{ "uniprot_canonical_ac": "P59644-1", "uniprot_ac": "P59644", "uniprot_id": "PI5PA_MOUSE", "mass": { "chemical_mass": 107544.0, "monoisotopic_mass": 107544.0 }, "refseq": { "ac": "NP_766027", "name": "phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027" }, "gene_names": [ { "name": "Inpp5j", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P59644", "id": "P59644" }, { "name": "Inpp5j", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027", "id": "NP_766027" }, { "name": "Pib5pa; Pipp", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027", "id": "NP_766027" }, { "name": "Pib5pa", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P59644", "id": "P59644" } ], "protein_names": [ { "name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P59644" }, { "name": "3.1.3.36", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59644" }, { "name": "3.1.3.56", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59644" }, { "name": "Inositol polyphosphate 5-phosphatase J", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59644" }, { "name": "Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59644" }, { "name": "Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59644" }, { "name": "phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027", "id": "NP_766027" }, { "name": "proline-rich inositol polyphosphate 5-phosphatase; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A; phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027", "id": "NP_766027" } ], "function": [ { "annotation": "Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_766027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027" }, { "database": "PubMed", "id": "33537929", "url": "https://glygen.org/publication/PubMed/33537929" } ] }, { "annotation": "Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles.", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644#function" }, { "database": "UniProtKB", "id": "Q9JMC1", "url": "https://www.uniprot.org/uniprot/Q9JMC1#function" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3389114110", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389114110" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 575, "end_pos": 575, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ILS->NLS).", "chr_id": "11", "chr_pos": "3450628", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I575", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389134020", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389134020" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 635, "end_pos": 635, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KNT->NNT).", "chr_id": "11", "chr_pos": "3449986", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K635", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Inpp5j", "url": "https://www.uniprot.org/uniprot/P59644", "locus": { "chromosome": "11", "start_pos": 3444375, "end_pos": 3454821, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000034570", "url": "https://www.ensembl.org/id/ENSMUSG00000034570" } ] } } ], "crossref": [ { "id": "ENSMUSG00000034570", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034570", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09094", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09094", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "170835", "url": "https://www.ncbi.nlm.nih.gov/gene/170835", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P59644", "url": "https://www.ebi.ac.uk/intact/interactors/id:P59644*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:170835", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:170835", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2158663", "url": "http://www.informatics.jax.org/marker/MGI:2158663", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P59644", "url": "https://oglcnac.org/atlas/detail/P59644", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P59644", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "SHTHGIL", "url": "https://omabrowser.org/oma/group/SHTHGIL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "21647at2759", "url": "http://www.orthodb.org/?query=21647at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11200:SF127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11200:SF127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "http://pfam.xfam.org/family/PF03372", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17751", "url": "http://pfam.xfam.org/family/PF17751", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P59644", "url": "http://purl.obolibrary.org/obo/PR_P59644", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1660499", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-1855183", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855183", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_766027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11392", "url": "https://www.rhea-db.org/rhea/11392", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19797", "url": "https://www.rhea-db.org/rhea/19797", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22764", "url": "https://www.rhea-db.org/rhea/22764", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A075B6D7", "url": "https://www.uniprot.org/uniprot/A0A075B6D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A075B6D7-1", "url": "https://www.uniprot.org/uniprot/A0A075B6D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z3P9", "url": "https://www.uniprot.org/uniprot/D3Z3P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z3P9-1", "url": "https://www.uniprot.org/uniprot/D3Z3P9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z3Q0", "url": "https://www.uniprot.org/uniprot/D3Z3Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z3Q0-1", "url": "https://www.uniprot.org/uniprot/D3Z3Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P59644-1", "url": "https://www.uniprot.org/uniprot/P59644-