{ "uniprot_canonical_ac": "P57790-1", "uniprot_ac": "P57790", "uniprot_id": "KEAP1_RAT", "mass": { "chemical_mass": 69399.0, "monoisotopic_mass": 69399.0 }, "refseq": { "ac": "NP_476493", "name": "kelch-like ECH-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, "gene_names": [ { "name": "Keap1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P57790", "id": "P57790" }, { "name": "Inrf2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493", "id": "NP_476493" }, { "name": "Inrf2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P57790", "id": "P57790" }, { "name": "Keap1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493", "id": "NP_476493" } ], "protein_names": [ { "name": "Kelch-like ECH-associated protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P57790" }, { "name": "Cytosolic inhibitor of Nrf2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P57790" }, { "name": "INrf2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P57790" }, { "name": "cytosolic inhibitor of Nrf2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493", "id": "NP_476493" }, { "name": "kelch-like ECH-associated protein 1 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006242653", "id": "XP_006242653" }, { "name": "kelch-like ECH-associated protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493", "id": "NP_476493" } ], "function": [ { "annotation": "Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, { "database": "PubMed", "id": "36736873", "url": "https://glygen.org/publication/PubMed/36736873" } ] }, { "annotation": "Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, { "database": "PubMed", "id": "33811899", "url": "https://glygen.org/publication/PubMed/33811899" } ] }, { "annotation": "Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head.", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, { "database": "PubMed", "id": "34185425", "url": "https://glygen.org/publication/PubMed/34185425" } ] }, { "annotation": "Keap1 negatively regulates Nrf2 by both enhancing its rate of proteasomal degradation and altering its subcellular distribution", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, { "database": "PubMed", "id": "12682069", "url": "https://glygen.org/publication/PubMed/12682069" } ] }, { "annotation": "Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, { "database": "PubMed", "id": "35026282", "url": "https://glygen.org/publication/PubMed/35026282" } ] }, { "annotation": "Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" }, { "database": "PubMed", "id": "34278476", "url": "https://glygen.org/publication/PubMed/34278476" } ] }, { "annotation": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790#function" }, { "database": "UniProtKB", "id": "Q14145", "url": "https://www.uniprot.org/uniprot/Q14145#function" }, { "database": "UniProtKB", "id": "Q9Z2X8", "url": "https://www.uniprot.org/uniprot/Q9Z2X8#function" } ] } ], "disease": [ { "disease_id": "DOID:2797", "recommended_name": { "id": "DOID:2797", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2797", "name": "idiopathic interstitial pneumonia", "description": "A pneumonia located_in the lung parenchyma of unknown cause." }, "synonyms": [ { "id": "DOID:2797", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2797", "name": "Diffuse idiopathic pulmonary fibrosis", "description": "" }, { "id": "DOID:2797", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2797", "name": "Idiopathic fibrosing alveolitis", "description": "" } ], "evidence": [ { "id": "2797", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2797" } ] }, { "disease_id": "DOID:3121", "recommended_name": { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "gallbladder cancer", "description": "A biliary tract cancer that is located_in the gallbladder." }, "synonyms": [ { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "gallbladder Ca", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "gallbladder neoplasm", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "localized malignant gallbladder neoplasm", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "malignant neoplasm of gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "malignant tumor of the gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "malignant tumour of gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "tumor of the gallbladder", "description": "" } ], "evidence": [ { "id": "3121", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3121" } ] }, { "disease_id": "DOID:332", "recommended_name": { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing." }, "synonyms": [ { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "ALS", "description": "" }, { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "Lou Gehrig's disease", "description": "" }, { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "motor neuron disease, bulbar", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis type 1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "ALS1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis type 1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "FALS", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, autosomal dominant", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, autosomal dominant amyotrophic lateral sclerosis 1, autosomal recessive, included", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, autosomal recessive", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, familial", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, autosomal dominant", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, familial", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, sporadic", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, sporadic, included", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, susceptibility to", "description": "" }, { "id": "MIM:105400", "resource": "MIM", "url": "https://www.omim.org/entry/105400", "name": "Amyotrophic lateral sclerosis 1", "description": "Amyotrophic lateral sclerosis 1" } ], "evidence": [ { "id": "332", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:332" } ] }, { "disease_id": "DOID:5199", "recommended_name": { "id": "DOID:5199", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5199", "name": "ureteral obstruction", "description": "" }, "synonyms": [], "evidence": [ { "id": "5199", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5199" } ] }, { "disease_id": "DOID:783", "recommended_name": { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease." }, "synonyms": [ { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal failure", "description": "" }, { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end-stage kidney disease", "description": "" } ], "evidence": [ { "id": "783", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:783" } ] }, { "disease_id": "DOID:8947", "recommended_name": { "id": "DOID:8947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8947", "name": "diabetic retinopathy", "description": "" }, "synonyms": [ { "id": "DOID:8947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8947", "name": "Retinal abnormality - diabetes-related", "description": "" } ], "evidence": [ { "id": "8947", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ] }, { "disease_id": "DOID:9675", "recommended_name": { "id": "DOID:9675", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9675", "name": "pulmonary emphysema", "description": "A chronic obstructive pulmonary disease that is characterized by permanent enlargement of air spaces distal to the terminal bronchioles and the destruction of the alveolar walls." }, "synonyms": [ { "id": "MONDO:0007535", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007535", "name": "emphysema, hereditary pulmonary", "description": "" }, { "id": "MONDO:0007535", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007535", "name": "emphysema, hereditary pulmonary", "description": "" } ], "evidence": [ { "id": "9675", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9675" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "common_name": "Rat" } ], "gene": [ { "name": "Keap1", "url": "https://www.uniprot.org/uniprot/P57790", "locus": { "chromosome": "8", "start_pos": 19768375, "end_pos": 19777862, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020878", "url": "https://www.ensembl.org/id/ENSRNOG00000020878" } ] } } ], "crossref": [ { "id": "ENSRNOG00000020878", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020878", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18458", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18458", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4523596", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4523596", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "117519", "url": "https://www.ncbi.nlm.nih.gov/gene/117519", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030563", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030563", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:117519", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:117519", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYHPEND", "url": "https://omabrowser.org/oma/group/CYHPEND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5472491at2759", "url": "http://www.orthodb.org/?query=5472491at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412:SF162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "http://pfam.xfam.org/family/PF00651", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "http://pfam.xfam.org/family/PF01344", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07707", "url": "http://pfam.xfam.org/family/PF07707", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P57790", "url": "http://purl.obolibrary.org/obo/PR_P57790", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9755511", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "621619", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621619", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZVM9", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZVM9-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V8U2", "url": "https://www.uniprot.org/uniprot/G3V8U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V8U2-1", "url": "https://www.uniprot.org/uniprot/G3V8U2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P57790-1", "url": "https://www.uniprot.org/uniprot/P57790-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASLSVPRNRSGGGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC", "length": 624, "header": "sp|P57790-1|KEAP1_RAT Isoform 1 of Kelch-like ECH-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Keap1 PE=2 SV=1 CANONICAL=P57790-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZVM9-1", "url": "", "sequence": { "sequence": "MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC", "length": 624, "header": "tr|A0A8I5ZVM9-1|A0A8I5ZVM9_RAT Computationally mapped isoform of Kelch-like ECH-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Keap1 PE=3 SV=1 CANONICAL=P57790-1" }, "locus": { "chromosome": "8", "start_pos": 19776220, "end_pos": 19769354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000101216.1", "url": "https://www.ensembl.org/id/ENSRNOT00000101216.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081740.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081740.1" } ] } }, { "isoform_ac": "G3V8U2-1", "url": "", "sequence": { "sequence": "MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC", "length": 620, "header": "tr|G3V8U2-1|KEAP1_RAT Computationally mapped isoform of Kelch-like ECH-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Keap1 PE=2 SV=2 CANONICAL=P57790-1" }, "locus": { "chromosome": "8", "start_pos": 19776220, "end_pos": 19769354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000028360.5", "url": "https://www.ensembl.org/id/ENSRNOT00000028360.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000028360.3", "url": "https://www.ensembl.org/id/ENSRNOP00000028360.3" } ] } }, { "isoform_ac": "P57790-1", "url": "", "sequence": { "sequence": "MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASLSVPRNRSGGGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC", "length": 624, "header": "sp|P57790-1|KEAP1_RAT Isoform 1 of Kelch-like ECH-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Keap1 PE=2 SV=1 CANONICAL=P57790-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.", "journal": "Oncogene", "date": "2001", "authors": "Dhakshinamoorthy S, Jaiswal AK", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "reference": [ { "type": "PubMed", "id": "11439354", "url": "https://glygen.org/publication/PubMed/11439354" } ] }, { "title": "Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "McMahon M, Itoh K, Yamamoto M, Hayes JD", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" } ], "reference": [ { "type": "PubMed", "id": "12682069", "url": "https://glygen.org/publication/PubMed/12682069" } ] }, { "title": "Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.", "journal": "Life sciences", "date": "2021", "authors": "Hussein RM, Sawy DM, Kandeil MA, Farghaly HS", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" } ], "reference": [ { "type": "PubMed", "id": "33811899", "url": "https://glygen.org/publication/PubMed/33811899" } ] }, { "title": "Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head.", "journal": "Clinical and translational medicine", "date": "2021", "authors": "Yang N, Sun H, Xue Y, Zhang W, Wang