{ "uniprot_canonical_ac": "P56706-1", "uniprot_ac": "P56706", "uniprot_id": "WNT7B_HUMAN", "mass": { "chemical_mass": 39327.0, "monoisotopic_mass": 39327.0 }, "refseq": { "ac": "NP_478679", "name": "protein Wnt-7b isoform 2 precursor", "summary": "This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" }, "gene_names": [ { "name": "WNT7B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P56706", "id": "P56706" } ], "protein_names": [ { "name": "Protein Wnt-7b", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P56706" }, { "name": "protein Wnt-7b isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679", "id": "NP_478679" }, { "name": "protein Wnt-7b; wingless-type MMTV integration site family, member 7B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679", "id": "NP_478679" } ], "function": [ { "annotation": "Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans.", "evidence": [ { "database": "RefSeq", "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" }, { "database": "PubMed", "id": "35790350", "url": "https://glygen.org/publication/PubMed/35790350" } ] }, { "annotation": "EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.", "evidence": [ { "database": "RefSeq", "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" }, { "database": "PubMed", "id": "36517590", "url": "https://glygen.org/publication/PubMed/36517590" } ] }, { "annotation": "Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" }, { "database": "PubMed", "id": "34573275", "url": "https://glygen.org/publication/PubMed/34573275" } ] }, { "annotation": "Inhibition of Wnt7b reduces the proliferation, invasion, and migration of colorectal cancer cells.", "evidence": [ { "database": "RefSeq", "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" }, { "database": "PubMed", "id": "36472725", "url": "https://glygen.org/publication/PubMed/36472725" } ] }, { "annotation": "Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706#function" }, { "database": "UniProtKB", "id": "P28047", "url": "https://www.uniprot.org/uniprot/P28047#function" }, { "database": "PubMed", "id": "30026314", "url": "https://glygen.org/publication/PubMed/30026314" } ] }, { "annotation": "Ligand for members of the frizzled family of seven transmembrane receptors.", "evidence": [ { "database": "UniProtKB", "id": "A8K0G1", "url": "https://www.uniprot.org/uniprot/A8K0G1#function" }, { "database": "UniProtKB", "id": "RU003500", "url": "https://www.uniprot.org/uniprot/RU003500#function" }, { "database": "UniProtKB", "id": "B8A597", "url": "https://www.uniprot.org/uniprot/B8A597#function" }, { "database": "UniProtKB", "id": "B8A598", "url": "https://www.uniprot.org/uniprot/B8A598#function" }, { "database": "UniProtKB", "id": "B8A595", "url": "https://www.uniprot.org/uniprot/B8A595#function" } ] }, { "annotation": "The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity.", "evidence": [ { "database": "RefSeq", "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" }, { "database": "PubMed", "id": "34999254", "url": "https://glygen.org/publication/PubMed/34999254" } ] }, { "annotation": "This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1016349709", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1016349709" }, { "id": "rs1016349709", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1016349709" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 127, "end_pos": 127, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->SLS).", "chr_id": "22", "chr_pos": "45931288", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N127", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P56706", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P56706" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 129, "end_pos": 129, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NLS->NLN).", "chr_id": "22", "chr_pos": "45931282", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S129", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, 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"BioXpress", "id": "P56706", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P56706" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P56706", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P56706" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": 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"https://www.ebi.ac.uk/interpro/entry/IPR018161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:7477", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7477", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "601967", "url": "http://www.omim.org/entry/601967", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P56706", "url": "https://www.nextprot.org/entry/NX_P56706", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "SRKWIFY", "url": "https://omabrowser.org/oma/group/SRKWIFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2874082at2759", "url": "http://www.orthodb.org/?query=2874082at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027", "url": 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Classification" ] }, { "id": "NP_478679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8K0G1", "url": "https://www.uniprot.org/uniprot/A8K0G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8K0G1-1", "url": "https://www.uniprot.org/uniprot/A8K0G1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8A595", "url": "https://www.uniprot.org/uniprot/B8A595", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8A595-1", "url": "https://www.uniprot.org/uniprot/B8A595-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8A597", "url": "https://www.uniprot.org/uniprot/B8A597", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8A597-1", "url": "https://www.uniprot.org/uniprot/B8A597-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8A598", "url": "https://www.uniprot.org/uniprot/B8A598", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8A598-1", "url": "https://www.uniprot.org/uniprot/B8A598-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P56706-1", "url": "https://www.uniprot.org/uniprot/P56706-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK", "length": 349, "header": "sp|P56706-1|WNT7B_HUMAN Isoform 1 of Protein Wnt-7b OS=Homo sapiens OX=9606 GN=WNT7B PE=1 SV=2 CANONICAL=P56706-1" }, "isoforms": [ { "isoform_ac": "A8K0G1-1", "url": "", "sequence": { "sequence": "MLLLSPRSALVSVYCPQIFLLLSSGSYLALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK", "length": 353, "header": "tr|A8K0G1-1|WNT7B_HUMAN Computationally mapped isoform of Protein Wnt-7b OS=Homo sapiens OX=9606 GN=WNT7B PE=1 SV=1 CANONICAL=P56706-1" }, "locus": { "chromosome": "22", "start_pos": 45972237, "end_pos": 45922859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000409496.7", "url": "https://www.ensembl.org/id/ENST00000409496.