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GX61", "url": "https://www.uniprot.org/uniprot/V9GX61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GX61-1", "url": "https://www.uniprot.org/uniprot/V9GX61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GXL7", "url": "https://www.uniprot.org/uniprot/V9GXL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GXL7-1", "url": "https://www.uniprot.org/uniprot/V9GXL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLPAKNSGPASSEPRLTLAPVGPRAAVSPPSERPRLVLSSPRPVLAPLSIAGEQKRPPPPHSSNRAAKSVGQLVVSAAAASKPPPVASVSILAPKSLGQLVISASAMPRPSPAPLGSVLTPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQEGHLAAASVTSTPASERQLPARQKDTAVPRPTPPADKCLYTPERAAGPATSPPRAQAFSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSPGLPESGTRSPGLLSPTFRPGIPSSQTVPPPLPKPPRSPSRSPSRSPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDNDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALHPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSSSRGSSEEGPSGLPGPWAFPPSVPRSLGLLPALRLETVDPGGGGSWGADQEAPDPNSLSPSPQGRLGLEEGGLGP", "length": 1003, "header": "sp|P59644-1|PI5PA_MOUSE Isoform 1 of Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=2 CANONICAL=P59644-1" }, "isoforms": [ { "isoform_ac": "A0A075B6D7-1", "url": "", "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLPAKNSGPASSEPRLTLAPVGPRAAVSPPSERPRLVLSSPRPVLAPLSIAGEQKRPPPPHSSNRAAKSVGQLVVSAAAASKPPPVASVSILAPKSLGQLVISASAMPRPSPAPLGSVLTPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQEGHLAAASVTSTPASERQLPARQKDTAVPRPTPPADKCLYTPERAAGPATSPPRAQAFSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSPGLPESGTRSPGLLSPTFRPGIPSSQTVPPPLPKPPRSPSRSPSRSPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDNDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQPLTTSATLSWPGAAYWGVPKLSPGTTSTVTISKASPGPSSGMMGGTDRYSHLGGHPLGIKFSSF", "length": 899, "header": "tr|A0A075B6D7-1|A0A075B6D7_MOUSE Computationally mapped isoform of Inositol polyphosphate 5-phosphatase J OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=1 CANONICAL=P59644-1" }, "locus": { "chromosome": "11", "start_pos": 3454748, "end_pos": 3444383, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000154756.2", "url": "https://www.ensembl.org/id/ENSMUST00000154756.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139302.2", "url": "https://www.ensembl.org/id/ENSMUSP00000139302.2" } ] } }, { "isoform_ac": "D3Z3P9-1", "url": "", "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKLPRRSSVKEKGRAGKWYPAVNPPMPLLSGSLWLHGMWGPPCPLMMSHLFFTWAVATTMMVQI", "length": 97, "header": "tr|D3Z3P9-1|D3Z3P9_MOUSE Computationally mapped isoform of Inositol polyphosphate 5-phosphatase J OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=2 CANONICAL=P59644-1" }, "locus": { "chromosome": "11", "start_pos": 3454748, "end_pos": 3451538, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110019.9", "url": "https://www.ensembl.org/id/ENSMUST00000110019.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000105646.3", "url": "https://www.ensembl.org/id/ENSMUSP00000105646.3" } ] } }, { "isoform_ac": "D3Z3Q0-1", "url": "", "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLPAKNSGPASSEPSP", "length": 57, "header": "tr|D3Z3Q0-1|D3Z3Q0_MOUSE Computationally mapped isoform of Inositol polyphosphate 5-phosphatase J OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=1 CANONICAL=P59644-1" }, "locus": { "chromosome": "11", "start_pos": 3454748, "end_pos": 3452149, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110018.8", "url": "https://www.ensembl.org/id/ENSMUST00000110018.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000105645.3", "url": "https://www.ensembl.org/id/ENSMUSP00000105645.3" } ] } }, { "isoform_ac": "P59644-1", "url": "", "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLPAKNSGPASSEPRLTLAPVGPRAAVSPPSERPRLVLSSPRPVLAPLSIAGEQKRPPPPHSSNRAAKSVGQLVVSAAAASKPPPVASVSILAPKSLGQLVISASAMPRPSPAPLGSVLTPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQEGHLAAASVTSTPASERQLPARQKDTAVPRPTPPADKCLYTPERAAGPATSPPRAQAFSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSPGLPESGTRSPGLLSPTFRPGIPSSQTVPPPLPKPPRSPSRSPSRSPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDNDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALHPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSSSRGSSEEGPSGLPGPWAFPPSVPRSLGLLPALRLETVDPGGGGSWGADQEAPDPNSLSPSPQGRLGLEEGGLGP", "length": 1003, "header": "sp|P59644-1|PI5PA_MOUSE Isoform 1 of Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=2 CANONICAL=P59644-1" }, "locus": { "chromosome": "11", "start_pos": 3454748, "end_pos": 3444663, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000044507", "url": "https://www.ensembl.org/id/ENSMUST00000044507" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000046625", "url": "https://www.ensembl.org/id/ENSMUSP00000046625" } ] } }, { "isoform_ac": "V9GX61-1", "url": "", "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKVRAPKP", "length": 41, "header": "tr|V9GX61-1|V9GX61_MOUSE Computationally mapped isoform of Inositol polyphosphate 5-phosphatase J OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=1 CANONICAL=P59644-1" }, "locus": {} }, { "isoform_ac": "V9GXL7-1", "url": "", "sequence": { "sequence": "XKPVTQAAGSGRCPSPNLQAQESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDNDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQTSSPTSLGLPTGKEGVGRLKSGVAPAASVLSRSRCLPQNLPAAAQTARAPARRGRMTALWSCWHPSPAAPALASPRDTVVAALA", "length": 548, "header": "tr|V9GXL7-1|V9GXL7_MOUSE Computationally mapped isoform of Inositol polyphosphate 5-phosphatase J OS=Mus musculus OX=10090 GN=Inpp5j PE=1 SV=1 CANONICAL=P59644-1" }, "locus": { "chromosome": "11", "start_pos": 3452134, "end_pos": 3445009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000148939.8", "url": "https://www.ensembl.org/id/ENSMUST00000148939.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139214.2", "url": "https://www.ensembl.org/id/ENSMUSP00000139214.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 110, "start_aa": "Ser", "end_pos": 110, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser110", "evidence": [ { "id": "P59644", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "P59644", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P59644" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 117, "start_aa": "Ser", "end_pos": 117, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser117", "evidence": [ { "id": "P59644", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "P59644", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P59644" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 122, "start_aa": "Ser", "end_pos": 122, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser122", "evidence": [ { "id": "P59644", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "P59644", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P59644" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 164, "start_aa": "Ser", "end_pos": 164, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser164", "evidence": [ { "id": "P59644", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "P59644", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P59644" }, { "id": "doi.org/10.3389/fragi.2021.757801", "database": "DOI", "url": "https://glygen.org/publication/DOI/doi.org/10.3389/fragi.2021.757801" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 304, "start_aa": "Thr", "end_pos": 304, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr304", "evidence": [ { "id": "P59644", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P59644" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 90, "start_aa": "Ser", "end_pos": 90, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser90", "evidence": [ { "id": "P59644", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "P59644", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P59644" }, { "id": "doi.org/10.3389/fragi.2021.757801", "database": "DOI", "url": "https://glygen.org/publication/DOI/doi.org/10.3389/fragi.2021.757801" } ] } ], "phosphorylation": [ { "start_pos": 171, "end_pos": 171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "site_lbl": "Ser171" }, { "start_pos": 292, "end_pos": 292, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P59644", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P59644" } ], "site_lbl": "Ser292" }, { "start_pos": 325, "end_pos": 325, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P59644", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P59644" } ], "site_lbl": "Ser325" }, { "start_pos": 900, "end_pos": 900, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "site_lbl": "Ser900" }, { "start_pos": 987, "end_pos": 987, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "site_lbl": "Ser987" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "reference": [ { "type": "PubMed", "id": "12536145", "url": "https://glygen.org/publication/PubMed/12536145" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" }, { "database": "iPTMnet", "id": "P59644", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P59644" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD", "evidence": [ { "database": "O-GlcNAc Database", "id": "P59644", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "database": "O-GlcNAc Atlas", "id": "P59644", "url": "https://oglcnac.org/atlas/detail/P59644" } ], "reference": [ { "type": "PubMed", "id": "22517741", "url": "https://glygen.org/publication/PubMed/22517741" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" }, { "database": "UniProtKB", "id": "A0A075B6D7", "url": "https://www.uniprot.org/uniprot/A0A075B6D7" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P59644", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "database": "O-GlcNAc Atlas", "id": "P59644", "url": "https://oglcnac.org/atlas/detail/P59644" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.", "journal": "In vitro cellular & developmental biology. Animal", "date": "2021", "authors": "Yu H, Yong W, Gao T, Na M, Zhang Y, Kuguminkiriza IH, Kenechukwu AA, Guo Q, Zhang G, Deng X", "evidence": [ { "database": "RefSeq", "id": "NP_766027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027" } ], "reference": [ { "type": "PubMed", "id": "33537929", "url": "https://glygen.org/publication/PubMed/33537929" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "P59644", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" }, { "database": "O-GlcNAc Atlas", "id": "P59644", "url": "https://oglcnac.org/atlas/detail/P59644" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "title": "Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.", "journal": "Frontiers in aging", "date": "2021", "authors": "Huynh Van N, Wang Sheng, Ouyang Xiaosen, Wani Willayat Y, Johnson Michelle S, Chacko Balu K, Jegga Anil G, Qian Wei-Jun, Chatham John C, Darley-Usmar Victor M, Zhang Jianhua", "evidence": [ { "database": "O-GlcNAc Database", "id": "P59644", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P59644" } ], "reference": [ { "type": "PubMed", "id": "35822049", "url": "https://glygen.org/publication/PubMed/35822049" } ] } ], "pathway": [ { "id": "mmu:170835", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:170835", "resource": "KEGG Pathway" }, { "id": "R-MMU-1660499", "name": "Synthesis of PIPs at the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-MMU-1855183", "name": "Synthesis of IP2, IP, and Ins in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855183", "resource": "Reactome", "description": "Synthesis of IP2, IP, and Ins in the cytosol" }, { "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "Q15735-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "INPP5J", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALAPVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDAPAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP", "length": 1006 }, "evidence": [ { "id": "45234758", "url": "http://www.informatics.jax.org/homology/45234758", "database": "MGI" }, { "id": "P59644", "url": "https://omabrowser.org/oma/group/P59644/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JMC1-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "Inpp5j", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGQSRSGSAKSGTRTGLGPLPGTHGALQTGTPSKKVNSSFQLPAKNTGPTPSEPRLALAPVGPRAAVSPPSERPRLALSSPRPILAPLSTAGEQKRPPPHRSSKPAPTSVGQLVVSAAAGPKPPPVASVSILAPKSLGQLVISASAMPRPTPAPLGPILSPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQESHLAPATVTSTPASERQLPARQKDTAVRRPIPPADGCLHTPVQAAGLATSPPRAQTSSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSSGLPESGTRSPGLLSPTFRPGIPSNQTVPPPLPKPPRSPSRSPSRSPNRSPCVPPAPEVALPRPVTQGAGPGKCPSPNLQTQESPVATATSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGHDSDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAARFLLQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALRPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSGSRGSSEEGPSGPPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDQEAPDPNSLSPSPQGRLGLEDGGLGP", "length": 1001 }, "evidence": [ { "id": "45234758", "url": "http://www.informatics.jax.org/homology/45234758", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "phosphatidylinositol phosphate 5-phosphatase activity", "id": "GO:0034595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034595", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "inositol-polyphosphate 5-phosphatase activity", "id": "GO:0004445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0052658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052658", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "id": "GO:0052659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052659", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "id": "GO:0004439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004439", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "negative regulation of neuron projection development", "id": "GO:0010977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "negative regulation of peptidyl-serine phosphorylation", "id": "GO:0033137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033137", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "negative regulation of microtubule polymerization", "id": "GO:0031115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031115", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cellular anatomical entity", "id": "GO:0110165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110165", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "dendritic shaft", "id": "GO:0043198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043198", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "P59644", "url": "https://www.uniprot.org/uniprot/P59644" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11392", "name": "", "equation": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "Q9JMC1-1", "P97573-1", "D3ZZX1-1", "Q9BT40-1", "Q14642-1", "Q01968-1", "Q92835-1", "Q15735-1", "Q8C5L6-1", "Q6NVF0-1", "P59644-1", "Q9ES52-1", "Q7TNC9-1" ], "evidence": [ { "id": "11392", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11392" } ] }, { "id": "19797", "name": "", "equation": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "Q9JMC1-1", "D3ZZX1-1", "Q9BT40-1", "Q14642-1", "Q01968-1", "Q15735-1", "Q8C5L6-1", "Q6NVF0-1", "P59644-1", "Q7TNC9-1" ], "evidence": [ { "id": "19797", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19797" } ] }, { "id": "22764", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JMC1-1", "D3ZGS3-1", "Q62910-1", "O55207-1", "P97573-1", "Q9WVR1-1", "Q9BT40-1", "Q9NRR6-1", "P32019-1", "Q01968-1", "Q92835-1", "O43426-1", "O15056-1", "Q15735-1", "Q92562-1", "Q8K337-1", "Q8C5L6-1", "Q9JII1-1", "Q6NVF0-1", "Q8CHC4-1", "Q9ES52-1", "Q9D2G5-1", "Q91WF7-1", "P59644-1", "P50942-1", "Q12271-1", "P40559-1", "Q08227-1", "Q9VTW2-1", "Q5U0V7-1" ], "evidence": [ { "id": "22764", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22764" } ] }, { "id": "R-MMU-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P549-1", "P59644-1", "Q9ES52-1", "Q8C5L6-1" ], "evidence": [ { "id": "R-MMU-1675949", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1675949" } ] }, { "id": "R-MMU-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-392417" ], "enzyme_list": [ "P59644-1", "Q8C5L6-1", "Q8CHC4-1", "Q9D2G5-1" ], "evidence": [ { "id": "R-MMU-1676177", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1676177" } ] }, { "id": "R-MMU-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629739" ], "enzyme_list": [ "P59644-1", "Q6NVF0-1", "Q8CHC4-1" ], "evidence": [ { "id": "R-MMU-1855174", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855174" } ] }, { "id": "R-MMU-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8BYN3-1", "Q6P549-1", "P59644-1", "Q9ES52-1", "Q6NVF0-1", "Q8CHC4-1" ], "evidence": [ { "id": "R-MMU-1855218", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855218" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1629739", "participant_name": "I(1,4)P2 [cytosol]", "crossref": [ { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-392417", "participant_name": "PI4P [plasma membrane]", "crossref": [ { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "D3ZGS3", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] } ] }, { "uniprot_ac": "D3ZZX1", "gene_name": "Inpp5a", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "D3ZZX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZX1" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "D3ZZX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZX1" } ] } ] }, { "uniprot_ac": "O15056", "gene_name": "SYNJ2", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15056" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15056" } ] } ] }, { "uniprot_ac": "O43426", "gene_name": "SYNJ1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O43426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43426" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O43426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43426" } ] } ] }, { "uniprot_ac": "O55207", "gene_name": "Synj2", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O55207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55207" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O55207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55207" } ] } ] }, { "uniprot_ac": "P32019", "gene_name": "INPP5B", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P32019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32019" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P32019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32019" } ] } ] }, { "uniprot_ac": "P40559", "gene_name": "INP51", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P40559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40559" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P40559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40559" } ] } ] }, { "uniprot_ac": "P50942", "gene_name": "INP52", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P50942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50942" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P50942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50942" } ] } ] }, { "uniprot_ac": "P59644", "gene_name": "Inpp5j", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] } ] }, { "uniprot_ac": "P97573", "gene_name": "Inpp5d", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] } ] }, { "uniprot_ac": "Q01968", "gene_name": "OCRL", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] } ] }, { "uniprot_ac": "Q08227", "gene_name": "INP54", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q08227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08227" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q08227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08227" } ] } ] }, { "uniprot_ac": "Q12271", "gene_name": "INP53", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q12271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12271" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q12271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12271" } ] } ] }, { "uniprot_ac": "Q14642", "gene_name": "INPP5A", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q14642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14642" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q14642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14642" } ] } ] }, { "uniprot_ac": "Q15735", "gene_name": "INPP5J", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] } ] }, { "uniprot_ac": "Q5U0V7", "gene_name": "Synj", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q5U0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U0V7" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q5U0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U0V7" } ] } ] }, { "uniprot_ac": "Q62910", "gene_name": "Synj1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] } ] }, { "uniprot_ac": "Q6NVF0", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] } ] }, { "uniprot_ac": "Q6P549", "gene_name": "Inppl1", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q6P549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P549" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q6P549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P549" } ] } ] }, { "uniprot_ac": "Q7TNC9", "gene_name": "Inpp5a", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q7TNC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q7TNC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ] } ] }, { "uniprot_ac": "Q8BYN3", "gene_name": "Itpk1", "activity": [ { "ec_number": "2.7.1.134", "activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q8BYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYN3" } ] }, { "ec_number": "2.7.1.159", "activity": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q8BYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYN3" } ] }, { "ec_number": "2.7.1.134", "activity": "", "evidence": [ { "id": "Q8BYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYN3" } ] } ] }, { "uniprot_ac": "Q8C5L6", "gene_name": "Inpp5k", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] } ] }, { "uniprot_ac": "Q8CHC4", "gene_name": "Synj1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q8CHC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHC4" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q8CHC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHC4" } ] } ] }, { "uniprot_ac": "Q8K337", "gene_name": "Inpp5b", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q8K337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K337" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q8K337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K337" } ] } ] }, { "uniprot_ac": "Q91WF7", "gene_name": "Fig4", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] } ] }, { "uniprot_ac": "Q92562", "gene_name": "FIG4", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q92562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92562" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q92562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92562" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q92562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92562" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q92562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92562" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q92562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92562" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q92562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92562" } ] } ] }, { "uniprot_ac": "Q92835", "gene_name": "INPP5D", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q92835", "database": 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