H, Tao H, Liang X, Li M, Xu Y, Chen L, Zhang L, Huang L, Geng D", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" } ], "reference": [ { "type": "PubMed", "id": "34185425", "url": "https://glygen.org/publication/PubMed/34185425" } ] }, { "title": "Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.", "journal": "Molecular medicine reports", "date": "2021", "authors": "Hu X, Mu L, Zhu L, Chang X, Nie L, Wang L, Li G", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" } ], "reference": [ { "type": "PubMed", "id": "34278476", "url": "https://glygen.org/publication/PubMed/34278476" } ] }, { "title": "Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.", "journal": "Experimental cell research", "date": "2022", "authors": "Xu F, Zhang J, Zhou X, Hao H", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" } ], "reference": [ { "type": "PubMed", "id": "35026282", "url": "https://glygen.org/publication/PubMed/35026282" } ] }, { "title": "Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer.", "journal": "Chemico-biological interactions", "date": "2023-03-01", "authors": "Washimkar Kaveri R, Tomar Manendra Singh, Ishteyaque Sharmeen, Kumar Akhilesh, Shrivastava Ashutosh, Mugale Madhav Nilakanth", "evidence": [ { "database": "RefSeq", "id": "NP_476493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476493" } ], "reference": [ { "type": "PubMed", "id": "36736873", "url": "https://glygen.org/publication/PubMed/36736873" } ] } ], "pathway": [ { "id": "rno:117519", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:117519", "resource": "KEGG Pathway" }, { "id": "R-RNO-5689880", "name": "Ub-specific processing proteases", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-RNO-8951664", "name": "Neddylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-RNO-9755511", "name": "KEAP1-NFE2L2 pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14145-1", "protein_name": "Kelch-like ECH-associated protein 1", "gene_name": "KEAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC", "length": 624 }, "evidence": [ { "id": "45225361", "url": "http://www.informatics.jax.org/homology/45225361", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2X8-1", "protein_name": "Kelch-like ECH-associated protein 1", "gene_name": "Keap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQPEPKLSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC", "length": 624 }, "evidence": [ { "id": "45225361", "url": "http://www.informatics.jax.org/homology/45225361", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "regulation of epidermal cell differentiation", "id": "GO:0045604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045604", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cytoplasmic sequestering of transcription factor", "id": "GO:0042994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042994", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "response to thyroid hormone", "id": "GO:0097066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097066", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cellular response to organic cyclic compound", "id": "GO:0071407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071407", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "response to immobilization stress", "id": "GO:0035902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035902", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cellular response to interleukin-4", "id": "GO:0071353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071353", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "response to metal ion", "id": "GO:0010038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010038", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cellular response to carbohydrate stimulus", "id": "GO:0071322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071322", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "selenium compound metabolic process", "id": "GO:0001887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001887", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cellular response to chemical stimulus", "id": "GO:0070887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070887", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 13, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "inclusion body", "id": "GO:0016234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016234", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "disordered domain specific binding", "id": "GO:0097718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097718", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "ubiquitin ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" }, { "name": "transcription regulator inhibitor activity", "id": "GO:0140416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140416", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Auto-ubiquitinated by the BCR(KEAP1) complex. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress.", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" }, { "database": "PubMed", "id": "Q14145", "url": "https://glygen.org/publication/PubMed/Q14145" } ] }, { "annotation": "Degraded via a proteasomal-independent process during selective autophagy: interaction with phosphorylated SQSTM1/p62 sequesters KEAP1 in inclusion bodies, leading to its degradation.", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" }, { "database": "PubMed", "id": "Q9Z2X8", "url": "https://glygen.org/publication/PubMed/Q9Z2X8" } ] }, { "annotation": "Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex. Accumulation of fumarate promotes the formation of cysteine S-succination (S-(2-succinyl)cysteine), leading to inactivate the BCR(KEAP1) complex and promote NFE2L2/NRF2 nuclear accumulation and activation. Nitric oxide-dependent 8-Nitro-cGMP formation promotes cysteine guanylation (S-cGMP-cysteine), leading to NFE2L2/NRF2 nuclear accumulation and activation. Itaconate, an anti-inflammatory metabolite generated in response to lipopolysaccharide, alkylates cysteines, activating NFE2L2/NRF2 (By similarity). Methylglyoxal, a reactive metabolite that accumulates when the glycolytic enzyme PGK1 is inhibited, promotes formation of a methylimidazole cross-link between proximal Cys-151 and Arg-135 on another KEAP1 molecule, resulting in an inactive dimer that inactivates the BCR(KEAP1) complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P57790", "url": "https://www.uniprot.org/uniprot/P57790" }, { "database": "PubMed", "id": "Q14145", "url": "https://glygen.org/publication/PubMed/Q14145" }, { "database": "PubMed", "id": "Q9Z2X8", "url": "https://glygen.org/publication/PubMed/Q9Z2X8" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }