Many pathogens such as Streptococcus pneumoniae have evolved lysozyme resistance to prevent peptidoglycan hydrolysis. The primary mechanism for lysozyme resistance in both Gram-positive and Gram-negative organisms appears to be direct modification of peptidoglycan; however, modification of other cell wall-linked components, such as teichoic acid, may also contribute to resistance (Amano K & Williams JC 1983; Bera A et al. 2005; Pushkaran AC et al. 2015).
LYZ is found in many human secretions such as tears, milk, mucus and saliva (Surna A et al. 2009; Minami J et al. 2015; Sahin O et al. 2016; Masschalck B & Michiels CW. 2003).",
"cellular_location": "extracellular region, peptidoglycan-based cell wall",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-6788982"
],
"enzyme_list": [
"P61626-1"
],
"evidence": [
{
"id": "R-HSA-8862320",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8862320"
}
]
},
{
"id": "R-HSA-976734",
"name": "Amyloid fibrils have additional components",
"equation": "",
"summary": "In addition to the main fibril peptide, mature amyloid fibrils have additional components. Serum amyloid P component (SAP) binds to all types of amyloid fibrils and is a universal constituent of amyloid deposits. SAP binding protects amyloid fibrils from proteolytic degradation (Tennent et al. 1995, Westermark 2005). SAP may function as a chaperone for amyloid formation (Coker et al. 2000).
Glycosaminoglycans (GAGs) and proteoglycans are found associated with all types of amyloid deposits (Alexandrescu 2005). Of the different types of GAG heparan sulfate and dermatan sulfate are the most prominent in amyloid deposits (Hirschfield & Hawkins, 2003). GAGs have been implicated in the nucleation of fibrils, they can also stabilize mature fibrils against dissociation (Yamaguchi et al. 2003) and proteolytic degradation (Gupta-Bansal et al. 1995).
Perlecan coimmunolocalizes with all types of amyloids (Snow & Wright 1989), accelerating fibril formation (Castillo et al. 1998), stabilizing them once formed (Castillo et al. 1997), and protecting them from proteolytic degradation (Gupta-Bansal et al. 1995).
APOE isoform 4 binds tightly to soluble ABeta peptide forming complexes that resist dissociation; it also binds to ABeta in its fibril form (Bales et al. 2002).",
"cellular_location": "extracellular region",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P61626-1",
"P02788-1"
],
"evidence": [
{
"id": "R-HSA-976734",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-976734"
}
]
},
{
"id": "R-HSA-977136",
"name": "Amyloid precursor proteins form ordered fibrils",
"equation": "",
"summary": "Amyloid fibril formation is associated with a wide range of diseases (Chiti & Dobson 2006), though the accumulation and deposition of fibrillar material does not correlate well with disease pathogenesis and it is now widely believed that oligomeric amyloid forms are largely responsible for the cytotoxic effects of amyloid (Glabe 2009). Fibrils have been described as more like crystalline polymer structures than the protein monomers they are derived from (Wetzel et al. 2007). In vitro, fibril formation is usually preceded by the association of monomers into oligomeric structures (Kodali & Wetzel 2007), though this remains to be established in vivo. Amyloid-beta forms spherical structures with around 12 units (Bernstein et al. 2005). Larger structures called protofibrils are also observed, non-spherical filamentous structures lacking a periodic substructure (Goldsbury 2005).",
"cellular_location": "extracellular region",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P61626-1",
"P02788-1"
],
"evidence": [
{
"id": "R-HSA-977136",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977136"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-6788982",
"participant_name": "betaGlcNAc [peptidoglycan-based cell wall]",
"crossref": [
{
"id": "28009",
"database": "ChEBI",
"url": ""
},
{
"id": "G49108TO",
"database": "GlyTouCan",
"url": ""
},
{
"id": "C03136",
"database": "COMPOUND",
"url": ""
},
{
"id": "000003983907",
"database": "ZINC",
"url": ""
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{
"id": "C03878",
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},
{
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},
{
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},
{
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"url": ""
},
{
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"url": ""
