{
    "uniprot_canonical_ac": "P56222-1",
    "uniprot_ac": "P56222",
    "uniprot_id": "PO3F2_RAT",
    "mass": {
        "chemical_mass": 47172.0,
        "monoisotopic_mass": 47172.0
    },
    "refseq": {
        "ac": "NP_742082",
        "name": "POU domain, class 3, transcription factor 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742082"
    },
    "gene_names": [
        {
            "name": "Pou3f2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P56222",
            "id": "P56222"
        },
        {
            "name": "Brn-2; oct-7; OTF-7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742082",
            "id": "NP_742082"
        },
        {
            "name": "Brn2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P56222",
            "id": "P56222"
        },
        {
            "name": "Otf7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P56222",
            "id": "P56222"
        },
        {
            "name": "Pou3f2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742082",
            "id": "NP_742082"
        }
    ],
    "protein_names": [
        {
            "name": "POU domain, class 3, transcription factor 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Brain-2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Brain-specific homeobox/POU domain protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Brn-2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Nervous system-specific octamer-binding transcription factor N-Oct-3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "OTF-7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Oct-7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Octamer-binding protein 7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "Octamer-binding transcription factor 7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P56222"
        },
        {
            "name": "POU domain, class 3, transcription factor 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742082",
            "id": "NP_742082"
        },
        {
            "name": "nervous system-specific octamer-binding transcription factor N-Oct-3; brain-specific homeobox/POU domain protein 2; brain-2; protein Brn-2; octamer-binding protein 7; octamer-binding transcription factor 7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742082",
            "id": "NP_742082"
        }
    ],
    "function": [
        {
            "annotation": "Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (PubMed:8276233). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P56222",
                    "url": "https://www.uniprot.org/uniprot/P56222#function"
                },
                {
                    "database": "PubMed",
                    "id": "8276233",
                    "url": "https://glygen.org/publication/PubMed/8276233"
                },
                {
                    "database": "UniProtKB",
                    "id": "P31360",
                    "url": "https://www.uniprot.org/uniprot/P31360#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P56222",
                    "url": "https://www.uniprot.org/uniprot/P56222"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Pou3f2",
            "url": "https://www.uniprot.org/uniprot/P56222",
            "locus": {
                "chromosome": "5",
                "start_pos": 36077930,
                "end_pos": 36083838,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000063836",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000063836"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000006908",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006908",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "29588",
            "url": "https://www.ncbi.nlm.nih.gov/gene/29588",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000327",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000327",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010982",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010982",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013847",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013847",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016362",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016362",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:29588",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29588",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MVHAEPP",
            "url": "https://omabrowser.org/oma/group/MVHAEPP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4250502at2759",
            "url": "http://www.orthodb.org/?query=4250502at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11636",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11636:SF115",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636:SF115",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00157",
            "url": "http://pfam.xfam.org/family/PF00157",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P56222",
            "url": "http://purl.obolibrary.org/obo/PR_P56222",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "61946",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=61946",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "G3V6U5",
            "url": "https://www.uniprot.org/uniprot/G3V6U5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3V6U5-1",
            "url": "https://www.uniprot.org/uniprot/G3V6U5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P56222",
            "url": "https://www.uniprot.org/uniprot/P56222",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P56222-1",
            "url": "https://www.uniprot.org/uniprot/P56222-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLQVQGDYGALQSNGHPLSHAHWITALSHGGSGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANNHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIASQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ",
        "length": 445,
        "header": "sp|P56222-1|PO3F2_RAT Isoform 1 of POU domain, class 3, transcription factor 2  OS=Rattus norvegicus OX=10116 GN=Pou3f2 PE=1 SV=1 CANONICAL=P56222-1"
    },
    "isoforms": [
        {
            "isoform_ac": "G3V6U5-1",
            "url": "",
            "sequence": {
                "sequence": "MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGSGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ",
                "length": 445,
                "header": "tr|G3V6U5-1|PO3F2_RAT Computationally mapped isoform of POU domain, class 3, transcription factor 2  OS=Rattus norvegicus OX=10116 GN=Pou3f2 PE=1 SV=1 CANONICAL=P56222-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 36083768,
                "end_pos": 36082434,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000120257.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000120257.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000078344.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000078344.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P56222-1",
            "url": "",
            "sequence": {
                "sequence": "MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLQVQGDYGALQSNGHPLSHAHWITALSHGGSGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANNHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIASQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ",
                "length": 445,
                "header": "sp|P56222-1|PO3F2_RAT Isoform 1 of POU domain, class 3, transcription factor 2  OS=Rattus norvegicus OX=10116 GN=Pou3f2 PE=1 SV=1 CANONICAL=P56222-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 343,
            "end_pos": 343,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P56222",
                    "url": "https://www.uniprot.org/uniprot/P56222"
                }
            ],
            "site_lbl": "Ser343"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P56222",
                    "url": "https://www.uniprot.org/uniprot/P56222"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        },
        {
            "title": "Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.",
            "journal": "Genes Dev.",
            "date": "1993",
            "authors": "He X., Li P., Rosenfeld M.G., Aggarwal A., Gerrero M.R., Mok M.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P56222",
                    "url": "https://www.uniprot.org/uniprot/P56222"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8276233",
                    "url": "https://glygen.org/publication/PubMed/8276233"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:29588",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29588",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P20265-1",
            "protein_name": "POU domain, class 3, transcription factor 2",
            "gene_name": "POU3F2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ",
                "length": 443
            },
            "evidence": [
                {
                    "id": "45224184",
                    "url": "http://www.informatics.jax.org/homology/45224184",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P31360-1",
            "protein_name": "POU domain, class 3, transcription factor 2",
            "gene_name": "Pou3f2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ",
                "length": 445
            },
            "evidence": [
                {
                    "id": "45224184",
                    "url": "http://www.informatics.jax.org/homology/45224184",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 23,
                "go_terms": [
                    {
                        "name": "regulation of axonogenesis",
                        "id": "GO:0050770",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cerebral cortex radially oriented cell migration",
                        "id": "GO:0021799",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021799",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "forebrain ventricular zone progenitor cell division",
                        "id": "GO:0021869",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021869",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell population proliferation",
                        "id": "GO:0008284",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of gene expression",
                        "id": "GO:0010629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "epidermis development",
                        "id": "GO:0008544",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008544",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to organic substance",
                        "id": "GO:0071310",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071310",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell differentiation",
                        "id": "GO:0045595",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045595",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
                                "url": "https://www.uniprot.org/uniprot/P56222"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "myelination in peripheral nervous system",
                        "id": "GO:0022011",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022011",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P56222",
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                        "name": "neuron development",
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