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000386546.3", "url": "https://www.ensembl.org/id/ENSP00000386546.3" } ] } }, { "isoform_ac": "B8A595-1", "url": "", "sequence": { "sequence": "MSAPPFYRALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK", "length": 333, "header": "tr|B8A595-1|WNT7B_HUMAN Computationally mapped isoform of Protein Wnt-7b OS=Homo sapiens OX=9606 GN=WNT7B PE=1 SV=1 CANONICAL=P56706-1" }, "locus": { "chromosome": "22", "start_pos": 45975567, "end_pos": 45922859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000410089.5", "url": "https://www.ensembl.org/id/ENST00000410089.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000386781.1", "url": "https://www.ensembl.org/id/ENSP00000386781.1" } ] } }, { "isoform_ac": "B8A597-1", "url": "", "sequence": { "sequence": "MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKGLLGQPRVTSSPLFP", "length": 205, "header": "tr|B8A597-1|WNT7B_HUMAN Computationally mapped isoform of Protein Wnt-7b OS=Homo sapiens OX=9606 GN=WNT7B PE=1 SV=1 CANONICAL=P56706-1" }, "locus": { "chromosome": "22", "start_pos": 45976754, "end_pos": 45927530, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000410058.1", "url": "https://www.ensembl.org/id/ENST00000410058.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000387217.1", "url": "https://www.ensembl.org/id/ENSP00000387217.1" } ] } }, { "isoform_ac": "B8A598-1", "url": "", "sequence": { "sequence": "MGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACS", "length": 57, "header": "tr|B8A598-1|WNT7B_HUMAN Computationally mapped isoform of Protein Wnt-7b OS=Homo sapiens OX=9606 GN=WNT7B PE=1 SV=1 CANONICAL=P56706-1" }, "locus": { "chromosome": "22", "start_pos": 45950016, "end_pos": 45931296, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000428540.1", "url": "https://www.ensembl.org/id/ENST00000428540.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000392750.1", "url": "https://www.ensembl.org/id/ENSP00000392750.1" } ] } }, { "isoform_ac": "P56706-1", "url": "", "sequence": { "sequence": "MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK", "length": 349, "header": "sp|P56706-1|WNT7B_HUMAN Isoform 1 of Protein Wnt-7b OS=Homo sapiens OX=9606 GN=WNT7B PE=1 SV=2 CANONICAL=P56706-1" }, "locus": { "chromosome": "22", "start_pos": 45976754, "end_pos": 45922859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000339464.9", "url": "https://www.ensembl.org/id/ENST00000339464.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000341032.4", "url": "https://www.ensembl.org/id/ENSP00000341032.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 127, "start_aa": "Asn", "end_pos": 127, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn127", "evidence": [ { "id": "P56706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56706#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 295, "start_aa": "Asn", "end_pos": 295, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn295", "evidence": [ { "id": "P56706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56706#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 83, "start_aa": "Asn", "end_pos": 83, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn83", "evidence": [ { "id": "P56706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56706#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Hsieh JC, Rattner A, Smallwood PM, Nathans J", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373080" } ], "reference": [ { "type": "PubMed", "id": "10097073", "url": "https://glygen.org/publication/PubMed/10097073" } ] }, { "title": "A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling.", "journal": "Trends in biochemical sciences", "date": "2000", "authors": "Hofmann K", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "10694878", "url": "https://glygen.org/publication/PubMed/10694878" } ] }, { "title": "Secretory protein trafficking and organelle dynamics in living cells.", "journal": "Annual review of cell and developmental biology", "date": "2000", "authors": "Lippincott-Schwartz J, Roberts TH, Hirschberg K", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "11031247", "url": "https://glygen.org/publication/PubMed/11031247" } ] }, { "title": "Membrane transport: retromer to the rescue.", "journal": "Current biology : CB", "date": "2001", "authors": "Pfeffer SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "11231171", "url": "https://glygen.org/publication/PubMed/11231171" } ] }, { "title": "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Lin HH, Stacey M, Saxby C, Knott V, Chaudhry Y, Evans D, Gordon S, McKnight AJ, Handford P, Lea S", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373080" } ], "reference": [ { "type": "PubMed", "id": "11297558", "url": "https://glygen.org/publication/PubMed/11297558" } ] }, { "title": "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.", "journal": "Nature cell biology", "date": "2001", "authors": "Xu Y, Hortsman H, Seet L, Wong SH, Hong W", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "11433298", "url": "https://glygen.org/publication/PubMed/11433298" } ] }, { "title": "Molecular cloning and characterization of human WNT7B.", "journal": "Int. J. Oncol.", "date": "2001", "authors": "Katoh M., Kirikoshi H., Sekihara H.", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "reference": [ { "type": "PubMed", "id": "11562755", "url": "https://glygen.org/publication/PubMed/11562755" } ] }, { "title": "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family.", "journal": "The Journal of endocrinology", "date": "2002", "authors": "Hansen IA, Jakob