},
{
"id": "C03878",
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},
{
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},
{
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{
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},
{
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},
{
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"url": ""
},
{
"id": "HMDB0000803",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C03878",
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"url": ""
},
{
"id": "C03136",
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"url": ""
},
{
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"url": ""
},
{
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{
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},
{
"id": "000003983907",
"database": "ZINC",
"url": ""
},
{
"id": "28009",
"database": "ChEBI",
"url": ""
},
{
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"url": ""
},
{
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},
{
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},
{
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},
{
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"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-HSA-6806202",
"participant_name": "LYZ [extracellular region]",
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"id": "1GBX",
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"url": ""
},
{
"id": "1B5U",
"database": "PDB",
"url": ""
},
{
"id": "1CJ8",
"database": "PDB",
"url": ""
},
{
"id": "P61626",
"database": "GeneCards",
"url": ""
},
{
"id": "1GF5",
"database": "PDB",
"url": ""
},
{
"id": "2HEC",
"database": "PDB",
"url": ""
},
{
"id": "1EQ5",
"database": "PDB",
"url": ""
},
{
"id": "2ZIL",
"database": "PDB",
"url": ""
},
{
"id": "1INU",
"database": "PDB",
"url": ""
},
{
"id": "1C43",
"database": "PDB",
"url": ""
},
{
"id": "4R0P",
"database": "PDB",
"url": ""
},
{
"id": "2BQD",
"database": "PDB",
"url": ""
},
{
"id": "1GEZ",
"database": "PDB",
"url": ""
},
{
"id": "2MEI",
"database": "PDB",
"url": ""
},
{
"id": "7XF7",
"database": "PDB",
"url": ""
},
{
"id": "P61626",
"database": "PRO",
"url": ""
},
{
"id": "1CKC",
"database": "PDB",
"url": ""
},
{
"id": "2BQI",
"database": "PDB",
"url": ""
},
{
"id": "1GB5",
"database": "PDB",
"url": ""
},
{
"id": "1BB3",
"database": "PDB",
"url": ""
},
{
"id": "1GBZ",
"database": "PDB",
"url": ""
},
{
"id": "16420",
"database": "Orphanet",
"url": ""
},
{
"id": "1GF9",
"database": "PDB",
"url": ""
},
{
"id": "1OUI",
"database": "PDB",
"url": ""
},
{
"id": "1CKF",
"database": "PDB",
"url": ""
},
{
"id": "1YAM",
"database": "PDB",
"url": ""
},
{
"id": "1BB4",
"database": "PDB",
"url": ""
},
{
"id": "1GAY",
"database": "PDB",
"url": ""
},
{
"id": "2HEF",
"database": "PDB",
"url": ""
},
{
"id": "2BQM",
"database": "PDB",
"url": ""
},
{
"id": "1GBW",
"database": "PDB",
"url": ""
},
{
"id": "2NWD",
"database": "PDB",
"url": ""
},
{
"id": "1UBZ",
"database": "PDB",
"url": ""
},
{
"id": "1C7P",
"database": "PDB",
"url": ""
},
{
"id": "2BQG",
"database": "PDB",
"url": ""
},
{
"id": "NP_000230.1",
"database": "RefSeq",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "O00391",
"gene_name": "QSOX1",
"activity": [
{
"ec_number": "1.8.3.2",
"activity": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'.",
"evidence": [
{
"id": "O00391",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00391"
}
]
},
{
"ec_number": "1.8.3.2",
"activity": "",
"evidence": [
{
"id": "O00391",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00391"
}
]
}
]
},
{
"uniprot_ac": "O00584",
"gene_name": "RNASET2",
"activity": [
{
"ec_number": "4.6.1.19",
"activity": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+).",
"evidence": [
{
"id": "O00584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00584"
}
]
},
{
"ec_number": "4.6.1.19",
"activity": "",
"evidence": [
{
"id": "O00584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00584"
}
]
}
]
},
{
"uniprot_ac": "O00754",
"gene_name": "MAN2B1",
"activity": [
{
"ec_number": "3.2.1.24",
"activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.",
"evidence": [
{
"id": "O00754",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00754"
}
]
},
{
"ec_number": "3.2.1.24",
"activity": "",
"evidence": [
{
"id": "O00754",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00754"
}
]
}
]
},
{
"uniprot_ac": "O00764",
"gene_name": "PDXK",
"activity": [
{
"ec_number": "2.7.1.35",
"activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.",
"evidence": [
{
"id": "O00764",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00764"
}
]
},
{
"ec_number": "2.7.1.35",
"activity": "",
"evidence": [
{
"id": "O00764",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00764"
}
]
}
]
},
{
"uniprot_ac": "O75874",
"gene_name": "IDH1",
"activity": [
{
"ec_number": "1.1.1.42",
"activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.",
"evidence": [
{
"id": "O75874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75874"
}
]
},
{
"ec_number": "1.1.1.42",
"activity": "",
"evidence": [
{
"id": "O75874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75874"
}
]
}
]
},
{
"uniprot_ac": "P00387",
"gene_name": "CYB5R3",
"activity": [
{
"ec_number": "1.6.2.2",
"activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).",
"evidence": [
{
"id": "P00387",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00387"
}
]
},
{
"ec_number": "1.6.2.2",
"activity": "",
"evidence": [
{
"id": "P00387",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00387"
}
]
}
]
},
{
"uniprot_ac": "P02788",
"gene_name": "LTF",
"activity": [
{
"ec_number": "3.4.21.-",
"activity": "",
"evidence": [
{
"id": "P02788",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02788"
}
]
}
]
},
{
"uniprot_ac": "P02794",
"gene_name": "FTH1",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P02794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02794"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P02794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02794"
}
]
}
]
},
{
"uniprot_ac": "P04066",
"gene_name": "FUCA1",
"activity": [
{
"ec_number": "3.2.1.51",
"activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.",
"evidence": [
{
"id": "P04066",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04066"
}
]
},
{
"ec_number": "3.2.1.51",
"activity": "",
"evidence": [
{
"id": "P04066",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04066"
}
]
}
]
},
{
"uniprot_ac": "P04075",
"gene_name": "ALDOA",
"activity": [
{
"ec_number": "4.1.2.13",
"activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.",
"evidence": [
{
"id": "P04075",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04075"
}
]
},
{
"ec_number": "4.1.2.13",
"activity": "",
"evidence": [
{
"id": "P04075",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04075"
}
]
}
]
},
{
"uniprot_ac": "P05089",
"gene_name": "ARG1",
"activity": [
{
"ec_number": "3.5.3.1",
"activity": "H2O + L-arginine = L-ornithine + urea.",
"evidence": [
{
"id": "P05089",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05089"
}
]
},
{
"ec_number": "3.5.3.1",
"activity": "",
"evidence": [
{
"id": "P05089",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05089"
}
]
}
]
},
{
"uniprot_ac": "P05164",
"gene_name": "MPO",
"activity": [
{
"ec_number": "1.11.2.2",
"activity": "chloride + H(+) + H2O2 = H2O + hypochlorous acid.",
"evidence": [
{
"id": "P05164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05164"
}
]
},
{
"ec_number": "1.11.2.2",
"activity": "",
"evidence": [
{
"id": "P05164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05164"
}
]
}
]
},
{
"uniprot_ac": "P06280",
"gene_name": "GLA",
"activity": [
{
"ec_number": "3.2.1.-",
"activity": "",
"evidence": [
{
"id": "P06280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06280"
}
]
},
{
"ec_number": "3.2.1.22",
"activity": "globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose.",
"evidence": [
{
"id": "P06280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06280"
}
]
},
{
"ec_number": "3.2.1.22",
"activity": "",
"evidence": [
{
"id": "P06280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06280"
}
]
}
]
},
{
"uniprot_ac": "P07339",
"gene_name": "CTSD",
"activity": [
{
"ec_number": "3.4.23.5",
"activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.",
"evidence": [
{
"id": "P07339",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07339"
}
]
},
{
"ec_number": "3.4.23.5",
"activity": "",
"evidence": [
{
"id": "P07339",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07339"
}
]
}
]
},
{
"uniprot_ac": "P07478",
"gene_name": "PRSS2",
"activity": [
{
"ec_number": "3.4.21.4",
"activity": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.",
"evidence": [
{
"id": "P07478",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07478"
}
]
},
{
"ec_number": "3.4.21.4",
"activity": "",
"evidence": [
{
"id": "P07478",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07478"
}
