{ "uniprot_canonical_ac": "P60755-1", "uniprot_ac": "P60755", "uniprot_id": "MDGA2_MOUSE", "mass": { "chemical_mass": 106689.0, "monoisotopic_mass": 106689.0 }, "refseq": { "ac": "NP_001180195", "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" }, "gene_names": [ { "name": "Mdga2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P60755", "id": "P60755" }, { "name": "6720489L24Rik; 9330209L04Rik; Adp; Mamdc1; Tg(Prnp-PFN1*G118V)838Kiaei", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195", "id": "NP_001180195" }, { "name": "Mamdc1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P60755", "id": "P60755" }, { "name": "Mdga2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195", "id": "NP_001180195" } ], "protein_names": [ { "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P60755" }, { "name": "MAM domain containing 1; MAM domain-containing glycosylphosphatidylinositol anchor protein 2; acrodysplasia", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893", "id": "NP_996893" }, { "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform A precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195", "id": "NP_001180195" }, { "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform B precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893", "id": "NP_996893" }, { "name": "MAM domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P60755" } ], "function": [ { "annotation": "Early postnatal development of the MDGA2[+/-] mouse model of synaptic dysfunction.", "evidence": [ { "database": "RefSeq", "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893" }, { "database": "PubMed", "id": "37499910", "url": "https://glygen.org/publication/PubMed/37499910" }, { "database": "RefSeq", "id": "NP_001180195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" } ] }, { "annotation": "MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 and not neuroligin-1 excitatory synapse organizer.", "evidence": [ { "database": "RefSeq", "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893" }, { "database": "PubMed", "id": "23358245", "url": "https://glygen.org/publication/PubMed/23358245" }, { "database": "RefSeq", "id": "NP_001180195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" } ] }, { "annotation": "May be involved in cell-cell interactions.", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755#function" } ] }, { "annotation": "The transgene was inserted into the intronic sequences between exon 3 and exon 4 of the Mdga2 gene;the transgene was highly or under methylated in normal and deformed mice, respectively.", "evidence": [ { "database": "RefSeq", "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893" }, { "database": "PubMed", "id": "22281501", "url": "https://glygen.org/publication/PubMed/22281501" }, { "database": "RefSeq", "id": "NP_001180195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3389173063", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389173063" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 116, "end_pos": 116, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGL->NGS).", "chr_id": "12", "chr_pos": "66844443", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L116", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mdga2", "url": "https://www.uniprot.org/uniprot/P60755", "locus": { "chromosome": "12", "start_pos": 66512834, "end_pos": 67269323, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000034912", "url": "https://www.ensembl.org/id/ENSMUSG00000034912" } ] } } ], "crossref": [ { "id": "ENSMUSG00000034912", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034912", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "320772", "url": "https://www.ncbi.nlm.nih.gov/gene/320772", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2501", "url": "https://glyconnect.expasy.org/browser/proteins/2501", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "GPDB0003733", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003733", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0004952", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0004952", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR000998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:320772", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320772", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2444706", "url": "http://www.informatics.jax.org/marker/MGI:2444706", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P60755", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P60755", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "AYSLEWT", "url": "https://omabrowser.org/oma/group/AYSLEWT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2963083at2759", "url": "http://www.orthodb.org/?query=2963083at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23282:SF137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23282:SF137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45080", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45080", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45080:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45080:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00629", "url": "http://pfam.xfam.org/family/PF00629", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "http://pfam.xfam.org/family/PF13927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P60755", "url": "http://purl.obolibrary.org/obo/PR_P60755", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-163125", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1Y7VIL8", "url": "https://www.uniprot.org/uniprot/A0A1Y7VIL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1Y7VIL8-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VIL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1Y7VJM7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1Y7VJM7-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A217FL82", "url": "https://www.uniprot.org/uniprot/A0A217FL82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A217FL82-1", "url": "https://www.uniprot.org/uniprot/A0A217