O, Wortmann S, Arzberger T, Allolio B, Blind E", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373080" } ], "reference": [ { "type": "PubMed", "id": "12098667", "url": "https://glygen.org/publication/PubMed/12098667" } ] }, { "title": "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor.", "journal": "Neuropharmacology", "date": "2003", "authors": "Della Penna K, Kinose F, Sun H, Koblan KS, Wang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373080" } ], "reference": [ { "type": "PubMed", "id": "12559132", "url": "https://glygen.org/publication/PubMed/12559132" } ] }, { "title": "Wnt proteins are lipid-modified and can act as stem cell growth factors.", "journal": "Nature", "date": "2003", "authors": "Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, Nusse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "12717451", "url": "https://glygen.org/publication/PubMed/12717451" } ] }, { "title": "Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.", "journal": "Journal of leukocyte biology", "date": "2005", "authors": "Kwakkenbos MJ, Pouwels W, Matmati M, Stacey M, Lin HH, Gordon S, van Lier RA, Hamann J", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373080" } ], "reference": [ { "type": "PubMed", "id": "15498814", "url": "https://glygen.org/publication/PubMed/15498814" } ] }, { "title": "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Capurro MI, Shi W, Sandal S, Filmus J", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "reference": [ { "type": "PubMed", "id": "16227623", "url": "https://glygen.org/publication/PubMed/16227623" } ] }, { "title": "Release and trafficking of lipid-linked morphogens.", "journal": "Current opinion in genetics & development", "date": "2006", "authors": "Eaton S", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "16364628", "url": "https://glygen.org/publication/PubMed/16364628" } ] }, { "title": "Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.", "journal": "PLoS biology", "date": "2006", "authors": "Mikels AJ, Nusse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": 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], "reference": [ { "type": "PubMed", "id": "16678095", "url": "https://glygen.org/publication/PubMed/16678095" } ] }, { "title": "Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.", "journal": "Cell", "date": "2006", "authors": "Bartscherer K, Pelte N, Ingelfinger D, Boutros M", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "16678096", "url": "https://glygen.org/publication/PubMed/16678096" } ] }, { "title": "Sprinter: a novel transmembrane protein required for Wg secretion and signaling.", "journal": "Development (Cambridge, England)", "date": "2006", "authors": "Goodman RM, Thombre S, Firtina Z, Gray D, Betts D, Roebuck J, Spana EP, Selva EM", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "17108000", "url": "https://glygen.org/publication/PubMed/17108000" } ] }, { "title": "Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.", "journal": "The Biochemical journal", "date": "2007", "authors": "Kurayoshi M, Yamamoto H, Izumi S, Kikuchi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "17117926", "url": "https://glygen.org/publication/PubMed/17117926" } ] }, { "title": "Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.", "journal": "Developmental cell", "date": "2006", "authors": "Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "17141155", "url": 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and porcupine impair secretion of the wingless protein.", "journal": "The EMBO journal", "date": "1993", "authors": "van den Heuvel M, Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3238698" } ], "reference": [ { "type": "PubMed", "id": "8262072", "url": "https://glygen.org/publication/PubMed/8262072" } ] }, { "title": "Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.", "journal": "Endocrinology", "date": "1993", "authors": "Schipani E, Karga H, Karaplis AC, Potts JT Jr, Kronenberg HM, Segre GV, Abou-Samra AB, Juppner H", "evidence": [ { "database": "Reactome", "id": "R-HSA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373080" } ], "reference": [ { "type": "PubMed", "id": "8386612", "url": "https://glygen.org/publication/PubMed/8386612" } ] }, { "title": 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"" }, { "name": "endocytic vesicle membrane", "id": "GO:0030666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030666", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 41, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "system development", "id": "GO:0048731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048731", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "tissue development", "id": "GO:0009888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009888", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "trachea cartilage morphogenesis", "id": "GO:0060535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060535", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "establishment or maintenance of polarity of embryonic epithelium", "id": "GO:0016332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016332", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "regulation of cell projection size", "id": "GO:0032536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032536", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "lobar bronchus development", "id": "GO:0060482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060482", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "outer medullary collecting duct development", "id": "GO:0072060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072060", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "metanephric epithelium development", "id": "GO:0072207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072207", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "lung development", "id": "GO:0030324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030324", "evidence": [ { "database": "UniProtKB", "id": "P56706", "url": "https://www.uniprot.org/uniprot/P56706" } ], "pmid": "" }, { "name": "neuron projection 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