]
}
]
},
{
"uniprot_ac": "P07686",
"gene_name": "HEXB",
"activity": [
{
"ec_number": "3.2.1.52",
"activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.",
"evidence": [
{
"id": "P07686",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07686"
}
]
},
{
"ec_number": "3.2.1.52",
"activity": "",
"evidence": [
{
"id": "P07686",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07686"
}
]
}
]
},
{
"uniprot_ac": "P08236",
"gene_name": "GUSB",
"activity": [
{
"ec_number": "3.2.1.31",
"activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.",
"evidence": [
{
"id": "P08236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08236"
}
]
},
{
"ec_number": "3.2.1.31",
"activity": "",
"evidence": [
{
"id": "P08236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08236"
}
]
}
]
},
{
"uniprot_ac": "P08246",
"gene_name": "ELANE",
"activity": [
{
"ec_number": "3.4.21.37",
"activity": "Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.",
"evidence": [
{
"id": "P08246",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08246"
}
]
},
{
"ec_number": "3.4.21.37",
"activity": "",
"evidence": [
{
"id": "P08246",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08246"
}
]
}
]
},
{
"uniprot_ac": "P08311",
"gene_name": "CTSG",
"activity": [
{
"ec_number": "3.4.21.20",
"activity": "Specificity similar to chymotrypsin C.",
"evidence": [
{
"id": "P08311",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08311"
}
]
},
{
"ec_number": "3.4.21.20",
"activity": "",
"evidence": [
{
"id": "P08311",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08311"
}
]
}
]
},
{
"uniprot_ac": "P09110",
"gene_name": "ACAA1",
"activity": [
{
"ec_number": "2.3.1.16",
"activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.",
"evidence": [
{
"id": "P09110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09110"
}
]
},
{
"ec_number": "2.3.1.9",
"activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.",
"evidence": [
{
"id": "P09110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09110"
}
]
},
{
"ec_number": "2.3.1.155",
"activity": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA.",
"evidence": [
{
"id": "P09110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09110"
}
]
},
{
"ec_number": "2.3.1.16",
"activity": "",
"evidence": [
{
"id": "P09110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09110"
}
]
}
]
},
{
"uniprot_ac": "P09960",
"gene_name": "LTA4H",
"activity": [
{
"ec_number": "3.3.2.6",
"activity": "H2O + leukotriene A4 = leukotriene B4.",
"evidence": [
{
"id": "P09960",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09960"
}
]
},
{
"ec_number": "3.4.11.4",
"activity": "Release of the N-terminal residue from a tripeptide.",
"evidence": [
{
"id": "P09960",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09960"
}
]
},
{
"ec_number": "3.3.2.6",
"activity": "",
"evidence": [
{
"id": "P09960",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09960"
}
]
}
]
},
{
"uniprot_ac": "P09972",
"gene_name": "ALDOC",
"activity": [
{
"ec_number": "4.1.2.13",
"activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.",
"evidence": [
{
"id": "P09972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09972"
}
]
},
{
"ec_number": "4.1.2.13",
"activity": "",
"evidence": [
{
"id": "P09972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09972"
}
]
}
]
},
{
"uniprot_ac": "P10153",
"gene_name": "RNASE2",
"activity": [
{
"ec_number": "4.6.1.18",
"activity": "an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].",
"evidence": [
{
"id": "P10153",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10153"
}
]
},
{
"ec_number": "4.6.1.18",
"activity": "",
"evidence": [
{
"id": "P10153",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10153"
}
]
}
]
},
{
"uniprot_ac": "P10619",
"gene_name": "CTSA",
"activity": [
{
"ec_number": "3.4.16.-",
"activity": "",
"evidence": [
{
"id": "P10619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10619"
}
]
},
{
"ec_number": "3.4.16.5",
"activity": "Release of a C-terminal amino acid with broad specificity.",
"evidence": [
{
"id": "P10619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10619"
}
]
},
{
"ec_number": "3.4.16.5",
"activity": "",
"evidence": [
{
"id": "P10619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10619"
}
]
}
]
},
{
"uniprot_ac": "P11216",
"gene_name": "PYGB",
"activity": [
{
"ec_number": "2.4.1.1",
"activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.",
"evidence": [
{
"id": "P11216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11216"
