{ "uniprot_canonical_ac": "P59511-1", "uniprot_ac": "P59511", "uniprot_id": "ATS20_MOUSE", "mass": { "chemical_mass": 212068.0, "monoisotopic_mass": 212068.0 }, "refseq": { "ac": "NP_803180", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein", "summary": "This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a 'belted' phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" }, "gene_names": [ { "name": "Adamts20", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P59511", "id": "P59511" }, { "name": "Adamst20; bt", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180", "id": "NP_803180" }, { "name": "Adamts20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180", "id": "NP_803180" } ], "protein_names": [ { "name": "A disintegrin and metalloproteinase with thrombospondin motifs 20", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P59511" }, { "name": "3.4.24.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59511" }, { "name": "A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180", "id": "NP_803180" }, { "name": "ADAM-TS 20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59511" }, { "name": "ADAM-TS20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59511" }, { "name": "ADAMTS-20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P59511" }, { "name": "a disintegrin and metalloproteinase with thrombospondin motifs 20; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180", "id": "NP_803180" } ], "function": [ { "annotation": "ADAMTS-9 and ADAMTS-20 have an identical modular structure, are distinct in possessing 15 thrombospondin type I repeats and a unique C-terminal domain, and have a similar gene structure", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" }, { "database": "PubMed", "id": "12514189", "url": "https://glygen.org/publication/PubMed/12514189" } ] }, { "annotation": "Adamts20 mutations in belted (bt) mice cause white spotting of the dorsal and ventral torso, indicative of defective neural crest (NC)-derived melanoblast development. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" }, { "database": "PubMed", "id": "18454205", "url": "https://glygen.org/publication/PubMed/18454205" } ] }, { "annotation": "May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511#function" } ] }, { "annotation": "Results provide compelling evidence that ADAMTS9 and ADAMTS20 were differentially sensitive to B3GLCT inactivation and suggest that the developmental defects in PTRPLS result from disruption of a subset of highly sensitive POFUT2/B3GLCT targets such as ADAMTS20. Erratum:[Hum Mol Genet. 2020 Oct 10;29(17):2986-2987. PMID: 32533185]", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" }, { "database": "PubMed", "id": "31600785", "url": "https://glygen.org/publication/PubMed/31600785" } ] }, { "annotation": "Results suggest that the role of ADAMTS proteases, including ADAMTS20, in the regulation of cell migration has been conserved in mammalian development.", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" }, { "database": "PubMed", "id": "12925592", "url": "https://glygen.org/publication/PubMed/12925592" } ] }, { "annotation": "This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a 'belted' phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" } ] }, { "annotation": "This protein is identified and characterized and its relation to other disintegrins and thrombospondin 1 repeats is examined. Erratum:[J Biol Chem. 2018 Jul 27;293(30):11785. PMID: 30054291]", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" }, { "database": "PubMed", "id": "12562771", "url": "https://glygen.org/publication/PubMed/12562771" } ] } ], "disease": [ { "disease_id": "DOID:0060249", "recommended_name": { "id": "DOID:0060249", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060249", "name": "scoliosis", "description": "A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine." }, "synonyms": [], "evidence": [ { "id": "0060249", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060249" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. 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"https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": 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"noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Adamts20", "url": "https://www.uniprot.org/uniprot/P59511", "locus": { "chromosome": "15", "start_pos": 94168044, "end_pos": 94363299, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000022449", "url": "https://www.ensembl.org/id/ENSMUSG00000022449" } ] } } ], "crossref": [ { "id": "ENSMUSG00000022449", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022449", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04273", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04273", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "223838", "url": "https://www.ncbi.nlm.nih.gov/gene/223838", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010294", "database": 