FL82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6UYI7", "url": "https://www.uniprot.org/uniprot/F6UYI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6UYI7-1", "url": "https://www.uniprot.org/uniprot/F6UYI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P60755-1", "url": "https://www.uniprot.org/uniprot/P60755-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UUB8", "url": "https://www.uniprot.org/uniprot/Q3UUB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UUB8-1", "url": "https://www.uniprot.org/uniprot/Q3UUB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UV20", "url": "https://www.uniprot.org/uniprot/Q3UV20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UV20-1", "url": "https://www.uniprot.org/uniprot/Q3UV20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLTWVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTGEFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR", "length": 949, "header": "sp|P60755-1|MDGA2_MOUSE Isoform 1 of MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "isoforms": [ { "isoform_ac": "A0A1Y7VIL8-1", "url": "", "sequence": { "sequence": "MNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKKFQHGLYVSLVCCGPWCHGAYGIQQIMSLAHDLYSCKRTDGCLVTKSDSGP", "length": 319, "header": "tr|A0A1Y7VIL8-1|MDGA2_MOUSE Computationally mapped isoform of MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 66597308, "end_pos": 66514361, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000222987.2", "url": "https://www.ensembl.org/id/ENSMUST00000222987.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152049.2", "url": "https://www.ensembl.org/id/ENSMUSP00000152049.2" } ] } }, { "isoform_ac": "A0A1Y7VJM7-1", "url": "", "sequence": { "sequence": "MNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR", "length": 297, "header": "tr|A0A1Y7VJM7-1|MDGA2_MOUSE Computationally mapped isoform of MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 66597308, "end_pos": 66518292, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000222623.2", "url": "https://www.ensembl.org/id/ENSMUST00000222623.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152548.2", "url": "https://www.ensembl.org/id/ENSMUSP00000152548.2" } ] } }, { "isoform_ac": "A0A217FL82-1", "url": "", "sequence": { "sequence": "XSAHGRRQGRTDGQCFLPLLAVPGHLDSARAQVERALLAAGLQKVPLRPPWAGYVHVHVKMDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLTWVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTGEFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR", "length": 1009, "header": "tr|A0A217FL82-1|A0A217FL82_MOUSE Computationally mapped isoform of MAM domain containing glycosylphosphatidylinositol anchor 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 67267995, "end_pos": 66518291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000178814.9", "url": "https://www.ensembl.org/id/ENSMUST00000178814.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000137608.4", "url": "https://www.ensembl.org/id/ENSMUSP00000137608.4" } ] } }, { "isoform_ac": "F6UYI7-1", "url": "", "sequence": { "sequence": "XQGRTDGQCFLPLLAVPGHLDSARAQVERALLAAGLQKVPLRPPWAGYVHVHVKMDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQVDQNSRKRL", "length": 134, "header": "tr|F6UYI7-1|F6UYI7_MOUSE Computationally mapped isoform of MAM domain containing glycosylphosphatidylinositol anchor 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=4 SV=3 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 67267976, "end_pos": 66844543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000101379.10", "url": "https://www.ensembl.org/id/ENSMUST00000101379.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000098930.5", "url": "https://www.ensembl.org/id/ENSMUSP00000098930.5" } ] } }, { "isoform_ac": "P60755-1", "url": "", "sequence": { "sequence": "MDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLTWVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTGEFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR", "length": 949, "header": "sp|P60755-1|MDGA2_MOUSE Isoform 1 of MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 67267816, "end_pos": 66518292, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000223141", "url": "https://www.ensembl.org/id/ENSMUST00000223141" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152613", "url": "https://www.ensembl.org/id/ENSMUSP00000152613" } ] } }, { "isoform_ac": "Q3UUB8-1", "url": "", "sequence": { "sequence": "KQGTWRAGIYFPFKKVLCRELNKCRPFYLWLLPFLENTPNSELFKGFISLPALSHPTFTVVWVLFLLFLLFLLLLLFVVVLFFFLFSFFFLPHMAKLDNCMMSLFACTTIQDGKPGLTYYTGLSEFACGHLTPKLRHLFL", "length": 140, "header": "tr|Q3UUB8-1|MDGA2_MOUSE Computationally mapped isoform of MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 66517832, "end_pos": 66517413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113942.3", "url": "https://www.ensembl.org/id/ENSMUST00000113942.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109575.3", "url": "https://www.ensembl.org/id/ENSMUSP00000109575.3" } ] } }, { "isoform_ac": "Q3UV20-1", "url": "", "sequence": { "sequence": "MSVGCVGLQRSAHGRRQGRTDGQCFLPLLAVPGHLDSARAQVERALLAAGLQKVPLRPPWAGYVHVHVKMDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLTWVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR", "length": 1025, "header": "tr|Q3UV20-1|MDGA2_MOUSE Computationally mapped isoform of MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Mus musculus OX=10090 GN=Mdga2 PE=1 SV=1 CANONICAL=P60755-1" }, "locus": { "chromosome": "12", "start_pos": 67268023, "end_pos": 66518292, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000037181.16", "url": "https://www.ensembl.org/id/ENSMUST00000037181.16" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000046761.11", "url": "https://www.ensembl.org/id/ENSMUSP00000046761.11" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G23863VK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 213, "start_aa": "Asn", "end_pos": 213, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn213", "evidence": [ { "id": "2501", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2501" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G80223IX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 213, "start_aa": "Asn", "end_pos": 213, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn213", "evidence": [ { "id": "2501", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2501" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 213, "start_aa": "Asn", "end_pos": 213, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn213", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 237, "start_aa": "Asn", "end_pos": 237, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn237", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 434, "start_aa": "Asn", "end_pos": 434, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn434", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 443, "start_aa": "Asn", "end_pos": 443, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn443", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 504, "start_aa": "Asn", "end_pos": 504, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn504", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 610, "start_aa": "Asn", "end_pos": 610, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn610", "evidence": [ { "id": "2501", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2501" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 610, "start_aa": "Asn", "end_pos": 610, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn610", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 703, "start_aa": "Asn", "end_pos": 703, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn703", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 92, "start_aa": "Asn", "end_pos": 92, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn92", "evidence": [ { "id": "2501", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2501" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 92, "start_aa": "Asn", "end_pos": 92, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn92", "evidence": [ { "id": "2501", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2501" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 92, "start_aa": "Asn", "end_pos": 92, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn92", "evidence": [ { "id": "P60755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60755#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P60755", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P60755" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Transgene insertion in intronic sequences of Mdga2 gene shows methylation in an imprinted manner in an Acrodysplasia (Adp) mouse line.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Suzuki M, Solter D, Watanabe T", "evidence": [ { "database": "RefSeq", "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893" }, { "database": "RefSeq", "id": "NP_001180195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" } ], "reference": [ { "type": "PubMed", "id": "22281501", "url": "https://glygen.org/publication/PubMed/22281501" } ] }, { "title": "MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2013", "authors": "Lee K, Kim Y, Lee SJ, Qiang Y, Lee D, Lee HW, Kim H, Je HS, Sudhof TC, Ko J", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "reference": [ { "type": "PubMed", "id": "23248271", "url": "https://glygen.org/publication/PubMed/23248271" } ] }, { "title": "Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development.", "journal": "J. Cell Biol.", "date": "2013", "authors": "Pettem KL, Yokomaku D, Takahashi H, Ge Y, Craig AM", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" }, { "database": "RefSeq", "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893" }, { "database": "RefSeq", "id": "NP_001180195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" } ], "reference": [ { "type": "PubMed", "id": "23358245", "url": "https://glygen.org/publication/PubMed/23358245" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2501", "url": "https://glyconnect.expasy.org/browser/proteins/2501" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "P60755", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P60755" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Early postnatal development of the MDGA2+/- mouse model of synaptic dysfunction.", "journal": "Behavioural brain research", "date": "2023-08-24", "authors": "Fertan Emre, Wong Aim\u00e9e A, Montbrun Thalia S Garvock-de, Purdon Michaela K, Roddick Kyle M, Yamamoto Tohru, Brown Richard E", "evidence": [ { "database": "RefSeq", "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893" }, { "database": "RefSeq", "id": "NP_001180195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180195" } ], "reference": [ { "type": "PubMed", "id": "37499910", "url": "https://glygen.org/publication/PubMed/37499910" } ] } ], "pathway": [ { "id": "mmu:320772", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320772", "resource": "KEGG Pathway" }, { "id": "R-MMU-163125", "name": "Post-translational modification: synthesis of GPI-anchored proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "P60756-1", "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2", "gene_name": "Mdga2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITSIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPMPSLTWVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTGEFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR", "length": 949 }, "evidence": [ { "id": "45226106", "url": "http://www.informatics.jax.org/homology/45226106", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z553-1", "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2", "gene_name": "MDGA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR", "length": 956 }, "evidence": [ { "id": "45226106", "url": "http://www.informatics.jax.org/homology/45226106", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "P60755", "url": "https://www.uniprot.org/uniprot/P60755" } ], "pmid": "" }, { "name": "pattern specification process", "id": "GO:0007389", 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