}
]
},
{
"ec_number": "2.4.1.1",
"activity": "",
"evidence": [
{
"id": "P11216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11216"
}
]
}
]
},
{
"uniprot_ac": "P12724",
"gene_name": "RNASE3",
"activity": [
{
"ec_number": "3.1.27.-",
"activity": "",
"evidence": [
{
"id": "P12724",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12724"
}
]
}
]
},
{
"uniprot_ac": "P14780",
"gene_name": "MMP9",
"activity": [
{
"ec_number": "3.4.24.35",
"activity": "Cleavage of gelatin types I and V and collagen types IV and V.",
"evidence": [
{
"id": "P14780",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14780"
}
]
},
{
"ec_number": "3.4.24.35",
"activity": "",
"evidence": [
{
"id": "P14780",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14780"
}
]
}
]
},
{
"uniprot_ac": "P15289",
"gene_name": "ARSA",
"activity": [
{
"ec_number": "3.1.6.8",
"activity": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate.",
"evidence": [
{
"id": "P15289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15289"
}
]
},
{
"ec_number": "3.1.6.8",
"activity": "",
"evidence": [
{
"id": "P15289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15289"
}
]
}
]
},
{
"uniprot_ac": "P15586",
"gene_name": "GNS",
"activity": [
{
"ec_number": "3.1.6.14",
"activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.",
"evidence": [
{
"id": "P15586",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15586"
}
]
},
{
"ec_number": "3.1.6.14",
"activity": "",
"evidence": [
{
"id": "P15586",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15586"
}
]
}
]
},
{
"uniprot_ac": "P15848",
"gene_name": "ARSB",
"activity": [
{
"ec_number": "3.1.6.12",
"activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.",
"evidence": [
{
"id": "P15848",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15848"
}
]
},
{
"ec_number": "3.1.6.12",
"activity": "",
"evidence": [
{
"id": "P15848",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15848"
}
]
}
]
},
{
"uniprot_ac": "P16278",
"gene_name": "GLB1",
"activity": [
{
"ec_number": "3.2.1.23",
"activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.",
"evidence": [
{
"id": "P16278",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16278"
}
]
},
{
"ec_number": "3.2.1.23",
"activity": "",
"evidence": [
{
"id": "P16278",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16278"
}
]
}
]
},
{
"uniprot_ac": "P19801",
"gene_name": "AOC1",
"activity": [
{
"ec_number": "1.4.3.22",
"activity": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+).",
"evidence": [
{
"id": "P19801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19801"
}
]
},
{
"ec_number": "1.4.3.22",
"activity": "",
"evidence": [
{
"id": "P19801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19801"
}
]
},
{
"ec_number": "1.4.3.-",
"activity": "",
"evidence": [
{
"id": "P19801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19801"
}
]
}
]
},
{
"uniprot_ac": "P20839",
"gene_name": "IMPDH1",
"activity": [
{
"ec_number": "1.1.1.205",
"activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.",
"evidence": [
{
"id": "P20839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20839"
}
]
},
{
"ec_number": "1.1.1.205",
"activity": "",
"evidence": [
{
"id": "P20839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20839"
}
]
}
]
},
{
"uniprot_ac": "P20933",
"gene_name": "AGA",
"activity": [
{
"ec_number": "3.5.1.26",
"activity": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine.",
"evidence": [
{
"id": "P20933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20933"
}
]
},
{
"ec_number": "3.5.1.26",
"activity": "",
"evidence": [
{
"id": "P20933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20933"
}
]
}
]
},
{
"uniprot_ac": "P22894",
"gene_name": "MMP8",
"activity": [
{
"ec_number": "3.4.24.34",
"activity": "Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.",
"evidence": [
{
"id": "P22894",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22894"
}
]
},
{
"ec_number": "3.4.24.34",
"activity": "",
"evidence": [
{
"id": "P22894",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22894"
}
]
}
]
},
{
"uniprot_ac": "P24158",
"gene_name": "PRTN3",
"activity": [
{
"ec_number": "3.4.21.76",
"activity": "Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.",
"evidence": [
{
"id": "P24158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24158"
}
]
},
{
"ec_number": "3.4.21.76",
"activity": "",
"evidence": [
{
"id": "P24158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24158"