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"https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:223838", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2660628", "url": "http://www.informatics.jax.org/marker/MGI:2660628", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "SRESYCV", "url": "https://omabrowser.org/oma/group/SRESYCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2910701at2759", "url": "http://www.orthodb.org/?query=2910701at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723:SF165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "http://pfam.xfam.org/family/PF00090", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01421", "url": "http://pfam.xfam.org/family/PF01421", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01562", "url": "http://pfam.xfam.org/family/PF01562", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05986", "url": "http://pfam.xfam.org/family/PF05986", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08685", "url": "http://pfam.xfam.org/family/PF08685", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17771", "url": "http://pfam.xfam.org/family/PF17771", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19030", "url": "http://pfam.xfam.org/family/PF19030", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19236", "url": "http://pfam.xfam.org/family/PF19236", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P59511", "url": "http://purl.obolibrary.org/obo/PR_P59511", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5173214", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P59511-1", "url": "https://www.uniprot.org/uniprot/P59511-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P59511-2", "url": "https://www.uniprot.org/uniprot/P59511-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1906, "header": "sp|P59511-1|ATS20_MOUSE Isoform 1 of A disintegrin and metalloproteinase with thrombospondin motifs 20 OS=Mus musculus OX=10090 GN=Adamts20 PE=2 SV=2 CANONICAL=P59511-1" }, "isoforms": [ { "isoform_ac": "P59511-1", "url": "", "sequence": { "sequence": "MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVTPTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGTPVPGPGGRSTESPDLRHCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRADGSAHDDDHNKPHLIYRQELKRNSFARSHKPCEVSENQMEKTALPSQSSRNTTGDVDIEEEAVFRLEGERSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQQSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSFKCKEAGIKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFGPGSQVCPYLKHCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDINGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNMDCELRWHIIGKSDCSSQCGQGYRTLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVLTRWHYSEWSQCSRSCGGGDKTRESYCVNGFGHRLAESECRELPRVVLENCNEFPCPSWATSEWSECPVTCGKGMKQRQVWCQLSEDPMRDGFCNASTKPESLRPCELRACASWHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPCLAIPEVGATSLPAIPLGRAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDEVADESNCAHLPRPAAVSLCFSPCGEWQAGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECSLAACPPLYSRAPSSSEQPSHVPSRNVPLTHKPGENQDQGAQLSIRGNQWRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATSCDGSSKPPESRHCGSGPCPHWNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHSCELPKPPSMMQCHLHACPEDVSWYRGPWKSCSASCGKGVKYREVLCIDQFQRKLEEKYCSHLHKPRTHKACRSGRCPSWKANKWKECSVTCGSGVQQREVYCRLRGTGRVSEDMCDPSTRPQGQRQCWRQDCMRYQWTTGDWLDCSTSCKKKETYRLVKCVNEQNVQANESLCDPLTKPLSIKKCRNPHCKYSVVTGDSSQCAGNCGFTSPQKITYCTKIQSSKKHTFHQLRPVVYGECPVIPSPQAYKCDLRSCLHVATWKVGKWSKCSVTCGIGIMERRVACRTENGWPSDLCLKRLKPDAQKKCYANDCKLLTTCKELQVTNNVTKDGDYDLNVRGRILKIHCSGMQLENPREYLPLVKSEDNFSEIYGLRLQNPYECPFNGSRRPDCACENDYLPAGYTVFSKVRVDLESMQIKTADLLFSQTLSGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKISNTAKWLAQGRYASVIIHRSQDGTKVYGRCGGFCGKCIPHMATGLSIQVL", "length": 1906, "header": "sp|P59511-1|ATS20_MOUSE Isoform 1 of A disintegrin and metalloproteinase with thrombospondin motifs 20 OS=Mus musculus OX=10090 GN=Adamts20 PE=2 SV=2 CANONICAL=P59511-1" }, "locus": { "chromosome": "15", "start_pos": 94301970, "end_pos": 94168184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000035342", "url": "https://www.ensembl.org/id/ENSMUST00000035342" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000036330", "url": "https://www.ensembl.org/id/ENSMUSP00000036330" } ] } }, { "isoform_ac": "P59511-2", "url": "", "sequence": { "sequence": "MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVTPTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGTPVPGPGGRSTESPDLRHCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRADGSAHDDDHNKPHLIYRQELKRNSFARSHKPCEVSENQMEKTALPSQSSRNTTGDVDIEEEAVFRLEGERSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQQSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSFKCKEAGIKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFGPGSQVCPYLKHCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDINGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNMDCELRWHIIGKSDCSSQCGQGYRTLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVLTRWHYSEWSQCSRSCGGGDKTRESYCVNGFGHRLAESECRELPRVVLENCNEFPCPSWATSEWSECPVTCGKGMKQRQVWCQLSEDPMRDGFCNASTKPESLRPCELRACASWHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPCLAIPEVGATSLPAIPLGRAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDEVADESNCAHLPRPAAVSLCFSPCGEWQAGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECSLAACPPLYSRAPSSSEQPSHVPSRNVPLTHKPGENQDQGAQLSIRGNQWRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATSCDGSSKPPESRHCGSGPCPHWNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHSCELPKPPSMMQCHLHACPEDVSWYRGPWKSVR", "length": 