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030518",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cold-induced thermogenesis",
                        "id": "GO:0120162",
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P62509",
                                "url": "https://www.uniprot.org/uniprot/P62509"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
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    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
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