}
]
}
]
},
{
"uniprot_ac": "P25774",
"gene_name": "CTSS",
"activity": [
{
"ec_number": "3.4.22.27",
"activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.",
"evidence": [
{
"id": "P25774",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25774"
}
]
},
{
"ec_number": "3.4.22.27",
"activity": "",
"evidence": [
{
"id": "P25774",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25774"
}
]
}
]
},
{
"uniprot_ac": "P28482",
"gene_name": "MAPK1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28482",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28482"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P28482",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28482"
}
]
}
]
},
{
"uniprot_ac": "P29350",
"gene_name": "PTPN6",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P29350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29350"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P29350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29350"
}
]
}
]
},
{
"uniprot_ac": "P30041",
"gene_name": "PRDX6",
"activity": [
{
"ec_number": "1.11.1.27",
"activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.",
"evidence": [
{
"id": "P30041",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30041"
}
]
},
{
"ec_number": "3.1.1.4",
"activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).",
"evidence": [
{
"id": "P30041",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30041"
}
]
},
{
"ec_number": "2.3.1.23",
"activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.",
"evidence": [
{
"id": "P30041",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30041"
}
]
},
{
"ec_number": "1.11.1.27",
"activity": "",
"evidence": [
{
"id": "P30041",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30041"
}
]
}
]
},
{
"uniprot_ac": "P32320",
"gene_name": "CDA",
"activity": [
{
"ec_number": "3.5.4.5",
"activity": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+).",
"evidence": [
{
"id": "P32320",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32320"
}
]
},
{
"ec_number": "3.5.4.5",
"activity": "",
"evidence": [
{
"id": "P32320",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32320"
}
]
}
]
},
{
"uniprot_ac": "P34059",
"gene_name": "GALNS",
"activity": [
{
"ec_number": "3.1.6.4",
"activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.",
"evidence": [
{
"id": "P34059",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34059"
}
]
},
{
"ec_number": "3.1.6.4",
"activity": "",
"evidence": [
{
"id": "P34059",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34059"
}
]
}
]
},
{
"uniprot_ac": "P35030",
"gene_name": "PRSS3",
"activity": [
{
"ec_number": "3.4.21.4",
"activity": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.",
"evidence": [
{
"id": "P35030",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35030"
}
]
},
{
"ec_number": "3.4.21.4",
"activity": "",
"evidence": [
{
"id": "P35030",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35030"
}
]
}
]
},
{
"uniprot_ac": "P36871",
"gene_name": "PGM1",
"activity": [
{
"ec_number": "5.4.2.2",
"activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.",
"evidence": [
{
"id": "P36871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36871"
}
]
},
{
"ec_number": "5.4.2.2",
"activity": "",
"evidence": [
{
"id": "P36871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36871"
}
]
}
]
},
{
"uniprot_ac": "P42685",
"gene_name": "FRK",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P42685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42685"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P42685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42685"
}
]
}
]
},
{
"uniprot_ac": "P49184",
"gene_name": "DNASE1L1",
"activity": [
{
"ec_number": "3.1.21.-",
"activity": "",
"evidence": [
{
"id": "P49184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49184"
}
]
}
]
},
{
"uniprot_ac": "P51159",
"gene_name": "RAB27A",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P51159",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51159"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P51159",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51159"
}
]
}
]
},
{
"uniprot_ac": "P53396",
"gene_name": "ACLY",
"activity": [
{
"ec_number": "2.3.3.8",
"activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.",
"evidence": [
{
"id": "P53396",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53396"
}
]
},
{
"ec_number": "2.3.3.8",
"activity": "",
"evidence": [