1425, "header": "sp|P59511-2|ATS20_MOUSE Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 20 OS=Mus musculus OX=10090 GN=Adamts20 PE=2 SV=2 CANONICAL=P59511-1" }, "locus": { "chromosome": "15", "start_pos": 94301970, "end_pos": 94220657, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000155907", "url": "https://www.ensembl.org/id/ENSMUST00000155907" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121696", "url": "https://www.ensembl.org/id/ENSMUSP00000121696" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1057, "start_aa": "Asn", "end_pos": 1057, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1057", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1562, "start_aa": "Asn", "end_pos": 1562, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1562", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1719, "start_aa": "Asn", "end_pos": 1719, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1719", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1759, "start_aa": "Asn", "end_pos": 1759, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1759", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1777, "start_aa": "Asn", "end_pos": 1777, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1777", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 221, "start_aa": "Asn", "end_pos": 221, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn221", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 714, "start_aa": "Asn", "end_pos": 714, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn714", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 798, "start_aa": "Asn", "end_pos": 798, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn798", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 805, "start_aa": "Asn", "end_pos": 805, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn805", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 92, "start_aa": "Asn", "end_pos": 92, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn92", "evidence": [ { "id": "P59511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59511#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko S, Wight TN, Leduc R, Apte SS", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" } ], "reference": [ { "type": "PubMed", "id": "12514189", "url": "https://glygen.org/publication/PubMed/12514189" } ] }, { "title": "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Llamazares M, Cal S, Quesada V, Lopez-Otin C", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" }, { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" } ], "reference": [ { "type": "PubMed", "id": "12562771", "url": "https://glygen.org/publication/PubMed/12562771" } ] }, { "title": "A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.", "journal": "Development", "date": "2003", "authors": "Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ, Beier DR", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" }, { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" } ], "reference": [ { "type": "PubMed", "id": "12925592", "url": "https://glygen.org/publication/PubMed/12925592" } ] }, { "title": "The secreted metalloprotease ADAMTS20 is required for melanoblast survival.", "journal": "PLoS genetics", "date": "2008", "authors": "Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" } ], "reference": [ { "type": "PubMed", "id": "18454205", "url": "https://glygen.org/publication/PubMed/18454205" } ] }, { "title": "ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.", "journal": "Human molecular genetics", "date": "2019", "authors": "Holdener BC, Percival CJ, Grady RC, Cameron DC, Berardinelli SJ, Zhang A, Neupane S, Takeuchi M, Jimenez-Vega JC, Uddin SMZ, Komatsu DE, Honkanen R, Dubail J, Apte SS, Sato T, Narimatsu H, McClain SA, Haltiwanger RS", "evidence": [ { "database": "RefSeq", "id": "NP_803180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803180" } ], "reference": [ { "type": "PubMed", "id": "31600785", "url": "https://glygen.org/publication/PubMed/31600785" } ] } ], "pathway": [ { "id": "mmu:223838", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:223838", "resource": "KEGG Pathway" }, { "id": "R-MMU-5173214", "name": "O-glycosylation of TSR domain-containing proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "endopeptidase activity", "id": "GO:0004175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" } ], "pmid": "" }, { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P59511", "url": "https://www.uniprot.org/uniprot/P59511" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", 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"reactions": [ { "id": "R-MMU-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P59384-1", "Q769J6-1", "Q8BHT6-1", "Q8BNJ2-1", "Q8C9W3-1", "P57110-1", "P59509-1", "P59511-1", "P97857-1", "Q4VC17-1", "Q68SA9-1", "Q9R001-1", "P58459-1", "Q69Z28-1", "Q811B3-1" ], "evidence": [ { "id": "R-MMU-5173005", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5173005" } ] }, { "id": "R-MMU-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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