{
"id": "P53396",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53396"
}
]
}
]
},
{
"uniprot_ac": "P53634",
"gene_name": "CTSC",
"activity": [
{
"ec_number": "3.4.14.1",
"activity": "Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.",
"evidence": [
{
"id": "P53634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53634"
}
]
},
{
"ec_number": "3.4.14.1",
"activity": "",
"evidence": [
{
"id": "P53634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53634"
}
]
}
]
},
{
"uniprot_ac": "P55072",
"gene_name": "VCP",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P55072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55072"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P55072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55072"
}
]
}
]
},
{
"uniprot_ac": "P61626",
"gene_name": "LYZ",
"activity": [
{
"ec_number": "3.2.1.17",
"activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.",
"evidence": [
{
"id": "P61626",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61626"
}
]
},
{
"ec_number": "3.2.1.17",
"activity": "",
"evidence": [
{
"id": "P61626",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61626"
}
]
}
]
},
{
"uniprot_ac": "P98066",
"gene_name": "TNFAIP6",
"activity": [
{
"ec_number": "3.1.1.-",
"activity": "",
"evidence": [
{
"id": "P98066",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98066"
}
]
}
]
},
{
"uniprot_ac": "Q05655",
"gene_name": "PRKCD",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q05655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05655"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q05655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05655"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q05655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05655"
}
]
}
]
},
{
"uniprot_ac": "Q13231",
"gene_name": "CHIT1",
"activity": [
{
"ec_number": "3.2.1.14",
"activity": "Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.",
"evidence": [
{
"id": "Q13231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13231"
}
]
},
{
"ec_number": "3.2.1.14",
"activity": "",
"evidence": [
{
"id": "Q13231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13231"
}
]
}
]
},
{
"uniprot_ac": "Q13510",
"gene_name": "ASAH1",
"activity": [
{
"ec_number": "3.5.1.23",
"activity": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine.",
"evidence": [
{
"id": "Q13510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13510"
}
]
},
{
"ec_number": "3.5.1.23",
"activity": "",
"evidence": [
{
"id": "Q13510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13510"
}
]
},
{
"ec_number": "3.5.1.-",
"activity": "",
"evidence": [
{
"id": "Q13510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13510"
}
]
}
]
},
{
"uniprot_ac": "Q16769",
"gene_name": "QPCT",
"activity": [
{
"ec_number": "2.3.2.5",
"activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).",
"evidence": [
{
"id": "Q16769",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16769"
}
]
},
{
"ec_number": "2.3.2.5",
"activity": "",
"evidence": [
{
"id": "Q16769",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16769"
}
]
}
]
},
{
"uniprot_ac": "Q6XQN6",
"gene_name": "NAPRT",
"activity": [
{
"ec_number": "6.3.4.21",
"activity": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate.",
"evidence": [
{
"id": "Q6XQN6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XQN6"
}
]
},
{
"ec_number": "6.3.4.21",
"activity": "",
"evidence": [
{
"id": "Q6XQN6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XQN6"
}
]
}
]
},
{
"uniprot_ac": "Q8NBS9",
"gene_name": "TXNDC5",
"activity": [
{
"ec_number": "1.8.4.-",
"activity": "",
"evidence": [
{
"id": "Q8NBS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBS9"
}
]
},
{
"ec_number": "5.3.4.1",
"activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.",
"evidence": [
{
"id": "Q8NBS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBS9"
}
]
},
{
"ec_number": "5.3.4.1",
"activity": "",
"evidence": [
{
"id": "Q8NBS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBS9"
}
]
}
]
},
{
"uniprot_ac": "Q8WVQ1",
"gene_name": "CANT1",
"activity": [
{
"ec_number": "3.6.1.6",
"activity": "ADP + H2O = AMP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8WVQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVQ1"
}
]
},
{
"ec_number": "3.6.1.6",
"activity": "",
"evidence": [
{
"id": "Q8WVQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVQ1"
}
]
}
]
},
{
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